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2020-10-26 19:53:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_017534               6163 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens myosin, heavy chain 2, skeletal muscle, adult (MYH2),
            transcript variant 1, mRNA.
ACCESSION   NM_017534
VERSION     NM_017534.5  GI:153792662
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6163)
  AUTHORS   van den Dries,K., Meddens,M.B., de Keijzer,S., Shekhar,S.,
            Subramaniam,V., Figdor,C.G. and Cambi,A.
  TITLE     Interplay between myosin IIA-mediated contractility and actin
            network integrity orchestrates podosome composition and
            oscillations
  JOURNAL   Nat Commun 4, 1412 (2013)
   PUBMED   23361003
  REMARK    GeneRIF: A previously unrecognized interplay between actin and
            myosin IIA in podosomes, is demonstrated.
REFERENCE   2  (bases 1 to 6163)
  AUTHORS   Wang,L., Zhang,J., Fu,W., Guo,D., Jiang,J. and Wang,Y.
  TITLE     Association of smooth muscle cell phenotypes with extracellular
            matrix disorders in thoracic aortic dissection
  JOURNAL   J. Vasc. Surg. 56 (6), 1698-1709 (2012)
   PUBMED   22960022
  REMARK    GeneRIF: Phenotypic expression of alpha-smooth muscle actin, smooth
            muscle myosin heavy chain 2, and smoothelin were significantly
            decreased in the dissected media, whereas that of osteopontin was
            elevated.
REFERENCE   3  (bases 1 to 6163)
  AUTHORS   Iresjo,B.M. and Lundholm,K.
  TITLE     Myosin heavy chain 2A and alpha-actin expression in human and
            murine skeletal muscles at feeding; particularly amino acids
  JOURNAL   J Transl Med 10, 238 (2012)
   PUBMED   23190566
  REMARK    GeneRIF: Myosin heavy chain 2A transcripts decreased significantly
            in skeletal muscle tissue from overnight parenterally fed patients
            but did not change significantly in orally refed mice
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6163)
  AUTHORS   Tajsharghi,H., Darin,N., Rekabdar,E., Kyllerman,M., Wahlstrom,J.,
            Martinsson,T. and Oldfors,A.
  TITLE     Mutations and sequence variation in the human myosin heavy chain
            IIa gene (MYH2)
  JOURNAL   Eur. J. Hum. Genet. 13 (5), 617-622 (2005)
   PUBMED   15741996
  REMARK    GeneRIF: analysis of normal variation indicates that there is
            strong selective pressure against mutations in MYH2; On the basis
            of these results, we suggest that MyHC genes should be regarded as
            candidate genes in hereditary myopathies of unknown etiology.
REFERENCE   5  (bases 1 to 6163)
  AUTHORS   Martinsson,T., Oldfors,A., Darin,N., Berg,K., Tajsharghi,H.,
            Kyllerman,M. and Wahlstrom,J.
  TITLE     Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in
            the myosin heavy chain IIa gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (26), 14614-14619 (2000)
   PUBMED   11114175
REFERENCE   6  (bases 1 to 6163)
  AUTHORS   Weiss,A., Schiaffino,S. and Leinwand,L.A.
  TITLE     Comparative sequence analysis of the complete human sarcomeric
            myosin heavy chain family: implications for functional diversity
  JOURNAL   J. Mol. Biol. 290 (1), 61-75 (1999)
   PUBMED   10388558
REFERENCE   7  (bases 1 to 6163)
  AUTHORS   Weiss,A., McDonough,D., Wertman,B., Acakpo-Satchivi,L.,
            Montgomery,K., Kucherlapati,R., Leinwand,L. and Krauter,K.
  TITLE     Organization of human and mouse skeletal myosin heavy chain gene
            clusters is highly conserved
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (6), 2958-2963 (1999)
   PUBMED   10077619
REFERENCE   8  (bases 1 to 6163)
  AUTHORS   Smerdu,V., Karsch-Mizrachi,I., Campione,M., Leinwand,L. and
            Schiaffino,S.
