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2024-03-29 07:56:54, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_018218               5623 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ubiquitin specific peptidase 40 (USP40), mRNA.
ACCESSION   NM_018218 XM_291008
VERSION     NM_018218.2  GI:116063563
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5623)
  AUTHORS   Zhao,B., Song,W., Chen,Y.P., Huang,R., Chen,K., Cao,B., Yang,Y. and
            Shang,H.F.
  TITLE     Association analysis of single-nucleotide polymorphisms of USP24
            and USP40 with Parkinson's disease in the Han Chinese population
  JOURNAL   Eur. Neurol. 68 (3), 181-184 (2012)
   PUBMED   22923019
  REMARK    GeneRIF: present study is the first to report a lack of association
            between SNPs of USP40 and parkinson disease in Han Chinese
            patients. Other
REFERENCE   2  (bases 1 to 5623)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet. 8 (3), E1002559 (2012)
   PUBMED   22412388
REFERENCE   3  (bases 1 to 5623)
  AUTHORS   Bielinski,S.J., Chai,H.S., Pathak,J., Talwalkar,J.A., Limburg,P.J.,
            Gullerud,R.E., Sicotte,H., Klee,E.W., Ross,J.L., Kocher,J.P.,
            Kullo,I.J., Heit,J.A., Petersen,G.M., de Andrade,M. and Chute,C.G.
  TITLE     Mayo Genome Consortia: a genotype-phenotype resource for
            genome-wide association studies with an application to the analysis
            of circulating bilirubin levels
  JOURNAL   Mayo Clin. Proc. 86 (7), 606-614 (2011)
   PUBMED   21646302
REFERENCE   4  (bases 1 to 5623)
  AUTHORS   Wu,Y.R., Chen,C.M., Chen,Y.C., Chao,C.Y., Ro,L.S., Fung,H.C.,
            Hsiao,Y.C., Hu,F.J. and Lee-Chen,G.J.
  TITLE     Ubiquitin specific proteases USP24 and USP40 and ubiquitin
            thiolesterase UCHL1 polymorphisms have synergic effect on the risk
            of Parkinson's disease among Taiwanese
  JOURNAL   Clin. Chim. Acta 411 (13-14), 955-958 (2010)
   PUBMED   20302855
  REMARK    GeneRIF: USP24 alone plays a role in PD susceptibility among
            Taiwanese people >or=60 years of age, or acting synergistically
            with USP40 and UCHL1 in the total subjects.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 5623)
  AUTHORS   Li,Y., Schrodi,S., Rowland,C., Tacey,K., Catanese,J. and Grupe,A.
  TITLE     Genetic evidence for ubiquitin-specific proteases USP24 and USP40
            as candidate genes for late-onset Parkinson disease
  JOURNAL   Hum. Mutat. 27 (10), 1017-1023 (2006)
   PUBMED   16917932
  REMARK    GeneRIF: Da suggest that genetic variants in USP40 affect the risk
            for late-onset Parkinson disease (PD), which is consistent with the
            predicted role of the ubiquitination pathway in PD etiology.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5623)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
REFERENCE   7  (bases 1 to 5623)
  AUTHORS   Quesada,V., Diaz-Perales,A., Gutierrez-Fernandez,A., Garabaya,C.,
            Cal,S. and Lopez-Otin,C.
  TITLE     Cloning and enzymatic analysis of 22 novel human ubiquitin-specific
            proteases
  JOURNAL   Biochem. Biophys. Res. Commun. 314 (1), 54-62 (2004)
   PUBMED   14715245
REFERENCE   8  (bases 1 to 5623)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat. Rev. Genet. 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
REFERENCE   9  (bases 1 to 5623)
  AUTHORS   Bass,B.L.
  TITLE     RNA editing by adenosine deaminases that act on RNA
  JOURNAL   Annu. Rev. Biochem. 71, 817-846 (2002)
   PUBMED   12045112
  REMARK    Review article
REFERENCE   10 (bases 1 to 5623)
  AUTHORS   Chen,X., Zhang,Y., Douglas,L. and Zhou,P.
  TITLE     UV-damaged DNA-binding proteins are targets of CUL-4A-mediated
            ubiquitination and degradation
  JOURNAL   J. Biol. Chem. 276 (51), 48175-48182 (2001)
   PUBMED   11673459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ583821.2, AC019072.8, AK001647.1, AL833371.1 and AI375976.1.
            On Oct 12, 2006 this sequence version replaced gi:41055952.
            
            Summary: Modification of cellular proteins by ubiquitin is an
            essential regulatory mechanism controlled by the coordinated action
            of multiple ubiquitin-conjugating and deubiquitinating enzymes.
