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2024-03-29 01:10:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_018947               5544 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens cytochrome c, somatic (CYCS), mRNA.
ACCESSION   NM_018947
VERSION     NM_018947.5  GI:300863084
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5544)
  AUTHORS   Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager
            PL, Farrer LA, Saykin AJ, Shulman JM and Green RC.
  CONSRTM   The GENAROADS Consortium, and The Alzheimer's Disease Neuroimaging
            Initiative
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement (2013) In press
   PUBMED   23535033
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5544)
  AUTHORS   Li,T., Zeng,L., Gao,W., Cui,M.Z., Fu,X. and Xu,X.
  TITLE     PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial
            apoptotic pathway independent of Bcl-2 family proteins
  JOURNAL   Biochim. Biophys. Acta 1832 (3), 453-474 (2013)
   PUBMED   23207240
  REMARK    GeneRIF: Data indicate that the formation of cytochrome c-Apaf-1
            apoptosome and the presence of Smac are absolutely required for
            PSAP-induced apoptosis.
REFERENCE   3  (bases 1 to 5544)
  AUTHORS   San Francisco,B., Bretsnyder,E.C. and Kranz,R.G.
  TITLE     Human mitochondrial holocytochrome c synthase's heme binding,
            maturation determinants, and complex formation with cytochrome c
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (9), E788-E797 (2013)
   PUBMED   23150584
  REMARK    GeneRIF: Spectroscopic analyses of HCCS alone and complexes of HCCS
            with site-directed variants of cytochrome c revealed the
            fundamental steps of heme attachment and maturation.
REFERENCE   4  (bases 1 to 5544)
  AUTHORS   Simon,M., Metzinger-Le Meuth,V., Chevance,S., Delalande,O. and
            Bondon,A.
  TITLE     Versatility of non-native forms of human cytochrome c: pH and
            micellar concentration dependence
  JOURNAL   J. Biol. Inorg. Chem. 18 (1), 27-38 (2013)
   PUBMED   23070294
  REMARK    GeneRIF: structural characterization of cytochrome c in micelle
REFERENCE   5  (bases 1 to 5544)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     The human genome has 49 cytochrome c pseudogenes, including a relic
            of a primordial gene that still functions in mouse
  JOURNAL   Gene 312, 61-72 (2003)
   PUBMED   12909341
REFERENCE   6  (bases 1 to 5544)
  AUTHORS   Lynch,S.R., Sherman,D. and Copeland,R.A.
  TITLE     Cytochrome c binding affects the conformation of cytochrome a in
            cytochrome c oxidase
  JOURNAL   J. Biol. Chem. 267 (1), 298-302 (1992)
   PUBMED   1309738
REFERENCE   7  (bases 1 to 5544)
  AUTHORS   Garber,E.A. and Margoliash,E.
  TITLE     Interaction of cytochrome c with cytochrome c oxidase: an
            understanding of the high- to low-affinity transition
  JOURNAL   Biochim. Biophys. Acta 1015 (2), 279-287 (1990)
   PUBMED   2153405
REFERENCE   8  (bases 1 to 5544)
  AUTHORS   Evans,M.J. and Scarpulla,R.C.
  TITLE     The human somatic cytochrome c gene: two classes of processed
            pseudogenes demarcate a period of rapid molecular evolution
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (24), 9625-9629 (1988)
   PUBMED   2849112
REFERENCE   9  (bases 1 to 5544)
  AUTHORS   Bedetti,C.D.
  TITLE     Immunocytochemical demonstration of cytochrome c oxidase with an
            immunoperoxidase method: a specific stain for mitochondria in
            formalin-fixed and paraffin-embedded human tissues
  JOURNAL   J. Histochem. Cytochem. 33 (5), 446-452 (1985)
   PUBMED   2580882
REFERENCE   10 (bases 1 to 5544)
  AUTHORS   Ng,S., Smith,M.B., Smith,H.T. and Millett,F.
  TITLE     Effect of modification of individual cytochrome c lysines on the
            reaction with cytochrome b5
  JOURNAL   Biochemistry 16 (23), 4975-4978 (1977)
   PUBMED   199233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004129.2, DB447825.1,
            BC024216.1, AC007487.2 and AI365318.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 20, 2010 this sequence version replaced gi:34328939.
            
            Summary: This gene encodes a small heme protein that functions as a
            central component of the electron transport chain in mitochondria.
