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2024-03-29 00:15:58, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_016937               5455 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens polymerase (DNA directed), alpha 1, catalytic subunit
            (POLA1), mRNA.
ACCESSION   NM_016937
VERSION     NM_016937.3  GI:291045203
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5455)
  AUTHORS   Vaara,M., Itkonen,H., Hillukkala,T., Liu,Z., Nasheuer,H.P.,
            Schaarschmidt,D., Pospiech,H. and Syvaoja,J.E.
  TITLE     Segregation of replicative DNA polymerases during S phase: DNA
            polymerase epsilon, but not DNA polymerases alpha/delta, are
            associated with lamins throughout S phase in human cells
  JOURNAL   J. Biol. Chem. 287 (40), 33327-33338 (2012)
   PUBMED   22887995
  REMARK    GeneRIF: Pol epsilon and Pol alpha/delta seem to pursue their
            functions at least in part independently in late S phase
REFERENCE   2  (bases 1 to 5455)
  AUTHORS   Kilkenny,M.L., De Piccoli,G., Perera,R.L., Labib,K. and
            Pellegrini,L.
  TITLE     A conserved motif in the C-terminal tail of DNA polymerase alpha
            tethers primase to the eukaryotic replisome
  JOURNAL   J. Biol. Chem. 287 (28), 23740-23747 (2012)
   PUBMED   22593576
  REMARK    GeneRIF: Findings indicate that tethering of primase to the
            replisome by DNA polymerase alpha (pol alpha) is critical for the
            normal action of DNA replication forks in eukaryotic cells.
REFERENCE   3  (bases 1 to 5455)
  AUTHORS   Cui,X.A., Zhang,H. and Palazzo,A.F.
  TITLE     p180 promotes the ribosome-independent localization of a subset of
            mRNA to the endoplasmic reticulum
  JOURNAL   PLoS Biol. 10 (5), E1001336 (2012)
   PUBMED   22679391
  REMARK    GeneRIF: Depletion of p180 in U2OS cells increases cell size.
REFERENCE   4  (bases 1 to 5455)
  AUTHORS   Warren,E.M., Huang,H., Fanning,E., Chazin,W.J. and Eichman,B.F.
  TITLE     Physical interactions between Mcm10, DNA, and DNA polymerase alpha
  JOURNAL   J. Biol. Chem. 284 (36), 24662-24672 (2009)
   PUBMED   19608746
  REMARK    GeneRIF: DNA and p180 binding to an Mcm10 construct that contains
            both the ID and CTD, provide the first mechanistic insight into how
            Mcm10 might use a handoff mechanism to load and stabilize pol alpha
            within the replication fork.
REFERENCE   5  (bases 1 to 5455)
  AUTHORS   Taricani,L., Shanahan,F. and Parry,D.
  TITLE     Replication stress activates DNA polymerase alpha-associated Chk1
  JOURNAL   Cell Cycle 8 (3), 482-489 (2009)
   PUBMED   19177015
  REMARK    GeneRIF: Results show that depletion of DNA polymerase alpha and
            not Polepsilon or Poldelta by siRNA induces phosphorylation of Chk1
            on Ser345, thus phenocopying antimetabolite exposure.
REFERENCE   6  (bases 1 to 5455)
  AUTHORS   Coverley,D., Kenny,M.K., Lane,D.P. and Wood,R.D.
  TITLE     A role for the human single-stranded DNA binding protein HSSB/RPA
            in an early stage of nucleotide excision repair
  JOURNAL   Nucleic Acids Res. 20 (15), 3873-3880 (1992)
   PUBMED   1508673
REFERENCE   7  (bases 1 to 5455)
  AUTHORS   Dornreiter,I., Erdile,L.F., Gilbert,I.U., von Winkler,D.,
            Kelly,T.J. and Fanning,E.
  TITLE     Interaction of DNA polymerase alpha-primase with cellular
            replication protein A and SV40 T antigen
  JOURNAL   EMBO J. 11 (2), 769-776 (1992)
   PUBMED   1311258
REFERENCE   8  (bases 1 to 5455)
  AUTHORS   Popanda,O. and Thielmann,H.W.
