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2024-04-25 08:41:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_017572 1778 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens MAP kinase interacting serine/threonine kinase 2
(MKNK2), transcript variant 1, mRNA.
ACCESSION NM_017572
VERSION NM_017572.3 GI:150378531
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1778)
AUTHORS Joshi,S., Sharma,B., Kaur,S., Majchrzak,B., Ueda,T., Fukunaga,R.,
Verma,A.K., Fish,E.N. and Platanias,L.C.
TITLE Essential role for Mnk kinases in type II interferon (IFNgamma)
signaling and its suppressive effects on normal hematopoiesis
JOURNAL J. Biol. Chem. 286 (8), 6017-6026 (2011)
PUBMED 21149447
REMARK GeneRIF: siRNA-mediated Mnk1/2 knockdown results in partial
reversal of the suppressive effects of IFNgamma on human
CD34+-derived myeloid (CFU-GM) and erythroid (BFU-E) progenitors.
REFERENCE 2 (bases 1 to 1778)
AUTHORS Dolniak,B., Katsoulidis,E., Carayol,N., Altman,J.K., Redig,A.J.,
Tallman,M.S., Ueda,T., Watanabe-Fukunaga,R., Fukunaga,R. and
Platanias,L.C.
TITLE Regulation of arsenic trioxide-induced cellular responses by Mnk1
and Mnk2
JOURNAL J. Biol. Chem. 283 (18), 12034-12042 (2008)
PUBMED 18299328
REFERENCE 3 (bases 1 to 1778)
AUTHORS Buxade,M., Parra-Palau,J.L. and Proud,C.G.
TITLE The Mnks: MAP kinase-interacting kinases (MAP kinase
signal-integrating kinases)
JOURNAL Front. Biosci. 13, 5359-5373 (2008)
PUBMED 18508592
REMARK Review article
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 1778)
AUTHORS Wang,P., Wang,X., Wang,F., Cai,T. and Luo,Y.
TITLE Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex
JOURNAL Sci. China, C, Life Sci. 49 (3), 265-273 (2006)
PUBMED 16856496
REMARK GeneRIF: Mnk2 can interact with CBC(VHL) complex, and is probably
one of the new substrates of the CBC(VHL) complex.
REFERENCE 5 (bases 1 to 1778)
AUTHORS Jauch,R., Jakel,S., Netter,C., Schreiter,K., Aicher,B., Jackle,H.
and Wahl,M.C.
TITLE Crystal structures of the Mnk2 kinase domain reveal an inhibitory
conformation and a zinc binding site
JOURNAL Structure 13 (10), 1559-1568 (2005)
PUBMED 16216586
REFERENCE 6 (bases 1 to 1778)
AUTHORS Knauf,U., Tschopp,C. and Gram,H.
TITLE Negative regulation of protein translation by mitogen-activated
protein kinase-interacting kinases 1 and 2
JOURNAL Mol. Cell. Biol. 21 (16), 5500-5511 (2001)
PUBMED 11463832
REFERENCE 7 (bases 1 to 1778)
AUTHORS Scheper,G.C., Morrice,N.A., Kleijn,M. and Proud,C.G.
TITLE The mitogen-activated protein kinase signal-integrating kinase Mnk2
is a eukaryotic initiation factor 4E kinase with high levels of
basal activity in mammalian cells
JOURNAL Mol. Cell. Biol. 21 (3), 743-754 (2001)
PUBMED 11154262
REFERENCE 8 (bases 1 to 1778)
AUTHORS Slentz-Kesler,K., Moore,J.T., Lombard,M., Zhang,J.,
Hollingsworth,R. and Weiner,M.P.
TITLE Identification of the human Mnk2 gene (MKNK2) through protein
interaction with estrogen receptor beta
JOURNAL Genomics 69 (1), 63-71 (2000)
PUBMED 11013076
REFERENCE 9 (bases 1 to 1778)
AUTHORS Waskiewicz,A.J., Flynn,A., Proud,C.G. and Cooper,J.A.