  TITLE     Type IIx myosin heavy chain transcripts are expressed in type IIb
            fibers of human skeletal muscle
  JOURNAL   Am. J. Physiol. 267 (6 PT 1), C1723-C1728 (1994)
   PUBMED   7545970
REFERENCE   9  (bases 1 to 6163)
  AUTHORS   Schwartz,C.E., McNally,E., Leinwand,L. and Skolnick,M.H.
  TITLE     A polymorphic human myosin heavy chain locus is linked to an
            anonymous single copy locus (D17S1) at 17p13
  JOURNAL   Cytogenet. Cell Genet. 43 (1-2), 117-120 (1986)
   PUBMED   2877813
REFERENCE   10 (bases 1 to 6163)
  AUTHORS   Barton,P.J. and Buckingham,M.E.
  TITLE     The myosin alkali light chain proteins and their genes
  JOURNAL   Biochem. J. 231 (2), 249-261 (1985)
   PUBMED   3904738
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC379233.1, BC126409.1 and
            BC093082.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jul 25, 2007 this sequence version replaced gi:142384467.
            
            Summary: Myosins are actin-based motor proteins that function in
            the generation of mechanical force in eukaryotic cells. Muscle
            myosins are heterohexamers composed of 2 myosin heavy chains and 2
            pairs of nonidentical myosin light chains. This gene encodes a
            member of the class II or conventional myosin heavy chains, and
            functions in skeletal muscle contraction. This gene is found in a
            cluster of myosin heavy chain genes on chromosome 17. A mutation in
            this gene results in inclusion body myopathy-3. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX510904.2, BC126409.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               DC379233.1         1-524
            525-5977            BC126409.1         468-5920
            5978-6163           BC093082.1         2224-2409
FEATURES             Location/Qualifiers
     source          1..6163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6163
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="myosin, heavy chain 2, skeletal muscle, adult"
                     /db_xref="GeneID:4620"
                     /db_xref="HGNC:7572"
                     /db_xref="MIM:160740"
     exon            1..65
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            66..108
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    102..104
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="upstream in-frame stop codon"
     exon            109..332
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     CDS             129..5954
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="myosin, heavy polypeptide 2, skeletal muscle,
                     adult; type IIA myosin heavy chain; fast 2a myosin heavy
                     chain; myosin heavy chain 2; myosin heavy chain 2a; myosin
                     heavy chain IIa; myosin heavy chain, skeletal muscle,
                     adult 2"
                     /codon_start=1
                     /product="myosin-2"
                     /protein_id="NP_060004.3"
                     /db_xref="GI:153792663"
                     /db_xref="CCDS:CCDS11156.1"
                     /db_xref="GeneID:4620"
                     /db_xref="HGNC:7572"
                     /db_xref="MIM:160740"
                     /translation="
MSSDSELAVFGEAAPFLRKSERERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKDDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDYNITGWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE
"
     misc_feature    231..356
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="Myosin N-terminal SH3-like domain; Region:
                     Myosin_N; pfam02736"
                     /db_xref="CDD:111612"
     misc_feature    369..2480
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="Myosin. Large ATPases; Region: MYSc; smart00242"
                     /db_xref="CDD:197599"
     misc_feature    372..2477
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="Myosin motor domain, type II myosins. Myosin II
                     mediates cortical contraction in cell motility, and is the
                     motor in smooth and skeletal muscle. This catalytic (head)
                     domain has ATPase activity and belongs to the larger group
