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2020-10-24 07:10:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_016953               9285 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens phosphodiesterase 11A (PDE11A), transcript variant 4,
            mRNA.
ACCESSION   NM_016953
VERSION     NM_016953.3  GI:116536084
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9285)
  AUTHORS   Vezzosi,D., Libe,R., Baudry,C., Rizk-Rabin,M., Horvath,A., Levy,I.,
            Rene-Corail,F., Ragazzon,B., Stratakis,C.A., Vandecasteele,G. and
            Bertherat,J.
  TITLE     Phosphodiesterase 11A (PDE11A) gene defects in patients with
            acth-independent macronodular adrenal hyperplasia (AIMAH):
            functional variants may contribute to genetic susceptibility of
            bilateral adrenal tumors
  JOURNAL   J. Clin. Endocrinol. Metab. 97 (11), E2063-E2069 (2012)
   PUBMED   22996146
  REMARK    GeneRIF: PDE11A genetic variants may increase predisposition to
            ACTH-independent macronodular adrenal hyperplasia.
REFERENCE   2  (bases 1 to 9285)
  AUTHORS   Uckert,S., Oelke,M., Albrecht,K., Breitmeier,D., Kuczyk,M.A. and
            Hedlund,P.
  TITLE     Expression and distribution of key enzymes of the cyclic GMP
            signaling in the human clitoris: relation to phosphodiesterase type
            5 (PDE5)
  JOURNAL   Int. J. Impot. Res. 23 (5), 206-212 (2011)
   PUBMED   21697861
  REMARK    GeneRIF: found in single nerve trunks in the clitoral stroma
REFERENCE   3  (bases 1 to 9285)
  AUTHORS   Libe,R., Horvath,A., Vezzosi,D., Fratticci,A., Coste,J.,
            Perlemoine,K., Ragazzon,B., Guillaud-Bataille,M., Groussin,L.,
            Clauser,E., Raffin-Sanson,M.L., Siegel,J., Moran,J.,
            Drori-Herishanu,L., Faucz,F.R., Lodish,M., Nesterova,M.,
            Bertagna,X., Bertherat,J. and Stratakis,C.A.
  TITLE     Frequent phosphodiesterase 11A gene (PDE11A) defects in patients
            with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may
            contribute to adrenal and testicular tumors in CNC as a modifier of
            the phenotype
  JOURNAL   J. Clin. Endocrinol. Metab. 96 (1), E208-E214 (2011)
   PUBMED   21047926
  REMARK    GeneRIF: We demonstrate, in a large cohort of Carney Complex
            patients, a high frequency of PDE11A variants, suggesting that
            PDE11A is a genetic modifying factor for the development of
            testicular and adrenal tumors in patients with germline PRKAR1A
            mutation.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 9285)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   5  (bases 1 to 9285)
  AUTHORS   DeWan,A.T., Triche,E.W., Xu,X., Hsu,L.I., Zhao,C., Belanger,K.,
            Hellenbrand,K., Willis-Owen,S.A., Moffatt,M., Cookson,W.O.,
            Himes,B.E., Weiss,S.T., Gauderman,W.J., Baurley,J.W., Gilliland,F.,
            Wilk,J.B., O'Connor,G.T., Strachan,D.P., Hoh,J. and Bracken,M.B.
  TITLE     PDE11A associations with asthma: results of a genome-wide
            association scan
  JOURNAL   J. Allergy Clin. Immunol. 126 (4), 871-873 (2010)
   PUBMED   20920776
  REMARK    GeneRIF: PDE11A SNP assocaited with allergic asthma.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 9285)
  AUTHORS   Hetman,J.M., Robas,N., Baxendale,R., Fidock,M., Phillips,S.C.,
            Soderling,S.H. and Beavo,J.A.
  TITLE     Cloning and characterization of two splice variants of human
            phosphodiesterase 11A
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (23), 12891-12895 (2000)
   PUBMED   11050148
REFERENCE   7  (bases 1 to 9285)
  AUTHORS   Yuasa,K., Kotera,J., Fujishige,K., Michibata,H., Sasaki,T. and
            Omori,K.
  TITLE     Isolation and characterization of two novel phosphodiesterase
            PDE11A variants showing unique structure and tissue-specific
            expression
  JOURNAL   J. Biol. Chem. 275 (40), 31469-31479 (2000)
   PUBMED   10906126
REFERENCE   8  (bases 1 to 9285)
  AUTHORS   Fawcett,L., Baxendale,R., Stacey,P., McGrouther,C., Harrow,I.,
            Soderling,S., Hetman,J., Beavo,J.A. and Phillips,S.C.
