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2024-03-28 20:09:58, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_017966               2711 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens vacuolar protein sorting 37 homolog C (S. cerevisiae)
            (VPS37C), mRNA.
ACCESSION   NM_017966 XM_373413
VERSION     NM_017966.4  GI:57863313
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Hosgood,H.D. III, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 2711)
  AUTHORS   Eastman,S.W., Martin-Serrano,J., Chung,W., Zang,T. and
            Bieniasz,P.D.
  TITLE     Identification of human VPS37C, a component of endosomal sorting
            complex required for transport-I important for viral budding
  JOURNAL   J. Biol. Chem. 280 (1), 628-636 (2005)
   PUBMED   15509564
  REMARK    GeneRIF: VPS37C as a functional component of mammalian endosomal
            sorting complex required for transport-I
REFERENCE   3  (bases 1 to 2711)
  AUTHORS   Stuchell,M.D., Garrus,J.E., Muller,B., Stray,K.M., Ghaffarian,S.,
            McKinnon,R., Krausslich,H.G., Morham,S.G. and Sundquist,W.I.
  TITLE     The human endosomal sorting complex required for transport
            (ESCRT-I) and its role in HIV-1 budding
  JOURNAL   J. Biol. Chem. 279 (34), 36059-36071 (2004)
   PUBMED   15218037
REFERENCE   4  (bases 1 to 2711)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu. Rev. Cell Dev. Biol. 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL834261.1 and BM450171.1.
            On or before Jan 26, 2005 this sequence version replaced
            gi:42659665, gi:38490555.
            
            Summary: VPS37C is a subunit of ESCRT-I (endosomal sorting complex
            required for transport I), a complex in the class E vacuolar
            protein sorting (VPS) pathway required for sorting ubiquitinated
            transmembrane proteins into internal vesicles of multivesicular
            bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM,
            Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834261.1, AK302384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088, ERS025092 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               AL834261.1         9-612
            605-652             BM450171.1         575-622
            653-2711            AL834261.1         661-2719
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2711
                     /gene="VPS37C"
                     /note="vacuolar protein sorting 37 homolog C (S.
                     cerevisiae)"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:26097"
                     /db_xref="HPRD:15652"
                     /db_xref="MIM:610038"
     exon            1..54
                     /gene="VPS37C"
                     /inference="alignment:Splign:1.39.8"
     exon            55..153
                     /gene="VPS37C"
                     /inference="alignment:Splign:1.39.8"
     CDS             61..1128
                     /gene="VPS37C"
                     /note="hVps37C; ESCRT-I complex subunit VPS37C; vacuolar
                     protein sorting 37C"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 37C"
                     /protein_id="NP_060436.4"
                     /db_xref="GI:57863314"
                     /db_xref="CCDS:CCDS31573.1"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:26097"
                     /db_xref="HPRD:15652"
                     /db_xref="MIM:610038"
                     /translation="
METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY
"
     misc_feature    70..519
                     /gene="VPS37C"
                     /note="Modifier of rudimentary (Mod(r)) protein; Region:
                     Mod_r; pfam07200"
                     /db_xref="CDD:203593"
     exon            154..325
                     /gene="VPS37C"
                     /inference="alignment:Splign:1.39.8"
     exon            326..408
                     /gene="VPS37C"
                     /inference="alignment:Splign:1.39.8"
     exon            409..2692
                     /gene="VPS37C"
                     /inference="alignment:Splign:1.39.8"
     variation       605
                     /gene="VPS37C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2232142"
     variation       653
                     /gene="VPS37C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:754382"
     variation       719
                     /gene="VPS37C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232143"
     variation       1146
                     /gene="VPS37C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232144"
     variation       1194
                     /gene="VPS37C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232145"
     variation       1195
