LOCUS       NM_018951               2648 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens homeobox A10 (HOXA10), transcript variant 1, mRNA.
ACCESSION   NM_018951
VERSION     NM_018951.3  GI:83977447
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2648)
  AUTHORS   Ekici,A.B., Strissel,P.L., Oppelt,P.G., Renner,S.P., Brucker,S.,
            Beckmann,M.W. and Strick,R.
  TITLE     HOXA10 and HOXA13 sequence variations in human female genital
            malformations including congenital absence of the uterus and vagina
  JOURNAL   Gene 518 (2), 267-272 (2013)
   PUBMED   23376215
  REMARK    GeneRIF: Rare DNA sequence variations in the HOXA10 gene could
            contribute to the misdevelopment of female internal genitalia.
REFERENCE   2  (bases 1 to 2648)
  AUTHORS   Gallo,M., Ho,J., Coutinho,F.J., Vanner,R., Lee,L., Head,R.,
            Ling,E.K., Clarke,I.D. and Dirks,P.B.
  TITLE     A tumorigenic MLL-homeobox network in human glioblastoma stem cells
  JOURNAL   Cancer Res. 73 (1), 417-427 (2013)
   PUBMED   23108137
  REMARK    GeneRIF: We found that MLL directly activates the Homeobox gene
            HOXA10 in human glioblastoma
REFERENCE   3  (bases 1 to 2648)
  AUTHORS   Bei,L., Shah,C., Wang,H., Huang,W., Roy,R. and Eklund,E.A.
  TITLE     beta-Catenin activates the HOXA10 and CDX4 genes in myeloid
            progenitor cells
  JOURNAL   J. Biol. Chem. 287 (47), 39589-39601 (2012)
   PUBMED   23038246
  REMARK    GeneRIF: a molecular mechanisms through which increased expression
            of HoxA10 increases Cdx4 expression by direct CDX4 activation and
            by Fgf2-induced beta-catenin activity. This results in Cdx4-induced
            HoxA10-expression, creating a positive feedback mechanism
REFERENCE   4  (bases 1 to 2648)
  AUTHORS   Zhang,Y.J., Jia,X.H., Li,J.C. and Xu,Y.H.
  TITLE     [Effect of HOXA10 gene silenced by shRNA on proliferation and
            apoptosis of U937cell line]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 14 (10), 785-791 (2012)
   PUBMED   23092574
  REMARK    GeneRIF: Compared with the negative control and untreated groups,
            mRNA level of HOXA10 decreased by (92.3+/-1.3)%, protein levels
            decreased by 91.1%, and the inhibition rate of U937 cells
            [(43.9+/-0.7)%] increased in the interference group
REFERENCE   5  (bases 1 to 2648)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2648)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2648)
  AUTHORS   Lowney,P., Corral,J., Detmer,K., LeBeau,M.M., Deaven,L.,
            Lawrence,H.J. and Largman,C.
  TITLE     A human Hox 1 homeobox gene exhibits myeloid-specific expression of
            alternative transcripts in human hematopoietic cells
  JOURNAL   Nucleic Acids Res. 19 (12), 3443-3449 (1991)
   PUBMED   1676505
REFERENCE   8  (bases 1 to 2648)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 2648)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   10 (bases 1 to 2648)
  AUTHORS   Shen,W.F., Largman,C., Lowney,P., Corral,J.C., Detmer,K.,
            Hauser,C.A., Simonitch,T.A., Hack,F.M. and Lawrence,H.J.
  TITLE     Lineage-restricted expression of homeobox-containing genes in human
            hematopoietic cell lines
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (21), 8536-8540 (1989)
   PUBMED   2573064
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX439708.2, BC013971.2 and
            BF196481.1.
            On Dec 23, 2005 this sequence version replaced gi:24497548.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor that
            may regulate gene expression, morphogenesis, and differentiation.