TITLE Mitogen-activated protein kinases activate the serine/threonine
kinases Mnk1 and Mnk2
JOURNAL EMBO J. 16 (8), 1909-1920 (1997)
PUBMED 9155017
REFERENCE 10 (bases 1 to 1778)
AUTHORS Haribabu,B. and Snyderman,R.
TITLE Identification of additional members of human G-protein-coupled
receptor kinase multigene family
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (20), 9398-9402 (1993)
PUBMED 8415712
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA950743.1, BC073140.1 and
AL137615.1.
On Jul 3, 2007 this sequence version replaced gi:40018630.
Summary: This gene encodes a member of the
calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein
kinase family, which belongs to the protein kinase superfamily.
This protein contains conserved DLG (asp-leu-gly) and ENIL
(glu-asn-ile-leu) motifs, and an N-terminal polybasic region which
binds importin A and the translation factor scaffold protein
eukaryotic initiation factor 4G (eIF4G). This protein is one of the
downstream kinases activated by mitogen-activated protein (MAP)
kinases. It phosphorylates the eukaryotic initiation factor 4E
(eIF4E), thus playing important roles in the initiation of mRNA
translation, oncogenic transformation and malignant cell
proliferation. In addition to eIF4E, this protein also interacts
with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1)
and Cullin2 (Cul2), which are all components of the CBC(VHL)
ubiquitin ligase E3 complex. Multiple alternatively spliced
transcript variants have been found, but the full-length nature and
biological activity of only two variants are determined. These two
variants encode distinct isoforms which differ in activity and
regulation, and in subcellular localization. [provided by RefSeq,
Aug 2011].
Transcript Variant: This variant (1) differs in the 3' exon
including 3' coding region and 3' UTR, compared to variant 2. The
resulting protein (isoform 1, also known as isoform b) has a
shorter and distinct C-terminus, compared to isoform 2. This
isoform is found in the nucleus and lacks the MAP kinase-binding
region.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC073140.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-20 DA950743.1 1-20
21-1595 BC073140.1 1-1575
1596-1778 AL137615.1 1307-1489
FEATURES Location/Qualifiers
source 1..1778
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.3"
gene 1..1778
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="MAP kinase interacting serine/threonine kinase 2"
/db_xref="GeneID:2872"
/db_xref="HGNC:7111"
/db_xref="MIM:605069"
exon 1..149
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 150..296
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
CDS 246..1490
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/EC_number="2.7.11.1"
/note="isoform 1 is encoded by transcript variant 1; G
protein-coupled receptor kinase 7; MAP kinase-interacting
serine/threonine-protein kinase 2; MAP kinase
signal-integrating kinase 2; MAPK signal-integrating
kinase 2"
/codon_start=1
/product="MAP kinase-interacting serine/threonine-protein
kinase 2 isoform 1"
/protein_id="NP_060042.2"
/db_xref="GI:40018631"
/db_xref="CCDS:CCDS12079.1"
/db_xref="GeneID:2872"
/db_xref="HGNC:7111"
/db_xref="MIM:605069"
/translation="
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRWDSHFLLPPHPCRIHVRPGGLVRTVTVNE
"
misc_feature 324..326
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
misc_feature 423..443
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HBH9.3);
Region: Nuclear localization signal"
misc_feature 492..1349
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 513..1346
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(513..527,537..539,576..578,582..584,720..731,
741..743,747..749,858..860,864..866,870..875,879..881,
921..923,930..932,999..1010)
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(513..527,537..539,576..578,582..584,720..731,
741..743,858..860,864..866,870..875,879..881,921..923)
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(525..527,741..743,747..749,858..860,864..866,
870..872,930..932,999..1010)
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature 723..731
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HBH9.3);
Region: Staurosporine binding"
misc_feature 903..905
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