                     /gene="VPS37C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232146"
     variation       1222
                     /gene="VPS37C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232147"
     variation       1244
                     /gene="VPS37C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232148"
     variation       2196
                     /gene="VPS37C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232149"
     STS             2468..2632
                     /gene="VPS37C"
                     /standard_name="RH12137"
                     /db_xref="UniSTS:66108"
     variation       2508
                     /gene="VPS37C"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7876"
     polyA_signal    2671..2676
                     /gene="VPS37C"
     polyA_site      2692
                     /gene="VPS37C"
ORIGIN      
tgggcgcggctgcggtttaacccgcggtggcggcggcgacggcggccctggcagggaaggatggagacgctgaaggataagaccctgcaggagctggaggagttgcagaatgactcggaggcgattgaccagctggccctggagtcccctgaggtccaggacctacagctggaacgggagatggcactggccaccaaccggagcctggcagagcggaacttggagttccagggtcccctggagatcagccgctcaaacctctcggatagataccaggagctccggaagctcgtggagcggtgccaggagcagaaggcaaagctggagaaattttcttcagcactgcagccagggaccttgttagaccttctgcaggtggaaggcatgaagatcgaagaagagtccgaggccatggctgagaagttcctggagggcgaggtgcccctggaaacgttcctggagaatttttcctccatgaggatgctgtcccacctgcgccgggttcgcgtggaaaagctccaggaagtggtgaggaagcccagggcttcccaggagctggccggcgatgcccctccaccccgtccaccacccccggtgcgcccagtcccccagggaacaccccctgtggttgaagagcagccgcagccaccattagccatgcctccctaccctttgccctacagcccatcccccagcctgcctgtgggccccactgcccatggagccctgccaccggcccctttcccagtagtgtcccagccctccttctacagcgggcctctgggccccacttacccggcagcccagcttggacccaggggtgctgcgggttactcctggtccccacagaggagcatgccaccccggccgggctatcctgggaccccaatgggtgcctctgggcctgggtaccccttgcggggaggcagggcccccagtcctggttatcctcaacagtccccataccccgcaacaggaggaaaacctccctacccaatacagcctcagctccccagctttccaggccagccccagccctcagtgcccctgcagcccccttatccccccgggcccgcccctccctatgggttcccaccaccgccggggcctgcctggcctgggtattagacacactcctggccctcggcccctccctagtcccacccacgctcaacctttggcccagccatcgccgagattcgagggtcaactggaagtggcgttggtgctccctgtggacttgcgtcggcacccagaggccttggagggacaaggcactgggcggtgtgactggtcatggcacttgctggccttctggccagaggtcctcctggaagcccctcctttcagtgcctggctgcagcggtgctagccaggctggagtccagcacctctcgccggtgtctgtgtgagtgagcgcatgtgcgcatttatgagcatctacttgcggctgcactcagggccatttgaacccagtgcagagttatctctatgaggaggccccgggtctccagccccctccatctcccctggggtttggcatatttgacatggagccccatgccaagggatgcagctgttggtgtctgtccagtccattcaaggctagcctgcccatgcactgtggcaggggttggattggagggagagaacagagttgggaaaaacaacaggtttgagtcctataaagccataatttaactccagtagctgatgtcagacaagcttgtcctatgtcctatttgagtggcagcagcgccagcccagcaagaaggctgggggttgtcaaggttgtccccagaccttgcttgcagtggttggagaacccagggggctgccttgggccctctggccagagggaagcgggcagctctagccctggagattgtggtcacattggggcttgtttaggattggagggccaggtcacctccccagccaccctcccttctctcctctggggtccccactttagggcgactttgcccgaggcccacgcatccatccactcctttagtgccttgaatctcattcacaagcagccccctcccttcccctccccttctcactctgttgatgtaatcctcccacccccagtgtccatcctaagacaggcatcaaaagaggccctaactttacttcccaaatggtgctttttaaaaaacaccatcactacattaggggcaattttttcacacctccctgtcttcagaatgtaaagggtggggattatgtctctgtttaatatgcagccccctgcactgtggggtttggggcatgttcagtaataagaatgaatacaatagacaaagggggtgtgatgagtgttaacttggttgttccagaggtaaaccaggtctcagggaagagcctggagctgctattgcttaggaagttgtacgtgccttgaaatgtccactacctgaggacgcagcatctggtgggcccggggctgctggggccaaggagggaccttgaccttctggtgcctgcccctccccggcctatgtgccatccgcgtgacgctaggtcagcgctgccggttctttaccaaatgtgcttgcttctcctaagttatttataaagagaaatcactaatggactctactggtttgagtgcttctgagctggatgaccgaccgcctgtatgtttgtgtaattaattgccataataaactttgatgagtcacataaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55048 -> Biological process: GO:0015031 [protein transport] evidence: IEA
            GeneID:55048 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:55048 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
            GeneID:55048 -> Biological process: GO:0016197 [endosomal transport] evidence: TAS
            GeneID:55048 -> Biological process: GO:0019067 [viral assembly, maturation, egress, and release] evidence: TAS
            GeneID:55048 -> Biological process: GO:0019068 [virion assembly] evidence: TAS
            GeneID:55048 -> Biological process: GO:0019082 [viral protein processing] evidence: TAS
            GeneID:55048 -> Biological process: GO:0046788 [egress of virus within host cell] evidence: TAS
            GeneID:55048 -> Cellular component: GO:0000813 [ESCRT I complex] evidence: IDA
            GeneID:55048 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:55048 -> Cellular component: GO:0010008 [endosome membrane] evidence: TAS
            GeneID:55048 -> Cellular component: GO:0031902 [late endosome membrane] evidence: IEA
            GeneID:55048 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA

by @meso_cacase at DBCLS
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