  TITLE     The function of DNA polymerases in DNA repair synthesis of
            ultraviolet-irradiated human fibroblasts
  JOURNAL   Biochim. Biophys. Acta 1129 (2), 155-160 (1992)
   PUBMED   1730053
REFERENCE   9  (bases 1 to 5455)
  AUTHORS   Collins,K.L. and Kelly,T.J.
  TITLE     Effects of T antigen and replication protein A on the initiation of
            DNA synthesis by DNA polymerase alpha-primase
  JOURNAL   Mol. Cell. Biol. 11 (4), 2108-2115 (1991)
   PUBMED   1848671
REFERENCE   10 (bases 1 to 5455)
  AUTHORS   Fisher,P.A. and Korn,D.
  TITLE     DNA polymerase-alpha. Purification and structural characterization
            of the near homogeneous enzyme from human KB cells
  JOURNAL   J. Biol. Chem. 252 (18), 6528-6535 (1977)
   PUBMED   893425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X06745.1, BX648513.1,
            BU508486.1, CN364591.1 and BM664024.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 13, 2010 this sequence version replaced gi:106507300.
            
            Summary: This gene encodes the catalytic subunit of DNA polymerase,
            which together with a regulatory and two primase subunits, forms
            the DNA polymerase alpha complex. The catalytic subunit plays an
            essential role in the initiation of DNA replication. [provided by
            RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06745.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1522              X06745.1           2-1523
            1523-1535           X06745.1           1525-1537
            1536-1683           BX648513.1         1561-1708
            1684-2524           X06745.1           1685-2525
            2525-3123           BU508486.1         8-606
            3124-4750           X06745.1           3125-4751
            4751-5335           CN364591.1         99-683
            5336-5455           BM664024.1         1-120               c
FEATURES             Location/Qualifiers
     source          1..5455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.1-p21.3"
     gene            1..5455
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="polymerase (DNA directed), alpha 1, catalytic
                     subunit"
                     /db_xref="GeneID:5422"
                     /db_xref="HGNC:9173"
                     /db_xref="MIM:312040"
     exon            1..40
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     CDS             16..4404
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /EC_number="2.7.7.7"
                     /note="polymerase (DNA-directed), alpha (70kD); DNA
                     polymerase alpha p180 subunit; DNA polymerase alpha 1
                     catalytic subunit; DNA polymerase alpha catalytic subunit
                     p180"
                     /codon_start=1
                     /product="DNA polymerase alpha catalytic subunit"
                     /protein_id="NP_058633.2"
                     /db_xref="GI:106507301"
                     /db_xref="CCDS:CCDS14214.1"
                     /db_xref="GeneID:5422"
                     /db_xref="HGNC:9173"
                     /db_xref="MIM:312040"
                     /translation="
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS
"
     misc_feature    166..3690
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="DNA polymerase (pol2); Region: pol2; TIGR00592"
                     /db_xref="CDD:161943"
     misc_feature    <166..300
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="DNA polymerase alpha subunit p180 N terminal;
                     Region: DNA_pol_alpha_N; pfam12254"
                     /db_xref="CDD:192970"
     misc_feature    385..390
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage; propagated from UniProtKB/Swiss-Prot
                     (P09884.2); cleavage site"
     misc_feature    535..537
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P09884.2); phosphorylation site"
     misc_feature    571..573
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09884.2); phosphorylation site"
     misc_feature    583..585
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09884.2); phosphorylation site"
     misc_feature    640..642
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P09884.2); phosphorylation site"
     misc_feature    1618..2316
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="inactive DEDDy 3'-5' exonuclease domain of
                     eukaryotic DNA polymerase alpha, a family-B DNA
                     polymerase; Region: DNA_polB_alpha_exo; cd05776"
                     /db_xref="CDD:99819"
     misc_feature    1963..2160
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09884.2);
                     Region: DNA-binding region (Potential)"
     misc_feature    2542..3741
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="DNA polymerase type-B alpha subfamily catalytic
                     domain. Three DNA-dependent DNA polymerases type B (alpha,
                     delta, and epsilon) have been identified as essential for
                     nuclear DNA replication in eukaryotes. DNA polymerase
                     (Pol) alpha is almost exclusively...; Region: POLBc_alpha;
                     cd05532"
                     /db_xref="CDD:99915"
     misc_feature    order(2593..2595,2602..2610,2779..2781,2863..2865,
                     2875..2877,3025..3027)
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="active site"
                     /db_xref="CDD:99915"
     misc_feature    order(3019..3021,3025..3030)
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="metal-binding site"
                     /db_xref="CDD:99915"
     misc_feature    3748..4143
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09884.2);
                     Region: DNA-binding region (Potential)"
     misc_feature    3802..4380
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /note="DNA Polymerase alpha zinc finger; Region:
                     zf-DNA_Pol; pfam08996"
                     /db_xref="CDD:204112"
     misc_feature    4057..4137
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P09884.2);
                     Region: CysB motif"
     exon            41..165
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     STS             53..135
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /standard_name="GDB:192498"
                     /db_xref="UniSTS:99129"
     variation       86
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:146733808"
     variation       106
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138282947"
     variation       107
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371458274"
     variation       121
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201128590"
     variation       129
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188570672"
     variation       150
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377252389"
     variation       156
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41562912"
     exon            166..262
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       182
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200995449"
     variation       232
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369800589"
     exon            263..343
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       315
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369570755"
     variation       318
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373482765"
     exon            344..459
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       358
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141903278"
     variation       361
