2024-03-29 21:12:40, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018434 1865 bp mRNA linear PRI 11-MAY-2013 DEFINITION Homo sapiens ring finger protein 130 (RNF130), mRNA. ACCESSION NM_018434 VERSION NM_018434.4 GI:38176162 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1865) AUTHORS Guais,A., Siegrist,S., Solhonne,B., Jouault,H., Guellaen,G. and Bulle,F. TITLE h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes JOURNAL Gene 374, 112-120 (2006) PUBMED 16549277 REMARK GeneRIF: GOLIATH, a paralog of GRAIL, is a new E3 ligase protein, expressed in leukocytes. REFERENCE 2 (bases 1 to 1865) AUTHORS Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z., Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V., Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and Wrana,J.L. TITLE High-throughput mapping of a dynamic signaling network in mammalian cells JOURNAL Science 307 (5715), 1621-1625 (2005) PUBMED 15761153 REFERENCE 3 (bases 1 to 1865) AUTHORS Guais,A., Solhonne,B., Melaine,N., Guellaen,G. and Bulle,F. TITLE Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat leydig cells JOURNAL Biol. Reprod. 70 (1), 204-213 (2004) PUBMED 13679316 REMARK GeneRIF: Cloning and functional analysis of the rat counterpart. REFERENCE 4 (bases 1 to 1865) AUTHORS Baker,S.J. and Reddy,E.P. TITLE Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1 JOURNAL Gene 248 (1-2), 33-40 (2000) PUBMED 10806348 REMARK GeneRIF: Cloning and functional analysis of the mouse counterpart. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX404014.2, AL515761.3, AY083998.1 and BQ447530.1. On Nov 5, 2003 this sequence version replaced gi:29788757. Summary: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AY083998.1, BC108306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-186 BX404014.2 52-237 187-297 AL515761.3 253-363 298-1841 AY083998.1 289-1832 1842-1865 BQ447530.1 1-24 c FEATURES Location/Qualifiers source 1..1865 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5q35.3" gene 1..1865 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="ring finger protein 130" /db_xref="GeneID:55819" /db_xref="HGNC:18280" /db_xref="HPRD:11504" exon 1..654 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" misc_feature 354..356 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="upstream in-frame stop codon" CDS 408..1667 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="g1-related zinc finger protein; goliath homolog; E3 ubiquitin-protein ligase RNF130; H-Goliath" /codon_start=1 /product="E3 ubiquitin-protein ligase RNF130 precursor" /protein_id="NP_060904.2" /db_xref="GI:29788758" /db_xref="CCDS:CCDS4451.1" /db_xref="GeneID:55819" /db_xref="HGNC:18280" /db_xref="HPRD:11504" /translation="
MSCAGRAGPARLAALALLTCSLWPARADNASQEYYTALINVTVQEPGRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFFVPPNIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNLPCTDNVAFDMERLTRTQAVNRRSALGDLAGDNSLGLEPLRTSGISPLPQDGELTPRTGEINIAVTKEWFIIASFGLLSALTLCYMIIRATASLNANEVEWF
" sig_peptide 408..488 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 525..944 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3...; Region: PA_GRAIL_like; cd02122" /db_xref="CDD:80344" misc_feature 825..833 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="PA/protease or protease-like domain interface [polypeptide binding]; other site" /db_xref="CDD:80344" misc_feature 990..1058 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q86XS8.1); transmembrane region" misc_feature 1197..1331 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in...; Region: RING; cd00162" /db_xref="CDD:29102" misc_feature order(1197..1199,1206..1208,1251..1253,1257..1259, 1266..1268,1275..1277,1308..1310,1317..1319) /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /note="cross-brace motif; other site" /db_xref="CDD:29102" misc_feature 1428..1430 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q86XS8.1); phosphorylation site" variation 452 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /replace="a" /replace="c" /db_xref="dbSNP:3828698" variation 515 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:3749821" exon 655..849 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 850..1100 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1101..1172 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1173..1255 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1256..1352 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1353..1557 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1558..1651 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" exon 1652..1847 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /inference="alignment:Splign:1.39.8" polyA_signal 1813..1818 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" polyA_signal 1822..1827 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" polyA_signal 1834..1839 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" polyA_site 1841 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /experiment="experimental evidence, no additional details recorded" polyA_site 1845 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" /experiment="experimental evidence, no additional details recorded" polyA_site 1847 /gene="RNF130" /gene_synonym="G1RZFP; GOLIATH; GP" ORIGIN
cgcgagagggactttgtgttccgctgaccctcctcggggcgcttcctcccgtgccgcccttcccctcccccgccgcgtccttgcgaggcgcctcccattcggtgggaccgacccggggggatggagggggcacgcttctacaaccctcctgggaccccgaagagacgcccgcgtgcgacctgagacgccgccctcgccgagggcccatgggcgcgtccccacaggcgggcagtggacgtgagggcggcgagcggcggggccgcggcgtccaggagggccgcgctcgggctcggccccgcgcaggccgcgcgcgcgcgctcccgccgccgcccgggccgcgcccgccccgcctctaggcgccggccccggagcccggtccgcgagcagcggcggctgccggagggacgatgagctgcgcggggcgggcgggccctgcccggctcgccgcgctcgccctgctgacctgcagcctgtggccggcacgggcagacaacgcgagccaggagtactacacggcgctcatcaacgtgacggtgcaggagcccggccgcggcgccccgctcacgtttcgcatcgaccgcgggcgctacgggcttgactcccccaaggccgaggtccgcggccaggtgctggcgccgctgcccctccacggagttgctgatcatctgggctgtgatccacaaacccggttctttgtccctcctaatatcaaacagtggattgccttgctgcagaggggaaactgcacgtttaaagagaaaatatcacgggccgctttccacaatgcagttgctgtagtcatctacaataataaatccaaagaggagccagttaccatgactcatccaggcactggagatattattgctgtcatgataacagaattgaggggtaaggatattttgagttatctggagaaaaacatctctgtacaaatgacaatagctgttggaactcgaatgccaccgaagaacttcagccgtggctctctagtcttcgtgtcaatatcctttattgttttgatgattatttcttcagcatggctcatattctacttcattcagaagatcaggtacacaaatgcacgcgacaggaaccagcgtcgtctcggagatgcagccaagaaagccatcagtaaattgacaaccaggacagtaaagaagggtgacaaggaaactgacccagactttgatcattgtgcagtctgcatagagagctataagcagaatgatgtcgtccgaattctcccctgcaagcatgttttccacaaatcctgcgtggatccctggcttagtgaacattgtacctgtcctatgtgcaaacttaatatattgaaggccctgggaattgtgccgaatttgccatgtactgataacgtagcattcgatatggaaaggctcaccagaacccaagctgttaaccgaagatcagccctcggcgacctcgccggcgacaactcccttggccttgagccacttcgaacttcggggatctcacctcttcctcaggatggggagctcactccgagaacaggagaaatcaacattgcagtaacaaaagaatggtttattattgccagttttggcctcctcagtgccctcacactctgctacatgatcatcagagccacagctagcttgaatgctaatgaggtagaatggttttgaagaagaaaaaacctgctttctgactgattttgccttgaaggaaaaaagaacctatttttgtgcatcatttaccaatcatgccacacaagcatttatttttagtacattttattttttcataaaattgctaatgccaaagctttgtattaaaagaaataaataataaaataaaaagtctgtaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:55819 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA GeneID:55819 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:55819 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:55819 -> Biological process: GO:0012501 [programmed cell death] evidence: ISS GeneID:55819 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:55819 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:55819 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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