2024-03-28 20:09:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_017966 2711 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens vacuolar protein sorting 37 homolog C (S. cerevisiae) (VPS37C), mRNA. ACCESSION NM_017966 XM_373413 VERSION NM_017966.4 GI:57863313 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2711) AUTHORS Hosgood,H.D. III, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R., Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S., Smith,M. and Lan,Q. TITLE Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity JOURNAL Occup Environ Med 66 (12), 848-853 (2009) PUBMED 19773279 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 2 (bases 1 to 2711) AUTHORS Eastman,S.W., Martin-Serrano,J., Chung,W., Zang,T. and Bieniasz,P.D. TITLE Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding JOURNAL J. Biol. Chem. 280 (1), 628-636 (2005) PUBMED 15509564 REMARK GeneRIF: VPS37C as a functional component of mammalian endosomal sorting complex required for transport-I REFERENCE 3 (bases 1 to 2711) AUTHORS Stuchell,M.D., Garrus,J.E., Muller,B., Stray,K.M., Ghaffarian,S., McKinnon,R., Krausslich,H.G., Morham,S.G. and Sundquist,W.I. TITLE The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding JOURNAL J. Biol. Chem. 279 (34), 36059-36071 (2004) PUBMED 15218037 REFERENCE 4 (bases 1 to 2711) AUTHORS Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K. TITLE Secretory protein trafficking and organelle dynamics in living cells JOURNAL Annu. Rev. Cell Dev. Biol. 16, 557-589 (2000) PUBMED 11031247 REMARK Review article COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL834261.1 and BM450171.1. On or before Jan 26, 2005 this sequence version replaced gi:42659665, gi:38490555. Summary: VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]. ##Evidence-Data-START## Transcript exon combination :: AL834261.1, AK302384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088, ERS025092 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-604 AL834261.1 9-612 605-652 BM450171.1 575-622 653-2711 AL834261.1 661-2719 FEATURES Location/Qualifiers source 1..2711 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q12.2" gene 1..2711 /gene="VPS37C" /note="vacuolar protein sorting 37 homolog C (S. cerevisiae)" /db_xref="GeneID:55048" /db_xref="HGNC:26097" /db_xref="HPRD:15652" /db_xref="MIM:610038" exon 1..54 /gene="VPS37C" /inference="alignment:Splign:1.39.8" exon 55..153 /gene="VPS37C" /inference="alignment:Splign:1.39.8" CDS 61..1128 /gene="VPS37C" /note="hVps37C; ESCRT-I complex subunit VPS37C; vacuolar protein sorting 37C" /codon_start=1 /product="vacuolar protein sorting-associated protein 37C" /protein_id="NP_060436.4" /db_xref="GI:57863314" /db_xref="CCDS:CCDS31573.1" /db_xref="GeneID:55048" /db_xref="HGNC:26097" /db_xref="HPRD:15652" /db_xref="MIM:610038" /translation="
METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY
" misc_feature 70..519 /gene="VPS37C" /note="Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200" /db_xref="CDD:203593" exon 154..325 /gene="VPS37C" /inference="alignment:Splign:1.39.8" exon 326..408 /gene="VPS37C" /inference="alignment:Splign:1.39.8" exon 409..2692 /gene="VPS37C" /inference="alignment:Splign:1.39.8" variation 605 /gene="VPS37C" /replace="a" /replace="t" /db_xref="dbSNP:2232142" variation 653 /gene="VPS37C" /replace="c" /replace="t" /db_xref="dbSNP:754382" variation 719 /gene="VPS37C" /replace="a" /replace="g" /db_xref="dbSNP:2232143" variation 1146 /gene="VPS37C" /replace="a" /replace="g" /db_xref="dbSNP:2232144" variation 1194 /gene="VPS37C" /replace="c" /replace="t" /db_xref="dbSNP:2232145" variation 1195 /gene="VPS37C" /replace="a" /replace="g" /db_xref="dbSNP:2232146" variation 1222 /gene="VPS37C" /replace="a" /replace="g" /db_xref="dbSNP:2232147" variation 1244 /gene="VPS37C" /replace="c" /replace="t" /db_xref="dbSNP:2232148" variation 2196 /gene="VPS37C" /replace="c" /replace="t" /db_xref="dbSNP:2232149" STS 2468..2632 /gene="VPS37C" /standard_name="RH12137" /db_xref="UniSTS:66108" variation 2508 /gene="VPS37C" /replace="c" /replace="t" /db_xref="dbSNP:7876" polyA_signal 2671..2676 /gene="VPS37C" polyA_site 2692 /gene="VPS37C" ORIGIN
tgggcgcggctgcggtttaacccgcggtggcggcggcgacggcggccctggcagggaaggatggagacgctgaaggataagaccctgcaggagctggaggagttgcagaatgactcggaggcgattgaccagctggccctggagtcccctgaggtccaggacctacagctggaacgggagatggcactggccaccaaccggagcctggcagagcggaacttggagttccagggtcccctggagatcagccgctcaaacctctcggatagataccaggagctccggaagctcgtggagcggtgccaggagcagaaggcaaagctggagaaattttcttcagcactgcagccagggaccttgttagaccttctgcaggtggaaggcatgaagatcgaagaagagtccgaggccatggctgagaagttcctggagggcgaggtgcccctggaaacgttcctggagaatttttcctccatgaggatgctgtcccacctgcgccgggttcgcgtggaaaagctccaggaagtggtgaggaagcccagggcttcccaggagctggccggcgatgcccctccaccccgtccaccacccccggtgcgcccagtcccccagggaacaccccctgtggttgaagagcagccgcagccaccattagccatgcctccctaccctttgccctacagcccatcccccagcctgcctgtgggccccactgcccatggagccctgccaccggcccctttcccagtagtgtcccagccctccttctacagcgggcctctgggccccacttacccggcagcccagcttggacccaggggtgctgcgggttactcctggtccccacagaggagcatgccaccccggccgggctatcctgggaccccaatgggtgcctctgggcctgggtaccccttgcggggaggcagggcccccagtcctggttatcctcaacagtccccataccccgcaacaggaggaaaacctccctacccaatacagcctcagctccccagctttccaggccagccccagccctcagtgcccctgcagcccccttatccccccgggcccgcccctccctatgggttcccaccaccgccggggcctgcctggcctgggtattagacacactcctggccctcggcccctccctagtcccacccacgctcaacctttggcccagccatcgccgagattcgagggtcaactggaagtggcgttggtgctccctgtggacttgcgtcggcacccagaggccttggagggacaaggcactgggcggtgtgactggtcatggcacttgctggccttctggccagaggtcctcctggaagcccctcctttcagtgcctggctgcagcggtgctagccaggctggagtccagcacctctcgccggtgtctgtgtgagtgagcgcatgtgcgcatttatgagcatctacttgcggctgcactcagggccatttgaacccagtgcagagttatctctatgaggaggccccgggtctccagccccctccatctcccctggggtttggcatatttgacatggagccccatgccaagggatgcagctgttggtgtctgtccagtccattcaaggctagcctgcccatgcactgtggcaggggttggattggagggagagaacagagttgggaaaaacaacaggtttgagtcctataaagccataatttaactccagtagctgatgtcagacaagcttgtcctatgtcctatttgagtggcagcagcgccagcccagcaagaaggctgggggttgtcaaggttgtccccagaccttgcttgcagtggttggagaacccagggggctgccttgggccctctggccagagggaagcgggcagctctagccctggagattgtggtcacattggggcttgtttaggattggagggccaggtcacctccccagccaccctcccttctctcctctggggtccccactttagggcgactttgcccgaggcccacgcatccatccactcctttagtgccttgaatctcattcacaagcagccccctcccttcccctccccttctcactctgttgatgtaatcctcccacccccagtgtccatcctaagacaggcatcaaaagaggccctaactttacttcccaaatggtgctttttaaaaaacaccatcactacattaggggcaattttttcacacctccctgtcttcagaatgtaaagggtggggattatgtctctgtttaatatgcagccccctgcactgtggggtttggggcatgttcagtaataagaatgaatacaatagacaaagggggtgtgatgagtgttaacttggttgttccagaggtaaaccaggtctcagggaagagcctggagctgctattgcttaggaagttgtacgtgccttgaaatgtccactacctgaggacgcagcatctggtgggcccggggctgctggggccaaggagggaccttgaccttctggtgcctgcccctccccggcctatgtgccatccgcgtgacgctaggtcagcgctgccggttctttaccaaatgtgcttgcttctcctaagttatttataaagagaaatcactaatggactctactggtttgagtgcttctgagctggatgaccgaccgcctgtatgtttgtgtaattaattgccataataaactttgatgagtcacataaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:55048 -> Biological process: GO:0015031 [protein transport] evidence: IEA GeneID:55048 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:55048 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS GeneID:55048 -> Biological process: GO:0016197 [endosomal transport] evidence: TAS GeneID:55048 -> Biological process: GO:0019067 [viral assembly, maturation, egress, and release] evidence: TAS GeneID:55048 -> Biological process: GO:0019068 [virion assembly] evidence: TAS GeneID:55048 -> Biological process: GO:0019082 [viral protein processing] evidence: TAS GeneID:55048 -> Biological process: GO:0046788 [egress of virus within host cell] evidence: TAS GeneID:55048 -> Cellular component: GO:0000813 [ESCRT I complex] evidence: IDA GeneID:55048 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:55048 -> Cellular component: GO:0010008 [endosome membrane] evidence: TAS GeneID:55048 -> Cellular component: GO:0031902 [late endosome membrane] evidence: IEA GeneID:55048 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
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