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376350416"
     variation       380
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150650096"
     variation       393
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138887775"
     variation       408
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187670867"
     exon            460..522
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       474
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373642183"
     variation       487
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199741223"
     exon            523..615
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       525
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371106471"
     variation       526
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201649929"
     variation       536
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368651244"
     variation       554
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61756399"
     variation       585
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147524515"
     variation       587
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140202293"
     variation       614
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200756660"
     exon            616..703
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       619
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376454156"
     variation       675
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367625269"
     exon            704..905
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       717
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144168156"
     variation       718
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372776800"
     variation       775
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375784471"
     variation       817
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182025721"
     exon            906..1084
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       938
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148411107"
     variation       943
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142553261"
     variation       974
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150967644"
     variation       1009
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139566864"
     variation       1018
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143377461"
     variation       1057
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146743254"
     exon            1085..1197
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1106
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61756361"
     variation       1125
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200673768"
     variation       1137
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376852543"
     variation       1164
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11573338"
     exon            1198..1314
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1214
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368074893"
     variation       1218
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370743195"
     variation       1229
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375241795"
     variation       1282
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367843843"
     variation       1290
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371460244"
     exon            1315..1389
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1359
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372526139"
     exon            1390..1528
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1435
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34146393"
     variation       1500
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375636711"
     variation       1501
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145623455"
     variation       1506
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369492115"
     variation       1518
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372950114"
     exon            1529..1683
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1531
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145173850"
     variation       1623
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189663317"
     variation       1630
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192188948"
     variation       1658
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149149281"
     exon            1684..1768
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     exon            1769..1830
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1784..1785
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:36086506"
     variation       1786
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143288590"
     variation       1790
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373842557"
     exon            1831..1920
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1857
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367871412"
     exon            1921..2037
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       1954
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148326076"
     variation       1972
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200384693"
     variation       2007
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370454721"
     exon            2038..2213
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2112
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199912686"
     variation       2139
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141500749"
     variation       2188
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199701006"
     variation       2210
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184477391"
     exon            2214..2343
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2233
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230927"
     variation       2264
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2230928"
     variation       2286
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144074224"
     variation       2334
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147334287"
     exon            2344..2463
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2345
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367639262"
     variation       2406
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201734540"
     exon            2464..2563
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2468
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139024287"
     exon            2564..2688
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2571
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192287717"
     exon            2689..2838
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2761
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149469482"
     exon            2839..2961
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2881
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:202169782"
     variation       2946
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370595759"
     exon            2962..2994
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       2976
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373198180"
     exon            2995..3087
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3078
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368483249"
     variation       3084
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143911626"
     exon            3088..3293
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3096
