2024-03-29 00:15:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016937 5455 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens polymerase (DNA directed), alpha 1, catalytic subunit (POLA1), mRNA. ACCESSION NM_016937 VERSION NM_016937.3 GI:291045203 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5455) AUTHORS Vaara,M., Itkonen,H., Hillukkala,T., Liu,Z., Nasheuer,H.P., Schaarschmidt,D., Pospiech,H. and Syvaoja,J.E. TITLE Segregation of replicative DNA polymerases during S phase: DNA polymerase epsilon, but not DNA polymerases alpha/delta, are associated with lamins throughout S phase in human cells JOURNAL J. Biol. Chem. 287 (40), 33327-33338 (2012) PUBMED 22887995 REMARK GeneRIF: Pol epsilon and Pol alpha/delta seem to pursue their functions at least in part independently in late S phase REFERENCE 2 (bases 1 to 5455) AUTHORS Kilkenny,M.L., De Piccoli,G., Perera,R.L., Labib,K. and Pellegrini,L. TITLE A conserved motif in the C-terminal tail of DNA polymerase alpha tethers primase to the eukaryotic replisome JOURNAL J. Biol. Chem. 287 (28), 23740-23747 (2012) PUBMED 22593576 REMARK GeneRIF: Findings indicate that tethering of primase to the replisome by DNA polymerase alpha (pol alpha) is critical for the normal action of DNA replication forks in eukaryotic cells. REFERENCE 3 (bases 1 to 5455) AUTHORS Cui,X.A., Zhang,H. and Palazzo,A.F. TITLE p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum JOURNAL PLoS Biol. 10 (5), E1001336 (2012) PUBMED 22679391 REMARK GeneRIF: Depletion of p180 in U2OS cells increases cell size. REFERENCE 4 (bases 1 to 5455) AUTHORS Warren,E.M., Huang,H., Fanning,E., Chazin,W.J. and Eichman,B.F. TITLE Physical interactions between Mcm10, DNA, and DNA polymerase alpha JOURNAL J. Biol. Chem. 284 (36), 24662-24672 (2009) PUBMED 19608746 REMARK GeneRIF: DNA and p180 binding to an Mcm10 construct that contains both the ID and CTD, provide the first mechanistic insight into how Mcm10 might use a handoff mechanism to load and stabilize pol alpha within the replication fork. REFERENCE 5 (bases 1 to 5455) AUTHORS Taricani,L., Shanahan,F. and Parry,D. TITLE Replication stress activates DNA polymerase alpha-associated Chk1 JOURNAL Cell Cycle 8 (3), 482-489 (2009) PUBMED 19177015 REMARK GeneRIF: Results show that depletion of DNA polymerase alpha and not Polepsilon or Poldelta by siRNA induces phosphorylation of Chk1 on Ser345, thus phenocopying antimetabolite exposure. REFERENCE 6 (bases 1 to 5455) AUTHORS Coverley,D., Kenny,M.K., Lane,D.P. and Wood,R.D. TITLE A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair JOURNAL Nucleic Acids Res. 20 (15), 3873-3880 (1992) PUBMED 1508673 REFERENCE 7 (bases 1 to 5455) AUTHORS Dornreiter,I., Erdile,L.F., Gilbert,I.U., von Winkler,D., Kelly,T.J. and Fanning,E. TITLE Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen JOURNAL EMBO J. 11 (2), 769-776 (1992) PUBMED 1311258 REFERENCE 8 (bases 1 to 5455) AUTHORS Popanda,O. and Thielmann,H.W. TITLE The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts JOURNAL Biochim. Biophys. Acta 1129 (2), 155-160 (1992) PUBMED 1730053 REFERENCE 9 (bases 1 to 5455) AUTHORS Collins,K.L. and Kelly,T.J. TITLE Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase JOURNAL Mol. Cell. Biol. 11 (4), 2108-2115 (1991) PUBMED 1848671 REFERENCE 10 (bases 1 to 5455) AUTHORS Fisher,P.A. and Korn,D. TITLE DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells JOURNAL J. Biol. Chem. 252 (18), 6528-6535 (1977) PUBMED 893425 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X06745.1, BX648513.1, BU508486.1, CN364591.1 and BM664024.1. This sequence is a reference standard in the RefSeqGene project. On Mar 13, 2010 this sequence version replaced gi:106507300. Summary: This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X06745.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1522 X06745.1 2-1523 1523-1535 X06745.1 1525-1537 1536-1683 BX648513.1 1561-1708 1684-2524 X06745.1 1685-2525 2525-3123 BU508486.1 8-606 3124-4750 X06745.1 3125-4751 4751-5335 CN364591.1 99-683 5336-5455 BM664024.1 1-120 c FEATURES Location/Qualifiers source 1..5455 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xp22.1-p21.3" gene 1..5455 /gene="POLA1" /gene_synonym="p180; POLA" /note="polymerase (DNA directed), alpha 1, catalytic subunit" /db_xref="GeneID:5422" /db_xref="HGNC:9173" /db_xref="MIM:312040" exon 1..40 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" CDS 16..4404 /gene="POLA1" /gene_synonym="p180; POLA" /EC_number="2.7.7.7" /note="polymerase (DNA-directed), alpha (70kD); DNA polymerase alpha p180 subunit; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit p180" /codon_start=1 /product="DNA polymerase alpha catalytic subunit" /protein_id="NP_058633.2" /db_xref="GI:106507301" /db_xref="CCDS:CCDS14214.1" /db_xref="GeneID:5422" /db_xref="HGNC:9173" /db_xref="MIM:312040" /translation="
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS
" misc_feature 166..3690 /gene="POLA1" /gene_synonym="p180; POLA" /note="DNA polymerase (pol2); Region: pol2; TIGR00592" /db_xref="CDD:161943" misc_feature <166..300 /gene="POLA1" /gene_synonym="p180; POLA" /note="DNA polymerase alpha subunit p180 N terminal; Region: DNA_pol_alpha_N; pfam12254" /db_xref="CDD:192970" misc_feature 385..390 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="Cleavage; propagated from UniProtKB/Swiss-Prot (P09884.2); cleavage site" misc_feature 535..537 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (P09884.2); phosphorylation site" misc_feature 571..573 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P09884.2); phosphorylation site" misc_feature 583..585 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P09884.2); phosphorylation site" misc_feature 640..642 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P09884.2); phosphorylation site" misc_feature 1618..2316 /gene="POLA1" /gene_synonym="p180; POLA" /note="inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase; Region: DNA_polB_alpha_exo; cd05776" /db_xref="CDD:99819" misc_feature 1963..2160 /gene="POLA1" /gene_synonym="p180; POLA" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P09884.2); Region: DNA-binding region (Potential)" misc_feature 2542..3741 /gene="POLA1" /gene_synonym="p180; POLA" /note="DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively...; Region: POLBc_alpha; cd05532" /db_xref="CDD:99915" misc_feature order(2593..2595,2602..2610,2779..2781,2863..2865, 2875..2877,3025..3027) /gene="POLA1" /gene_synonym="p180; POLA" /note="active site" /db_xref="CDD:99915" misc_feature order(3019..3021,3025..3030) /gene="POLA1" /gene_synonym="p180; POLA" /note="metal-binding site" /db_xref="CDD:99915" misc_feature 3748..4143 /gene="POLA1" /gene_synonym="p180; POLA" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P09884.2); Region: DNA-binding region (Potential)" misc_feature 3802..4380 /gene="POLA1" /gene_synonym="p180; POLA" /note="DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996" /db_xref="CDD:204112" misc_feature 4057..4137 /gene="POLA1" /gene_synonym="p180; POLA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P09884.2); Region: CysB motif" exon 41..165 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" STS 53..135 /gene="POLA1" /gene_synonym="p180; POLA" /standard_name="GDB:192498" /db_xref="UniSTS:99129" variation 86 /gene="POLA1" /gene_synonym="p180; POLA" /replace="" /replace="a" /db_xref="dbSNP:146733808" variation 106 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:138282947" variation 107 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:371458274" variation 121 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:201128590" variation 129 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:188570672" variation 150 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:377252389" variation 156 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:41562912" exon 166..262 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 182 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:200995449" variation 232 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:369800589" exon 263..343 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 315 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:369570755" variation 318 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:373482765" exon 344..459 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 358 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:141903278" variation 361 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:376350416" variation 380 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:150650096" variation 393 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:138887775" variation 408 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:187670867" exon 460..522 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 474 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:373642183" variation 487 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:199741223" exon 523..615 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 525 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:371106471" variation 526 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:201649929" variation 536 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:368651244" variation 554 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:61756399" variation 585 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:147524515" variation 587 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:140202293" variation 614 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:200756660" exon 616..703 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 619 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:376454156" variation 675 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:367625269" exon 704..905 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 717 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:144168156" variation 718 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:372776800" variation 775 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:375784471" variation 817 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:182025721" exon 906..1084 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 938 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:148411107" variation 943 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:142553261" variation 974 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:150967644" variation 1009 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:139566864" variation 1018 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:143377461" variation 1057 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:146743254" exon 1085..1197 