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2024-04-25 00:01:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018556 1720 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens signal-regulatory protein gamma (SIRPG), transcript
variant 1, mRNA.
ACCESSION NM_018556
VERSION NM_018556.3 GI:94538334
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1720)
AUTHORS Barrett,J.C., Clayton,D.G., Concannon,P., Akolkar,B., Cooper,J.D.,
Erlich,H.A., Julier,C., Morahan,G., Nerup,J., Nierras,C.,
Plagnol,V., Pociot,F., Schuilenburg,H., Smyth,D.J., Stevens,H.,
Todd,J.A., Walker,N.M. and Rich,S.S.
CONSRTM Type 1 Diabetes Genetics Consortium
TITLE Genome-wide association study and meta-analysis find that over 40
loci affect risk of type 1 diabetes
JOURNAL Nat. Genet. 41 (6), 703-707 (2009)
PUBMED 19430480
REFERENCE 2 (bases 1 to 1720)
AUTHORS Kawasaki,M., Sekigawa,I., Nozawa,K., Kaneko,H., Takasaki,Y.,
Takamori,K. and Ogawa,H.
TITLE Changes in the gene expression of peripheral blood mononuclear
cells during the menstrual cycle of females is associated with a
gender bias in the incidence of systemic lupus erythematosus
JOURNAL Clin. Exp. Rheumatol. 27 (2), 260-266 (2009)
PUBMED 19473566
REMARK GeneRIF: tumor necrosis factor receptor superfamily, member 14
(TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to
contribute to gender difference in incidence of systemic lupus
erythematosus.
REFERENCE 3 (bases 1 to 1720)
AUTHORS Stefanidakis,M., Newton,G., Lee,W.Y., Parkos,C.A. and
Luscinskas,F.W.
TITLE Endothelial CD47 interaction with SIRPgamma is required for human
T-cell transendothelial migration under shear flow conditions in
vitro
JOURNAL Blood 112 (4), 1280-1289 (2008)
PUBMED 18524990
REMARK GeneRIF: CD47 is enriched at endothelial junctions, and its
interaction with SIRPgamma is required for human T-cell
transendothelial migration
REFERENCE 4 (bases 1 to 1720)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 5 (bases 1 to 1720)
AUTHORS Barclay,A.N. and Brown,M.H.
TITLE The SIRP family of receptors and immune regulation
JOURNAL Nat. Rev. Immunol. 6 (6), 457-464 (2006)
PUBMED 16691243
REMARK Review article
REFERENCE 6 (bases 1 to 1720)
AUTHORS van den Berg,T.K., van Beek,E.M., Buhring,H.J., Colonna,M.,
Hamaguchi,M., Howard,C.J., Kasuga,M., Liu,Y., Matozaki,T.,
Neel,B.G., Parkos,C.A., Sano,S., Vignery,A., Vivier,E., Wright,M.,
Zawatzky,R. and Barclay,A.N.
TITLE A nomenclature for signal regulatory protein family members
JOURNAL J. Immunol. 175 (12), 7788-7789 (2005)
PUBMED 16339511
REFERENCE 7 (bases 1 to 1720)
AUTHORS Piccio,L., Vermi,W., Boles,K.S., Fuchs,A., Strader,C.A.,
Facchetti,F., Cella,M. and Colonna,M.
TITLE Adhesion of human T cells to antigen-presenting cells through
SIRPbeta2-CD47 interaction costimulates T-cell proliferation
JOURNAL Blood 105 (6), 2421-2427 (2005)
PUBMED 15383453
REFERENCE 8 (bases 1 to 1720)
AUTHORS Brooke,G., Holbrook,J.D., Brown,M.H. and Barclay,A.N.
TITLE Human lymphocytes interact directly with CD47 through a novel
member of the signal regulatory protein (SIRP) family
JOURNAL J. Immunol. 173 (4), 2562-2570 (2004)
PUBMED 15294972
REMARK GeneRIF: a novel member of the signal regulatory protein (SIRP)
family- with unique characteristics from both alpha and beta genes-
termed SIRPgamma
REFERENCE 9 (bases 1 to 1720)
AUTHORS Ichigotani,Y., Matsuda,S., Machida,K., Oshima,K., Iwamoto,T.,
Yamaki,K., Hayakawa,T. and Hamaguchi,M.