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78040616"
     variation       3119
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148640944"
     variation       3177
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367896351"
     variation       3180
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61751428"
     variation       3190
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182314888"
     exon            3294..3426
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3306
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367653348"
     variation       3381
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372929140"
     exon            3427..3558
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3462
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61756362"
     variation       3467
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369599709"
     variation       3469
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200688540"
     variation       3471
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373509257"
     variation       3476
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375300732"
     variation       3513
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200148911"
     variation       3543
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146732787"
     exon            3559..3733
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3591
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186345669"
     variation       3618
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113522473"
     variation       3619
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41548013"
     variation       3714
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11573423"
     variation       3724
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375778112"
     variation       3726
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151022301"
     exon            3734..3912
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3743
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140910158"
     variation       3801
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:150195244"
     variation       3898
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56090108"
     exon            3913..4044
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       3940
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201607896"
     variation       3954
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145742505"
     variation       3963
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201791899"
     variation       3991
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368309852"
     variation       3996
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200968329"
     variation       3999
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141666924"
     variation       4022
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147068943"
     exon            4045..4161
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       4083
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138462379"
     variation       4122
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144039189"
     exon            4162..4258
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       4182
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61756363"
     variation       4202
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375609607"
     variation       4218
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200725778"
     variation       4236..4237
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34669169"
     variation       4238
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370763508"
     exon            4259..5440
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /inference="alignment:Splign:1.39.8"
     variation       4314
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148378121"
     variation       4353
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11573531"
     variation       4380
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150514156"
     variation       4381
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200953586"
     variation       4392
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144848232"
     variation       4404
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141613908"
     variation       4409
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11573532"
     variation       4430
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374941044"
     variation       4466
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183032566"
     variation       4517
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111446313"
     variation       4549
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11573533"
     variation       4626
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188734545"
     variation       4711
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:191161539"
     variation       4746
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76747593"
     variation       4778
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182945492"
     variation       4840
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6629934"
     variation       4849
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139099348"
     variation       4946
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:202047108"
     STS             5048..5266
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /standard_name="STS-X06745"
                     /db_xref="UniSTS:79899"
     variation       5100
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149902648"
     variation       5121
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11573534"
     variation       5278
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187585802"
     variation       5293
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112928837"
     variation       5319
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370361721"
     variation       5359
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11573535"
     polyA_signal    5419..5424
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
     polyA_site      5440
                     /gene="POLA1"
                     /gene_synonym="p180; POLA"
ORIGIN      
gggagattcgggaccatggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcgagcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaaggctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaagttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtggatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaagatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaagaggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgcttgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggtgacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgatactgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacggcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcctgttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaagagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagttgaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagcagaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagttttctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaagaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagtattccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtatttctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtgaaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacggggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaaatagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgcttttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaaatgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaacacatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaagtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggctttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatggctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatggcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcagtcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaagtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggttttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttatgggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtccaagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggtgaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattgattcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagggttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatacctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaatgttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctgatgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaactatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagatgaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgctggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggacttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaaagagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgagttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaacggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattcttcagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctgggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaaggaagggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttatggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaagttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacattgatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgttgagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagttagaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctttctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattggagaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgacaaaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctggataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgtcaggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaacaggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtggctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttgggacttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctctacttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaatgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcgggaacagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctgacctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaagtactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcaccttccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaaccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgatgcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaattttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattcttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtgaaatcctaagggaatcccaggagtaaccaaggagggggtagttgaaaaatcccagcttcctctgtgcctccactctggccctaaatgctcctccagcatctgtttctcccttgggactgtgtctcatgtttgtgtgaatgtagaccaggaaagggggctgcaaaaatgttgagtctaatgttcgtaagcatcatagaaattcctgtcttcatattaagatgtactgctttaaaacacaactccagagcccctccccaagctcccctccccaagctcctgaagacccggtttctgagggagggaaattgctacttggattgagagtagctggaatgtaagtgaccccaggctttgcctcagggcctttagcctatgtcccccccacataaagagagcttctcagagcctgactgaagagctgacgttttgctttttcatatgccaattaaacccggtctaaatccaaatgcttctccagccatccaggagtggctgtccttttcagtcttgtcttttatataggtagctgagggggaagatttagaagccttgcactcactaaatagattaaacagagcaggcttgtttgttgaattgctccaaagtccaacagacacacactgagcaggtgttttacactcacattccctttttgccccttaaatagaaagtgcaggtaaaggtttatacaacaagaaagcacattgaaaataatttgatactctaacaatccattaacatgtgtaggggttacggtgaggatcactgtgttgtattcagaaaaacggggagagggatgcttaattggccctggcgcttgctatttttttctcatttcttcacaataggaccgtctttggcagcagcaaaatgtatttcagtatggcagtctttcctctcttacattattggtaagattatactaacaaaatgtttccccttgtacaattatgctgtgtttttaaaaaacattgacctgtgtgtttttataaaagaaaaagtatgttgtgccttcttcttaagaataaagttttctaaagggaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5422 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IDA
            GeneID:5422 -> Molecular function: GO:0001882 [nucleoside binding] evidence: IEA
            GeneID:5422 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:5422 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
            GeneID:5422 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:5422 -> Molecular function: GO:0003887 [DNA-directed DNA polymerase activity] evidence: IDA
            GeneID:5422 -> Molecular function: GO:0003887 [DNA-directed DNA polymerase activity] evidence: IMP
            GeneID:5422 -> Molecular function: GO:0003896 [DNA primase activity] evidence: IDA
            GeneID:5422 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5422 -> Molecular function: GO:0008408 [3'-5' exonuclease activity] evidence: IBA
            GeneID:5422 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:5422 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:5422 -> Molecular function: GO:0051539 [4 iron, 4 sulfur cluster binding] evidence: IEA
            GeneID:5422 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5422 -> Biological process: GO:0000083 [regulation of transcription involved in G1/S phase of mitotic cell cycle] evidence: TAS
            GeneID:5422 -> Biological process: GO:0000084 [S phase of mitotic cell cycle] evidence: IDA
            GeneID:5422 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5422 -> Biological process: GO:0000722 [telomere maintenance via recombination] evidence: TAS
            GeneID:5422 -> Biological process: GO:0000723 [telomere maintenance] evidence: TAS
            GeneID:5422 -> Biological process: GO:0000731 [DNA synthesis involved in DNA repair] evidence: IMP
            GeneID:5422 -> Biological process: GO:0006260 [DNA replication] evidence: IMP
            GeneID:5422 -> Biological process: GO:0006269 [DNA replication, synthesis of RNA primer] evidence: IDA
            GeneID:5422 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IDA
            GeneID:5422 -> Biological process: GO:0006270 [DNA replication initiation] evidence: TAS
            GeneID:5422 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: IMP
            GeneID:5422 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS
            GeneID:5422 -> Biological process: GO:0006272 [leading strand elongation] evidence: IDA
            GeneID:5422 -> Biological process: GO:0006273 [lagging strand elongation] evidence: IDA
            GeneID:5422 -> Biological process: GO:0006281 [DNA repair] evidence: IDA
            GeneID:5422 -> Biological process: GO:0006297 [nucleotide-excision repair, DNA gap filling] evidence: IBA
            GeneID:5422 -> Biological process: GO:0006303 [double-strand break repair via nonhomologous end joining] evidence: IMP
            GeneID:5422 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:5422 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:5422 -> Biological process: GO:0019985 [translesion synthesis] evidence: IBA
            GeneID:5422 -> Biological process: GO:0032201 [telomere maintenance via semi-conservative replication] evidence: TAS
            GeneID:5422 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5422 -> Cellular component: GO:0005658 [alpha DNA polymerase:primase complex] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005658 [alpha DNA polymerase:primase complex] evidence: TAS
            GeneID:5422 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA
            GeneID:5422 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_058633 -> EC 2.7.7.7

by @meso_cacase at DBCLS
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