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2024-04-19 19:01:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018471 2149 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens zinc finger CCCH-type containing 15 (ZC3H15), mRNA.
ACCESSION NM_018471
VERSION NM_018471.2 GI:118150659
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2149)
AUTHORS Capalbo,G., Muller-Kuller,T., Dietrich,U., Hoelzer,D., Ottmann,O.G.
and Scheuring,U.J.
TITLE Inhibition of X4-tropic HIV type 1 replication by knockdown of the
cellular protein LEREPO4
JOURNAL AIDS Res. Hum. Retroviruses 26 (10), 1155-1161 (2010)
PUBMED 20925576
REMARK GeneRIF: down-regulation of LEREPO4 expression caused a significant
inhibition of HIV replication
REFERENCE 2 (bases 1 to 2149)
AUTHORS Ishikawa,K., Akiyama,T., Ito,K., Semba,K. and Inoue,J.
TITLE Independent stabilizations of polysomal Drg1/Dfrp1 complex and
non-polysomal Drg2/Dfrp2 complex in mammalian cells
JOURNAL Biochem. Biophys. Res. Commun. 390 (3), 552-556 (2009)
PUBMED 19819225
REFERENCE 3 (bases 1 to 2149)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 4 (bases 1 to 2149)
AUTHORS Gregory,R.C., Lord,K.A., Panek,L.B., Gaines,P., Dillon,S.B. and
Wojchowski,D.M.
TITLE Subtraction cloning and initial characterization of novel
epo-immediate response genes
JOURNAL Cytokine 12 (7), 845-857 (2000)
PUBMED 10880228
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL040058.1 and BC021102.1.
On Nov 19, 2006 this sequence version replaced gi:8923807.
##Evidence-Data-START##
Transcript exon combination :: AF220184.1, AF289586.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-314 AL040058.1 3-316
315-2149 BC021102.1 127-1961
FEATURES Location/Qualifiers
source 1..2149
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q32.1"
gene 1..2149
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/note="zinc finger CCCH-type containing 15"
/db_xref="GeneID:55854"
/db_xref="HGNC:29528"
exon 1..300
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 120
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:151060399"
variation 136
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:112632752"
variation 167
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:370694339"
variation 171
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:11555007"
variation 179
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:373604344"
variation 181
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:367625673"
misc_feature 196..198
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/note="upstream in-frame stop codon"
variation 198
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:201620446"
variation 221
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:370300614"
CDS 226..1506
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/note="DRG family-regulatory protein 1; likely ortholog of
mouse immediate early response erythropoietin 4"
/codon_start=1
/product="zinc finger CCCH domain-containing protein 15"
/protein_id="NP_060941.2"
/db_xref="GI:118150660"
/db_xref="CCDS:CCDS42791.1"
/db_xref="GeneID:55854"
/db_xref="HGNC:29528"
/translation="
MPPKKQAQAGGSKKAEQKKKEKIIEDKTFGLKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNEREGTENGAIDAVPVDENLFTGEDLDELEEELNTLDLEE
"
misc_feature 307..1200
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/note="Uncharacterized conserved protein, contains
CCCH-type Zn-finger protein [General function prediction
only]; Region: COG5252"
/db_xref="CDD:34849"
misc_feature 520..600
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/note="zinc finger; Region: ZnF_C3H1; smart00356"
/db_xref="CDD:197677"
misc_feature 931..1005
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8WU90.1);
Region: Required for interaction with DRG1 (By
similarity)"
misc_feature 1276..1278
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8WU90.1); phosphorylation site"
misc_feature 1366..1368
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8WU90.1); phosphorylation site"
misc_feature 1366..1368
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 229
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:375523117"
exon 301..402
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 312
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:372032569"
variation 390
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:192365428"
variation 394
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="g"
/db_xref="dbSNP:200269989"
exon 403..514
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
exon 515..667
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 576
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:201251883"
variation 579
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:369951838"
exon 668..759
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:370251587"
variation 681
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:373725374"
variation 732
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:376370244"
variation 738
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:141122638"
exon 760..942
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 812
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:75733604"
variation 836
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:200591705"
variation 843
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="g"
/db_xref="dbSNP:199772043"
variation 848
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:368067879"
variation 891
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:3211121"
variation 912
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:200893884"
variation 936
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:80016924"
exon 943..1089
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 987
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:369740479"
variation 1011