TITLE Molecular cloning of a novel human gene (SIRP-B2) which encodes a
new member of the SIRP/SHPS-1 protein family
JOURNAL J. Hum. Genet. 45 (6), 378-382 (2000)
PUBMED 11185750
REFERENCE 10 (bases 1 to 1720)
AUTHORS Kharitonenkov,A., Chen,Z., Sures,I., Wang,H., Schilling,J. and
Ullrich,A.
TITLE A family of proteins that inhibit signalling through tyrosine
kinase receptors
JOURNAL Nature 386 (6621), 181-186 (1997)
PUBMED 9062191
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA008008.1, BC064532.1,
AY748247.1, DB046293.1 and AA446468.1.
On May 4, 2006 this sequence version replaced gi:18426907.
Summary: The protein encoded by this gene is a member of the
signal-regulatory protein (SIRP) family, and also belongs to the
immunoglobulin superfamily. SIRP family members are receptor-type
transmembrane glycoproteins known to be involved in the negative
regulation of receptor tyrosine kinase-coupled signaling processes.
Alternatively spliced transcript variants encoding different
isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
##Evidence-Data-START##
Transcript exon combination :: AK292745.1, BC064532.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025089 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-39 DA008008.1 4-42
40-1159 BC064532.1 1-1120
1160-1229 AY748247.1 762-831
1230-1423 DB046293.1 263-456
1424-1720 AA446468.1 1-297 c
FEATURES Location/Qualifiers
source 1..1720
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20p13"
gene 1..1720
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="signal-regulatory protein gamma"
/db_xref="GeneID:55423"
/db_xref="HGNC:15757"
/db_xref="MIM:605466"
exon 1..138
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
misc_feature 36..38
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="upstream in-frame stop codon"
CDS 66..1229
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="isoform 1 precursor is encoded by transcript
variant 1; signal-regulatory protein beta 2; CD172g
antigen; SIRP beta 2; SIRP-gamma; SIRP-beta-2;
signal-regulatory protein beta-2; CD172 antigen-like
family member B"
/codon_start=1
/product="signal-regulatory protein gamma isoform 1
precursor"
/protein_id="NP_061026.2"
/db_xref="GI:94538335"
/db_xref="CCDS:CCDS13020.2"
/db_xref="GeneID:55423"
/db_xref="HGNC:15757"
/db_xref="MIM:605466"
/translation="
MPVPASWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLLIAVLLGPIYVPWKQKT
"
sig_peptide 66..149
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 150..1226
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/product="signal-regulatory protein gamma isoform 1"
misc_feature 162..482
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="Immunoglobulin V-set domain; Region: V-set;
pfam07686"
/db_xref="CDD:203725"
misc_feature 186..479
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="Immunoglobulin variable domain (IgV); Region: IgV;
cd00099"
/db_xref="CDD:143167"
misc_feature order(228..230,249..251)
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="L1 hypervariable region; other site"
/db_xref="CDD:143167"
misc_feature order(249..254,258..260,429..431)
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="antigen binding site; other site"
/db_xref="CDD:143167"
misc_feature order(252..254,258..260,264..266,270..272,285..287,
291..293,411..413,417..419,423..425,459..461,468..473)
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:143167"
misc_feature 366..368
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="L2 hypervariable region; other site"
/db_xref="CDD:143167"
misc_feature order(429..431,456..458)
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="L3 hypervariable region; other site"
/db_xref="CDD:143167"
misc_feature 495..821
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:213125"
misc_feature 855..1070
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="Immunoglobulin Constant domain; Region: IgC;
cd00098"
/db_xref="CDD:143166"
misc_feature order(867..869,873..875,879..881,885..887,987..998,
