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2024-04-20 12:07:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018031 4273 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens WD repeat domain 6 (WDR6), mRNA.
ACCESSION NM_018031 NM_052825 NM_052826
VERSION NM_018031.3 GI:197927447
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4273)
AUTHORS Chiba,T., Inoue,D., Mizuno,A., Komatsu,T., Fujita,S., Kubota,H.,
Luisa Tagliaro,M., Park,S., Trindade,L.S., Hayashida,T.,
Hayashi,H., Yamaza,H., Higami,Y. and Shimokawa,I.
TITLE Identification and characterization of an insulin receptor
substrate 4-interacting protein in rat brain: implications for
longevity
JOURNAL Neurobiol. Aging 30 (3), 474-482 (2009)
PUBMED 17720279
REMARK GeneRIF: Transgenic rat gene WDR6 is expressed in the hypothalamus
and interacts with insulin receptor substrate 4 (IRS-4) in the
brain.
REFERENCE 2 (bases 1 to 4273)
AUTHORS Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
TITLE Characterization of the human COP9 signalosome complex using
affinity purification and mass spectrometry
JOURNAL J. Proteome Res. 7 (11), 4914-4925 (2008)
PUBMED 18850735
REFERENCE 3 (bases 1 to 4273)
AUTHORS Xie,X., Wang,Z. and Chen,Y.
TITLE Association of LKB1 with a WD-repeat protein WDR6 is implicated in
cell growth arrest and p27(Kip1) induction
JOURNAL Mol. Cell. Biochem. 301 (1-2), 115-122 (2007)
PUBMED 17216128
REMARK GeneRIF: Results suggest that WDR6 is implicated in the cell growth
inhibitory pathway of LKB1 via regulation of p27(Kip1).
REFERENCE 4 (bases 1 to 4273)
AUTHORS Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
TITLE A germline-specific class of small RNAs binds mammalian Piwi
proteins
JOURNAL Nature 442 (7099), 199-202 (2006)
PUBMED 16751776
REFERENCE 5 (bases 1 to 4273)
AUTHORS Li,D. and Roberts,R.
TITLE WD-repeat proteins: structure characteristics, biological function,
and their involvement in human diseases
JOURNAL Cell. Mol. Life Sci. 58 (14), 2085-2097 (2001)
PUBMED 11814058
REMARK Review article
REFERENCE 6 (bases 1 to 4273)
AUTHORS Li,D., Burch,P., Gonzalez,O., Kashork,C.D., Shaffer,L.G.,
Bachinski,L.L. and Roberts,R.
TITLE Molecular cloning, expression analysis, and chromosome mapping of
WDR6, a novel human WD-repeat gene
JOURNAL Biochem. Biophys. Res. Commun. 274 (1), 117-123 (2000)
PUBMED 10903905
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC400613.1, DC389885.1,
BC113467.1, AK092079.1, AK022719.1 and AI636120.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 4, 2008 this sequence version replaced gi:11072092.
Summary: This gene encodes a member of the WD repeat protein
family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
which may facilitate formation of heterotrimeric or multiprotein
complexes. The encoded protein interacts with serine/threonine
kinase 11, and is implicated in cell growth arrest. [provided by
RefSeq, Aug 2008].