            USP40 belongs to a large family of cysteine proteases that function
            as deubiquitinating enzymes (Quesada et al., 2004 [PubMed
            14715245]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ583821.2 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1194              AJ583821.2         1-1194
            1195-1203           AC019072.8         135341-135349
            1204-3462           AK001647.1         1166-3424
            3463-5610           AL833371.1         575-2722
            5611-5623           AI375976.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..5623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..5623
                     /gene="USP40"
                     /note="ubiquitin specific peptidase 40"
                     /db_xref="GeneID:55230"
                     /db_xref="HGNC:20069"
                     /db_xref="HPRD:07166"
                     /db_xref="MIM:610570"
     CDS             1..3744
                     /gene="USP40"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin specific protease 40;
                     ubiquitin-specific-processing protease 40;
                     deubiquitinating enzyme 40; ubiquitin thioesterase 40;
                     ubiquitin thiolesterase 40"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase 40"
                     /protein_id="NP_060688.1"
                     /db_xref="GI:41055953"
                     /db_xref="CCDS:CCDS46547.1"
                     /db_xref="GeneID:55230"
                     /db_xref="HGNC:20069"
                     /db_xref="HPRD:07166"
                     /db_xref="MIM:610570"
                     /translation="
MSLFLRVVFSFTMFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEEKSKPDVNLKDLQSEEEIDHPLMILKAILLEENNLIPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFLQLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWFDINDSKVQPIREKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMDAANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWNGVEVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVIESPHVFPANAEVGTVLTALAIPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSILIQDSHDDNSLLTKEEKWVTSMNEIDWLHVKNLCQLESEEKQVKISATVNTMVFDIRIKAIKELKLMKELADNSCLRPIDRNGKLLCPVPDSYTLKEAELKMGSSLGLCLGKAPSSSQLFLFFAMGSDVQPGTEMEIVVEETISVRDCLKLMLKKSGLQGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIHVGSFR
"
     misc_feature    151..1068
                     /gene="USP40"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; Region:
                     peptidase_C19C; cd02659"
                     /db_xref="CDD:73065"
     misc_feature    157..969
                     /gene="USP40"
                     /note="Ubiquitin carboxyl-terminal hydrolase; Region:
                     UCH_1; pfam13423"
                     /db_xref="CDD:205601"
     misc_feature    order(169..171,184..186,949..951,1003..1005)
                     /gene="USP40"
                     /note="active site"
                     /db_xref="CDD:73065"
     misc_feature    <1378..1476
                     /gene="USP40"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; Region:
                     Peptidase_C19; cd02257"
                     /db_xref="CDD:73062"
     exon            1..235
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       7..8
                     /gene="USP40"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:371356658"
     variation       13..14
                     /gene="USP40"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:112086362"
     variation       14..15
                     /gene="USP40"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:60563116"
     exon            236..303
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            304..417
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            418..582
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            583..729
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            730..873
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            874..1002
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1003..1098
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1099..1203
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       1195
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2167884"
     exon            1204..1504
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1505..1586
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1587..1758
