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2024-04-26 17:18:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018145 2251 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens regulator of microtubule dynamics 3 (RMDN3), mRNA.
ACCESSION NM_018145
VERSION NM_018145.1 GI:8922531
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2251)
AUTHORS Brobeil,A., Bobrich,M., Tag,C. and Wimmer,M.
TITLE PTPIP51 in protein interactions: regulation and in situ interacting
partners
JOURNAL Cell Biochem. Biophys. 63 (3), 211-222 (2012)
PUBMED 22544307
REMARK GeneRIF: The presented data confirms a tyrosine
phosphorylation-dependent interaction of PTPIP51 with 14-3-3beta
and Raf-1 in vivo and a tyrosine-dependent interaction profile with
DAGKalpha and PKA.
REFERENCE 2 (bases 1 to 2251)
AUTHORS Petri,M.K., Koch,P., Stenzinger,A., Kuchelmeister,K., Nestler,U.,
Paradowska,A., Steger,K., Brobeil,A., Viard,M. and Wimmer,M.
TITLE PTPIP51, a positive modulator of the MAPK/Erk pathway, is
upregulated in glioblastoma and interacts with 14-3-3beta and PTP1B
in situ
JOURNAL Histol. Histopathol. 26 (12), 1531-1543 (2011)
PUBMED 21972092
REMARK GeneRIF: In glioblastoma PTPIP51 expression increases with the
grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and
PTP1B.
REFERENCE 3 (bases 1 to 2251)
AUTHORS Brobeil,A., Bobrich,M., Graf,M., Kruchten,A., Blau,W., Rummel,M.,
Oeschger,S., Steger,K. and Wimmer,M.
TITLE PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking
dephosphorylation by PTP1B in acute myeloid leukemia
JOURNAL Leuk. Res. 35 (10), 1367-1375 (2011)
PUBMED 21513978
REMARK GeneRIF: PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking
dephosphorylation by PTP1B in acute myeloid leukemia.
REFERENCE 4 (bases 1 to 2251)
AUTHORS Brobeil,A., Graf,M., Oeschger,S., Steger,K. and Wimmer,M.
TITLE PTPIP51-a myeloid lineage specific protein interacts with PTP1B in
neutrophil granulocytes
JOURNAL Blood Cells Mol. Dis. 45 (2), 159-168 (2010)
PUBMED 20627780
REMARK GeneRIF: PTPIP51 expression was restricted to myeloid precursor
cells undergoing differentiation. In blood cells therefore, PTPIP51
expression is restricted to differentiating and mature neutrophil
granulocytes.
REFERENCE 5 (bases 1 to 2251)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2251)
AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
Dunham,I., Hill,D.E. and Vidal,M.
TITLE hORFeome v3.1: a resource of human open reading frames representing
over 10,000 human genes
JOURNAL Genomics 89 (3), 307-315 (2007)
PUBMED 17207965
REFERENCE 7 (bases 1 to 2251)
AUTHORS Lv,B.F., Yu,C.F., Chen,Y.Y., Lu,Y., Guo,J.H., Song,Q.S., Ma,D.L.,
Shi,T.P. and Wang,L.
TITLE Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a
novel mitochondria protein with an N-terminal mitochondrial
targeting sequence and induces apoptosis
JOURNAL Apoptosis 11 (9), 1489-1501 (2006)
PUBMED 16820967
REMARK GeneRIF: PTPIP51 is a mitochondrial protein with apoptosis-inducing
function and that the N-terminal TM domain is required for both the
correct targeting of the protein to mitochondria and its apoptotic
functions.
REFERENCE 8 (bases 1 to 2251)
AUTHORS Stenzinger,A., Kajosch,T., Tag,C., Porsche,A., Welte,I.,
Hofer,H.W., Steger,K. and Wimmer,M.
