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2024-04-20 08:55:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_017566 1944 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens kelch domain containing 4 (KLHDC4), transcript variant
1, mRNA.
ACCESSION NM_017566
VERSION NM_017566.3 GI:296434230
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1944)
AUTHORS Suzuki,Y., Yamashita,R., Shirota,M., Sakakibara,Y., Chiba,J.,
Mizushima-Sugano,J., Nakai,K. and Sugano,S.
TITLE Sequence comparison of human and mouse genes reveals a homologous
block structure in the promoter regions
JOURNAL Genome Res. 14 (9), 1711-1718 (2004)
PUBMED 15342556
REFERENCE 2 (bases 1 to 1944)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP215584.1 and BC022969.1.
On May 21, 2010 this sequence version replaced gi:21314674.
Transcript Variant: Transcript Variant: This variant (1) represents
the longest transcript and encodes the longest isoform (1).
##Evidence-Data-START##
Transcript exon combination :: BC022969.1, AK023986.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-56 BP215584.1 1-56
57-1944 BC022969.1 1-1888
FEATURES Location/Qualifiers
source 1..1944
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q24.3"
gene 1..1944
/gene="KLHDC4"
/note="kelch domain containing 4"
/db_xref="GeneID:54758"
/db_xref="HGNC:25272"
/db_xref="HPRD:11180"
exon 1..201
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
CDS 103..1665
/gene="KLHDC4"
/note="isoform 1 is encoded by transcript variant 1"
/codon_start=1
/product="kelch domain-containing protein 4 isoform 1"
/protein_id="NP_060036.2"
/db_xref="GI:21314675"
/db_xref="CCDS:CCDS10963.1"
/db_xref="GeneID:54758"
/db_xref="HGNC:25272"
/db_xref="HPRD:11180"
/translation="
MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED
"
misc_feature 325..483
/gene="KLHDC4"
/note="Galactose oxidase, central domain; Region: Kelch_3;
pfam13415"
/db_xref="CDD:205593"
misc_feature 331..489
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 1"
misc_feature 442..444
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 493..654
/gene="KLHDC4"
/note="Galactose oxidase, central domain; Region: Kelch_3;
pfam13415"
/db_xref="CDD:205593"
misc_feature 499..663
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 2"
misc_feature 628..771
/gene="KLHDC4"
/note="Galactose oxidase, central domain; Region: Kelch_4;
pfam13418"
/db_xref="CDD:205596"
misc_feature 664..825
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 3"
misc_feature 790..966
/gene="KLHDC4"
/note="Galactose oxidase, central domain; Region: Kelch_3;
cl02701"
/db_xref="CDD:207702"
misc_feature 829..969
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 4"
misc_feature 985..1128
/gene="KLHDC4"
/note="Galactose oxidase, central domain; Region: Kelch_3;
cl02701"
/db_xref="CDD:207702"
misc_feature 1024..1185
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 5"
misc_feature 1339..1341
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8TBB5.1); phosphorylation site"
misc_feature 1339..1341
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1354..1356
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8TBB5.1); phosphorylation site"
misc_feature 1354..1356
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1429..1584
/gene="KLHDC4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
Region: Kelch 6"
exon 202..293
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 294..372
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 373..471
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 472..608
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
variation 486
/gene="KLHDC4"
/replace="g"
/replace="t"
/db_xref="dbSNP:35970259"
variation 491
/gene="KLHDC4"
/replace="g"
/replace="t"
/db_xref="dbSNP:34779002"
exon 609..701
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 702..861
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 862..937
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 938..1146
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 1147..1549
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 1550..1666
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
exon 1667..1930
/gene="KLHDC4"
/inference="alignment:Splign:1.39.8"
variation 1686
/gene="KLHDC4"
/replace="g"
/replace="t"
/db_xref="dbSNP:2290019"
STS 1772..1901
/gene="KLHDC4"
/standard_name="RH48429"
/db_xref="UniSTS:2507"
ORIGIN
atttctgtgcgccgagctccgccccacgagcacctgtttccgagcggagagcgcgggccgttttctttcctggtgtcccgtcgcggcttgggacccggcaagatgggcaagaagggcaagaaggagaagaagggccgcggcgcggagaagacggccgccaagatggagaagaaggtgtctaagcgctcgcggaaggaggaggaagacctggaagcgctcatagcccatttccagacactcgatgccaagaggactcagactgtggaacttccgtgccccccaccctcaccaaggttaaatgcctccctctcggttcatcctgagaaagatgagttaatcctttttggaggtgaatatttcaacggccaaaaaacttttttgtataacgagctctatgtctacaataccagaaaggacacctggaccaaagttgacatccccagtccacctccgaggcgctgtgctcaccaggcggtggtagtgcctcaaggtggcggacagctgtgggtctttggaggggagtttgcctctcccaacggagagcagttctaccactacaaggatctctgggtcctgcatttggccaccaagacctgggaacaagtcaaatcaacaggcggtccttcgggtcggagtggacatcggatggtggcctggaagagacaattgatcctgtttggtggcttccatgaaagtacacgggattacatctactacaacgacgtgtatgcctttaatctggacaccttcacatggagcaagctgtccccgtcagggacggggcccacacccagatcaggctgccagatgtccgtcactccccagggcggcatcgtcgtctatgggggctactcgaaacagagagttaagaaagacgtggacaagggcacacggcactcagacatgttcctgctgaagccagaggacggaagagaagacaagtgggtttggactcggatgaacccttcgggggtcaagcccaccccacggtctggcttttccgtggccatggccccgaatcaccagacactgttcttcgggggtgtctgtgacgaggaagaggaggagagcctgtcgggcgagttcttcaacgatctgtacttctacgacgccaccaggaaccgttggtttgagggacagctgaagggacccaagtctgaaaagaagaaacgcaggcggggcagaaaagaggagcccgaaggtggtagcaggccggcgtgtgggggagctggcacccaggggcctgtgcagctggtcaaggaggtggtggccgaggatggcaccgtggtcaccattaagcaggtgctcaccgcgccaggctcggcggggcagccccggtctgaggacgaagacagccttgaggaggccggcagccccgcacctgggccgtgtccacgctccaacgccatgctggctgtgaagcatggggtgctctacgtctatgggggcatgtttgaggccggcgaccgccaggtcaccctcagcgacctgcactgcctggacctgcacaggatggaggcgtggaaggccttggtggagatggacccagaaactcaggagtggctggaggagacggactcggaagaggacagtgaggaggttgagggcgccgagggtggggtcgacgacgaagacagcggagaggagagcggtgcggaggactgagaagagcccctgccaggggcgcctggcaagtgctgtgcccacgtccgcccaggacccagccgtgttgagtgaagctcttggggccagcgtgcgtcctgacgcacaggagagagctgaaggtgggtggcccaggccagggtgtgaactttctcccatggtttagtctctgacgcggcactgggccggaagttcaactgagtgcagtgcaggtggattccctcagcagcctgtgtgttgtgtgaaataaattggacttgaaacaagaaaaaaaaaaaaaaa
//
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@meso_cacase at
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