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1106 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:61756361" variation 1125 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:200673768" variation 1137 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:376852543" variation 1164 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:11573338" exon 1198..1314 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1214 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:368074893" variation 1218 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:370743195" variation 1229 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:375241795" variation 1282 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:367843843" variation 1290 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:371460244" exon 1315..1389 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1359 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:372526139" exon 1390..1528 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1435 /gene="POLA1" /gene_synonym="p180; POLA" /replace="" /replace="t" /db_xref="dbSNP:34146393" variation 1500 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:375636711" variation 1501 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:145623455" variation 1506 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:369492115" variation 1518 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="t" /db_xref="dbSNP:372950114" exon 1529..1683 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1531 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:145173850" variation 1623 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:189663317" variation 1630 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:192188948" variation 1658 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:149149281" exon 1684..1768 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" exon 1769..1830 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1784..1785 /gene="POLA1" /gene_synonym="p180; POLA" /replace="" /replace="a" /db_xref="dbSNP:36086506" variation 1786 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:143288590" variation 1790 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:373842557" exon 1831..1920 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1857 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:367871412" exon 1921..2037 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 1954 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:148326076" variation 1972 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:200384693" variation 2007 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:370454721" exon 2038..2213 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2112 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:199912686" variation 2139 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:141500749" variation 2188 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:199701006" variation 2210 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:184477391" exon 2214..2343 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2233 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:2230927" variation 2264 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:2230928" variation 2286 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:144074224" variation 2334 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:147334287" exon 2344..2463 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2345 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:367639262" variation 2406 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:201734540" exon 2464..2563 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2468 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:139024287" exon 2564..2688 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2571 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:192287717" exon 2689..2838 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2761 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:149469482" exon 2839..2961 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2881 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="t" /db_xref="dbSNP:202169782" variation 2946 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:370595759" exon 2962..2994 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 2976 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:373198180" exon 2995..3087 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3078 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:368483249" variation 3084 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:143911626" exon 3088..3293 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3096 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:78040616" variation 3119 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:148640944" variation 3177 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:367896351" variation 3180 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:61751428" variation 3190 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:182314888" exon 3294..3426 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3306 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:367653348" variation 3381 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:372929140" exon 3427..3558 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3462 