            The encoded protein associates with the inner membrane of the
            mitochondrion where it accepts electrons from cytochrome b and
            transfers them to the cytochrome oxidase complex. This protein is
            also involved in initiation of apoptosis. Mutations in this gene
            are associated with autosomal dominant nonsyndromic
            thrombocytopenia. Numerous processed pseudogenes of this gene are
            found throughout the human genome.[provided by RefSeq, Jul 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB447825.1, AL713681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC004129.2         493-495             c
            4-190               DB447825.1         4-190
            191-1363            BC024216.1         133-1305
            1364-5445           AC007487.2         16857-20938         c
            5446-5544           AI365318.1         1-99                c
FEATURES             Location/Qualifiers
     source          1..5544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..5544
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /note="cytochrome c, somatic"
                     /db_xref="GeneID:54205"
                     /db_xref="HGNC:19986"
                     /db_xref="HPRD:00479"
                     /db_xref="MIM:123970"
     exon            1..162
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /inference="alignment:Splign:1.39.8"
     exon            163..339
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /inference="alignment:Splign:1.39.8"
     variation       165
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11267038"
     CDS             171..488
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /codon_start=1
                     /product="cytochrome c"
                     /protein_id="NP_061820.1"
                     /db_xref="GI:11128019"
                     /db_xref="CCDS:CCDS5393.1"
                     /db_xref="GeneID:54205"
                     /db_xref="HGNC:19986"
                     /db_xref="HPRD:00479"
                     /db_xref="MIM:123970"
                     /translation="
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
"
     misc_feature    174..485
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /note="Cytochrome c; Region: Cytochrom_C; cl11414"
                     /db_xref="CDD:214175"
     misc_feature    <174..470
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /note="Cytochrome c, mono- and diheme variants [Energy
                     production and conversion]; Region: CccA; COG2010"
                     /db_xref="CDD:32193"
     misc_feature    174..176
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylglycine; propagated from
                     UniProtKB/Swiss-Prot (P99999.2); acetylation site"
     variation       261
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11548796"
     variation       263
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548779"
     variation       274
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548805"
     variation       285
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11548791"
     variation       290
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11548812"
     variation       300
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548807"
     variation       312
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11548783"
     variation       337
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548795"
     exon            340..5538
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /inference="alignment:Splign:1.39.8"
     variation       412
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11548778"
     variation       433
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11548785"
     variation       455
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3211448"
     STS             607..784
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="SHGC-60475"
                     /db_xref="UniSTS:82647"
     STS             911..1260
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="D1S3438"
                     /db_xref="UniSTS:28510"
     polyA_signal    1338..1343
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
     polyA_site      1363
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
     STS             2499..3171
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     STS             2499..2752
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="GDB:434012"
                     /db_xref="UniSTS:157204"
     STS             2500..3846