                     of P-loop NTPases. Myosins...; Region: MYSc_type_II;
                     cd01377"
                     /db_xref="CDD:30099"
     misc_feature    order(507..518,522..527,669..692)
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="ATP-binding site [chemical binding]; other site"
                     /db_xref="CDD:30099"
     misc_feature    855..872
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="switch I region; other site"
                     /db_xref="CDD:30099"
     misc_feature    1521..1544
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="switch II region; other site"
                     /db_xref="CDD:30099"
     misc_feature    order(1605..1640,1647..1676)
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="relay loop; other site"
                     /db_xref="CDD:30099"
     misc_feature    2109..2177
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKX2.1);
                     Region: Actin-binding (By similarity)"
     misc_feature    2229..2273
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:30099"
     misc_feature    order(2268..2273,2280..2282,2298..2300,2307..2312,
                     2319..2321,2412..2414,2421..2423,2427..2432,2436..2444,
                     2454..2456,2463..2471)
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:30099"
     misc_feature    2415..2459
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKX2.1);
                     Region: Actin-binding (By similarity)"
     misc_feature    3405..5921
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /note="Myosin tail; Region: Myosin_tail_1; pfam01576"
                     /db_xref="CDD:144972"
     exon            333..476
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            477..633
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            634..661
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            662..776
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            777..869
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            870..933
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            934..1032
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1033..1136
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1137..1275
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1276..1394
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1395..1544
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1545..1715
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            1716..2025
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2026..2102
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2103..2190
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2191..2308
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2309..2432
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2433..2569
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2570..2825
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            2826..3068
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            3069..3245
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     STS             3189..3315
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="D17S1498E"
                     /db_xref="UniSTS:151703"
     exon            3246..3391
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            3392..3482
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            3483..3872
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     STS             3498..3630
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="D17S1497E"
                     /db_xref="UniSTS:151702"
     exon            3873..3999
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       3881
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139428"
     variation       3905
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139429"
     variation       3921
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1139430"
     variation       3927
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139431"
     variation       3965
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1139432"
     variation       3968
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139433"
