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2024-03-29 01:53:48, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_017523               3638 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens XIAP associated factor 1 (XAF1), transcript variant 1,
            mRNA.
ACCESSION   NM_017523
VERSION     NM_017523.3  GI:378925606
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3638)
  AUTHORS   Kim,S.K., Park,H.J., Seok,H., Jeon,H.S., Kim,J.W., Chung,J.H.,
            Kwon,K.H., Woo,S.H., Lee,B.W. and Baik,H.H.
  TITLE     Missense polymorphisms in XIAP-associated factor-1 (XAF1) and risk
            of papillary thyroid cancer: correlation with clinicopathological
            features
  JOURNAL   Anticancer Res. 33 (5), 2205-2210 (2013)
   PUBMED   23645777
  REMARK    GeneRIF: Missense polymorphisms in XIAP-associated factor-1 is
            associated with papillary thyroid cancer.
REFERENCE   2  (bases 1 to 3638)
  AUTHORS   Long,X., Li,Y., Qi,Y., Xu,J., Wang,Z., Zhang,X., Zhang,D., Zhang,L.
            and Huang,J.
  TITLE     XAF1 contributes to dengue virus-induced apoptosis in vascular
            endothelial cells
  JOURNAL   FASEB J. 27 (3), 1062-1073 (2013)
   PUBMED   23207547
  REMARK    GeneRIF: the role of XAF1 in promoting apoptosis in vascular
            endothelial cells after DENV2 infection.
REFERENCE   3  (bases 1 to 3638)
  AUTHORS   Wang,Y., Mao,H., Hao,Q., Wang,Y., Yang,Y., Shen,L., Huang,S. and
            Liu,P.
  TITLE     Association of expression of XIAP-associated factor 1 (XAF1) with
            clinicopathologic factors, overall survival, microvessel density
            and cisplatin-resistance in ovarian cancer
  JOURNAL   Regul. Pept. 178 (1-3), 36-42 (2012)
   PUBMED   22759793
  REMARK    GeneRIF: XAF1 may be involved in ovarian cancer development and
            up-regulation of XAF1 may confer sensitivity of ovarian cancer
            cells to cisplatin-mediated apoptosis.
REFERENCE   4  (bases 1 to 3638)
  AUTHORS   Tse,M.K., Cho,C.K., Wong,W.F., Zou,B., Hui,S.K., Wong,B.C. and
            Sze,K.H.
  TITLE     Domain organization of XAF1 and the identification and
            characterization of XIAP(RING) -binding domain of XAF1
  JOURNAL   Protein Sci. 21 (10), 1418-1428 (2012)
   PUBMED   22811387
  REMARK    GeneRIF: The search of XIAP binding region within XAF1 revealed a
            modest affinity XIAP(RING) binding site is located at the
            C-terminal portion of XAF1.We also mapped the interaction sites for
            XAF1(RBD) on XIAP(RING) by using NMR.
REFERENCE   5  (bases 1 to 3638)
  AUTHORS   Chen,X.Y., He,Q.Y. and Guo,M.Z.
  TITLE     XAF1 is frequently methylated in human esophageal cancer
  JOURNAL   World J. Gastroenterol. 18 (22), 2844-2849 (2012)
   PUBMED   22719195
  REMARK    GeneRIF: XAF1 is frequently methylated in esophageal cancer, and
            XAF1 expression is regulated by promoter region hypermethylation.
REFERENCE   6  (bases 1 to 3638)
  AUTHORS   Byun,D.S., Cho,K., Ryu,B.K., Lee,M.G., Kang,M.J., Kim,H.R. and
            Chi,S.G.
  TITLE     Hypermethylation of XIAP-associated factor 1, a putative tumor
            suppressor gene from the 17p13.2 locus, in human gastric
            adenocarcinomas
  JOURNAL   Cancer Res. 63 (21), 7068-7075 (2003)
   PUBMED   14612497
  REMARK    GeneRIF: Epigenetic silencing of XAF1 by aberrant promoter
            methylation may contribute to the malignant progression of human
            gastric tumors.
REFERENCE   7  (bases 1 to 3638)
  AUTHORS   Leaman,D.W., Chawla-Sarkar,M., Vyas,K., Reheman,M., Tamai,K.,
            Toji,S. and Borden,E.C.
  TITLE     Identification of X-linked inhibitor of apoptosis-associated
            factor-1 as an interferon-stimulated gene that augments TRAIL
            Apo2L-induced apoptosis
  JOURNAL   J. Biol. Chem. 277 (32), 28504-28511 (2002)
   PUBMED   12029096
  REMARK    GeneRIF: XAF1 augments TRAIL-induced apoptosis
REFERENCE   8  (bases 1 to 3638)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol. Vis. 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3638)
  AUTHORS   Liston,P., Fong,W.G., Kelly,N.L., Toji,S., Miyazaki,T., Conte,D.,
            Tamai,K., Craig,C.G., McBurney,M.W. and Korneluk,R.G.
  TITLE     Identification of XAF1 as an antagonist of XIAP anti-Caspase
            activity
  JOURNAL   Nat. Cell Biol. 3 (2), 128-133 (2001)
   PUBMED   11175744
REFERENCE   10 (bases 1 to 3638)
  AUTHORS   Fong,W.G., Liston,P., Rajcan-Separovic,E., St Jean,M., Craig,C. and
            Korneluk,R.G.
  TITLE     Expression and genetic analysis of XIAP-associated factor 1 (XAF1)
            in cancer cell lines
  JOURNAL   Genomics 70 (1), 113-122 (2000)
   PUBMED   11087668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056908.1, BQ639060.1, BM153640.1, BM475564.1, BC058017.1,
            BC032776.1, BX649188.1, BX648588.1, AC034305.6 and BM459605.1.
            On Mar 1, 2012 this sequence version replaced gi:40288190.
            
            Summary: This gene encodes a protein which binds to and counteracts
            the inhibitory effect of a member of the IAP (inhibitor of
            apoptosis) protein family. IAP proteins bind to and inhibit
            caspases which are activated during apoptosis. The proportion of
            IAPs and proteins which interfere with their activity, such as the
            encoded protein, affect the progress of the apoptosis signaling
            pathway. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073156.1, AK292710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AK056908.1         391-535
            146-168             BQ639060.1         112-134
            169-274             BM153640.1         168-273
            275-749             BM475564.1         46-520
            750-1573            BC058017.1         460-1283
            1574-2087           BC032776.1         1101-1614
            2088-2560           BX649188.1         4335-4807
            2561-2674           BX648588.1         2891-3004
            2675-2744           BX649188.1         4922-4991
            2745-2839           BX648588.1         3075-3169
            2840-2840           AC034305.6         26940-26940
            2841-3621           BX649188.1         5088-5868
            3622-3638           BM459605.1         708-724
FEATURES             Location/Qualifiers
     source          1..3638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3638
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="XIAP associated factor 1"
                     /db_xref="GeneID:54739"
                     /db_xref="HGNC:30932"
                     /db_xref="HPRD:06978"
                     /db_xref="MIM:606717"
     exon            1..274
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       7
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112366084"
     variation       9
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17525966"
     variation       17
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200032696"
     variation       113..114
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78899576"
     variation       114
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3785792"
     misc_feature    150..152
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="upstream in-frame stop codon"
     variation       169
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3785793"
     variation       173
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114050758"
     variation       174
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:193161810"
     variation       199
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369360551"
     variation       210
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372936289"
     variation       229
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75191221"
     CDS             243..1148
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="isoform 1 is encoded by transcript variant 1; BIRC4
                     binding protein; XIAP-associated factor 1; BIRC4-binding
                     protein"
                     /codon_start=1
                     /product="XIAP-associated factor 1 isoform 1"
                     /protein_id="NP_059993.2"
                     /db_xref="GI:40288191"
                     /db_xref="CCDS:CCDS11080.1"
                     /db_xref="GeneID:54739"
                     /db_xref="HGNC:30932"
                     /db_xref="HPRD:06978"
                     /db_xref="MIM:606717"
                     /translation="
MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS
"
     misc_feature    <243..602
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="PRLI-interacting factor K; Provisional; Region:
                     PLN03086"
                     /db_xref="CDD:178635"
     exon            275..410
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       277
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201546164"
     variation       309
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142006994"
     variation       322
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200500047"
     variation       392
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376820356"
     exon            411..467
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       443
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12943770"
     variation       448
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:114531225"
     variation       452
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139863841"
     variation       453
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149801864"
     exon            468..663
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       472
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61731569"
     variation       480
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370468679"
     variation       496
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34195599"
     variation       498
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367805632"
     variation       545
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199511229"
     variation       546
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186202043"
     variation       551
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36014307"
     variation       556
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147667185"
     variation       565
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148910934"
     variation       588
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144018972"
     variation       606
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150987933"
     variation       610
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35205123"
     variation       615
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372380890"
     variation       637
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2271232"
     variation       638
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2271231"
     variation       640
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140283887"
     variation       642
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146752602"
     variation       657
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34048764"
     exon            664..749
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       677
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115439945"
     variation       688
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143375195"
     variation       699
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61730352"
     variation       726..727
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34779232"
     variation       743
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182886479"
     variation       744
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376949183"
     exon            750..1091
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       760
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375225505"
     variation       780
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370570744"
     variation       783
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141501429"
     variation       784
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149170701"
     variation       804
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34625877"
     variation       848
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140032811"
     variation       856
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371250443"
     variation       857
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143903776"
     variation       882
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147254786"
     variation       898
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3736433"
     variation       975
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375870927"
     variation       981
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374645108"
     variation       1004
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35588057"
     variation       1029
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373581793"
     variation       1034
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149963509"
     variation       1089
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377021489"
     exon            1092..3626
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:1.39.8"
     variation       1102
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147129551"
     variation       1129
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148666603"
     variation       1198
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375175465"
     variation       1207
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115485040"
     variation       1254
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368143001"
     variation       1255
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187158287"
     variation       1328
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142960467"
     STS             1363..1550
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /standard_name="RH71308"
                     /db_xref="UniSTS:83938"
     variation       1464
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116781794"
     variation       1478
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114707182"
     variation       1562
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151094017"
     variation       1606
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377372080"
     variation       1668
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139916113"
     variation       1734
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149364115"
     variation       1738
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143776099"
     variation       1972
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:59356327"
     variation       2000
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140603525"
     variation       2016..2017
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:201946644"
     variation       2017
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:372928764"
     variation       2056
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116593120"
     variation       2070
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145641804"
     variation       2106
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146532827"
     variation       2225
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:59775513"
     variation       2345
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:115592224"
     variation       2368
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114520909"
     variation       2378
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374226882"
     variation       2459
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368802475"
     variation       2484
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191143973"
     variation       2527
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183088341"
     variation       2561
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62063982"
     variation       2570
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375781575"
     variation       2649
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:118188887"
     variation       2659..2660
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34764881"
     variation       2686
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187983218"
     variation       2720
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371808429"
     variation       2741
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149116720"
     variation       2830
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189729420"
     variation       2840
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:8081725"
     variation       2880
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12449410"
     variation       2881
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140347814"
     variation       2889
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9916600"
     STS             2900..2989
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /standard_name="PMC156606P1"
                     /db_xref="UniSTS:271408"
     variation       2902
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182343875"
     variation       2912
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112479245"
     variation       2925
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187815604"
     variation       2935
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117123173"
     variation       2950
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377173942"
     variation       2958..2959
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35812684"
     variation       3006
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138023465"
     variation       3020..3021
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:372476663"
     variation       3020
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:60246444"
     variation       3033..3034
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:57323394"
     variation       3047
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35682891"
     variation       3109
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28412469"
     variation       3246
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28663460"
     variation       3290
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35997067"
     variation       3402..3403
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:199936717"
     variation       3426
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375892083"
     variation       3441
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147145750"
     STS             3462..3581
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /standard_name="RH48221"
                     /db_xref="UniSTS:73981"
     variation       3540
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368914217"
     variation       3613
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138362390"
ORIGIN      
ggtagatgcggctgtgacagcagcaaagaatgacggccaagggcgacagcaggggctggccatgctgtaaaggggcttcttgggagggtccagcctcaggaatcaaggggaactcctgagccgagaattctgaagatctcctccctccctgaagctgtgggctgggccatcggaaaactttcagttttgtttccttgcctgcaagaaacgaaactcaaccgaaagcctgcagagagcagaacatggaaggagacttctcggtgtgcaggaactgtaaaagacatgtagtctctgccaacttcaccctccatgaggcttactgcctgcggttcctggtcctgtgtccggagtgtgaggagcctgtccccaaggaaaccatggaggagcactgcaagcttgagcaccagcaggttgggtgtacgatgtgtcagcagagcatgcagaagtcctcgctggagtttcataaggccaatgagtgccaggagcgccctgttgagtgtaagttctgcaaactggacatgcagctcagcaagctggagctccacgagtcctactgtggcagccggacagagctctgccaaggctgtggccagttcatcatgcaccgcatgctcgcccagcacagagatgtctgtcgcagtgaacaggcccagctcgggaaaggggaaagaatttcagctcctgaaagggaaatctactgtcattattgcaaccaaatgattccagaaaataagtatttccaccatatgggtaaatgttgtccagactcagagtttaagaaacactttcctgttggaaatccagaaattcttccttcatctcttccaagtcaagctgctgaaaatcaaacttccacgatggagaaagatgttcgtccaaagacaagaagtataaacagatttcctcttcattctgaaagttcatcaaagaaagcaccaagaagcaaaaacaaaaccttggatccacttttgatgtcagagcccaagcccaggaccagctcccctagaggagataaagcagcctatgacattctgaggagatgttctcagtgtggcatcctgcttcccctgccgatcctaaatcaacatcaggagaaatgccggtggttagcttcatcaaaaggaaaacaagtgagaaatttcagctagatttggaaaaggaaaggtactacaaattcaaaagatttcacttttaacactggcattcctgcctacttgctgtggtggtcttgtgaaaggtgatgggttttattcgttgggctttaaaagaaaaggtttggcagaactaaaaacaaaactcacgtatcatctcaatagatacagaaaaggcttttgataaaattcaacttgacttcatgttaaaaaccctcaacaaaccaggcgtcgaaggaacatacctcaaaataataagagccatctatgacaaaaccacagccaacatcatactgaatgagcaaaagctggagcattactcttgagaagtagaacaaggcacttcagtcctattcaacatagtactggaagtcctcgccacagcaatcaggcaagagaaagaaataaaaggcaaccaaaaagaaaggaagtcgaagtatctctgtttgcagacgatatgattctatatctagaaaaccccatgatcttggcccaaaagctcctagatctgataaacaacttcagctaactttcaggagacaaaatcaatatacaaaatatggtagcatttttatacaccaacgacatccaagctgagagccaaatcaagaatgcaatcctattcacaattgccacaaaaagaataaaatacctaggaatacagctaaccagggagatgaaagatctctacaacaaaaattacaaaacactgctgaaagaaatcagagatgacacaaatggaaaaacattccatacttatggataggaagaatcaatattgttaaaatggccatactacccaaagcaatttatagattcaatgctattcctatcaaactaccaataacattcttcacagaatcagaaaaaaaaagcattaaaatttatttgaaaccaaaaaagagcccaaaaagccaaagcaatcctaagcaaaaagaacaaagctggaggcatcgcattacccaacttcaaactatactacagggctacagtaaccaaaactgcatgatactggtacaaaagcatggtgctggtacaaaagcagacacatagatcaatggaacagaatagagggcccagaaataaagctacacacctacaaccatctaatctttgacaaagttgacaaaaatacgcaatggggaaagaattccccattcagtaagtggtactgggataactagctagccatatgcagaggattgaaactgaaccacttccttacaccatatgcaaaaatcaactcaagatggattaaagacttaaatgtaaaaccccaaactataaaaactctggaagataacctaggcaataccattctggacataggaacggaaaaagatttcatgacaaagatcccaaaaataattgtaacgaaagcaaaaattgacaaatgggacatgattaaacagaattaccatttgactcagcaatcccattattggttatatacccaaaggaatctaaatcattctgtcataaagacatatatacacaaatgttcacggcagcactatacacaatcgcaaagtcagggaatcaaactaaatgtccatcagtggtagaaaggataaagaaaatgtggtggcagggagtggtggctcatgtctgtaatcccagcactttgggaggctgaggcgggtggttcacctgaggtcaggagtttgagaccagcctggccaacatggagaaactccgtctccgctaaaaatacgaaaattagccaggcgtggtggcgagcacctgtcatcccagctacttgggaggcctaggcgtgagaatcgcttgaacctggaaggtggtggttgcagtgagccgagatcctgccactgcactccagcctgggcaaccaagcgagactctgccttaaaaaaaaaaaaaagaaaatgtggcacatatacaccatggaatactatgcagccataaaaaagaatgggatcatgtcctgtgcagcaacgtggatggagctggaagccattatcctaaatgaactcactcagaaacagaaaaccaaataccacatgttctcacttataagtagaagctaaacattgagtacacatggatacaaagaagggaaccgcagacactggggcctacctgaggtcggagcatggaaggagggtgaggatcaaaaaactacctatctggtactatgctttttatctggatgatgaaataatctgtacaacaaaccctggtgacatgcaatttacctatatagcaagcctacacatgtgcccctgaacctaaaaaaaaagttaaaagaaaaacgtttggattattttccctctttcgaacaaagacattggtttgcccaaggactacaaataaaccaacgggaaaaaagaaaggttccagttttgtctgaaaattctgattaagcctctgggccctacagcctggagaacctggagaatcctacacccacagaacccggctttgtccccaaagaataaaaacacctctctaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:54739 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:54739 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:54739 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
            GeneID:54739 -> Biological process: GO:0035456 [response to interferon-beta] evidence: IDA
            GeneID:54739 -> Biological process: GO:0060337 [type I interferon-mediated signaling pathway] evidence: TAS
            GeneID:54739 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:54739 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
            GeneID:54739 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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