            More specifically, it may function in fertility, embryo viability,
            and regulation of hematopoietic lineage commitment. Alternatively
            spliced transcript variants have been described. Read-through
            transcription also exists between this gene and the downstream
            homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: An upstream start codon is selected for this RefSeq
            based on conservation in at least 24 vertebrate species including
            mouse, rat, human, chimp, macaque, dog, cow, chicken, lizard,
            Xenopus tropicalis, Tetraodon and Fugu. Historically, a start codon
            that is 17 aa downstream has been used as the translation AUG start
            codon. No experimental evidence exists regarding which site is
            preferentially used.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013971.2, BM920206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BX439708.2         1-32
            33-2199             BC013971.2         1-2167
            2200-2563           BF196481.1         10-373              c
            2564-2648           BC013971.2         2534-2618
FEATURES             Location/Qualifiers
     source          1..2648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2648
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="homeobox A10"
                     /db_xref="GeneID:3206"
                     /db_xref="HGNC:5100"
                     /db_xref="MIM:142957"
     exon            1..988
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1..3
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="upstream in-frame stop codon"
     CDS             31..1263
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="homeo box A10; homeobox protein 1H; homeobox
                     protein HOXA10; homeobox protein Hox-1H; homeobox protein
                     Hox-1.8"
                     /codon_start=1
                     /product="homeobox protein Hox-A10"
                     /protein_id="NP_061824.3"
                     /db_xref="GI:182765442"
                     /db_xref="CCDS:CCDS5410.2"
                     /db_xref="GeneID:3206"
                     /db_xref="HGNC:5100"
                     /db_xref="MIM:142957"
                     /translation="

MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAHGGVYLPPAADLPYGLQSCGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALASGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQNRRMKLKKMNRENRIRELTANFNFS

"
     misc_feature    82..84
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="Region: alternative translation initiation codon"
     misc_feature    1039..1215
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1039..1053,1057..1059,1108..1110,1126..1128,
                     1165..1167,1171..1176,1183..1188,1192..1200,1204..1209)
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1045..1047,1054..1056,1174..1176,1183..1188,
                     1195..1197)
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             74..531
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="PMC140663P1"
                     /db_xref="UniSTS:270953"
     STS             121..393
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100657"
                     /db_xref="UniSTS:425454"
     variation       394
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34720764"
     variation       611
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34338986"
     variation       729
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34283323"
     exon            989..2571
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /inference="alignment:Splign:1.39.8"
     STS             1092..1988
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="HOXA10_1370"
                     /db_xref="UniSTS:462252"
     STS             1153..1405
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100649"
                     /db_xref="UniSTS:425446"
     STS             1232..2147
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="ECD00308"
                     /db_xref="UniSTS:281421"
     variation       1233
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34957925"
     STS             1337..1675
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="D7S2774"
                     /db_xref="UniSTS:51285"
     STS             1348..1595
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100648"