     variation       3971
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1062469"
     variation       3989
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139434"
     exon            4000..4118
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       4004
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139436"
     variation       4006
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139437"
     variation       4019
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139438"
     variation       4037
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139439"
     variation       4040
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1139440"
     variation       4043
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139441"
     variation       4055
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139442"
     variation       4073
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1139443"
     STS             4113..4243
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="RH98750"
                     /db_xref="UniSTS:85561"
     exon            4119..4315
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       4160
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042074"
     variation       4243
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042075"
     variation       4271
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042076"
     exon            4316..4499
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            4500..4665
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            4666..4790
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            4791..5099
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       4967
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042185"
     variation       5075
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3181659"
     variation       5089
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1126556"
     STS             5094..5242
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="D17S1493E"
                     /db_xref="UniSTS:151698"
     exon            5100..5303
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       5162
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042236"
     exon            5304..5429
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       5345
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042297"
     variation       5357
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1042299"
     variation       5360
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1042300"
     variation       5378
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1062504"
     variation       5379
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1062507"
     variation       5405
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126619"
     exon            5430..5600
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     variation       5480
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042314"
     exon            5601..5705
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     exon            5706..5801
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     STS             5791..6023
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="D17S1489E"
                     /db_xref="UniSTS:151693"
     STS             5798..5941
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="RH65760"
                     /db_xref="UniSTS:19394"
     exon            5802..6086
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /inference="alignment:Splign:1.39.8"
     STS             5854..6023
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="D17S1489E"
                     /db_xref="UniSTS:151693"
     variation       5908
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34161789"
     STS             5919..6063
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
                     /standard_name="RH71315"
                     /db_xref="UniSTS:34929"
     polyA_signal    6057..6062
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
     polyA_site      6086
                     /gene="MYH2"
                     /gene_synonym="MYH2A; MYHas8; MyHC-2A; MyHC-IIa; MYHSA2"
ORIGIN      
atagctatccatataaaagagcccttggaatgaggctgactcgtcctgctttaaaaagctccaagaactgtctcactcccaggctacatcttctcacttgctaacaaggacctctgagttcagcagccatgagttcagactcagaattggctgtttttggggaggctgctcctttcctccgaaagtctgaaagggagcgcattgaggcccagaataggccctttgatgccaaaacatctgtctttgtggcggagcccaaagaatcctttgtcaaagggaccatccagagcagagaaggaggaaaagtgacggtgaagactgagggaggagcgactctgacagtgaaggatgatcaggtcttccccatgaaccctcccaaatatgacaagatcgaggatatggccatgatgactcatctgcatgagcctgctgtgctgtacaacctcaaagaacgttatgcagcctggatgatctacacctattcaggtctcttctgtgtcactgtcaacccctacaagtggctgcctgtgtataagcccgaggtggtgacagcctaccgaggcaaaaagcgccaggaggccccgccccacatcttctccatctctgacaacgcctatcagttcatgctgactgaccgagagaatcagtcaatcctgatcactggagaatctggtgcagggaagactgtgaacaccaagcgtgtcatccagtactttgcaacaattgcagttactggtgagaagaagaaggaagaaattacttctggcaaaatacaggggactctggaagatcaaatcatcagtgccaaccccctactggaggcctttggcaacgccaagaccgtgaggaatgacaactcctctcgctttggtaaattcatcagaatccactttggcactactggaaaactggcatctgctgatattgaaacatatctgctagagaagtctagagttgttttccagcttaaggctgagagaagttatcatattttttaccagattacatcgaataagaaaccagaacttattgaaatgcttctgattaccacgaacccatatgattacccatttgtcagtcaaggggagatcagtgtggccagcatcgatgatcaggaagaactgatggccacagatagtgctattgatattttgggctttactaatgaagaaaaggtctccatttacaagctcacgggggctgtgatgcattatgggaacctaaaatttaagcaaaagcagcgtgaggagcaagcagagccagatggcacagaagttgctgacaaggcggcctacctccagagtctgaactctgcagatctgctcaaagctctctgctaccccagggtcaaggtcggcaatgagtatgtcaccaaaggccagactgtagaacaggtgtccaacgcagtaggtgctctggccaaagccgtctacgagaagatgttcctgtggatggttgcccgcatcaaccagcagctggacaccaagcagcccaggcagtacttcatcggggtcttggacattgctggttttgagatttttgatttcaacagcctggagcagctgtgcatcaacttcaccaatgagaaactgcaacagtttttcaaccaccacatgttcgtgctggagcaggaggagtacaagaaggaaggcatcgagtggacgttcatcgacttcgggatggacctggctgcctgcatcgagctcatcgagaagcctatgggcatcttctccatcctggaagaggagtgcatgttccctaaggcaacagacacctccttcaagaacaagctgtatgaccagcacctgggcaagtctgccaacttccagaagcccaaggtggtcaaaggcaaggccgaggcccacttcgctctgattcactatgctggtgttgtggactacaacattactggctggctggagaagaacaaggaccccctgaatgagaccgtggttggactgtaccagaagtctgcaatgaaaactctagctcagctcttctctggggctcaaactgctgaaggagagggagctggtggaggggccaagaaaggtggtaagaagaagggctcttctttccagacagtgtctgcccttttcagagagaatttgaacaagctgatgaccaacctcaggagtacccatcctcactttgtgaggtgtatcatccccaatgagacaaaaactcctggtgccatggagcatgagcttgtcctccaccagctgaggtgtaacggtgtgctggaaggcatccgcatctgtaggaaaggatttccaagcagaatcctttatgcagacttcaaacagagatacaaggtattaaatgcaagtgcaatccctgaagggcaattcattgatagcaagaaggcctctgagaagctccttgcatccatcgacattgaccacacccagtataaatttgggcacaccaaggtctttttcaaagctggtcttctggggctcctagaggagatgcgagatgacaagctggcccagctgattacccgaacccaggccaggtgcagagggttcttggcaagagtggagtaccagaggatggtggagagaagggaggccatcttctgtatccagtacaatatcagatccttcatgaatgtcaagcactggccctggatgaaactcttcttcaagatcaagcctctgttgaagagtgcagaaactgagaaggagatggccaccatgaaggaagaatttcagaaaattaaagacgaacttgccaagtcagaggcaaaaaggaaggaactggaagaaaagatggtgacgctgttgaaagaaaaaaatgacttgcagctccaagttcaggctgaagccgaaggcttggctgatgcagaggaaaggtgtgaccagctaatcaaaaccaaaatccagctagaagccaaaatcaaagaggtgactgagagagctgaggatgaggaagagatcaatgctgagctgacagccaagaagaggaaactggaggatgaatgttcagaactcaagaaagacattgatgaccttgagctgacactggccaaggttgagaaggagaaacatgccacagaaaacaaggtgaaaaacctcacagaagagatggcaggtctggatgaaaccattgctaagctgaccaaggagaagaaggctctccaggaggcccaccagcagaccctggatgacctgcaggcagaggaggacaaagtcaacaccctgaccaaagctaaaatcaaacttgaacaacaagtggatgatcttgaagggtccttggagcaagaaaagaaacttcgcatggacctagaaagggctaagaggaaacttgagggtgacttgaagttggcccaagaatccataatggacattgaaaatgagaaacagcaacttgatgaaaagctcaaaaagaaagagtttgaaatcagcaatctgcaaagcaagattgaagatgaacaggcacttggcattcaattgcagaagaaaattaaagaattgcaagcccgcattgaggagctggaggaggaaatcgaggcagagcgggcctcccgggccaaagcagagaagcagcgctctgacctctcccgggagctggaggagatcagcgagaggctggaagaagccggtggggccacttcagcccagattgagatgaacaagaagcgggaggctgagttccagaaaatgcgcagggacctggaggaggccaccctacagcatgaagccacagcggccaccctgaggaagaagcatgcagatagtgtggccgagcttggggagcagattgacaacctgcagcgagtgaagcagaagctggagaaggagaagagtgagatgaagatggagattgatgaccttgctagtaatgtagaaacggtctccaaagccaagggaaacctagagaaaatgtgccggactctagaggaccaactgagtgaactgaaatcaaaggaagaggagcagcagcggctgatcaatgacctgactgcgcagagggggcgcctgcagactgaatctggtgagttttcacgccagcttgatgaaaaggaagctctggtgtctcagttatcaagaggcaaacaagcctttactcaacagattgaagaattaaagaggcaacttgaagaggagataaaagccaagaacgccctggcgcatgccctgcagtcttcccgccacgactgtgacctgctgcgggaacagtatgaggaggagcaggaatccaaggccgagctgcagagagcactgtccaaggccaacaccgaggttgcccaatggaggaccaaatacgagacggacgccatccagcgcacagaggagctggaggaggccaagaagaagctggcccagcggctgcaggcagctgaggaacatgtagaagctgtgaacgccaaatgtgcttccctcgaaaagacgaagcagcggctgcagaatgaggtcgaggacctcatgcttgatgtggagaggacaaatgccgcctgtgccgcccttgacaaaaagcaaaggaacttcgataagatcctggcagaatggaaacagaaatgtgaggaaacgcatgctgagcttgaggcctcccagaaggaggcccgttcccttggcactgagctgttcaagataaagaatgcctatgaggaatctttggatcagctagaaaccctgaagcgagagaacaaaaacttacagcaggagatttctgacctcacggaacagattgcagaaggagggaaacgtatccatgaactggagaaaataaagaaacaagtggaacaagaaaagtgtgaacttcaggctgctttagaagaagcagaggcatctcttgaacatgaagagggaaagatcctgcgcatccagcttgagttgaaccaagtcaagtctgaggttgataggaaaattgctgaaaaagatgaggaaattgaccagctgaagagaaaccacattagaatcgtggagtccatgcagagcacgctggatgctgagatcaggagtaggaatgatgccattaggctcaagaagaagatggagggagacctcaatgaaatggaaatccagctgaaccatgccaaccgcatggctgctgaggccctgaggaactacaggaacacccaaggcatcctcaaggatacccagatccacctggatgatgctctccggagccaggaggacctgaaggaacagctggccatggtggagcgcagagccaacctgctgcaggctgagatcgaggagctgcgggccactctggaacagacagagaggagcagaaaaatcgcagaacaggagctcctggatgccagtgagcgtgttcagctactgcacacccagaacaccagcctgatcaacaccaagaagaagctggagacagatatttcccaaatgcaaggagagatggaggacattctccaggaagcccgcaatgcagaagaaaaggccaagaaggccatcactgatgccgccatgatggctgaggagctgaagaaggagcaggacaccagcgcccacctggagcggatgaagaagaacatggagcagaccgtgaaggatctgcagctccgtctggatgaggctgagcagctggccctgaagggtgggaagaagcagatccagaaactggaggccagggtacgggagctggaaggagaggttgagagtgagcaaaagcgtaatgctgaggctgtcaaaggtctgcgcaaacatgagaggcgagtgaaggaactcacttaccagacggaagaagatagaaagaatattctcaggcttcaagatttggtagataaacttcaggcaaaagtgaaatcttataagagacaagctgaggaggctgaggaacaatccaacaccaatctagctaaattccgcaagctccagcatgagctggaggaggccgaggaacgggctgacattgctgagtcccaggtgaacaaactgcgggtgaagagccgggaggttcacacaaaagtcataagtgaagagtgatcatgtcctgatgccatggaatgactgaagacaggcacaaaatgtgacatctttggtcatttccctctgtaattattgtgtattctaccctgttgcaaaggaaataaagcatagggtagtttgcaaacaataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4620 -> Molecular function: GO:0000146 [microfilament motor activity] evidence: TAS
            GeneID:4620 -> Molecular function: GO:0003779 [actin binding] evidence: NAS
            GeneID:4620 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4620 -> Molecular function: GO:0005516 [calmodulin binding] evidence: NAS
            GeneID:4620 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS
            GeneID:4620 -> Molecular function: GO:0008307 [structural constituent of muscle] evidence: NAS
            GeneID:4620 -> Biological process: GO:0001778 [plasma membrane repair] evidence: IEA
            GeneID:4620 -> Biological process: GO:0006936 [muscle contraction] evidence: IDA
            GeneID:4620 -> Biological process: GO:0006936 [muscle contraction] evidence: TAS
            GeneID:4620 -> Biological process: GO:0014823 [response to activity] evidence: IEA
            GeneID:4620 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
            GeneID:4620 -> Biological process: GO:0030049 [muscle filament sliding] evidence: NAS
            GeneID:4620 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:4620 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:4620 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:4620 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:4620 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
            GeneID:4620 -> Cellular component: GO:0005826 [actomyosin contractile ring] evidence: IEA
            GeneID:4620 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:4620 -> Cellular component: GO:0005859 [muscle myosin complex] evidence: NAS
            GeneID:4620 -> Cellular component: GO:0005859 [muscle myosin complex] evidence: TAS
            GeneID:4620 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
            GeneID:4620 -> Cellular component: GO:0030016 [myofibril] evidence: IDA
            GeneID:4620 -> Cellular component: GO:0030017 [sarcomere] evidence: NAS
            GeneID:4620 -> Cellular component: GO:0031672 [A band] evidence: IEA
            GeneID:4620 -> Cellular component: GO:0032982 [myosin filament] evidence: IEA
            GeneID:4620 -> Cellular component: GO:0043234 [protein complex] evidence: IDA

by @meso_cacase at DBCLS
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