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2024-03-29 21:12:40, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_018434               1865 bp    mRNA    linear   PRI 11-MAY-2013
DEFINITION  Homo sapiens ring finger protein 130 (RNF130), mRNA.
ACCESSION   NM_018434
VERSION     NM_018434.4  GI:38176162
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Guais,A., Siegrist,S., Solhonne,B., Jouault,H., Guellaen,G. and
            Bulle,F.
  TITLE     h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed
            in human leukocytes
  JOURNAL   Gene 374, 112-120 (2006)
   PUBMED   16549277
  REMARK    GeneRIF: GOLIATH, a paralog of GRAIL, is a new E3 ligase protein,
            expressed in leukocytes.
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Guais,A., Solhonne,B., Melaine,N., Guellaen,G. and Bulle,F.
  TITLE     Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing
            hormone/human chorionic gonadotropin in rat leydig cells
  JOURNAL   Biol. Reprod. 70 (1), 204-213 (2004)
   PUBMED   13679316
  REMARK    GeneRIF: Cloning and functional analysis of the rat counterpart.
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Baker,S.J. and Reddy,E.P.
  TITLE     Cloning of murine G1RP, a novel gene related to Drosophila
            melanogaster g1
  JOURNAL   Gene 248 (1-2), 33-40 (2000)
   PUBMED   10806348
  REMARK    GeneRIF: Cloning and functional analysis of the mouse counterpart.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX404014.2, AL515761.3,
            AY083998.1 and BQ447530.1.
            On Nov 5, 2003 this sequence version replaced gi:29788757.
            
            Summary: The protein encoded by this gene contains a RING finger
            motif and is similar to g1, a Drosophila zinc-finger protein that
            is expressed in mesoderm and involved in embryonic development. The
            expression of the mouse counterpart was found to be upregulated in
            myeloblastic cells following IL3 deprivation, suggesting that this
            gene may regulate growth factor withdrawal-induced apoptosis of
            myeloid precursor cells. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY083998.1, BC108306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               BX404014.2         52-237
            187-297             AL515761.3         253-363
            298-1841            AY083998.1         289-1832
            1842-1865           BQ447530.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1865
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="ring finger protein 130"
                     /db_xref="GeneID:55819"
                     /db_xref="HGNC:18280"
                     /db_xref="HPRD:11504"
     exon            1..654
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    354..356
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="upstream in-frame stop codon"
     CDS             408..1667
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="g1-related zinc finger protein; goliath homolog; E3
                     ubiquitin-protein ligase RNF130; H-Goliath"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RNF130 precursor"
                     /protein_id="NP_060904.2"
                     /db_xref="GI:29788758"
                     /db_xref="CCDS:CCDS4451.1"
                     /db_xref="GeneID:55819"
                     /db_xref="HGNC:18280"
                     /db_xref="HPRD:11504"
                     /translation="
MSCAGRAGPARLAALALLTCSLWPARADNASQEYYTALINVTVQEPGRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFFVPPNIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNLPCTDNVAFDMERLTRTQAVNRRSALGDLAGDNSLGLEPLRTSGISPLPQDGELTPRTGEINIAVTKEWFIIASFGLLSALTLCYMIIRATASLNANEVEWF
"
     sig_peptide     408..488
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    525..944
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="PA _GRAIL_like: Protease-associated (PA) domain
                     GRAIL-like. This group includes PA domain containing E3
                     (ubiquitin ligases) similar to human GRAIL (gene related
                     to anergy in lymphocytes) protein. Proteins in this group
                     contain a C3H2C3 RING finger. E3...; Region:
                     PA_GRAIL_like; cd02122"
                     /db_xref="CDD:80344"
     misc_feature    825..833
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="PA/protease or protease-like domain interface
                     [polypeptide binding]; other site"
                     /db_xref="CDD:80344"
     misc_feature    990..1058
