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2020-10-26 19:45:07, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_018207               3865 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens tripartite motif containing 62 (TRIM62), mRNA.
ACCESSION   NM_018207
VERSION     NM_018207.2  GI:217035094
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3865)
  AUTHORS   Lott,S.T., Chen,N., Chandler,D.S., Yang,Q., Wang,L., Rodriguez,M.,
            Xie,H., Balasenthil,S., Buchholz,T.A., Sahin,A.A., Chaung,K.,
            Zhang,B., Olufemi,S.E., Chen,J., Adams,H., Band,V., El-Naggar,A.K.,
            Frazier,M.L., Keyomarsi,K., Hunt,K.K., Sen,S., Haffty,B.,
            Hewitt,S.M., Krahe,R. and Killary,A.M.
  TITLE     DEAR1 is a dominant regulator of acinar morphogenesis and an
            independent predictor of local recurrence-free survival in
            early-onset breast cancer
  JOURNAL   PLoS Med. 6 (5), E1000068 (2009)
   PUBMED   19536326
  REMARK    GeneRIF: The evidence for the genetic alteration and loss of
            expression of DEAR1 in breast cancer and for the functional role of
            DEAR1 in the dominant regulation of acinar morphogenesis in 3D
            culture
REFERENCE   2  (bases 1 to 3865)
  AUTHORS   Muthuswamy,S.K.
  TITLE     A new tumor suppressor that regulates tissue architecture
  JOURNAL   PLoS Med. 6 (5), E1000073 (2009)
   PUBMED   19536324
  REMARK    GeneRIF: DEAR1 is a predictive biomarker for early onset breast
            cancer.
REFERENCE   3  (bases 1 to 3865)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res. 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA338982.1, BM722392.1, BC007999.1, AK001621.1 and CX872720.1.
            On Dec 10, 2008 this sequence version replaced gi:8922647.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001222.1, AK001621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               DA338982.1         11-568
            559-1009            BM722392.1         214-664
            1010-2463           BC007999.1         405-1858
            2464-2953           AK001621.1         2060-2549
            2954-3305           CX872720.1         358-709
            3306-3865           BC007999.1         2700-3259
FEATURES             Location/Qualifiers
     source          1..3865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..3865
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="tripartite motif containing 62"
                     /db_xref="GeneID:55223"
                     /db_xref="HGNC:25574"
     exon            1..1046
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    264..266
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="upstream in-frame stop codon"
     CDS             639..2066
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="ductal epithelium-associated RING Chromosome 1;
                     tripartite motif-containing 62"
                     /codon_start=1
                     /product="tripartite motif-containing protein 62"
                     /protein_id="NP_060677.2"
                     /db_xref="GI:217035095"
                     /db_xref="CCDS:CCDS376.1"
                     /db_xref="GeneID:55223"
                     /db_xref="HGNC:25574"
                     /translation="
MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
"
     misc_feature    657..803
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="Zinc finger, C3HC4 type (RING finger); Region:
                     zf-C3HC4_2; pfam13923"
                     /db_xref="CDD:206094"
     misc_feature    669..809
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="RING-finger (Really Interesting New Gene) domain, a
                     specialized type of Zn-finger of 40 to 60 residues that
                     binds two atoms of zinc; defined by the 'cross-brace'
                     motif C-X2-C-X(9-39)-C-X(1-3)-
                     H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
                     in...; Region: RING; cd00162"
                     /db_xref="CDD:29102"
     misc_feature    order(669..671,678..680,714..716,720..722,729..731,
                     738..740,786..788,795..797)
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="cross-brace motif; other site"
                     /db_xref="CDD:29102"
     misc_feature    900..1022
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="B-Box-type zinc finger; zinc binding domain
                     (CHC3H2); often present in combination with other motifs,
                     like RING zinc finger, NHL motif, coiled-coil or RFP
                     domain in functionally unrelated proteins, most likely
                     mediating protein-protein interaction; Region: BBOX;
                     cl00034"
                     /db_xref="CDD:206793"
     misc_feature    order(915..917,924..926,978..980,996..998)
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28905"
     misc_feature    1044..1403
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="B-Box C-terminal domain; Region: BBC; smart00502"
                     /db_xref="CDD:128778"
     misc_feature    1527..1676
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="SPRY-associated domain; Region: PRY; pfam13765"
                     /db_xref="CDD:205938"
     misc_feature    1680..2012
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /note="Domain in SPla and the RYanodine Receptor; Region:
                     SPRY; smart00449"
                     /db_xref="CDD:128725"
     exon            1047..1142
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:1.39.8"
     exon            1143..1399
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:1.39.8"
     exon            1400..1515
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:1.39.8"
     exon            1516..3841
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1681
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2335238"
     variation       2611
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:4045741"
     variation       2684
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4045742"
     variation       2689
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4045743"
     variation       2771
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4045744"
     variation       2954..2955
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4045745"
     STS             3605..3744
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /standard_name="D1S3575"
                     /db_xref="UniSTS:16848"
     STS             3643..3775
                     /gene="TRIM62"
                     /gene_synonym="DEAR1"
                     /standard_name="SHGC-74539"
                     /db_xref="UniSTS:603"
ORIGIN      
accggcagctcggattcggctggttccgggttgagaggctgcgctggaccgaagcggtggctgctaagctcgcgggggtaaggggtcgcgctgggccagggtttggggccgggatccggcagctgagcgggccggcacccctcctcttctctgccggtcacagccaatgtacggctcggcctggctgccccctcccccaggattccccatccccagcttctcgccctccccgcaccgcccccaccccgggatttcgacccccttaagggctccaccccgctccgggatccccttctcccagctcctatcccttaggactgccccgccccctagaacctccccgtcaggatctccgtccctcagccgctcacagcctcctcccagcgcccatcgccttgagctgcccactacctctagactgccctcccgggctggcgtcccacggagtctcagccgcgcaccccttcctcgcgttaccctccttccggacagcaccccctcccttctccggtagctcctacccctgcctgtgcgggcctcgtccccgcgcccagccctcggtgctgcctccgacagcgccgcgctctctcagccgcccccctgcccctcgggcccccctctctgctgcccctggcgccatggcgtgcagcctcaaggacgagctgctgtgctccatctgcctgagcatctaccaggacccggtgagcctgggctgcgagcattacttctgccgccgctgcatcacggagcactgggtgcggcaggaggcgcagggcgcccgcgactgccccgagtgccggcgcacgttcgccgagcccgcgctggcgcccagcctcaagctggccaacatcgtggagcgctacagctccttcccgctggacgccatcctcaacgcgcgccgcgccgcgcgaccctgccaggcgcacgacaaggtcaagctcttctgcctcacggaccgcgcgcttctctgcttcttctgcgacgagcctgcactgcacgagcagcatcaggtcaccggcatcgacgacgccttcgacgagctgcagagggagctgaaggaccaacttcaggcccttcaagacagcgagcgggaacacaccgaagcgctgcagctgctcaagcgacaactggcggagaccaagtcttccaccaagagcctgcggaccactatcggcgaggccttcgagcggctgcaccggctgctgcgtgaacgccagaaggccatgctagaggagctggaggcggacacggcccgcacgctgaccgacatcgagcagaaagtccagcgctacagccagcagctgcgcaaggtccaggagggagcccagatcctgcaggagcggctggctgaaaccgaccggcacaccttcctggctggggtggcctcactgtccgagcggctcaagggaaaaatccatgagaccaacctcacatatgaagacttcccgacctccaagtacacaggccccctgcagtacaccatctggaagtccctgttccaggacatccacccagtgccagccgccctaaccctggacccgggcacagcccaccagcgcctgatcctgtcggacgactgcaccattgtggcttacggcaacttgcacccacagccactgcaggactcgccaaagcgcttcgatgtggaggtgtcggtgctgggttctgaagccttcagtagtggcgtccactactgggaggtggtggtggcggagaagacccagtgggtgatcgggctggcacacgaagccgcaagccgcaagggcagcatccagatccagcccagccgcggcttctactgcatcgtgatgcacgatggcaaccagtacagcgcctgcacggagccctggacgcggcttaacgtccgggacaagcttgacaaggtgggtgtcttcctggactatgaccaaggcttgctcatcttctacaatgctgatgacatgtcctggctctacaccttccgcgagaagttccctggcaagctctgctcttacttcagccctggccagagccacgccaatggcaagaacgttcagccgctgcggatcaacaccgtccgcatctagtccaggcagaaggagaccacaacctcctgggaccactgccacctgcaagagccctgcccaggagatagaagacctggactccagcccaccgtggccactggagacctcaggccagttgtttaccctccagcctccagtctgtaaaatggaggttgcattccctacttcctaaactctcttccagcatcgatgttctgtagctctgaccttgatagggatacagctttgatccaaggatgtgacatggcttctcctcagggcaacccctgcccaaccctcatccccatcttctcaggggcaggggactaccttccagtgtctccctccagcccagccctgacctcaggaagtgtcagagcatggccagtagttggcagcccgaaagacacacagcaccctcttatgtcccatggcctaagacttacccctgaccaagctagtgatgggccatttacccttgaccccagtccacagtggtcacaggtagtacctggtcctagggttgcctgagagccaacctctcctgccacccccacaccaagaactatatggttcctacttctcccactgatctgctggtcagtgatgatgctgtggcctgtggaaggcacctggtagttgagtccacacattatagtcatgtgccaccaccttcctgcccacaggccgagggacagggtgagggtatacccaaagctgatgcagagcccattagcctaaaagcaactgcaggacaagcctccctggatgatcgaggtccccagtagctctgaacaagagtccagccaaccctcttcagccaggcctctgtgacctgctagggtgcaggaggcttccagaagcagttgttgtaattaggacccaagcactgggaggggctgttggctggaccccttgtcagacttggcatctatctcagttaggatcctgctgcagaaaacaagagccacttgtagctggtttaattagacaaggatttactacctggcccctggtggcttgcaaaattgttggaagagctggagaagcagactctgctgaatttccaggaactcccagcgccagattcatcatgtctgttgtgaccaggaaagctgcccccatctgcaggaagccactatgccagaaagctgctgactgcagaactaggctccctctgccacggtccgtgccagccaatagatgtcctgaggcctgcccctctcccacttcactcagttcccaaatctaaatttttacaagagattctgtttgggggaacttaagtcagatccagaaccttggctgcaagggagtctgggaaatgtcatttccctagaaggaagttagggtgggtggagcaagccccacctgcgtttttctgccacagcatccaatcgtgaagaactcgggagagggtggagtccacatctagggttgtcctgccccttggctctatccctgcccagaggtgggaactggaggagtgggctgcaagactgagcctaaatgtctccccggccttgacttttctttctagtcctggggcctagattctgcacttggggtctctgacacaacacaccatcccaaagtagccggaagagctaaacacagggggttcttaaaatggctgcccccgccacccgggcctcccttgggcaaaaggaattgtcagccctaccccaacccttcaactaccagaatctgggccaccccagcagtatttttatttaaaatgttgcccattttatgagttatgatcaatttgtattaaattaaagttacagatgtcaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55223 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:55223 -> Cellular component: GO:0005622 [intracellular] evidence: IEA

by @meso_cacase at DBCLS
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