1002..1004,1008..1013)
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:143166"
misc_feature 1146..1214
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9P1W8.3);
transmembrane region"
exon 139..495
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
exon 496..813
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
exon 814..1146
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
exon 1147..1231
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
variation 1168
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:35062363"
variation 1181
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:34442420"
exon 1232..1716
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/inference="alignment:Splign:1.39.8"
STS 1352..1495
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/standard_name="SHGC-56794"
/db_xref="UniSTS:53846"
STS 1391..1547
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/standard_name="RH94120"
/db_xref="UniSTS:87507"
variation 1452
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:1048055"
polyA_signal 1697..1703
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
polyA_site 1716
/gene="SIRPG"
/gene_synonym="bA77C3.1; CD172g; SIRP-B2; SIRPB2;
SIRPgamma"
ORIGIN
agagcagggcctgacatctccccagaacagacgtttgaacagagcaggcttctgaggtctccaaaatgcctgtcccagcctcctggccccatcctcctggtcctttcctgcttctgactctactgctgggacttacagaagtggcaggtgaggaggagctacagatgattcagcctgagaagctcctgttggtcacagttggaaagacagccactctgcactgcactgtgacctccctgcttcccgtgggacccgtcctgtggttcagaggagttggaccaggccgggaattaatctacaatcaaaaagaaggccacttccccagggtaacaacagtttcagacctcacaaagagaaacaacatggacttttccatccgcatcagtagcatcaccccagcagatgtcggcacatactactgtgtgaagtttcgaaaagggagccctgagaacgtggagtttaagtctggaccaggcactgagatggctttgggtgccaaaccctctgcccccgtggtattgggccctgcggcgaggaccacacctgagcatacagtgagtttcacctgtgagtcccatggcttctctcccagagacatcaccctgaaatggttcaaaaatgggaatgagctctcagacttccagaccaacgtggaccccacaggacagagtgtggcctacagcatccgcagcacagccagggtggtactggacccctgggacgttcgctctcaggtcatctgcgaggtggcccatgtcaccttgcagggggaccctcttcgtgggactgccaacttgtctgaggccatccgagttccacccaccttggaggttactcaacagcccatgagggtggggaaccaggtaaacgtcacctgccaggtgaggaagttctacccccagagcctacagctgacctggtcggagaatggaaacgtgtgccagagagaaacagcctcgacccttacagagaacaaggatggtacctacaactggacaagctggttcctggtgaacatatctgaccaaagggatgatgtggtcctcacctgccaggtgaagcatgatgggcagctggcggtcagcaaacgccttgccctagaggtcacagtccaccagaaggaccagagctcagatgctacccctggcccggcatcatcccttactgcgctgctcctcatagctgtcctcctgggccccatctacgtcccctggaagcagaagacctgactctccttccttcctcccctgccacgtgggaccctcatctctgctgcctccttcctttcctgagaggctcagcttgagagaatgagccagtgagaagcttctctagacttggctccaaacatctcccctcccaagacatctgcctgcccacaggctcctgttgctccttcacacagacctggatgccccagagcaaggtcttcattcatggtcctgagcaggtgccatgggattgggctctgggcactgacttaacggcacctccctagaaggcgagaaacatgccaaatctaaacacaccaggactcccatccatcgccttgagactgaccgtaaaccacagacgctctccaggttctcaagagttatcctgccttccagattcctgcctatcccaactccccagccttgttgaggttctctattgcctcttgaatacaaatgcactcccaaagtggttttaagaaaataaaaagattatccttccaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55423 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:55423 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:55423 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
GeneID:55423 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:55423 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:55423 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: TAS
GeneID:55423 -> Biological process: GO:0022409 [positive regulation of cell-cell adhesion] evidence: IDA
GeneID:55423 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: TAS
GeneID:55423 -> Biological process: GO:0050870 [positive regulation of T cell activation] evidence: IDA
GeneID:55423 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
GeneID:55423 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:55423 -> Cellular component: GO:0016020 [membrane] evidence: IDA
GeneID:55423 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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