##Evidence-Data-START##
Transcript exon combination :: AF099100.1, AK295145.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-105 DC400613.1 1-105
106-199 DC389885.1 1-94
200-3657 BC113467.1 1-3458
3658-4091 AK092079.1 1125-1558
4092-4258 AK022719.1 2139-2305
4259-4273 AI636120.1 1-15 c
FEATURES Location/Qualifiers
source 1..4273
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.31"
gene 1..4273
/gene="WDR6"
/note="WD repeat domain 6"
/db_xref="GeneID:11180"
/db_xref="HGNC:12758"
/db_xref="MIM:606031"
exon 1..328
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
misc_feature 121..123
/gene="WDR6"
/note="upstream in-frame stop codon"
CDS 139..3594
/gene="WDR6"
/codon_start=1
/product="WD repeat-containing protein 6"
/protein_id="NP_060501.3"
/db_xref="GI:197927448"
/db_xref="CCDS:CCDS2782.2"
/db_xref="GeneID:11180"
/db_xref="HGNC:12758"
/db_xref="MIM:606031"
/translation="
MGSAARWEGSFSREFSSLLSRGCLSTSRIDMDALEDYVWPRATSELILLPVTGLECVGDRLLAGEGPDVLVYSLDFGGHLRMIKRVQNLLGHYLIHGFRVRPEPNGDLDLEAMVAVFGSKGLRVVKISWGQGHFWELWRSGLWNMSDWIWDARWLEGNIALALGHNSVVLYDPVVGCILQEVPCTDRCTLSSACLIGDAWKELTIVAGAVSNQLLVWYPATALADNKPVAPDRRISGHVGIIFSMSYLESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGEDCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQAWVITGGDDSGIRLWHLVGRGYRGLGVSALCFKSRSRPGTLKAVTLAGSWRLLAVTDTGALYLYDVEVKCWEQLLEDKHFQSYCLLEAAPGPEGFGLCAMANGEGRVKVVPINTPTAAVDQTLFPGKVHSLSWALRGYEELLLLASGPGGVVACLEISAAPSGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNAFTGLGPVSTLPSLHGKQGVTSVTCHGGYVYTTGRDGAYYQLFVRDGQLQPVLRQKSCRGMNWLAGLRIVPDGSMVILGFHANEFVVWNPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLYRALGGCTRPHVILREGLHGREITCVKRVGTITLGPEYGVPSFMQPDDLEPGSEGPDLTDIVITCSEDTTVCVLALPTTTGSAHALTAVCNHISSVRAVAVWGIGTPGGPQDPQPGLTAHVVSAGGRAEMHCFSIMVTPDPSTPSRLACHVMHLSSHRLDEYWDRQRNRHRMVKVDPETRYMSLAVCELDQPGLGPLVAAACSDGAVRLFLLQDSGRILQLLAETFHHKRCVLKVHSFTHEAPNQRRRLLLCSAATDGSLAFWDLTTMLDHDSTVLEPPVDPGLPYRLGTPSLTLQAHSCGINSLHTLPTREGHHLVASGSEDGSLHVFVLAVEMLQLEEAVGEAGLVPQLRVLEEYSVPCAHAAHVTGLKILSPSIMVSASIDQRLTFWRLGHGEPTFMNSTVFHVPDVADMDCWPVSPEFGHRCALGGQGLEVYNWYD
"
misc_feature <574..1080
/gene="WDR6"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
misc_feature <613..1569
/gene="WDR6"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature order(622..624,649..654,691..696,757..759,769..771,
787..789,811..813,847..852,901..903,916..918,934..939,
994..999,1045..1047,1057..1059,1075..1080)
/gene="WDR6"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature 835..1782
/gene="WDR6"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
misc_feature order(850..852,904..906,916..918,934..939,994..999,
1045..1047,1057..1059,1075..1080,1111..1116,1168..1170,
1183..1185,1201..1206,1267..1269,1318..1320,1330..1332,
1348..1353,1396..1401,1453..1455,1468..1470,1486..1491,
1525..1530,1588..1590,1603..1605,1621..1626,1693..1698,
1750..1752,1762..1764,1780..1782)
/gene="WDR6"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature 2854..3471