TITLE The novel protein PTPIP51 exhibits tissue- and cell-specific
expression
JOURNAL Histochem. Cell Biol. 123 (1), 19-28 (2005)
PUBMED 15609043
REMARK GeneRIF: PTPIP51 might be involved in the regulation of cellular
processes associated with differentiation, movement, or
cytoskeletal organization
REFERENCE 9 (bases 1 to 2251)
AUTHORS Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
TITLE Proteomic, functional, and domain-based analysis of in vivo 14-3-3
binding proteins involved in cytoskeletal regulation and cellular
organization
JOURNAL Curr. Biol. 14 (16), 1436-1450 (2004)
PUBMED 15324660
REFERENCE 10 (bases 1 to 2251)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AK001441.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK001441.1, BC063844.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2251
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15.1"
gene 1..2251
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/note="regulator of microtubule dynamics 3"
/db_xref="GeneID:55177"
/db_xref="HGNC:25550"
/db_xref="HPRD:07687"
/db_xref="MIM:611873"
exon 1..178
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
misc_feature 72..74
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/note="upstream in-frame stop codon"
exon 179..372
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
CDS 186..1598
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/note="family with sequence similarity 82, member C;
microtubule-associated protein; family with sequence
similarity 82, member A2; cerebral protein 10;
TCPTP-interacting protein 51; protein tyrosine
phosphatase-interacting protein 51"
/codon_start=1
/product="regulator of microtubule dynamics protein 3"
/protein_id="NP_060615.1"
/db_xref="GI:8922532"
/db_xref="CCDS:CCDS10063.1"
/db_xref="GeneID:55177"
/db_xref="HGNC:25550"
/db_xref="HPRD:07687"
/db_xref="MIM:611873"
/translation="
MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD
"
misc_feature 222..290
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96TC7.2);
transmembrane region"
misc_feature 315..317
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96TC7.2); phosphorylation site"
misc_feature 321..323
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96TC7.2); phosphorylation site"
misc_feature 819..821
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96TC7.2); phosphorylation site"
misc_feature 846..848
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
variation 284
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/replace="g"
/replace="t"
/db_xref="dbSNP:11558807"
exon 373..565
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 566..709
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 710..992
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 993..1095
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
STS 1066..1151
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="D5S447E"
/db_xref="UniSTS:147365"
exon 1096..1156
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1157..1232
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1233..1310
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1311..1409
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1410..1463
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1464..1544
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
exon 1545..2251
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/inference="alignment:Splign:1.39.8"
variation 1632
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043986"
STS 1907..2156
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="WI-20095"
/db_xref="UniSTS:39288"
STS 1986..2100
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="A002D30"
/db_xref="UniSTS:17414"
STS 1986..2100
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="G33072"
/db_xref="UniSTS:117648"
STS 2029..2211
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="STS-W60903"
/db_xref="UniSTS:20918"
STS 2031..2153
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/standard_name="RH77788"
/db_xref="UniSTS:65638"
variation 2101
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1801477"
variation 2133
/gene="RMDN3"
/gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1801506"
ORIGIN
gacgtcacggtcactgacagcgtgagcccgcggcggctgctgccatggtggctggcggccgggtaagggtctgagtggatctcctgccaggccagagcgccttcgggggccgcggcggaaggccaggagtttgcagccagggcgccgggtttgtggtctgcagtgtcgtgaggctgaggtgcagcatgtctagactgggagccctgggtggtgcccgtgccgggctgggactgttgctgggtaccgccgccggccttggattcctgtgcctcctttacagccagcgatggaaacggacccagcgtcatggccgcagccagagcctgcccaactccctggactatacgcagacttcagatcccggacgccacgtgatgctcctgcgggctgtcccaggtggggctggagatgcctcagtgctgcccagccttccacgggaaggacaggagaaggtgctggaccgcctggactttgtgctgaccagccttgtggcgctgcggcgggaggtggaggagctgagaagcagcctgcgagggcttgcgggggagattgttggggaggtccgatgccacatggaagagaaccagagagtggctcggcggcgaaggtttccgtttgtccgggagaggagtgactccactggctccagctctgtctacttcacggcctcctcgggagccacgttcacagatgctgagagtgaagggggttacacaacagccaatgcggagtctgacaatgagcgggactctgacaaagaaagtgaggacggggaagatgaagtgagctgtgagactgtgaagatggggagaaaggattctcttgacttggaggaagaggcagcttcaggtgcctccagtgccctggaggctggaggttcctcaggcttggaggatgtgctgcccctcctgcagcaggccgacgagctgcacaggggtgatgagcaaggcaagcgggagggcttccagctgctgctcaacaacaagctggtgtatggaagccggcaggactttctctggcgcctggcccgagcctacagtgacatgtgtgagctcactgaggaggtgagcgagaagaagtcatatgccctagatggaaaagaagaagcagaggctgctctggagaagggggatgagagtgctgactgtcacctgtggtatgcggtgctttgtggtcagctggctgagcatgagagcatccagaggcgcatccagagtggctttagcttcaaggagcatgtggacaaagccattgctctccagccagaaaaccccatggctcactttcttcttggcaggtggtgctatcaggtctctcacctgagctggctagaaaaaaaaactgctacagccttgcttgaaagccctctcagtgccactgtggaagatgccctccagagcttcctaaaggctgaagaactacagccaggattttccaaagcaggaagggtatatatttccaagtgctacagagaactagggaaaaactctgaagctagatggtggatgaagttggccctggagctgccagatgtcacgaaggaggatttggctatccagaaggacctggaagaactggaagtcattttacgagactaaccacgtttcactggccttcatgacttgatgccactatttaaggtgggggggcggggaggcttttttccttagaccttgctgagatcaggaaaccacacaaatctgtctcctgggtctgactgctacccactaccactccccattagttaatttattctaacctctaacctaatctagaattggggcagtactcatggcttccgtttctgttgttctctcccttgagtaatctcttaaaaaaatcaagattcacacctgccccaggattacacatgggtagagcctgcaagacctgagaccttccaattgctggtgaggtggatgaacttcaaagctataggaacaaagcacataacttgtcactttaatctttttcactgactaataggactcagtacatatagtcttaagatcataccttacctaccaaggtaaaaagagggatcagagtggcccacagacattgctttcttatcacctatcatgtgaattctacctgtattccagggctggaccacttgataacttccagtgtcctggcagcttttggaatgacagcagtggtatggggtttatgatgctataaaacaatgtctgaaaagttgcctagaatatattttgttacaaacttgaaataaaccaaatttgatgtt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55177 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:55177 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IMP
GeneID:55177 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:55177 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:55177 -> Cellular component: GO:0000922 [spindle pole] evidence: IEA
GeneID:55177 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:55177 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:55177 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: IDA
GeneID:55177 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
GeneID:55177 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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