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:61756362" variation 3467 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:369599709" variation 3469 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:200688540" variation 3471 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:373509257" variation 3476 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:375300732" variation 3513 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:200148911" variation 3543 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:146732787" exon 3559..3733 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3591 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:186345669" variation 3618 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:113522473" variation 3619 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:41548013" variation 3714 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:11573423" variation 3724 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:375778112" variation 3726 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:151022301" exon 3734..3912 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3743 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:140910158" variation 3801 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="t" /db_xref="dbSNP:150195244" variation 3898 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:56090108" exon 3913..4044 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 3940 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:201607896" variation 3954 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:145742505" variation 3963 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:201791899" variation 3991 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:368309852" variation 3996 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:200968329" variation 3999 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:141666924" variation 4022 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:147068943" exon 4045..4161 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 4083 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:138462379" variation 4122 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:144039189" exon 4162..4258 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 4182 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:61756363" variation 4202 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:375609607" variation 4218 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:200725778" variation 4236..4237 /gene="POLA1" /gene_synonym="p180; POLA" /replace="" /replace="a" /db_xref="dbSNP:34669169" variation 4238 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:370763508" exon 4259..5440 /gene="POLA1" /gene_synonym="p180; POLA" /inference="alignment:Splign:1.39.8" variation 4314 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:148378121" variation 4353 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:11573531" variation 4380 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:150514156" variation 4381 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:200953586" variation 4392 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:144848232" variation 4404 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:141613908" variation 4409 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="c" /db_xref="dbSNP:11573532" variation 4430 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:374941044" variation 4466 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:183032566" variation 4517 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:111446313" variation 4549 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:11573533" variation 4626 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:188734545" variation 4711 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:191161539" variation 4746 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:76747593" variation 4778 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="g" /db_xref="dbSNP:182945492" variation 4840 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:6629934" variation 4849 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:139099348" variation 4946 /gene="POLA1" /gene_synonym="p180; POLA" /replace="g" /replace="t" /db_xref="dbSNP:202047108" STS 5048..5266 /gene="POLA1" /gene_synonym="p180; POLA" /standard_name="STS-X06745" /db_xref="UniSTS:79899" variation 5100 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:149902648" variation 5121 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:11573534" variation 5278 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="g" /db_xref="dbSNP:187585802" variation 5293 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:112928837" variation 5319 /gene="POLA1" /gene_synonym="p180; POLA" /replace="c" /replace="t" /db_xref="dbSNP:370361721" variation 5359 /gene="POLA1" /gene_synonym="p180; POLA" /replace="a" /replace="t" /db_xref="dbSNP:11573535" polyA_signal 5419..5424 /gene="POLA1" /gene_synonym="p180; POLA" polyA_site 5440 /gene="POLA1" /gene_synonym="p180; POLA" ORIGIN