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     STS             2507..3132
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="GDB:314949"
                     /db_xref="UniSTS:156503"
     STS             2510..3156
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="L17709"
                     /db_xref="UniSTS:42599"
     STS             2849..3842
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="RH79802"
                     /db_xref="UniSTS:88688"
     STS             3304..3846
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /standard_name="GDB:631813"
                     /db_xref="UniSTS:158430"
     variation       3804
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060388"
     variation       3822
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060389"
     STS             3824..3955
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /db_xref="UniSTS:9484"
     variation       3830..3831
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137505"
     variation       3876
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137509"
     variation       3936
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137510"
     variation       3943
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137511"
     variation       3998
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137512"
     variation       4001
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1137513"
     variation       5445
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3173604"
     polyA_signal    5512..5517
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
     polyA_site      5538
                     /gene="CYCS"
                     /gene_synonym="CYC; HCS; THC4"
ORIGIN      
gtagccgccagctcggccgcacgtcagggcgcgggagcgcggagcgagtttggttgcacttacaccggtacttaagcgcggaccggcgtgtccttggacttagagagtggggacgtccggcttcggagcgggagtgttcgttgtgccagcgactaaaaagagaattaaatatgggtgatgttgagaaaggcaagaagatttttattatgaagtgttcccagtgccacaccgttgaaaagggaggcaagcacaagactgggccaaatctccatggtctctttgggcggaagacaggtcaggcccctggatactcttacacagccgccaataagaacaaaggcatcatctggggagaggatacactgatggagtatttggagaatcccaagaagtacatccctggaacaaaaatgatctttgtcggcattaagaagaaggaagaaagggcagacttaatagcttatctcaaaaaagctactaatgagtaataattggccactgccttatttattacaaaacagaaatgtctcatgacttttttatgtgtaccatcctttaatagatctcatacaccagaattcagatcatgaatgactgacagaatattttgttgggcagtcctgatttaaaactaagactggcttgtggttaaatgaatatgttcagtttttgaattttaatagtaactccaattcagtaaatggtatcactgtttaccccttttaaagatatgattagacttcgttagtaatgttcaacttttcacaaagatggtgagtgccatcttaaaacttactggagattggttttatatttagatttatataactggttatgtgaatatatttaaatactggggaaattgcttcactgtcttagaaccaagcaagattcacctgtgttttgtgttcatgttcatttgcctcttaaaggcaagggttgaagataaataaggtagcaatgtctatagttttggccttaactatgccaatctaattataattccctgtatttaaaatggtttcttttacttattgaaaggcattttagtgtggtttatgtgtaatattaaagattattcaacacctctcacatcttacagatctataaggtcacatgcttttaaaatagtagcaagttaaacttcactcttgaattctttacaatctaagtcaaactaagttataatttaggattgtctttaaacagccattcagaaacaaaactgtagaactgtgtatttgattgggaatggtgcttttgccaacttaaaaggattaaagtaacggagatatacacaaattttaaaattatgtgtgatcacaagactaaagataattaaaaagaaaaccacagatcatgactttttgactgtgcttgatttcatgactgatgcacaaattttaatgattaaaaagtgcaggagccctaaatgtcagtgcagcagccctaaatgtcagtgcagcagtgttaaccagtcatggtgctagattgtttacttggttttctaggactgcctcaactagaataacacttcactaattgactcttagtttctttgctcagattgagaactgcagcatttatgccagacatggacagaggaatgcctgtggtcatagttttgtgatgtgtaacagtgtataattacatactgaattatttcatgcatagtctgtgccatacacatttagagtagtccttggagattttatggagatggtgagcacaaggtaagtcataaagaataatgagaaaataaatctatgctggtgcagctgagaactgtatctttgtgggacagtgagaagactgagaagatgtgaatccatggtctcaaaggtgatagggacgattagataggtgttttaaggcctgaaagcaatttataacatatgagtcttatttttatttatagaaatgtggaaagcttgctgtaattcatatttgaagtcctagtctgagttctggtggggaatttaaaaatgcatcctggaaatcctttaaagatttcagactttgaaaggccttgtagcagaggacttggtgactgtataaagttagtggtattcagggacagtgtagcaagtagcttacaaggggacaattctggactaatgagaaagacctgaagtgaaggctagagagttgattttttttttttttggcatcctggaaatgatacaggaaacatattaagatagatacagaaatgtgttcaaccttccatcttggctagttgtggcgtttagtttgttttttgagacatggtcacgctgtgtcgccaaggctggagtgcagtggtgcgatctcggctggctgcaacctctatttcccaggctcaagcgattctctcacttcagcttcccaagtagctgggactacaggtgttcgccaccatgcccagctaatttttttgtagagatggagttttgccatgtggtcccaggctggtctcaaactcctgagctcaagcaatccgtccacttgccttggctccccaaagtgctgggattacaggcgtgagccaccaggccctgcctggttttcaaattcagaaatcttattatttaacccagaagtaatcagcccagtagtaacttaggtttaattttttttcaggtttaaaatttttctcatttattttttctgagacggagtttcgcccttttcgcccaggctgagtacagtggtgcaatctcactgcaacctccgccttccagttgcaagtgattctcctgcctcagcctcctgagtagctgggattacaggcacccgccaccacgcctggctaatttttgtatttttagtggagatggtgtttcaccatgttggccagactggtcttggactcctgacctcgtgatccacccaccttggcctcccaaagttctaggattacaggtgtgagccaccacgtccggccaatttttctcatttctatgcctcctatattaaggtctgtgttggcacagatgagtaactgccatgttctaggtcagttatacccaagcacttctggtggtttaaaatgtgattctgtaacttttttatttttatttttttgagataatttcactcttgttgcccaggctggagtgcaatggcgtgatcgctgctcaccgcaacctccgccttccaggttcaagcgattctcctgactcagcctctcaagtagctgggattacaagcatgcgccaccatgcccagcttattttgtgtttttagtagagacagggtttctccatgctggacaggctggtcttgaactcccgacgtcaggtgatctacctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccacgcctggccaattatgtaattttttaaaaaggacatttctatcagggatatataccttcagaaataaggaaataggggaaaaaaagagcactataaaccacatgttttcatttctagtgcttcgctgtaagtggctaggttggtagaatcaaaaacaagggccagatgtatttaaggggtattcagatgccacctacatgcttattttgtctagaacagtgctgtctaatagaactttctgtgacgatggatattttgtagacttttgctgtccagtgtggtagccactaaccacatgtggctgttaagcccttgaaatatagctagtgtgactagaaagtattttattttaaatttacataggcacaagtggctagtggctactgtattgacattctgggtctaggactagaaccagtggtctgtaacaaaagtactttctctttactctattaaatctagaattagccgggcatggtcgctcatgcctgtaatcccagcactttgggaggccaaggcaggcagatcacttgaggtcaggcgtttgagaccagcctggtcaacatggcgaaaccctgtctctacaaaaaacataaaaattagccaggtgtggtggtgggcacctgtaatctcagctacttgggaggctgaggcacaagaatcacttgaacttgggaggtggaggttgcagtgagccaagattgtgccactgcactcaagcctgggtgacgagtgaaactgtctccaaaaaaaaaaaaaaatctagaattcttggaagtacattatattgcccttcagaatagattccagttcctgttgtgctcacctttataattttaccataagttttacctattcgtaagttggcagttttagatagataacattctggtggtagctagggatttaccttttgtcatccttttcctgcacttctcttgaattcctttatagatgtacagttttgctttaaccactgaagattgctgtaaattataaagggtgtgatagaatccacatggctgtcaagaaggagatcttaccaaggacagttgactgactagtctcagattgtttcatatcatttatacttgggtaagagtaaactagataactgggcgtcgtggtgcacacctgtagtcccagccactctgaggcaggaggactgcttgtgcccagaagttcgaggctgcagtgtagctgtgattgtgctactgcactccagcctgggcaacagataaaggaaactccatctcttttaaaaaaaaaaaaagtggtctgggtgcagtaggtcatgcctgcaatcccagcactttgggaggccaaggcaggcagatcacctgaggtcaggagcttgagaccagcctggccaacatggtgaaaccccatctctaccaaaaatataaaaactagctgggcgtggtggcggcacctgtaattgcagctatttgagaggctgaggcaggagaatcgcttgaacctgggagatgggggttgcagtgagccaagaccgccccatcgcactccagcctgggcaacaatagtgaaactccgtctcaaaaagaaaaaaagtttccttagaatggaaaatattcattcatgagctcttttggcaatccgtcatcagtatattctgaaaaccaataagatgttgccaagttgggggcgagagctatgtaatgcaaggcatatgcctgatgaagtatacaaatacacctgaccagaaactttgtctcccacataagtctcttctaggcactgtcggggtacatactgagctgctgctttggctgtattttctgtgcctcagaataaccattgtcctggtgttcatatccttagagttcagtacaaaatgttggatatccatttaataggttccaggttatcttagttggagtttggggtatttgaaaacgtcatgccttcaggctatcatttccctcagaaagctaagtaaatttactgcattcatttctcaaagagtaaaagtgcaggttgtatgtgtctatgaacatttaaacatgttaaaatgttaaatttaacattttaaatttaaacatttaaatatgtctgtaacttgaacagtgtagtttcagaaaggaccactgggctagtgtaatgcagaaaatgctgggtctaggattaggagaaaattgtgtttagtgtgtatcaataaacagcccgtggacccaatctgaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:54205 -> Molecular function: GO:0004722 [protein serine/threonine phosphatase activity] evidence: TAS
            GeneID:54205 -> Molecular function: GO:0005506 [iron ion binding] evidence: IEA
            GeneID:54205 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:54205 -> Molecular function: GO:0020037 [heme binding] evidence: TAS
            GeneID:54205 -> Molecular function: GO:0045155 [electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity] evidence: IDA
            GeneID:54205 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: IMP
            GeneID:54205 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:54205 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: TAS
            GeneID:54205 -> Biological process: GO:0022904 [respiratory electron transport chain] evidence: TAS
            GeneID:54205 -> Biological process: GO:0044237 [cellular metabolic process] evidence: TAS
            GeneID:54205 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:54205 -> Biological process: GO:0045333 [cellular respiration] evidence: TAS
            GeneID:54205 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
            GeneID:54205 -> Cellular component: GO:0000159 [protein phosphatase type 2A complex] evidence: TAS
            GeneID:54205 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:54205 -> Cellular component: GO:0005743 [mitochondrial inner membrane] evidence: TAS
            GeneID:54205 -> Cellular component: GO:0005758 [mitochondrial intermembrane space] evidence: TAS
            GeneID:54205 -> Cellular component: GO:0005829 [cytosol] evidence: IMP
            GeneID:54205 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:54205 -> Cellular component: GO:0070469 [respiratory chain] evidence: IEA

by @meso_cacase at DBCLS
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