                     /db_xref="UniSTS:425445"
     STS             1567..1820
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100647"
                     /db_xref="UniSTS:425444"
     STS             1797..2046
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100646"
                     /db_xref="UniSTS:425443"
     STS             2020..2262
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100645"
                     /db_xref="UniSTS:425442"
     STS             2261..2509
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="REN100644"
                     /db_xref="UniSTS:425441"
     STS             2404..2524
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
                     /standard_name="RH80053"
                     /db_xref="UniSTS:83907"
     polyA_signal    2538..2543
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
     polyA_site      2557
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
     polyA_site      2571
                     /gene="HOXA10"
                     /gene_synonym="HOX1; HOX1.8; HOX1H; PL"
ORIGIN      

taatcgtattcagcatgttttgcacaagaaatgtcagccagaaagggctatctgctcccttcgccaaattatcccacaacaatgtcatgctcggagagccccgccgcgaactcttttttggtcgactcgctcatcagctcgggcagaggcgaggcaggcggcggtggtggtggcgcggggggcggcggcggtggcggttactacgcccacggcggggtctacctgccgcccgccgccgacctgccctacgggctgcagagctgcgggctcttccccacgctgggcggcaagcgcaatgaggcagcgtcgccgggcagcggtggcggtggcgggggtctaggtcccggggcgcacggctacgggccctcgcccatagacctgtggctagacgcgccccggtcttgccggatggagccgcctgacgggccgccgccgccgccccagcagcagccgccgcccccgccgcaaccaccccagccagcgccgcaggccacctcgtgctctttcgcgcagaacatcaaagaagagagctcctactgcctctacgactcggcggacaaatgccccaaagtctcggccaccgccgccgaactggctcccttcccgcggggcccgccgcccgacggctgcgccctgggcacctccagcggggtgccagtgcctggctacttccgcctttctcaggcctacggcaccgccaagggctatggcagcggcggcggcggcgcgcagcaactcggggctggcccgttccccgcgcagcccccggggcgcggtttcgatctcccgcccgcgctagcctccggctcggccgatgcggcccggaaggagcgagccctcgattcgccgccgccccccacgctggcttgcggcagcggcgggggctcgcagggcgacgaggaggcgcacgcgtcgtcctcggccgcggaggagctctccccggccccttccgagagcagcaaagcctcgccggagaaggattccctgggcaattccaaaggtgaaaacgcagccaactggctcacggcaaagagtggtcggaagaagcgctgcccctacacgaagcaccagacactggagctggagaaggagtttctgttcaatatgtaccttactcgagagcggcgcctagagattagccgcagcgtccacctcacggacagacaagtgaaaatctggtttcagaaccgcaggatgaaactgaagaaaatgaatcgagaaaaccggatccgggagctcacagccaactttaatttttcctgatgaatctccaggcgacgcggttttttcacttcccgagcgctggtcccctccctctgtcttcaggctctgcccaggaactcgcacctgtgctggagccctgttcctccctcccacactcgccatctcctgggccgttacatctgtgcagggctggtttgttctgactttttgtttctttgtgtttgcttggtgctggtttatttgttgttttctgggggaaaaagccatatcatgctaaaattctatagagatagatattgtcctaagtgtcaagtcctgactgggctgggtttgctgtcttggggtcccactgctcgaaatggcccctgtcttcggccgagctggtttcctgcccagcctggggcaaacctagccggaaggccgaggtcccattgttggcgctgaggtgtctggcctgaggtcaatggtgcaaaggagccgccaccgggcatgtctgcctggagtgctgtgctgtgtttaatcaggggatacaggcccctgggtttcttttttctttcttcctttcttccttggccaagagaagggcttacaggcatggacatgcaggttggcaaacgggcttgactttggctgatttaaaaagtgagaaagaaagtaaaaaaggttaatttttccttcctctgtaagatatcccagctttaaaaagaaaaaaaaagaattaccaagagaaggggacttctcttccagtttctgtaaggtcttacattgcctgactaaaatgtttcatttacctctaaatttccatatccttctggctgtagataaataatgtagttttgtttatgcatttggaattagtggatttttttgtcattaaaattgttaccactggtaacatgtgacaagcacaccacaattctccctatcttgtgaagttgtttttttaaatcgccttgaacaaaaagttttttttttgtttgtttttgctttctgaaattcacagaagcctaggaggactggggtaagcggaataaactagagaagggagacattgtttggatttcctttatactgtgaagttacatgcataaaagggtcaaacctgtagatgcagaaaaagaaaaaaactataaatacaaatctgtataaatgtctattattatgaagaattgccaatcttgttttaagcaaatgcattctatcgttattataaatgttagttctagctctatttacttctaatcttaaatcagaataaattaatattgtattgctgctgtgcgtggaaaaagacgatgtttatgttcttatagaataaaagctgtggaatgaagctttttaattttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3206 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3206 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3206 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3206 -> Biological process: GO:0001501 [skeletal system development] evidence: IEA
            GeneID:3206 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3206 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
            GeneID:3206 -> Biological process: GO:0007283 [spermatogenesis] evidence: TAS
            GeneID:3206 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3206 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
            GeneID:3206 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
            GeneID:3206 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA