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2024-04-19 22:59:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_017669 4224 bp mRNA linear PRI 18-APR-2013
DEFINITION Homo sapiens excision repair cross-complementing rodent repair
deficiency, complementation group 6-like (ERCC6L), mRNA.
ACCESSION NM_017669
VERSION NM_017669.2 GI:58331267
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4224)
AUTHORS Rouzeau,S., Cordelieres,F.P., Buhagiar-Labarchede,G., Hurbain,I.,
Onclercq-Delic,R., Gemble,S., Magnaghi-Jaulin,L., Jaulin,C. and
Amor-Gueret,M.
TITLE Bloom's syndrome and PICH helicases cooperate with topoisomerase
IIalpha in centromere disjunction before anaphase
JOURNAL PLoS ONE 7 (4), E33905 (2012)
PUBMED 22563370
REMARK GeneRIF: PICH protein was required for the correct recruitment to
the centromere of active topoisomerase IIalpha, an enzyme
specialized in the catenation/decatenation process.
REFERENCE 2 (bases 1 to 4224)
AUTHORS Ke,Y., Huh,J.W., Warrington,R., Li,B., Wu,N., Leng,M., Zhang,J.,
Ball,H.L., Li,B. and Yu,H.
TITLE PICH and BLM limit histone association with anaphase centromeric
DNA threads and promote their resolution
JOURNAL EMBO J. 30 (16), 3309-3321 (2011)
PUBMED 21743438
REMARK GeneRIF: PICH binds to BLM and enables BLM localization to anaphase
centromeric threads. PICH and BLM unravel centromeric chromatin and
keep anaphase DNA threads mostly free of nucleosomes.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4224)
AUTHORS Kurasawa,Y. and Yu-Lee,L.Y.
TITLE PICH and cotargeted Plk1 coordinately maintain prometaphase
chromosome arm architecture
JOURNAL Mol. Biol. Cell 21 (7), 1188-1199 (2010)
PUBMED 20130082
REMARK GeneRIF: the PICH-Plk1 complex plays a critical role in maintaining
prometaphase chromosome architecture
REFERENCE 4 (bases 1 to 4224)
AUTHORS Hubner,N.C., Wang,L.H., Kaulich,M., Descombes,P., Poser,I. and
Nigg,E.A.
TITLE Re-examination of siRNA specificity questions role of PICH and Tao1
in the spindle checkpoint and identifies Mad2 as a sensitive target
for small RNAs
JOURNAL Chromosoma 119 (2), 149-165 (2010)
PUBMED 19904549
REMARK GeneRIF: the spindle checkpoint failure formerly attributed to the
depletion of PICH most likely reflects an off-target effect that
causes the lowering of Mad2 transcript and protein.
REFERENCE 5 (bases 1 to 4224)
AUTHORS Leng,M., Bessuso,D., Jung,S.Y., Wang,Y. and Qin,J.
TITLE Targeting Plk1 to chromosome arms and regulating chromosome
compaction by the PICH ATPase
JOURNAL Cell Cycle 7 (10), 1480-1489 (2008)
PUBMED 18418076
REMARK GeneRIF: PICH phosphorylation and its ATPase activity are required
for mitotic chromosome compaction through the targeting of Plk1 to
chromosome arms.
REFERENCE 6 (bases 1 to 4224)
AUTHORS Spence,J.M., Phua,H.H., Mills,W., Carpenter,A.J., Porter,A.C. and
Farr,C.J.
TITLE Depletion of topoisomerase IIalpha leads to shortening of the
metaphase interkinetochore distance and abnormal persistence of
PICH-coated anaphase threads
JOURNAL J. Cell. Sci. 120 (PT 22), 3952-3964 (2007)
PUBMED 17956945
REMARK GeneRIF: The sensitivity to depletion of topo IIalpha might be
linked to structural alterations within the centromere domain,
indicated by shortening of the distance across metaphase sister
centromeres and persistence of PICH-coated connections.
REFERENCE 7 (bases 1 to 4224)
AUTHORS Baumann,C., Korner,R., Hofmann,K. and Nigg,E.A.
TITLE PICH, a centromere-associated SNF2 family ATPase, is regulated by
Plk1 and required for the spindle checkpoint
JOURNAL Cell 128 (1), 101-114 (2007)
PUBMED 17218258
REMARK GeneRIF: These data identify PICH as a novel essential component of
checkpoint signaling.
REFERENCE 8 (bases 1 to 4224)
AUTHORS Xu,Y., Chen,X. and Li,Y.
TITLE Ercc6l, a gene of SNF2 family, may play a role in the teratogenic
action of alcohol
JOURNAL Toxicol. Lett. 157 (3), 233-239 (2005)
PUBMED 15917148
REMARK GeneRIF: Functional characterization of the mouse Ercc6l ortholog.
REFERENCE 9 (bases 1 to 4224)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BU431499.1, BM454829.1, AK074719.1, BC008808.2 and AW015865.1.
On Jan 29, 2005 this sequence version replaced gi:8923111.
##Evidence-Data-START##
Transcript exon combination :: BU431499.1, BC111486.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-292 BU431499.1 8-299
293-826 BM454829.1 216-749
827-2761 AK074719.1 301-2235
2762-4197 BC008808.2 276-1711
4198-4224 AW015865.1 1-27 c
FEATURES Location/Qualifiers
source 1..4224
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq13.1"
gene 1..4224
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="excision repair cross-complementing rodent repair
deficiency, complementation group 6-like"
/db_xref="GeneID:54821"
/db_xref="HGNC:20794"
/db_xref="HPRD:10974"
/db_xref="MIM:300687"
exon 1..165
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/inference="alignment:Splign:1.39.8"
variation complement(54)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:41298504"
variation complement(58)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:372092078"
variation complement(60)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201100999"
variation complement(65..66)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace=""
/replace="aaactcc"
/db_xref="dbSNP:202000886"
misc_feature 74..76
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="upstream in-frame stop codon"
variation complement(78)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:369067469"
CDS 98..3850
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/EC_number="3.6.4.12"
/note="SNF2/RAD54 family protein; excision repair protein
ERCC6-like; excision repair cross-complementing rodent
repair deficiency complementation group 6 - like;
Plk1-interacting checkpoint helicase; tumor antigen
BJ-HCC-15; ATP-dependent helicase ERCC6-like"
/codon_start=1
/product="DNA excision repair protein ERCC-6-like"
/protein_id="NP_060139.2"
/db_xref="GI:58331268"
/db_xref="CCDS:CCDS35329.1"
/db_xref="GeneID:54821"
/db_xref="HGNC:20794"
/db_xref="HPRD:10974"
/db_xref="MIM:300687"
/translation="
MEASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEALEELAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTGSADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
"
misc_feature 137..139
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 158..259
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q2NKX8.1);
Region: TPR 1"
misc_feature 392..1348
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="SNF2 family N-terminal domain; Region: SNF2_N;
pfam00176"
/db_xref="CDD:201060"
misc_feature 443..874
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="DEAD-like helicases superfamily. A diverse family
of proteins involved in ATP-dependent RNA or DNA
unwinding. This domain contains the ATP-binding region;
Region: DEXDc; cd00046"
/db_xref="CDD:28927"
misc_feature 470..484
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:28927"
misc_feature 779..790
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q2NKX8.1);
Region: DEAH box"
misc_feature 779..790
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="putative Mg++ binding site [ion binding]; other
site"
/db_xref="CDD:28927"
misc_feature 1442..1843
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="Helicase superfamily c-terminal domain; associated
with DEXDc-, DEAD-, and DEAH-box proteins, yeast
initiation factor 4A, Ski2p, and Hepatitis C virus NS3
helicases; this domain is found in a wide variety of
helicases and helicase related proteins; may...; Region:
HELICc; cd00079"
/db_xref="CDD:28960"
misc_feature order(1547..1558,1616..1621,1703..1711)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="nucleotide binding region [chemical binding]; other
site"
/db_xref="CDD:28960"
misc_feature order(1727..1729,1790..1792,1802..1804,1811..1813)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:28960"
misc_feature 2360..2362
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 2417..2419
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 2516..2518
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 2525..2527
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 2534..2536
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q2NKX8.1); phosphorylation site"
misc_feature 2555..2557
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3065..3067
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[9]
misc_feature 3068..3070
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[9]
misc_feature 3080..3082
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3179..3181
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3284..3286
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PLK1; propagated from
UniProtKB/Swiss-Prot (Q2NKX8.1); phosphorylation site"
misc_feature 3302..3304
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3389..3391
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3638..3640
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3659..3661
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q2NKX8.1); phosphorylation site"
misc_feature 3695..3796
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q2NKX8.1);
Region: TPR 2"
variation complement(127)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375039338"
variation complement(136)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:375803995"
variation complement(163)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201304032"
exon 166..4207
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/inference="alignment:Splign:1.39.8"
variation complement(188)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200564074"
variation complement(256)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="t"
/db_xref="dbSNP:368590575"
variation complement(301)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:377168003"
variation complement(305)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:146213399"
variation complement(311)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:141181241"
variation complement(363)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148217488"
variation complement(366)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140278755"
variation complement(455)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:149451749"
variation complement(473)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:190982446"
variation complement(508)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:139365371"
variation complement(509)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201242720"
variation complement(525)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146896703"
variation complement(595)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:7056605"
variation complement(658)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:138446302"
variation complement(663)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142549919"
variation complement(781)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:200143714"
variation complement(826)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:182482991"
variation complement(831)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:151269287"
variation complement(852)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201800132"
variation complement(875)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374124933"
variation complement(898)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142293032"
variation complement(1124)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="g"
/db_xref="dbSNP:200073614"
variation complement(1134)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="t"
/db_xref="dbSNP:149128529"
variation complement(1287)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:189810726"
variation complement(1289)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:144123832"
variation complement(1290)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:139313430"
variation complement(1458)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="g"
/db_xref="dbSNP:367844894"
variation complement(1486)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:146254781"
variation complement(1496)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:202048178"
variation complement(1591)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:139531286"
variation complement(1634)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:187128885"
variation complement(1658)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:150532018"
variation complement(1672)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373424116"
variation complement(1687)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:376450208"
variation complement(1789)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:373407969"
variation complement(1794)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:370873689"
variation complement(1933)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:199578644"
variation complement(1978)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:148561399"
variation complement(1981)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:112298003"
variation complement(1983)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201713434"
variation complement(1988)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="g"
/db_xref="dbSNP:147328766"
variation complement(1993)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:181182650"
variation complement(2108)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:372955235"
variation complement(2162)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:188646020"
variation complement(2237)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200234671"
STS 2261..2320
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/standard_name="AF020151"
/db_xref="UniSTS:22237"
variation complement(2355)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:369492714"
variation complement(2373)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:45448501"
variation complement(2385)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375177556"
variation complement(2427)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:138539407"
variation complement(2438)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:373087197"
variation complement(2489)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="t"
/db_xref="dbSNP:200118335"
variation complement(2531)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:183569692"
variation complement(2576)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:368694497"
variation complement(2616)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:143780574"
variation complement(2633)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="g"
/db_xref="dbSNP:149400438"
variation complement(2638)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:138817796"
variation complement(2681)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:150211194"
variation complement(2695)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:377308473"
variation complement(2698)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:140936418"
variation complement(2769)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:146534560"
variation complement(2785)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:372744705"
variation complement(2837)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:75816027"
variation complement(2985)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:368349813"
variation complement(3062)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201618175"
variation complement(3094)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:371897834"
variation complement(3131)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:368082499"
variation complement(3136)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373855193"
variation complement(3187)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:145632661"
variation complement(3196)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201951072"
variation complement(3253)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:370268517"
variation complement(3260)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201813772"
variation complement(3316)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:367691365"
variation complement(3319..3320)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace=""
/replace="t"
/db_xref="dbSNP:59719505"
variation complement(3427)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200436150"
variation complement(3439)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369205278"
variation complement(3447)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:140453884"
variation complement(3479)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142136151"
variation complement(3488)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:374591932"
variation complement(3490)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:142184840"
variation complement(3505)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:148656966"
variation complement(3527)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:144948480"
variation complement(3538)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:140206006"
variation complement(3539)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:78660817"
variation complement(3572)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:139547199"
variation complement(3583)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:147364154"
variation complement(3623)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="g"
/replace="t"
/db_xref="dbSNP:201603911"
variation complement(3649)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:376875621"
variation complement(3697)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:142684980"
variation complement(3714)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140225715"
variation complement(3724)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373688535"
variation complement(3774)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:150894750"
variation complement(3853)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:4466531"
variation complement(3859)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:377194117"
variation complement(3881)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373722830"
variation complement(3996)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="c"
/replace="t"
/db_xref="dbSNP:6625979"
variation complement(4129)
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/replace="a"
/replace="c"
/db_xref="dbSNP:373993536"
polyA_signal 4180..4185
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
polyA_site 4197
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 4207
/gene="ERCC6L"
/gene_synonym="PICH; RAD26L"
ORIGIN
gcgaaattcaagctccaaactctaagctccaagctccaagctccaagctccaagctccaaactcccgccggggtaactggaacccaatccgagggtcatggaggcatcccgaaggtttccggaagccgaggccttgagcccagagcaggctgctcattacctaagatatgtgaaagaggccaaagaagcaactaagaatggagacctggaagaagcatttaaacttttcaatttggcaaaggacatttttcccaatgaaaaagtgctgagcagaatccaaaaaatacaggaagccttggaggagttggcagaacagggagatgatgaatttacagatgtgtgcaactctggcttgctactttatcgagaactgcacaaccaactctttgagcaccagaaggaaggcatagctttcctctatagcctgtatagggatggaagaaaaggtggtatattggctgatgatatgggattagggaagactgttcaaatcattgctttcctttccggtatgtttgatgcatcacttgtgaatcatgtgctgctgatcatgccaaccaatcttattaacacatgggtaaaagaattcatcaagtggactccaggaatgagagtcaaaacctttcatggtcctagcaaggatgaacggaccagaaacctcaatcggattcagcaaaggaatggtgttattatcactacataccaaatgttaatcaataactggcagcaactttcaagctttaggggccaagagtttgtgtgggactatgtcatcctcgatgaagcacataaaataaaaacctcatctactaagtcagcaatatgtgctcgtgctattcctgcaagtaatcgcctcctcctcacaggaaccccaatccagaataatttacaagaactatggtccctatttgattttgcttgtcaagggtccctgctgggaacattaaaaacttttaagatggagtatgaaaatcctattactagagcaagagagaaggatgctaccccaggagaaaaagccttgggatttaaaatatctgaaaacttaatggcaatcataaaaccctattttctcaggaggactaaagaagacgtacagaagaaaaagtcaagcaacccagaggccagacttaatgaaaagaatccagatgttgatgccatttgtgaaatgccttccctttccaggaaaaatgatttaattatttggatacgacttgtgcctttacaagaagaaatatacaggaaatttgtgtctttagatcatatcaaggagttgctaatggagacgcgctcacctttggctgagctaggtgtcttaaagaagctgtgtgatcatcctaggctgctgtctgcacgggcttgttgtttgctaaatcttgggacattctctgctcaagatggaaatgagggggaagattccccagatgtggaccatattgatcaagtaactgatgacacattgatggaagaatctggaaaaatgatattcctaatggacctacttaagaggctgcgagatgagggacatcaaactctggtgttttctcaatcgaggcaaattctaaacatcattgaacgcctcttaaagaataggcactttaagacattgcgaatcgatgggacagttactcatcttttggaacgagaaaaaagaattaacttattccagcaaaataaagattactctgtttttctgcttaccactcaagtaggtggtgtcggtttaacattaactgcagcaactagagtggtcatttttgaccctagctggaatcctgcaactgatgctcaagctgtggatagagtttaccgaattggacaaaaagagaatgttgtggtttataggctaatcacttgtgggactgtagaggaaaaaatatacagaagacaggttttcaaggactcattaataagacaaactactggtgaaaaaaagaaccctttccgatattttagtaaacaagaattaagagagctctttacaatcgaggatcttcagaactctgtaacccagctgcagcttcagtctttgcatgctgctcagaggaaatctgatataaaactagatgaacatattgcctacctgcagtctttggggatagctggaatctcagaccatgatttgatgtacacatgtgatctgtctgttaaagaagagcttgatgtggtagaagaatctcactatattcaacaaagggttcagaaagctcaattcctcgttgaattcgagtctcaaaataaagagttcctgatggaacaacaaagaactagaaatgagggggcctggctaagagaacctgtatttccttcttcaacaaagaagaaatgccctaaattgaataaaccacagcctcagccttcacctcttctaagtactcatcatactcaggaagaagatatcagttccaaaatggcaagtgtagtcattgatgatctgcccaaagagggtgagaaacaagatctctccagtataaaggtgaatgttaccaccttgcaagatggtaaaggtacaggtagtgctgactctatagctactttaccaaaggggtttggaagtgtagaagaactttgtactaactcttcattgggaatggaaaaaagctttgcaactaaaaatgaagctgtacaaaaagagacattacaagaggggcctaagcaagaggcactgcaagaggatcctctggaaagttttaattatgtacttagcaaatcaaccaaagctgatattgggccaaatttagatcaactaaaggatgatgagattttacgtcattgcaatccttggcccattatttccataacaaatgaaagtcaaaatgcagaatcaaatgtatccattattgaaatagctgatgacctttcagcatcccatagtgcactgcaggatgctcaagcaagtgaggccaagttggaagaggaaccttcagcatcttcaccacagtatgcatgtgatttcaatcttttcttggaagactcagcagacaacagacaaaatttttccagtcagtctttagagcatgttgagaaagaaaatagcttgtgtggctctgcacctaattccagagcagggtttgtgcatagcaaaacatgtctcagttgggagttttctgagaaagacgatgaaccagaagaagtagtagttaaagcaaaaatcagaagtaaagctagaaggattgtttcagatggcgaagatgaagatgattcttttaaagatacctcaagcataaatccattcaacacatctctctttcaattctcatctgtgaaacaatttgatgcttcaactcccaaaaatgacatcagtccaccaggaaggttcttttcatctcaaatacccagtagtgtaaataagtctatgaactctagaagatctctggcttctaggaggtctcttattaatatggttttagaccacgtggaggacatggaggaaagacttgacgacagcagtgaagcaaagggtcctgaagattatccagaagaaggggtggaggaaagcagtggcgaagcctccaagtatacagaagaggatccttccggagaaacactgtcttcagaaaacaagtccagctggttaatgacgtctaagcctagtgctctagctcaagagacctctcttggtgcccctgagcctttgtctggtgaacagttggttggttctccccaggataaggcggcagaggctacaaatgactatgagactcttgtaaagcgtggaaaagaactaaaagagtgtggaaaaatccaggaggccctaaactgcttagttaaagcgcttgacataaaaagtgcagatcctgaagttatgctcttgactttaagtttgtataagcaacttaataacaattgagaatgtaacctgtttattgtattttaaagtgaaactgaatatgagggaatttttgttcccataattggattctttgggaacatgaagcattcaggcttaaggcaagaaagatctcaaaaagcaacttctgccctgcaacgccccccactccatagtctggtattctgagcactagcttaatatttcttcacttgaatattcttatattttaggcatattctataaatttaactgtgttgtttcttggaaagttttgtaaaattattctggtcattcttaattttactctgaaagtgatcatctttgtatataacagttcagataagaaaattaaagttacttttctcaagtgttttcaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:54821 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:54821 -> Molecular function: GO:0004386 [helicase activity] evidence: IEA
GeneID:54821 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:54821 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:54821 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:54821 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:54821 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:54821 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA
GeneID:54821 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_060139 -> EC 3.6.4.12
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.