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XS8.1);
                     transmembrane region"
     misc_feature    1197..1331
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="RING-finger (Really Interesting New Gene) domain, a
                     specialized type of Zn-finger of 40 to 60 residues that
                     binds two atoms of zinc; defined by the 'cross-brace'
                     motif C-X2-C-X(9-39)-C-X(1-3)-
                     H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
                     in...; Region: RING; cd00162"
                     /db_xref="CDD:29102"
     misc_feature    order(1197..1199,1206..1208,1251..1253,1257..1259,
                     1266..1268,1275..1277,1308..1310,1317..1319)
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:29102"
     misc_feature    1428..1430
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q86XS8.1); phosphorylation site"
     variation       452
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3828698"
     variation       515
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3749821"
     exon            655..849
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            850..1100
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1101..1172
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1173..1255
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1256..1352
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1353..1557
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1558..1651
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     exon            1652..1847
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    1813..1818
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
     polyA_signal    1822..1827
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
     polyA_signal    1834..1839
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
     polyA_site      1841
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      1845
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      1847
                     /gene="RNF130"
                     /gene_synonym="G1RZFP; GOLIATH; GP"
ORIGIN      
cgcgagagggactttgtgttccgctgaccctcctcggggcgcttcctcccgtgccgcccttcccctcccccgccgcgtccttgcgaggcgcctcccattcggtgggaccgacccggggggatggagggggcacgcttctacaaccctcctgggaccccgaagagacgcccgcgtgcgacctgagacgccgccctcgccgagggcccatgggcgcgtccccacaggcgggcagtggacgtgagggcggcgagcggcggggccgcggcgtccaggagggccgcgctcgggctcggccccgcgcaggccgcgcgcgcgcgctcccgccgccgcccgggccgcgcccgccccgcctctaggcgccggccccggagcccggtccgcgagcagcggcggctgccggagggacgatgagctgcgcggggcgggcgggccctgcccggctcgccgcgctcgccctgctgacctgcagcctgtggccggcacgggcagacaacgcgagccaggagtactacacggcgctcatcaacgtgacggtgcaggagcccggccgcggcgccccgctcacgtttcgcatcgaccgcgggcgctacgggcttgactcccccaaggccgaggtccgcggccaggtgctggcgccgctgcccctccacggagttgctgatcatctgggctgtgatccacaaacccggttctttgtccctcctaatatcaaacagtggattgccttgctgcagaggggaaactgcacgtttaaagagaaaatatcacgggccgctttccacaatgcagttgctgtagtcatctacaataataaatccaaagaggagccagttaccatgactcatccaggcactggagatattattgctgtcatgataacagaattgaggggtaaggatattttgagttatctggagaaaaacatctctgtacaaatgacaatagctgttggaactcgaatgccaccgaagaacttcagccgtggctctctagtcttcgtgtcaatatcctttattgttttgatgattatttcttcagcatggctcatattctacttcattcagaagatcaggtacacaaatgcacgcgacaggaaccagcgtcgtctcggagatgcagccaagaaagccatcagtaaattgacaaccaggacagtaaagaagggtgacaaggaaactgacccagactttgatcattgtgcagtctgcatagagagctataagcagaatgatgtcgtccgaattctcccctgcaagcatgttttccacaaatcctgcgtggatccctggcttagtgaacattgtacctgtcctatgtgcaaacttaatatattgaaggccctgggaattgtgccgaatttgccatgtactgataacgtagcattcgatatggaaaggctcaccagaacccaagctgttaaccgaagatcagccctcggcgacctcgccggcgacaactcccttggccttgagccacttcgaacttcggggatctcacctcttcctcaggatggggagctcactccgagaacaggagaaatcaacattgcagtaacaaaagaatggtttattattgccagttttggcctcctcagtgccctcacactctgctacatgatcatcagagccacagctagcttgaatgctaatgaggtagaatggttttgaagaagaaaaaacctgctttctgactgattttgccttgaaggaaaaaagaacctatttttgtgcatcatttaccaatcatgccacacaagcatttatttttagtacattttattttttcataaaattgctaatgccaaagctttgtattaaaagaaataaataataaaataaaaagtctgtaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55819 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
            GeneID:55819 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:55819 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:55819 -> Biological process: GO:0012501 [programmed cell death] evidence: ISS
            GeneID:55819 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:55819 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:55819 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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