misc_feature order(918..938,999..1010)
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 975..977
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9HBH9.3); phosphorylation site"
misc_feature 990..992
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9HBH9.3); phosphorylation site"
misc_feature 1380..1382
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9HBH9.3); phosphorylation site"
misc_feature 1380..1382
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
exon 297..384
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 385..486
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
variation 449
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:34916924"
exon 487..584
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 585..664
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 665..738
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 739..843
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 844..899
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 900..995
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 996..1190
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
variation 1019
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11556609"
exon 1191..1355
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 1356..1399
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
exon 1400..1758
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
/inference="alignment:Splign:1.39.8"
polyA_signal 1738..1743
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
polyA_site 1758
/gene="MKNK2"
/gene_synonym="GPRK7; MNK2"
ORIGIN
cggctcctctcagcggcggtggcccaggtagaggggtccgcgctggcggcggcggcggcgctgttccccgcgcggtccgcggagcggggtccgggctgcgcgacgtggggcggcggcggcactgcggccccggcccaagcccgaccccgggtcccctcctcggccgccccccgcccggccgcccgccctcgggcctccccccgggccctcggtcccctcccccgctggcggggcccggacagaagatggtgcagaagaaaccagccgaacttcagggtttccaccgttcgttcaaggggcagaaccccttcgagctggccttctccctagaccagcccgaccacggagactctgactttggcctgcagtgctcagcccgccctgacatgcccgccagccagcccattgacatcccggacgccaagaagaggggcaagaagaagaagcgcggccgggccaccgacagcttctcgggcaggtttgaagacgtctaccagctgcaggaagatgtgctgggggagggcgctcatgcccgagtgcagacctgcatcaacctgatcaccagccaggagtacgccgtcaagatcattgagaagcagccaggccacattcggagcagggttttcagggaggtggagatgctgtaccagtgccagggacacaggaacgtcctagagctgattgagttcttcgaggaggaggaccgcttctacctggtgtttgagaagatgcggggaggctccatcctgagccacatccacaagcgccggcacttcaacgagctggaggccagcgtggtggtgcaggacgtggccagcgccttggactttctgcataacaaaggcatcgcccacagggacctaaagccggaaaacatcctctgtgagcaccccaaccaggtctcccccgtgaagatctgtgacttcgacctgggcagcggcatcaaactcaacggggactgctcccctatctccaccccggagctgctcactccgtgcggctcggcggagtacatggccccggaggtagtggaggccttcagcgaggaggctagcatctacgacaagcgctgcgacctgtggagcctgggcgtcatcttgtatatcctactcagcggctacccgcccttcgtgggccgctgtggcagcgactgcggctgggaccgcggcgaggcctgccctgcctgccagaacatgctgtttgagagcatccaggagggcaagtacgagttccccgacaaggactgggcccacatctcctgcgctgccaaagacctcatctccaagctgctggtccgtgacgccaagcagaggctgagtgccgcccaagtcctgcagcacccctgggttcaggggtgcgccccggagaacaccttgcccactcccatggtcctgcagaggtgggacagtcacttcctcctccctccccacccctgtcgcatccacgtgcgacctggaggactggtcagaaccgttactgtgaatgagtgaagatcctggaggaccctgggccccaggccagctcccatcgctgggggacggtgaacggccatgtgttaatgttacgatgtttttaaaagacaaaaaaaaaaaaaaaacctcaaaagtttttttaaagtgggggaaaaacatccaagcactttaattccaatgtaccaggtgaactgacggagctcagaagttttcctttacaccaactgtcaatgccggaattttgtattctgttttgtaaagatttaataaaagtcaaaaaacttgcaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2872 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:2872 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:2872 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:2872 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:2872 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:2872 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2872 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:2872 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:2872 -> Biological process: GO:0030097 [hemopoiesis] evidence: IDA
GeneID:2872 -> Biological process: GO:0071243 [cellular response to arsenic-containing substance] evidence: IDA
GeneID:2872 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:2872 -> Cellular component: GO:0016605 [PML body] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_060042 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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