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2020-10-26 19:09:06, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_017566               1944 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens kelch domain containing 4 (KLHDC4), transcript variant
            1, mRNA.
ACCESSION   NM_017566
VERSION     NM_017566.3  GI:296434230
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1944)
  AUTHORS   Suzuki,Y., Yamashita,R., Shirota,M., Sakakibara,Y., Chiba,J.,
            Mizushima-Sugano,J., Nakai,K. and Sugano,S.
  TITLE     Sequence comparison of human and mouse genes reveals a homologous
            block structure in the promoter regions
  JOURNAL   Genome Res. 14 (9), 1711-1718 (2004)
   PUBMED   15342556
REFERENCE   2  (bases 1 to 1944)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP215584.1 and BC022969.1.
            On May 21, 2010 this sequence version replaced gi:21314674.
            
            Transcript Variant: Transcript Variant: This variant (1) represents
            the longest transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022969.1, AK023986.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BP215584.1         1-56
            57-1944             BC022969.1         1-1888
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..1944
                     /gene="KLHDC4"
                     /note="kelch domain containing 4"
                     /db_xref="GeneID:54758"
                     /db_xref="HGNC:25272"
                     /db_xref="HPRD:11180"
     exon            1..201
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     CDS             103..1665
                     /gene="KLHDC4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="kelch domain-containing protein 4 isoform 1"
                     /protein_id="NP_060036.2"
                     /db_xref="GI:21314675"
                     /db_xref="CCDS:CCDS10963.1"
                     /db_xref="GeneID:54758"
                     /db_xref="HGNC:25272"
                     /db_xref="HPRD:11180"
                     /translation="
MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNASLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKKRRRGRKEEPEGGSRPACGGAGTQGPVQLVKEVVAEDGTVVTIKQVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPRSNAMLAVKHGVLYVYGGMFEAGDRQVTLSDLHCLDLHRMEAWKALVEMDPETQEWLEETDSEEDSEEVEGAEGGVDDEDSGEESGAED
"
     misc_feature    325..483
                     /gene="KLHDC4"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     pfam13415"
                     /db_xref="CDD:205593"
     misc_feature    331..489
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 1"
     misc_feature    442..444
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    493..654
                     /gene="KLHDC4"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     pfam13415"
                     /db_xref="CDD:205593"
     misc_feature    499..663
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 2"
     misc_feature    628..771
                     /gene="KLHDC4"
                     /note="Galactose oxidase, central domain; Region: Kelch_4;
                     pfam13418"
                     /db_xref="CDD:205596"
     misc_feature    664..825
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 3"
     misc_feature    790..966
                     /gene="KLHDC4"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     cl02701"
                     /db_xref="CDD:207702"
     misc_feature    829..969
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 4"
     misc_feature    985..1128
                     /gene="KLHDC4"
                     /note="Galactose oxidase, central domain; Region: Kelch_3;
                     cl02701"
                     /db_xref="CDD:207702"
     misc_feature    1024..1185
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 5"
     misc_feature    1339..1341
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q8TBB5.1); phosphorylation site"
     misc_feature    1339..1341
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1354..1356
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q8TBB5.1); phosphorylation site"
     misc_feature    1354..1356
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1429..1584
                     /gene="KLHDC4"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TBB5.1);
                     Region: Kelch 6"
     exon            202..293
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            294..372
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            373..471
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            472..608
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     variation       486
                     /gene="KLHDC4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35970259"
     variation       491
                     /gene="KLHDC4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34779002"
     exon            609..701
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            702..861
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            862..937
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            938..1146
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            1147..1549
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            1550..1666
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     exon            1667..1930
                     /gene="KLHDC4"
                     /inference="alignment:Splign:1.39.8"
     variation       1686
                     /gene="KLHDC4"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2290019"
     STS             1772..1901
                     /gene="KLHDC4"
                     /standard_name="RH48429"
                     /db_xref="UniSTS:2507"
ORIGIN      
atttctgtgcgccgagctccgccccacgagcacctgtttccgagcggagagcgcgggccgttttctttcctggtgtcccgtcgcggcttgggacccggcaagatgggcaagaagggcaagaaggagaagaagggccgcggcgcggagaagacggccgccaagatggagaagaaggtgtctaagcgctcgcggaaggaggaggaagacctggaagcgctcatagcccatttccagacactcgatgccaagaggactcagactgtggaacttccgtgccccccaccctcaccaaggttaaatgcctccctctcggttcatcctgagaaagatgagttaatcctttttggaggtgaatatttcaacggccaaaaaacttttttgtataacgagctctatgtctacaataccagaaaggacacctggaccaaagttgacatccccagtccacctccgaggcgctgtgctcaccaggcggtggtagtgcctcaaggtggcggacagctgtgggtctttggaggggagtttgcctctcccaacggagagcagttctaccactacaaggatctctgggtcctgcatttggccaccaagacctgggaacaagtcaaatcaacaggcggtccttcgggtcggagtggacatcggatggtggcctggaagagacaattgatcctgtttggtggcttccatgaaagtacacgggattacatctactacaacgacgtgtatgcctttaatctggacaccttcacatggagcaagctgtccccgtcagggacggggcccacacccagatcaggctgccagatgtccgtcactccccagggcggcatcgtcgtctatgggggctactcgaaacagagagttaagaaagacgtggacaagggcacacggcactcagacatgttcctgctgaagccagaggacggaagagaagacaagtgggtttggactcggatgaacccttcgggggtcaagcccaccccacggtctggcttttccgtggccatggccccgaatcaccagacactgttcttcgggggtgtctgtgacgaggaagaggaggagagcctgtcgggcgagttcttcaacgatctgtacttctacgacgccaccaggaaccgttggtttgagggacagctgaagggacccaagtctgaaaagaagaaacgcaggcggggcagaaaagaggagcccgaaggtggtagcaggccggcgtgtgggggagctggcacccaggggcctgtgcagctggtcaaggaggtggtggccgaggatggcaccgtggtcaccattaagcaggtgctcaccgcgccaggctcggcggggcagccccggtctgaggacgaagacagccttgaggaggccggcagccccgcacctgggccgtgtccacgctccaacgccatgctggctgtgaagcatggggtgctctacgtctatgggggcatgtttgaggccggcgaccgccaggtcaccctcagcgacctgcactgcctggacctgcacaggatggaggcgtggaaggccttggtggagatggacccagaaactcaggagtggctggaggagacggactcggaagaggacagtgaggaggttgagggcgccgagggtggggtcgacgacgaagacagcggagaggagagcggtgcggaggactgagaagagcccctgccaggggcgcctggcaagtgctgtgcccacgtccgcccaggacccagccgtgttgagtgaagctcttggggccagcgtgcgtcctgacgcacaggagagagctgaaggtgggtggcccaggccagggtgtgaactttctcccatggtttagtctctgacgcggcactgggccggaagttcaactgagtgcagtgcaggtggattccctcagcagcctgtgtgttgtgtgaaataaattggacttgaaacaagaaaaaaaaaaaaaaa
//

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