/gene="WDR6"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cl02567"
/db_xref="CDD:207648"
misc_feature order(2869..2871,2881..2883,2899..2904,2938..2940,
2953..2955,3028..3030,3040..3042,3058..3063,3079..3084,
3133..3135,3163..3165,3223..3225,3238..3240,3256..3258,
3301..3303,3313..3315,3331..3336,3355..3360,3406..3408,
3421..3423,3439..3444)
/gene="WDR6"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
exon 329..2810
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
exon 2811..2894
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
exon 2895..3011
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
exon 3012..3130
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
exon 3131..4259
/gene="WDR6"
/inference="alignment:Splign:1.39.8"
variation complement(3658)
/gene="WDR6"
/replace="a"
/replace="t"
/db_xref="dbSNP:8926"
variation complement(3844)
/gene="WDR6"
/replace="c"
/replace="t"
/db_xref="dbSNP:14370"
STS 3990..4215
/gene="WDR6"
/standard_name="RH80256"
/db_xref="UniSTS:86164"
polyA_signal 4235..4240
/gene="WDR6"
polyA_site 4259
/gene="WDR6"
ORIGIN
acgtgagggggcgaggggcgggatgcccctccgcgggccccgccaatgatgagctggattgcgtgggacgaagggtcgtcattggacaaccgccgcgggcgccctggtctctgctacctgtagctgagggcgctgttgatgggcagcgcggcgcgctgggaaggctcgttctcgcgagagttcagctcccttcttagccgtggctgcctcagcacctcgaggatcgacatggacgctctcgaggactacgtttggccgcgggcaacctcggagcttatactcctcccagtgacgggtctggagtgcgtgggggaccggctgttggcgggtgagggtcccgatgtcctggtgtacagcttggactttggtgggcatctgcggatgataaagcgagtgcagaacctgcttggccactatcttatccatggcttccgggtacggccagagcctaatggagaccttgacttggaggccatggtggctgtgtttggaagcaagggactccgagttgtgaaaattagctggggacagggccacttctgggagctttggcgctctggcctgtggaacatgtctgactggatttgggatgcacgctggcttgagggaaatatagccttggccctgggccacaactcagtggtgctatatgaccctgtagtagggtgcatcctgcaagaggtgccctgcacagacaggtgcaccctctcttcagcctgcctgattggagacgcctggaaggagctgaccatagtggcaggtgctgtttccaaccagctcttggtctggtacccagcaactgccttagcagacaacaaacctgtagcacctgaccgacgaatcagtgggcatgtgggcatcatcttcagcatgtcatacctggaaagcaagggattgctggctacagcttcagaagaccgaagcgttcgtatctggaaggtgggcgacctgcgagtgcctgggggtcgggtgcagaatattgggcactgctttgggcacagcgcccgtgtgtggcaggtcaagcttctagagaattaccttatcagtgcaggagaggattgtgtctgcttggtgtggagccatgaaggtgagatcctccaggcctttcggggacaccagggacgtgggatccgggccatagctgcccatgagaggcaggcctgggtgatcactgggggtgatgactcaggcattcggctgtggcacttggtagggcgtgggtaccggggattgggggtctcggctctctgcttcaagtcccgtagtaggccaggtacactcaaggctgtgactctggctggctcttggcgactgctggcagtgactgatacaggggccctgtatctctatgacgtcgaggtcaagtgctgggagcagctgctagaggataaacatttccagtcctactgcctgctggaggcagctcctggtcccgagggcttcggattgtgtgctatggccaatggggaaggtcgtgtcaaggttgtccccatcaacactccaactgctgctgtggaccagaccctgtttcctgggaaggtgcacagcttgagctgggccctgcgtggttatgaggagctcctgttgctggcatcgggccctggcggggtagtagcttgcctagagatctcagccgcaccctctggcaaggccatctttgtcaaggaacgttgtcggtacctgctgcccccaagcaagcagagatggcacacatgcagtgccttcctacccccaggtgacttcctggtgtgtggtgaccgccggggctctgtgctgctattcccctccagaccaggtctgctcaaggaccctggggtgggaggcaaggctcgggctggtgctggggcacctgtagtgggtagtggtagtagtgggggtgggaatgctttcactgggttgggcccagtgtctaccctgccctctctgcacgggaagcagggtgtgacctcagtcacatgccatggtggctatgtgtataccacagggcgtgatggagcctactaccagctgtttgtacgagacggccagctccagccagtcctaaggcagaagtcctgtcgaggcatgaactggctagctgggctccgtatagtgcccgatgggagcatggttatcctgggtttccatgccaatgagtttgtggtgtggaaccctcggtcacacgagaagctgcacatcgtcaactgtggtggagggcaccgttcgtgggcattctctgatactgaggcggccatggcctttgcttacctcaaggatggggatgtcatgctgtacagggctctgggtggctgcacccggccacacgtgattctccgggagggtctgcatggccgtgagatcacttgtgtaaagcgtgtgggcaccattaccctggggcctgaatatggagtgcccagcttcatgcagcctgatgacctggagcctggcagtgaggggcccgacttgactgacattgtgatcacatgtagtgaggacactactgtctgtgtcctagcactccctacaaccacaggctcagcccacgcactcacagctgtttgtaaccatatctcctcggtacgtgctgtggctgtgtggggcattggcaccccaggtggccctcaggatcctcagccaggcctgactgcccatgtggtgtctgcgggggggcgggctgagatgcactgcttcagcatcatggttactccggaccccagcaccccaagccgcctcgcctgccatgtcatgcacctttcgtcccaccggctagatgagtattgggaccggcaacgcaatcggcatcggatggttaaggtagacccagagaccaggtacatgtcccttgctgtgtgtgaacttgaccagcccggccttggcccccttgtggctgcagcctgtagtgatggggccgtaaggctctttcttttgcaggattctgggcggattctgcagctccttgctgaaaccttccaccataagcgatgtgtcctcaaggtccactcctttacacacgaggcacccaaccagaggcggaggctcctcctgtgcagcgcagctactgatggcagcctggctttctgggatctcaccaccatgctagaccatgactccactgtcctggagcctccagtggatcctgggcttccctaccggcttggcaccccctccctgactctccaggcccacagctgtggtatcaacagcctgcacaccttgcccacccgtgagggccaccatctcgtggccagtggcagtgaagatggatccctccatgtcttcgtgcttgctgtggagatgctacagctagaagaggctgtgggagaggctgggctggtaccccagctgcgtgtgctagaggaatactctgtcccctgtgcacatgctgcccatgtgacaggcctcaagatcctaagcccaagcatcatggtctcagcctccattgatcaacggctgaccttctggcgtctggggcatggtgaacccaccttcatgaatagcactgtgttccatgtgcctgatgtggctgacatggactgctggcctgtgagccctgagtttggccaccgttgtgcccttgggggtcaggggcttgaggtttacaactggtatgactgaggtatcctgcggtggctggcgtgctgggcatggggcctgctcacagacagcatggagcagggatgggctgtctgtgcccatgctcagcatgccttgaggggaggaggtggtggccgtgggttcctgatgtcggtgcaggagctgaaggtgagtggagtgctgccaagaatatgcccgactccccatgacaagacagaactttgtaacaaacagtaccaatttattttggccgtgggtttttgctttttttccagttgatgactttgtgaacattcccaggtattggagcctctgtggccttaaatgtggctcagtggagggagacccagcatagccaggccagtatggagcacctcacgcacagctctcagaagctgcaggcggacgaacatctgaccaaagaggtgtggtcgaggctcctgaaagagaaagggcctgctggtctcatcctctgcttcctttgcctttaccctatacctctctgcacgtcccaccccattttgctgtgtgctcacccccaggatgtgtacccggttgtagtaggagctgaaatccatgctgagctgtaccaggaacttgcatatctagagacagagactgagtcactggcccatctctttgctcttgtgccccaggccagaataaagaatagagtgtagagtgtcaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11180 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:11180 -> Molecular function: GO:0043560 [insulin receptor substrate binding] evidence: IEA
GeneID:11180 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IDA
GeneID:11180 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:11180 -> Biological process: GO:0010507 [negative regulation of autophagy] evidence: IMP
GeneID:11180 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:11180 -> Cellular component: GO:0008180 [COP9 signalosome] evidence: IDA
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