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:373154978"
variation 1027
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:140763694"
exon 1090..1191
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 1092
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="g"
/db_xref="dbSNP:376539999"
variation 1115
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:370941106"
variation 1118
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:374300681"
variation 1122
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:78867294"
exon 1192..1315
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 1237
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:181387795"
variation 1244
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:184966157"
variation 1250
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:11555006"
variation 1272
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:115750024"
exon 1316..2134
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/inference="alignment:Splign:1.39.8"
variation 1364
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:200049298"
variation 1387
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:199796169"
variation 1415
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:375616861"
variation 1423
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:200450618"
variation 1446
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:199634188"
variation 1447
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:1043497"
variation 1459
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:372792503"
variation 1479
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:376088217"
variation 1482
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:188110681"
variation 1485
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:368934202"
variation 1519
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:372530132"
variation 1538
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="g"
/db_xref="dbSNP:376346742"
variation 1547
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:190945914"
variation 1580
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:182654681"
variation 1593
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:187614814"
variation 1623
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:148746734"
variation 1651
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="g"
/db_xref="dbSNP:192536764"
STS 1748..2059
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/standard_name="T16069"
/db_xref="UniSTS:60413"
variation 1769
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:16827948"
variation 1900
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="t"
/db_xref="dbSNP:111489577"
variation 1903
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="a"
/replace="c"
/db_xref="dbSNP:184183195"
variation 1907
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="g"
/replace="t"
/db_xref="dbSNP:140181657"
variation 1958
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:187360153"
variation 1976
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace="c"
/replace="t"
/db_xref="dbSNP:145698165"
variation 2023
/gene="ZC3H15"
/gene_synonym="HT010; LEREPO4; MSTP012"
/replace=""
/replace="t"
/db_xref="dbSNP:71658012"
ORIGIN
ggcgcgcacgcgcagctccgcttccgggagccgctcctcgctacccactatgctctgcgacatcgacctgtcgcaaaggccgcgtttgcggggccaatgagcgactcgctttccgtgcggtgcggcgagtgaggccccggtcttcctcctcgtcctgccgcagggccagaacccctgacggtattcagctgcgcgtaagtctggccggtgccatctgtctccgcaatgccccccaagaaacaggctcaggccgggggcagcaaaaaggcggagcaaaaaaagaaggagaagattatcgaagacaaaactttcggtttgaagaataagaaaggagcaaagcaacagaagtttatcaaggctgtcacacatcaagttaaatttggtcaacaaaatccacgtcaggtagcacagagtgaagctgaaaagaaattgaagaaggatgacaagaagaaagaattgcaggagctaaatgagctgttcaaacctgtagttgctgctcaaaaaataagtaaaggtgcagatcccaagtctgtagtatgtgcattcttcaagcaaggacagtgtactaaaggagataagtgtaagttctcccatgacttgactctggagagaaaatgtgaaaagcgaagtgtttacattgatgcaagagatgaagaacttgaaaaagatactatggataattgggatgagaaaaagctggaagaagtagtgaacaagaagcacggtgaggcggaaaagaaaaaaccaaaaactcaaatagtgtgcaagcatttcctggaagctattgaaaacaacaagtatggctggttttgggtatgccctggagggggtgatatttgcatgtatcgtcatgcacttcctcctggatttgtgttgaaaaaagataaaaagaaagaagagaaagaagatgaaatttcattagaagatctaattgagagagagcgttctgccctaggtccaaatgttaccaaaatcactctagaatcttttcttgcctggaagaaaaggaaaagacaagaaaagattgataaacttgaacaagatatggaaagaaggaaagctgacttcaaagcagggaaagcactagtgatcagtggtcgtgaagtgtttgaatttcgtcctgaactggtcaatgatgatgatgaggaagcagatgatacccgctacacccagggaacaggtggtgatgaggttgatgattcagtgagtgtaaatgacatagatttaagcctgtacatcccaagagatgtagatgaaacaggtattactgtagccagtcttgaaagattcagcacatatacttcagataaagatgaaaacaaattaagtgaagcttctggaggtagggctgaaaatggtgaaagaagtgacttggaagaggacaacgagagggagggaacggaaaatggagccattgatgctgttcctgttgatgaaaatcttttcactggagaggatttggatgaactagaagaagaattaaatacacttgatttagaagaatgacaccaaacacatcgctgaaaaaattaagtcagctcagcacgagttgaaattgactacattaatttctttccacctagaatcaacaggatgtttatttcctatgctgattctggaggagttaacctcctgcaaaaaaggcatcttgtccctacatcttctcttctgactttggctacatctcatagtaagttcagagtagttcatgataaattgaaaatataatggtcattgcagaaaatgattgatgttgtaactgtccacccaagtaagaagtgtatctgcctttccatcttttggttttcatttgggcatgtgctattaccagaaacaacaaacttatatttaaaatacccttcatttgacacagtttttaatgagtgatttaatttcctctgtatttgtatgtttagaagactgcctaaaacatgagcactgtacttcataaaggaaactgcgtatgcagattcagtattgtgtatctttggacaattagatggacatttaaaatggaacttcttttatctgacaggatcagctacaatgccctgtgttaaattgtttaaaagtttcccttttcttttttgccaataaagttgtaaataaagaccatcatacattaaaatccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55854 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:55854 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:55854 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: IEA
GeneID:55854 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:55854 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:55854 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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