  TITLE     Molecular cloning and characterization of a distinct human
            phosphodiesterase gene family: PDE11A
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (7), 3702-3707 (2000)
   PUBMED   10725373
REFERENCE   9  (bases 1 to 9285)
  AUTHORS   Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
            Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
  TITLE     Isolation and characterization of cDNAs corresponding to two human
            calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
            phosphodiesterases
  JOURNAL   J. Biol. Chem. 271 (2), 796-806 (1996)
   PUBMED   8557689
REFERENCE   10 (bases 1 to 9285)
  AUTHORS   Beavo,J.A., Conti,M. and Heaslip,R.J.
  TITLE     Multiple cyclic nucleotide phosphodiesterases
  JOURNAL   Mol. Pharmacol. 46 (3), 399-405 (1994)
   PUBMED   7935318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB036704.1, AC011998.8,
            BC112393.1, AC073834.6 and AI919276.1.
            On Oct 24, 2006 this sequence version replaced gi:19923439.
            
            Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as
            second messengers in a wide variety of signal transduction
            pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)
            catalyze the hydrolysis of cAMP and cGMP to the corresponding
            5'-monophosphates and provide a mechanism to downregulate cAMP and
            cGMP signaling. This gene encodes a member of the PDE protein
            superfamily. Mutations in this gene are a cause of Cushing disease
            and adrenocortical hyperplasia. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB036704.1, BC112393.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-868               AB036704.1         1-868
            869-1110            AC011998.8         120246-120487       c
            1111-3081           BC112393.1         1102-3072
            3082-3242           BC112393.1         3076-3236
            3243-8974           AC073834.6         116649-122380       c
            8975-9285           AI919276.1         1-311               c
FEATURES             Location/Qualifiers
     source          1..9285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..9285
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="phosphodiesterase 11A"
                     /db_xref="GeneID:50940"
                     /db_xref="HGNC:8773"
                     /db_xref="MIM:604961"
     exon            1..1230
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    2
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="major transcription initiation site"
     misc_feature    253..255
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="upstream in-frame stop codon"
     CDS             319..3120
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /EC_number="3.1.4.35"
                     /EC_number="3.1.4.17"
                     /note="isoform 4 is encoded by transcript variant 4; cAMP
                     and cGMP cyclic nucleotide phosphodiesterase 11A; dual
                     3',5'-cyclic-AMP and -GMP phosphodiesterase 11A"
                     /codon_start=1
                     /product="dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
                     11A isoform 4"
                     /protein_id="NP_058649.3"
                     /db_xref="GI:116536085"
                     /db_xref="CCDS:CCDS33334.1"
                     /db_xref="GeneID:50940"
                     /db_xref="HGNC:8773"
                     /db_xref="MIM:604961"
                     /translation="
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
"
     misc_feature    925..1464
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="FOG: GAF domain [Signal transduction mechanisms];
                     Region: FhlA; COG2203"
                     /db_xref="CDD:32385"
     misc_feature    967..1458
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="Domain present in phytochromes and cGMP-specific
                     phosphodiesterases; Region: GAF; smart00065"
                     /db_xref="CDD:197499"
     misc_feature    1033..1035
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9HCR9.2); phosphorylation site"
     misc_feature    1480..2028
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="FOG: GAF domain [Signal transduction mechanisms];
                     Region: FhlA; COG2203"
                     /db_xref="CDD:32385"
     misc_feature    1522..2022
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="Domain present in phytochromes and cGMP-specific
                     phosphodiesterases; Region: GAF; smart00065"
                     /db_xref="CDD:197499"
     misc_feature    2236..3033
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCR9.2);
                     Region: Catalytic (By similarity)"
     misc_feature    2305..2835
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="Metal dependent phosphohydrolases with conserved
                     'HD' motif; Region: HDc; cd00077"
                     /db_xref="CDD:28958"
     misc_feature    order(2320..2322,2428..2433,2764..2766)
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28958"
     misc_feature    2431..2433
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /note="Mg2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28958"
     variation       465
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34556327"
     variation       473
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77972073"
     variation       922
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77063376"
     variation       983
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78860696"
     variation       1008
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78496158"
     variation       1110
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1435573"
     variation       1112
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77493999"
     variation       1117
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79233810"
     variation       1211
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78328794"
     exon            1231..1389
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       1234
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76865936"
     variation       1363
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77477862"
     exon            1390..1479
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     exon            1480..1620
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       1489
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78426895"
     variation       1551
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77789692"
     variation       1561
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74460362"
     variation       1569
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76725221"
     exon            1621..1685
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       1645
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75920749"
     exon            1686..1818
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       1716
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78731210"
     variation       1758
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77896877"
     exon            1819..1894
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     exon            1895..1962
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     exon            1963..2055
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     exon            2056..2106
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2075
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78384547"
     exon            2107..2253
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2131
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76110544"
     variation       2143
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77934668"
     variation       2157
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75157857"
     exon            2254..2361
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2291
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77597060"
     variation       2295
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77341035"
     variation       2352
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78730670"
     exon            2362..2471
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2404
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74666005"
     variation       2463
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35194777"
     exon            2472..2562
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2551
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79840971"
     exon            2563..2663
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2616
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78690307"
