LOCUS       NM_017970               4026 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens NRDE-2, necessary for RNA interference, domain
            containing (NRDE2), mRNA.
ACCESSION   NM_017970
VERSION     NM_017970.3  GI:341823678
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC393057.1, AK294958.1, BC008925.2 and AW196499.1.
            On Jul 27, 2011 this sequence version replaced gi:39932582.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294958.1, BC098568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               DC393057.1         2-197
            197-1753            AK294958.1         1-1557
            1754-3346           BC008925.2         1184-2776
            3347-4006           AK294958.1         3151-3810
            4007-4026           AW196499.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11"
     gene            1..4026
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing"
                     /db_xref="GeneID:55051"
                     /db_xref="HGNC:20186"
                     /db_xref="HPRD:12625"
     exon            1..297
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    204..206
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /note="upstream in-frame stop codon"
     CDS             234..3728
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /note="UPF0614 protein C14orf102"
                     /codon_start=1
                     /product="protein NRDE2 homolog"
                     /protein_id="NP_060440.2"
                     /db_xref="GI:39932583"
                     /db_xref="CCDS:CCDS9890.1"
                     /db_xref="GeneID:55051"
                     /db_xref="HGNC:20186"
                     /db_xref="HPRD:12625"
                     /translation="

MALFPAFAGLSEAPDGGSSRKELDWLSNPSFCVGSITSLSQQTEAAPAHVSEGLPLTRSHLKSESSDESDTNKKLKQTSRKKKKEKKKKRKHQHHKKTKRKHGPSSSSRSETDTDSEKDKPSRGVGGSKKESEEPNQGNNAAADTGHRFVWLEDIQAVTGETFRTDKKPDPANWEYKSLYRGDIARYKRKGDSCLGINPKKQCISWEGTSTEKKHSRKQVERYFTKKSVGLMNIDGVAISSKTEPPSSEPISFIPVKDLEDAAPVTTWLNPLGIYDQSTTHWLQGQGPPEQESKQPDAQPDSESAALKAKVEEFNRRVRENPRDTQLWMAFVAFQDEVMKSPGLYAIEEGEQEKRKRSLKLILEKKLAILERAIESNQSSVDLKLAKLKLCTEFWEPSTLVKEWQKLIFLHPNNTALWQKYLLFCQSQFSTFSISKIHSLYGKCLSTLSAVKDGSILSHPALPGTEEAMFALFLQQCHFLRQAGHSEKAISLFQAMVDFTFFKPDSVKDLPTKGQVEFFEPFWDSGEPRAGEKGARGWKAWMHQQERGGWVVINPDEDDDEPEEDDQEIKDKTLPRWQIWLAAERSRDQRHWRPWRPDKTKKQTEEDCEDPERQVLFDDIGQSLIRLSSHDLQFQLVEAFLQFLGVPSGFTPPASCLYLAMDENSIFDNGLYDEKPLTFFNPLFSGASCVGRMDRLGYPRWTRGQNREGEEFIRNVFHLVMPLFSGKEKSQLCFSWLQYEIAKVIWCLHTKNKKRLKSQGKNCKKLAKNLLKEPENCNNFCLWKQYAHLEWLLGNTEDARKVFDTALGMAGSRELKDSDLCELSLLYAELEVELSPEVRRAATARAVHILTKLTESSPYGPYTGQVLAVHILKARKAYEHALQDCLGDSCVSNPAPTDSCSRLISLAKCFMLFQYLTIGIDAAVQIYEQVFAKLNSSVFPEGSGEGDSASSQSWTSVLEAITLMHTSLLRFHMKVSVYPLAPLREALSQALKLYPGNQVLWRSYVQIQNKSHSASKTRRFFDTITRSAKPLEPWLFAIEAEKLRKRLVETVQRLDGREIHATIPETGLMHRIQALFENAMRSDSGSQCPLLWRMYLNFLVSLGNKERSKGVFYKALQNCPWAKVLYLDAVEYFPDEMQEILDLMTEKELRVRLPLEELELLLED

"
     misc_feature    1146..1244
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H7Z3.3);
                     Region: HAT 1"
     misc_feature    1152..2189
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /note="NRDE-2, necessary for RNA interference; Region:
                     NRDE-2; pfam08424"
                     /db_xref="CDD:203939"
     misc_feature    1416..1514
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H7Z3.3);
                     Region: HAT 2"
     misc_feature    2505..2609
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H7Z3.3);
                     Region: HAT 3"
     misc_feature    3165..3263
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H7Z3.3);
                     Region: HAT 4"
     misc_feature    3432..3536
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H7Z3.3);
                     Region: HAT 5"
     exon            298..406
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            407..640
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            641..790
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            791..1238
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            1239..1644
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            1645..1778
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     variation       1754
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3825661"
     exon            1779..1899
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            1900..2075
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            2076..2462
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     variation       2267
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3742671"
     exon            2463..3391
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            3392..3530
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            3531..3602
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     exon            3603..4010
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /inference="alignment:Splign:1.39.8"
     variation       3736
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10184"
     STS             3794..3980
                     /gene="NRDE2"
                     /gene_synonym="C14orf102"
                     /standard_name="RH98490"
                     /db_xref="UniSTS:84737"
ORIGIN      

ccccttggccccgccccaccctgctttgccctgcctctccctgccccgccgcgccccagtcccttgacgaccctcctctctgggccccgcccctcccgcttcggggtcaagccccagagagcgccgcgaaaaccacatttcccagagtgcaccgcgacggcaggggtcctcagaccggcgctcgctcgccggcgccatccctatagagaagaacggaggtacggcctgtggtcatggcgctgttcccagcctttgcggggcttagtgaggctcccgatggcgggagctccaggaaagagttagactggctgagcaacccaagcttttgtgttggatccataacgtccctgagccaacaaactgaagcagctccagcccatgtttctgaagggttaccgctgacaaggagtcatctgaaatcagagtcttcagatgaaagtgacactaacaaaaagctcaaacaaacaagtagaaaaaagaagaaagagaaaaagaaaaaaaggaagcatcagcatcataagaaaacaaagaggaagcatgggccgtcgagtagcagcaggtctgagacagacaccgattctgaaaaggacaaaccttccagaggcgttggaggcagtaaaaaggaatctgaggaaccgaatcaaggaaataatgctgcagctgatactggacatcgctttgtttggcttgaggacattcaggctgtgacgggagaaaccttcagaacagataagaaaccagatcctgcgaactgggagtacaagtctctctaccgaggggatatagcaagatacaagaggaaaggagactcctgccttggcattaaccctaagaagcagtgcatatcttgggaagggacttccacagagaagaagcattcacgcaagcaggttgaacgctattttactaagaagagtgtgggattaatgaacatcgatggagttgccattagcagtaaaactgaacctccctcatctgagcccatctcctttataccagtgaaggacttggaagatgcggctcctgttacaacctggttgaatcctctggggatttatgatcagtcaaccacacattggctacaaggacagggtcctccagagcaggaatcaaagcagccagacgcacagccagacagcgagagtgcggctctcaaggccaaggtggaggagtttaacaggagggtgcgggagaatcctcgggatacgcagctgtggatggcatttgttgcttttcaggacgaggtcatgaaaagtcctggcctgtatgccatcgaggaaggagagcaggaaaagcgaaagaggtccctgaagctcattctggagaagaagctggccattctggagcgggccattgagagcaaccagagcagtgtggatctgaaactggccaagctgaagctctgcacagagttctgggagccctccactctggtcaaagagtggcagaaactgatatttttgcatcccaataatacagccctttggcagaaataccttttattttgccagagccagtttagtaccttttcgatatcaaaaattcacagtctttatggaaaatgcttgagcactttgtctgctgttaaggacggcagcatcttatctcaccctgcgttgcctggcacggaagaggccatgtttgcactctttcttcagcagtgccactttctgcggcaggctggccactctgagaaggccatctcattgttccaggccatggtggacttcaccttcttcaaacccgacagcgtgaaagatctgcctaccaaaggacaggtggaattctttgaacccttttgggacagtggagagccccgggctggggagaagggagcccgaggctggaaggcgtggatgcaccagcaggaacgaggtggctgggtggtcatcaacccagatgaggatgacgatgaaccagaagaggatgaccaggaaataaaagataagactctgcccaggtggcagatctggcttgctgctgagcgttcccgtgaccagaggcactggcggccctggcgccctgataagaccaagaagcaaaccgaggaagactgtgaggatcccgagagacaggtgttgtttgatgatattgggcaatctttgatcagactttccagccatgatcttcagttccagctggtggaggccttcctgcagttcttgggtgtgccttctggctttactcctccagcctcctgtctttatctggccatggatgagaacagcatctttgataatggactttatgatgaaaagcccttgacttttttcaaccctttgttttctggggctagctgtgttggccgcatggataggttgggctatcctcgctggaccaggggtcagaaccgagagggcgaggagttcatccgcaatgtcttccaccttgtcatgcctttattttcaggcaaagagaagtcccagctctgcttctcctggttacagtatgagattgcaaaggtcatttggtgcctgcacactaaaaacaagaagagattaaagtctcaagggaagaactgcaaaaaactagccaagaatctccttaaggagccagaaaactgcaacaacttttgcctgtggaagcagtatgcacatctggagtggttgcttggcaacacggaggatgccagaaaagtttttgacacagcacttggcatggcaggaagcagagaactgaaagactctgacctctgtgagctcagtctgctctatgctgagctggaggtggagctgtcgccagaagtgagaagggctgccacagctcgagctgttcacatattaaccaagctgactgagagcagcccctatgggccctacactggacaggtgttggctgttcacattttgaaagcgcgaaaggcttatgagcacgcactgcaggactgtttgggtgacagctgtgtctccaatccagctcccaccgattcctgtagccgcctaattagcctggctaaatgcttcatgctcttccagtatttgaccatagggattgatgctgctgtgcagatatacgaacaggtgtttgcaaaactgaacagttctgttttcccagaaggctctggcgagggggacagtgccagctcccagagttggaccagtgttctcgaagccatcacactgatgcacacgagcctgctgagattccacatgaaagtgagtgtttacccgctggcccctctgcgagaggcactctcacaggctttaaagttgtatccaggcaaccaggttctttggaggtcctatgtacagattcagaataagtcccacagtgccagcaaaaccaggagattttttgacacaatcaccaggtctgccaaacccttggagccttggttgtttgcaattgaagctgagaaactgaggaagagactggtggaaactgtccagaggttagacggtagagagatccacgccacaattcctgagaccggcttaatgcatcggatccaagccctgtttgaaaatgccatgcgcagcgacagtggcagccagtgccccttgctgtggaggatgtatttgaactttctggtttccttaggaaataaagaaagaagcaaaggtgtattctacaaagcacttcagaattgcccttgggcaaaggtgttgtacctggacgccgtggagtatttccccgatgagatgcaggagatcctggacctgatgactgagaaggagctccgggtgcgcctgccgctggaggagctggagctgctgctggaggattagagagcagcgggaaaacgggctgtgcctgcgaggccaagttgcccaccctgcggagctaggaggcgcgagcagagaacgtgtgtgttaggagaactcggcttttgaaatgttctttctcgatagtaataatgtgggctgccagcctctcacatcttgcacactttttgggtgtgtaaatgacacaaaagttatttacatattatatatgtgaatatgtgtatatatgtacatagccagagagtcatgccacgtggtcattaaaccgatgatgattgaggcgtgaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55051 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
            GeneID:55051 -> Biological process: GO:0008150 [biological_process] evidence: ND
            GeneID:55051 -> Cellular component: GO:0005575 [cellular_component] evidence: ND