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1759..1843
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1844..1914
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            1915..2234
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       2033
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:838543"
     exon            2235..2358
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2359..2416
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2417..2470
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2471..2559
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2560..2646
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       2612
                     /gene="USP40"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2602392"
     exon            2647..2683
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2684..2748
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2749..2823
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2824..2950
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            2951..3045
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            3046..3164
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            3165..3230
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            3231..3441
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       3285
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2603547"
     variation       3367
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1048603"
     exon            3442..3537
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            3538..3632
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     exon            3633..5617
                     /gene="USP40"
                     /inference="alignment:Splign:1.39.8"
     variation       4030
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2242096"
     variation       4073
                     /gene="USP40"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2924809"
     variation       4506
                     /gene="USP40"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2242097"
     STS             5075..5263
                     /gene="USP40"
                     /standard_name="RH102130"
                     /db_xref="UniSTS:96464"
     variation       5186
                     /gene="USP40"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7724"
     STS             5333..5572
                     /gene="USP40"
                     /standard_name="RH79707"
                     /db_xref="UniSTS:84266"
     STS             5406..5531
                     /gene="USP40"
                     /standard_name="RH94290"
                     /db_xref="UniSTS:83890"
     polyA_signal    5587..5592
                     /gene="USP40"
     polyA_site      5609
                     /gene="USP40"
ORIGIN      
atgtcactttttttaagggtagtatttagtttcacaatgtttggggacctgtttgaagaggagtattccactgtgtctaataatcagtatggaaaagggaagaaattaaagactaaagctttggagccacctgctcctagagaattcaccaatttaagcggaatcagaaatcagggtggaacctgttacctcaattcccttcttcagactcttcatttcacacctgaattcagagaagctctattttctcttggcccagaagagcttggtttgtttgaagataaggataaacccgatgcaaaggttcgaatcatccctttacagttacagcgcttgtttgctcagcttctgctcttagaccaggaagctgcatccacagcagacctcactgacagctttgggtggaccagtaatgaggaaatgaggcaacatgatgtgcaggaactgaatcgaatcctcttcagcgctttggaaacttctttagttgggacctccggtcatgacctcatctatcgtctgtaccatggaaccattgttaaccagattgtttgtaaagaatgtaagaacgttagcgagaggcaggaagacttcttagatctaacagtagcagtcaaaaatgtatccggtttggaagatgctctctggaacatgtatgtagaagaggaagtttttgattgtgacaacttgtaccactgtggaacttgtgacaggctggttaaagcagcaaagtcggccaaattacgtaagctgcctccttttcttactgtttcattactaagatttaattttgattttgtgaaatgcgaacgctacaaggaaactagctgttatacattccctctccggattaatctcaagcccttttgtgaacagagtgaattggatgacttagaatatatatatgacctcttctcagttattatacacaaaggtggctgctacggaggccattaccatgtatatattaaagatgttgatcatttgggaaactggcagtttcaagaggaaaaaagtaaaccagatgtgaatctgaaagatctccagagtgaagaagagattgatcatccactgatgattctaaaagcaatcttattagaggagaataatctaattcctgttgatcagctgggccagaaacttttgaaaaagataggaatatcttggaacaagaagtacagaaaacagcatggaccactgcggaagttcttacagctccattctcagatatttctactcagttcagatgaaagtacagttcgtctcttgaagaatagttctctccaggctgagtctgatttccaaaggaatgaccagcaaattttcaagatgcttcctccagaatccccaggtttaaacaatagcatctcctgtccccactggtttgatataaatgattctaaagtccagccaatcagggaaaaggatattgaacagcaatttcagggtaaagaaagtgcctacatgttgttttatcggaaatcccagttgcagagaccccctgaagctcgagctaatccaagatatggggttccatgtcatttactgaatgaaatggatgcagctaacattgaactgcaaaccaaaagggcagaatgtgattctgcaaacaatacttttgaattgcatcttcacctgggccctcagtatcatttcttcaatggggctctgcacccagtagtctctcaaacagaaagcgtgtgggatttgacctttgataaaagaaaaactttaggagatctccggcagtcaatatttcagctgttagaattttgggaaggagacatggttcttagtgttgcaaagcttgtaccagcaggacttcacatttaccagtcacttggcggggatgaactgacactgtgtgaaactgaaattgctgatggggaagacatctttgtgtggaatggggtggaggttggtggagtccacattcaaactggtattgactgcgaacctctacttttaaatgttcttcatctagacacaagcagtgatggagaaaagtgttgtcaggtgatagaatctccacatgtctttccagctaatgcagaagtgggcactgtcctcacagccttagcaatcccagcaggtgtcatcttcatcaacagtgctggatgtccaggtggggagggttggacggccatccccaaggaagacatgaggaagacgttcagggagcaagggctcagaaatggaagctcaattttaattcaggattctcatgatgataacagcttgttgaccaaggaagagaaatgggtcactagtatgaatgagattgactggctccacgttaaaaatttatgccagttagaatctgaagagaagcaagttaaaatatcagcaactgttaacacaatggtgtttgatattcgaattaaagccataaaggaattaaaattaatgaaggaactagctgacaacagctgtttgagacctattgatagaaatgggaagcttctttgtccagtgccggacagctatactttgaaggaagcagaattgaagatgggaagttcattgggactgtgtcttggaaaagcaccaagttcgtctcagttgttcctgttttttgcaatggggagtgacgttcaacctgggacagaaatggaaatcgtagtagaagaaacaatatctgtgagagattgtttaaagttaatgctgaagaaatctggcctacaaggagatgcctggcatttacgaaaaatggattggtgctatgaagctggagagcctttatgtgaagaagatgcaacactgaaagaacttctgatatgttctggagatactttgcttttaattgaaggacaacttcctcctctgggtttcctgaaggtgcccatctggtggtaccagcttcagggtccctcaggacactgggagagtcatcaggaccagaccaactgtacttcgtcttggggcagagtttggagagccacttccagccaaggtgcttctgggaacgagcctgcgcaagtttctctcctctacttgggagacatagagatctcagaagatgccacgctggcggagctgaagtctcaggccatgaccttgcctcctttcctggagttcggtgtcccgtccccagcccacctcagagcctggacggtggagaggaagcgcccaggcaggcttttacgaactgaccggcagccactcagggaatataaactaggacggagaattgagatctgcttagagccccttcagaaaggcgaaaacttgggcccccaggacgtgctgctgaggacacaggtgcgcatccctggtgagaggacctatgcccctgccctggacctggtgtggaacgcggcccagggtgggactgccggctccctgaggcagagagttgccgatttctatcgtcttcccgtggagaagattgaaattgccaaatactttcccgaaaagttcgagtggcttccgatatctagctggaaccaacaaataaccaagaggaaaaagaaaaaaaaacaagattatttgcaaggggcaccgtattacttgaaagacggagatactattggtgttaagaatctcctgattgacgacgatgatgatttcagtacaatcagagatgacactggaaaagaaaagcagaaacaacgggccctggggagaaggaaaagccaagaagccctccatgagcagagcagctacatcctctccagtgcagagacgcctgcccggccccgagccccggaaacttctctctccatccacgtggggagcttcagataaccgcgccgctgcacggctctactcccgatgaactctccggctgatgccacaaacgtgggtttcctgggcatggggactggctgcctggcgcctccaatcccaaatcctctgcttcctttgagcacagggacggctcctctgaggcctggccagtgcatgtagtcacttagctctgcaacacgtggcagccacgggggctggtgcagctctggatgtcgcccacccagctgccagtaggtgctgggctctctcacacagcacccggccccagctgcctttttttttcttttaaccagaaaatgcacaacgtgtgcgtgaaccgcaggtatggaggcagcggcatgccgttgctccgctgtgggaggtgtgtggggtcaggccagccactttcctccgtgttcagatgactctcgttcgccctgaccggcttctcacagtgtctcaggccactgcgccaccgcgctggtgctgagcagaagcgggcagaagtggggtctgctttcaggacttcatttcccccactcgttccggccccgcatgctccacgtctgccctttggtctgagttaaaactgcgatgctgaaaagtgcgagctctttccacgaggaggagccacacagggtggcctccgagggtgagtcgctctgctaagcaagggcagccgctgcacgtcagcccgcaggccaagggtccagcttatcctgggtgctctgtgatcagaaggtccttggatcccgaggactgcagctgctgccgtccacagcgcctcagcctctcttcctgtgtggaagcggggcaggcagggctgtggcagacaggcctggcatagcccaggttccaggtgtcctgggcagcctgaccggtttcctgagtagcctcaatgaaaacacctgagaaaaagaaaatgtaaactaaggaagggttttcccacttaatccaacccagatttctattcaacttaaaggatttaattggcatttgtgagaaataatagtacctgtgtcactgagttgattgatttgggacatagacggttgactttcccagacagcagcttagcggaaagcagcatcccgaagacggtgtcgcatgtcctgagcctgcttgtcacctgggcctcacggtttctcgtcagccccgtcactgatgggaagcagcactgaagtgtgagggcagaaaggacaccgctggagtcaggcgctcccctgcctgtgacccttttccaacaagctgatgctgagccagcggcctgctttgtccctcatactcctcccaacagtccaaacccctaccagacagaagccacgtcgcttctgcacacgtgtctgagagcgtctgccatagacgtctgtgcgtttccgtgaagcactgcgccctaaggacccaactctgactagcagctgcctcccactcccaaacactaaccccgctcaggagactcgcactgggtgtagactgcgtctttgcagagggagatgatagaggcttctgatgacgccagagctgtaagtgtcgtgacgagctgggcgcccagcccttcttaagctgttctgtttctgtggctttaactgacatatttctgtagcatctgccttcatctcatctcagcgtaatgaaatattaatgaaatcgctgaaaagctttgccttcgagaggccagaagcctcgcggaatgtctgcaagtccaaagacgcgtgtgggttgtgccctgaagtgccgtccagcaggcgcgtgcggccgggccggcctgtgcgtgtggcctttgccttcttccctttcttcctgttttctgtttttttaatttggggattgagaaagctgtacgattttgttaaagaaaaaaataaaccattttttaaagttgtagcccttaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55230 -> Molecular function: GO:0004221 [ubiquitin thiolesterase activity] evidence: IEA
            GeneID:55230 -> Molecular function: GO:0008234 [cysteine-type peptidase activity] evidence: IEA
            GeneID:55230 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_060688 -> EC 3.4.19.12

by @meso_cacase at DBCLS
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