     exon            2664..2741
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2729
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75127279"
     exon            2742..2805
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     exon            2806..2880
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2815
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75950476"
     variation       2822
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75226037"
     variation       2836
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79903863"
     exon            2881..2964
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2894
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79384192"
     variation       2950
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74357545"
     exon            2965..9278
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /inference="alignment:Splign:1.39.8"
     variation       2965
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79400048"
     variation       2983
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75437575"
     variation       3040
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80129029"
     variation       3081..3082
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace=""
                     /replace="tcc"
                     /db_xref="dbSNP:3830637"
     variation       3097
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74326729"
     STS             3843..4532
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /standard_name="PDE11A_V281"
                     /db_xref="UniSTS:277573"
     polyA_signal    4416..4421
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
     polyA_site      4444
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
     STS             4925..5269
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /standard_name="RH79802"
                     /db_xref="UniSTS:88688"
     STS             7508..7673
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /standard_name="L30021"
                     /db_xref="UniSTS:3276"
     STS             8831..8991
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /standard_name="RH91242"
                     /db_xref="UniSTS:87167"
     variation       8974
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047884"
     STS             9127..9251
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
                     /standard_name="SHGC-37408"
                     /db_xref="UniSTS:1328"
     polyA_signal    9258..9263
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
     polyA_site      9278
                     /gene="PDE11A"
                     /gene_synonym="PPNAD2"
ORIGIN      
gcagcggcggcagccagaacaggagcagcgatagctcgggtttccggaacaggagccggggcagcggcggcagctcagtgctgggcacctgtgcggagcaggagtagcaggaccacggggtggggtcggcgccagccactctgagccagagaaggaaggggcatctcccagattccactgctgggaataatctccaggggaggtggcgctgaactgggaatactggtgggggtgaacatgtgcaggaacagctagaggcctcggggcaggaaaacatttggttcacgtgtaaacaggcaaggaaagctgtctgggaccatggcagcctcccgcctggactttggggaggtggaaactttcctggacaggcacccagagttgtttgaagattacttgatgcggaaggggaagcaggagatggttgaaaagtggctgcagaggcacagtcagggtcagggggctttaggtccaaggccctctttggctggtaccagcagcttggctcacagcacctgcagaggtggcagcagcgttggtggtggcactggaccaaatggctctgcccacagccagccccttcccggtggcggggactgtggtggggttcccttgagtcccagctgggccggtggcagcaggggcgatgggaacctgcagcggagagcttctcagaaagagctaaggaagagttttgcccgctccaaggccatccacgtgaacaggacctacgatgaacaggtgacctcccgggctcaggaacccctgagtagtgtacgacggagggcacttctccggaaggcaagctccctgccccccaccacagcccatattctcagtgcgctgctggaatcgagagtgaatctgcctcggtatccccctacagccatcgactacaagtgccatctgaaaaagcataatgagcgtcagttctttctggaattggtcaaagatatctccaatgaccttgacctcaccagcctgagctacaagattctcatctttgtctgccttatggtggatgctgaccgctgctctcttttcctggtggaaggggcagctgctggcaagaagaccttggtctccaaattctttgatgtgcatgcaggaacacctctgctgccttgcagcagcacagagaactcaaatgaggtgcaggtcccctggggcaaaggtatcattggctatgtcggggagcatggagaaacggtcaacattcctgatgcctaccaggatcgacgattcaatgatgaaatcgacaagctaactggatacaagacaaaatcattattgtgcatgcctatccgaagcagtgatggtgagattattggtgtggcccaagcgataaataagattcctgaaggagctccatttactgaagatgatgaaaaagttatgcagatgtatcttccattttgtggaatcgccatatctaacgctcagctctttgctgcctcaaggaaagaatatgaaagaagcagagctttgctagaggtggttaatgacctctttgaagaacagactgacctggagaaaattgtcaagaaaataatgcatcgggcccaaactctgctgaaatgtgaacgctgttctgttttactcctagaggacatcgaatcaccagtggtgaaatttaccaaatcctttgaattgatgtccccaaagtgcagtgctgatgctgagaacagtttcaaagaaagcatggagaaatcatcatactccgactggctaataaataacagcattgctgagctggttgcttcaacaggccttccagtgaacatcagtgatgcctaccaggatccgcgctttgatgcagaggcagaccagatatctggttttcacataagatctgttctttgtgtccctatttggaatagcaaccaccaaataattggagtggctcaagtgttaaacagacttgatgggaaaccttttgatgatgcagatcaacgactttttgaggcttttgtcatcttttgtggacttggcatcaacaacacaattatgtatgatcaagtgaagaagtcctgggccaagcagtctgtggctcttgatgtgctatcataccatgcaacatgttcaaaagctgaagttgacaagtttaaggcagccaacatccctctggtgtcagaacttgccatcgatgacattcattttgatgacttttctctcgacgttgatgccatgatcacagctgctctccggatgttcatggagctggggatggtacagaaatttaaaattgactatgagacactgtgtaggtggcttttgacagtgaggaaaaactatcggatggttctataccacaactggagacatgccttcaacgtgtgtcagctgatgttcgcgatgttaaccactgctgggtttcaagacattctgaccgaggtggaaattttagcggtgattgtgggatgcctgtgtcatgacctcgaccacaggggaaccaacaatgccttccaagctaagagtggctctgccctggcccaactctatggaacctctgctaccttggagcatcaccatttcaaccacgccgtgatgatccttcaaagtgagggtcacaatatctttgctaacctgtcctccaaggaatatagtgaccttatgcagcttttgaagcagtcaatattggcaacagacctcacgctgtactttgagaggagaactgaattctttgaacttgtcagtaaaggagaatacgattggaacatcaaaaaccatcgtgatatatttcgatcaatgttaatgacagcctgtgaccttggagccgtgaccaaaccgtgggagatctccagacaggtggcagaacttgtaaccagtgagttcttcgaacaaggagatcgggagagattagagctcaaactcactccttcagcaatttttgatcggaaccggaaggatgaactgcctcggttgcaactggagtggattgatagcatctgcatgcctttgtatcaggcactggtgaaggtcaacgtgaaactgaagccgatgctagattcagtagctacaaacagaagtaagtgggaagagctacaccaaaaacgactgctggcctcaactgcctcatcctcccctgccagtgttatggtagccaaggaagacaggaactaaacctccaggtcagctgcagctgcaaaatgactacagcctgaagggccattttcagtccagcaatgtcatccttttgttcttttagctcagaaagacctaacatctcaaggatgcactgggaagcatgcctgggctttcaccttgaagcatggtcagcagcagagagagcaacgggaaggacaaagaaagaggtggggcagggagcacaccccaggaccctcacttttccctaatgaacacgcatgggctgaaatgaaggctctgggtaggggactgttttggatccaaggacctgtggacagtcggcctacttactctgagctgagggaacactgaacagtaaaagcgtcattagcgctgcttcgttttgtatagggcttttctgtttgttacaagccaaacactgcctgtctttgcttcctgtccctgaatgcctttttgtgccagactgtcccaagaatcctaatttgtattccatagaggtattttatttttaatcctagagcttcttattgatggatcctttagaattgcctacctaaaaggtaaactatactatccttataaatactgatcaatcccagttctccccctaaaaatgaatacatagtaggactatagcaaatgtgtttgatgggtaattctagactgggactatggtacccttttccagagttttaaaattcaaccttcattacagacaaagttttctcccagaaggaatggattgatagattttgattaaagtaagggtggaaggaaatctgtagctggatttaccacaagtgacatctagaaactatagttcacaggacagagcagagccatggagactaagcattgactaccttgagttctcctagtgaggagttctggtataaaatttaagattactaccagtaaccaacttaaagcaaactataggggtccctaattttggatttttccttaagtgtaagaaacaatgcttcaaatgttaagaaataacagtctgggcaaagaacgcatattctataggaagccaggtttacaataggtaagaataaactgtattaagtagatgtaatgactagaaagctgctttgctccctatattgagaaattgtggacatggtatgtgttatccaaagaacattgggctagaagatagatttctatccttagctttggcattattgactggattgacttgaacaagtcacttaacttctacaagcttgtttccttatttgtcaaattagattacactaggaaacgattctcgaacatgttttaaccttacaactctttgttcaaataaatctttcaatgaatccccaacatataaaacgtcaaaaagctgaattcctatgtgaattataagcagggtttggacatccagagcacctacaaaccttcatctctttgattacgtacatgggggtccacagggactctgaagagtttgaaaatccctggcctagattaaacctgagagccattctagctcttaaaaaaatctgaaatttacaaaccatttttcttgttattgtttttgtttctttgtttgtttgttttttgagactgagttttcactcttgttgcccaggctggagtgcaatggcgtgatctcggcttactgcaacctctgcttcctgggttcaagcaattctccagcctcaacctcctgagaagctgggattacaggtgcctgccaccacgcctggctaatttttgtacttttagtagacacagggtttcaccatgtttgccaggctgatctcaaactcctgacctcaggtgagccacccacctctgcctccgaaagtgctgggattacaggcgtgagccaccgtacccggcccttgttattgttattaatcattatcaatcattaactttacagatattaaagaaataggggccatgttctacatgcgacattgttttcctggcacacagtagacaattcaggaaatgtctgaagaaggaatgggtaaaattaagataccaaaatggaattgaggggagagcaggtaattgtagagaaaaagactctttatggcaagaaacaaagtaaaagaaatgtatagaccgggcgcggtggctcacgcctgtaatcccagcaatttggaaggccgaggcgggcggatcacgaggtcaggagatcgagaccgtcctggctaacacggtgaaaccctgtctctactaaaaaacacaaaacaaattagccaggcgcggtggcaggcgtctgtagtcccagctactggggaggctgaggcaagagaatggcgggaacccgcgaggcggagcttgcagtgagtcgagatcacgtcactgccctccagcctgggcgaccagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagtataaaccagactaagaggggaataaaagcaagaagaaaaagaaacgtaagaacaccagtaaaggaaagacagggaccgagacaggtggttaagggaaatgaaaaaaaaaaaaaaaaggtgaaagtcaatccaaacaaagaaaaatggcacttccaaccaaaaaaaatgaaggtgtagaaccctgtcatcaattgctcagaaaagagagacacttgagcagggaggggtttgagaaaggggagaaggaaggagtgagagccctaaaaaataatgttcctagctaccctttacagctgtctctgcagggaagactggagaaagtagagggggaaatgaatgcaggaagaaactgcctctgcagagcaggtaagaggaggttgttcagatttatggattttattaagccagttttctgtatcactctgctataaaggaaaatagcttctgcagggctgtctctcctccttcaggtggggaacaaagggtgggtggagtcagggacagagtctggtctgcgagatcgtgacgtgtctgcagctccgaagcactgcaggtgtttctgggtaatgtgccacatcatgtttatatcacgaacgggaattgaaaatcagtctgtgtgaggcagagatgagcccacatctgttatcctccccaacaataaataaataaatagcccagacaaatggatgccagtccatctacagcaacattttaaagcatgtgctttatgacaaaactggacccagggtctgacagagactgcaggctgccgtgagcactgtagctatcctgaacattgatgctacatattgctaaggggaacataatttatagcataaaccctacaagcttccactaaggttgagttttcctctcattttcttgccgttttattggcttcactgcatggttgccaatagcaacatccactggtagcaaggggagttcaacaccattgcaatctgccatacagtggagccctgacaatgtcaaccatcaatctagtagctgtttgtaattgcctccatctatttctcctgtcttgaggtatctttcctattgtgggtcaagatttagaaactgctgactaatgccatgggtctgtgtctccatgactatgaagcagtggacaggaaggtagcagcttcctggtgccaacaaccccagaggttagaggttgaactcttgcgggtttcaggcgtttttaatcccttttctaaacaatttataattttgcaagaatgtgaggcatatgcagttatccatataatctgcttttccaaaaaagagaaaggaagtttcccagtccttattattaatgtttatttcctattggagaaagacatttgaaatatgagccttcttgtaaaaactcaaactgaccagattatgtttgcttcctcaggtctcttggcattaattgttgaaataacttcatcctactttttcgatgagatgtatttttttcagacatatttattcttactagtcactatgtagctattatgtgcacaatctacaatgtagtggcaatcctggtgggtagggacagcttcacatactgcaaagggtgccattcagtgcatagcagactggaactccctcctagcttggccaccagctgaacctgtaatcttaggactctccaagtcttagaatctccatctattacataaaagcactgacttttattcagtccccacaccaaaggaccaagacgtgtttagctttaaagaaattttccagataattttcttttttattcttctcaaataaaatagcaacaaacctaaagcagtcatcttcttaataaagacataataaaacttacatatatggggtagatgtaagcacaatcatactacagatgtatcttgagcctgtctctaattatgatgaaagatgtagtcatcaatacaatttaaaaaaagatatgtcctttttttgagacagggtcttgctctgtcacccaggctggagggcagtggcacaatcacagccactgcagccttgacctctccaacttaagtgatctttcctgcctcagcctcatgagtagctgggaccacaggtgtgcaccaccacacccagctaaattttgtattgtttgtaaagacgaggcctcactatgctgaccacactggtctcgaactcctgggctcaagcaatcctcctgccttggcctcccaaagtgttagggttagagatatgaaccaccacacccaccttatatgtccttttatttcataaaaaacaattttagattatctgatatcacacatatcccataaatggtagtcattaatttagaagtgaatttataaagttaagagaagttaaaattgcacatgcattttgtttctaaaatctgagatgtctatgcatttccaggtattgtatatttgcaaatacattgggttagaaatcatctttaacattttgtgttagtgtaataacaatattatctaatattaatgctgccagaatccagttgctttttctgtgtatcaaaatttatcataactttttccacttaacactaggtaattaaacagaatctgcccaatttattctgcagtaaaattattttaaaatctatttttcctgctgactcttagaaattgcagaaagacaaaaaccagtttcatctccagtaatagtgtgaaacaatttccttccagtgggacagaaacctagacatactagggaaagatttaaatataaagaaaaatgccttggctgaaaaaaaaaaaaaccaccaaaacacaaaaaggattcattaaagcaacagaacaaaacctaatttgggaccctaaaaactctggcaatgccactgtaatgaagtttcattatctgcttcagagtaacagtctctgaaattgttattctgctacatgctgtaaagaactcccaaaactcaaatgtatcaggaaatgtaaaggttaagtctgactacaagaaggccaaaattgcaccagcttcctaagtgaagaataatagaataaaacatatagagggcagaaataaaatgaggtgtatctggagaatttcatgatgagcatttagatttagcaatgcccaatgtcatgctgacactgtttgtcatgaccttgtcttcagctagtaatttggggttgtacttttttaaatttaattttgaatgttcttgcatgtttggtacctctctcctcactgctaaagataaattgtttatctgtataacataactacaccaatgtcatttttgtatacgctagtacacaaatgtgtttttttattaagtaatgaagtatttgctgtgaaaaatgtattatttgtgccaccgtttatatctgtgttcattttctgtgtgtatatgcgtgtgtattcgaatctcaatttttcttttactctagtttagattaagacatatttagatgaaattttaaaaataacattggaaataggaggctaagttttgttgagtctcattcccttggggggaaattgcttttgccattttattttcatgtacaataacctaaaaaggatctcctactgacttccttcctaattattattgttttacacgaaagaaaggaaatacgttttcaattgagttgtttgaaatcattcactttgtgtagatttcccagactgatgtttcattgtaagaatattacattatagacaggttggccatttcacaagcaactaatccatagttttggaagcccgctttaagagacctgaatatctttgtttttaataaaatacttagagtttaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:50940 -> Molecular function: GO:0004112 [cyclic-nucleotide phosphodiesterase activity] evidence: NAS
            GeneID:50940 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: TAS
            GeneID:50940 -> Molecular function: GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] evidence: IDA
            GeneID:50940 -> Molecular function: GO:0030552 [cAMP binding] evidence: IEA
            GeneID:50940 -> Molecular function: GO:0030553 [cGMP binding] evidence: IDA
            GeneID:50940 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:50940 -> Molecular function: GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA
            GeneID:50940 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
            GeneID:50940 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
            GeneID:50940 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:50940 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IEA
            GeneID:50940 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
            GeneID:50940 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:50940 -> Cellular component: GO:0043204 [perikaryon] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_058649 -> EC 3.1.4.17
            NP_058649 -> EC 3.1.4.35

by @meso_cacase at DBCLS
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