gggagattcgggaccatggcacctgtgcacggcgacgactctctgtcagattcagggagttttgtatcttctcgagcccggcgagaaaaaaaatcaaagaaggggcgccaagaagccctagaaagactgaaaaaggctaaagctggtgagaagtataaatatgaagtcgaggacttcacaggtgtttatgaagaagttgatgaagaacagtattcgaagctggttcaggcacgccaggatgatgactggattgtggatgatgatggtattggctatgtggaagatggccgagagatttttgatgatgaccttgaagatgatgcccttgatgctgatgagaaaggaaaagatggtaaagcacgcaataaagacaagaggaatgtaaagaagctcgcagtgacaaaaccgaacaacattaagtcaatgttcattgcttgtgctggaaagaaaactgcagataaagctgtagacttgtccaaggatggtctgctaggtgacattctacaggatcttaacactgagacacctcaaataactccaccacctgtaatgatactgaagaagaaaagatccattggagcttcaccgaatcctttctctgtgcacaccgccacggcagttccttcaggaaaaattgcttcccctgtctccagaaaggagcctccattaactcctgttcctcttaaacgtgctgaatttgctggcgatgatgtacaggtcgagagtacagaagaagagcaggagtcaggggcaatggagtttgaagatggtgactttgatgagcccatggaagttgaagaggtggacctggagcctatggctgccaaggcttgggacaaagagagtgagccagcagaggaagtgaaacaagaggcggattctgggaaagggaccgtgtcctacttaggaagttttctcccggatgtctcttgttgggacattgatcaagaaggtgatagcagtttctcagtgcaagaagttcaagtggattccagtcacctcccattggtaaaaggggcagatgaggaacaagtattccacttttattggttggatgcttatgaggatcagtacaaccaaccaggtgtggtatttctgtttgggaaagtttggattgaatcagccgagacccatgtgagctgttgtgtcatggtgaaaaatatcgagcgaacgctttacttccttccccgtgaaatgaaaattgatctaaatacggggaaagaaacaggaactccaatttcaatgaaggatgtttatgaggaatttgatgagaaaatagcaacaaaatataaaattatgaagttcaagtctaagccagtggaaaagaactatgcttttgagatacctgatgttccagaaaaatctgagtacttggaagttaaatactcggctgaaatgccacagcttcctcaagatttgaaaggagaaactttttctcatgtatttgggaccaacacatctagcctggaactgttcttgatgaacagaaagatcaaaggaccttgttggcttgaagtaaaaagtccacagctcttgaatcagccagtcagttggtgtaaagttgaggcaatggctttgaaaccagacctggtgaatgtaattaaggatgtcagtccaccaccgcttgtcgtgatggctttcagcatgaagacaatgcagaatgcaaagaaccatcaaaatgagattattgctatggcagctttggtccatcacagttttgcattggataaagcagccccaaagcctccctttcagtcacacttctgtgttgtgtctaaaccaaaggactgtatttttccatatgctttcaaagaagtcattgagaaaaagaatgtgaaggttgaggttgctgcaacagaaagaacactgctaggttttttccttgcaaaagttcacaaaattgatcctgatatcattgtgggtcataatatttatgggtttgaactggaagtactactgcagagaattaatgtgtgcaaagctcctcactggtccaagataggtcgactgaagcgatccaacatgccaaagcttgggggccggagtggatttggtgaaagaaatgctacctgtggtcgaatgatctgtgatgtggaaatttcagcaaaggaattgattcgttgtaaaagctaccatctgtctgaacttgttcagcagattctaaaaactgaaagggttgtaatcccaatggaaaatatacaaaatatgtacagtgaatcttctcaactgttatacctgttggaacacacctggaaagatgccaagttcattttgcagatcatgtgtgagctaaatgttcttccattagcattgcagatcactaacatcgctgggaacattatgtccaggacgctgatgggtggacgatccgagcgtaacgagttcttgttgcttcatgcattttacgaaaacaactatattgtgcctgacaagcagattttcagaaagcctcagcaaaaactgggagatgaagatgaagaaattgatggagataccaataaatacaagaaaggacgtaagaaagcagcttatgctggaggcttggttttggaccccaaagttggtttttatgataagttcattttgcttctggacttcaacagtctatatccttccatcattcaggaatttaacatttgttttacaacagtacaaagagttgcttcagaggcacagaaagttacagaggatggagaacaagaacagatccctgagttgccagatccaagcttagaaatgggcattttgcccagagagatccggaaactggtagaacggagaaaacaagtcaaacagctaatgaaacagcaagacttaaatccagaccttattcttcagtatgacattcgacagaaggctttgaagctcacagcgaacagtatgtatggttgcctgggattttcctatagcagattttacgccaaaccactggctgccttggtgacatacaaaggaagggagattttgatgcatacgaaagagatggtacaaaagatgaatcttgaagttatttatggagatacagattcaattatgataaacaccaatagcaccaatctggaagaagtatttaagttgggaaacaaggtaaaaagtgaagtgaataagttgtacaaactgcttgaaatagacattgatggggttttcaagtctctgctactgctgaaaaaaaagaagtacgctgctctggttgttgagccaacgtcggatgggaattatgtcaccaaacaggagctcaaaggattagatatagttagaagagattggtgtgatcttgctaaagacactggaaactttgtgattggccagattctttctgatcaaagccgggacactatagtggaaaacattcagaagaggctgatagaaattggagaaaatgtgctaaatggcagtgtcccagtgagccagtttgaaattaacaaggcattgacaaaggatccccaggattaccctgataaaaaaagcctacctcatgtacatgttgccctctggataaattctcaaggaggcagaaaggtgaaagctggagatactgtgtcatatgtcatctgtcaggatggatcaaacctcactgcaagtcagagggcctatgcgcctgagcagctgcagaaacaggataatctaaccattgacacccagtactacctggcccagcagatccacccagtcgtggctcggatctgtgaaccaatagacggaattgatgctgtcctcattgcaacgtggttgggacttgaccccacccaatttagagttcatcattatcataaagatgaagagaatgatgctctacttggtggcccagcacagctcactgatgaagagaaatacagggactgtgaaagattcaaatgtccatgccctacatgtggaactgagaatatttatgataatgtctttgatggttcgggaacagatatggagcccagcttgtatcgttgcagtaacatcgattgtaaggcttcacctctgacctttacagtacaactgagcaacaaattgatcatggacattagacgtttcattaaaaagtactatgatggctggttgatatgtgaagagccaacctgtcgcaatcgaactcgtcaccttccccttcaattctcccgaactgggcctctttgcccagcctgcatgaaagctacacttcaaccagagtattctgacaagtccctgtacacccagctgtgcttttaccggtacatttttgatgcggagtgtgcactggagaaacttactaccgatcatgagaaagataaattgaagaagcaattttttacccccaaagttctgcaggactacagaaaactcaagaacacagcagagcaattcttgtcccgaagtggctactccgaagtgaatctgagcaaactcttcgctggttgtgccgtgaaatcctaagggaatcccaggagtaaccaaggagggggtagttgaaaaatcccagcttcctctgtgcctccactctggccctaaatgctcctccagcatctgtttctcccttgggactgtgtctcatgtttgtgtgaatgtagaccaggaaagggggctgcaaaaatgttgagtctaatgttcgtaagcatcatagaaattcctgtcttcatattaagatgtactgctttaaaacacaactccagagcccctccccaagctcccctccccaagctcctgaagacccggtttctgagggagggaaattgctacttggattgagagtagctggaatgtaagtgaccccaggctttgcctcagggcctttagcctatgtcccccccacataaagagagcttctcagagcctgactgaagagctgacgttttgctttttcatatgccaattaaacccggtctaaatccaaatgcttctccagccatccaggagtggctgtccttttcagtcttgtcttttatataggtagctgagggggaagatttagaagccttgcactcactaaatagattaaacagagcaggcttgtttgttgaattgctccaaagtccaacagacacacactgagcaggtgttttacactcacattccctttttgccccttaaatagaaagtgcaggtaaaggtttatacaacaagaaagcacattgaaaataatttgatactctaacaatccattaacatgtgtaggggttacggtgaggatcactgtgttgtattcagaaaaacggggagagggatgcttaattggccctggcgcttgctatttttttctcatttcttcacaataggaccgtctttggcagcagcaaaatgtatttcagtatggcagtctttcctctcttacattattggtaagattatactaacaaaatgtttccccttgtacaattatgctgtgtttttaaaaaacattgacctgtgtgtttttataaaagaaaaagtatgttgtgccttcttcttaagaataaagttttctaaagggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5422 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IDA GeneID:5422 -> Molecular function: GO:0001882 [nucleoside binding] evidence: IEA GeneID:5422 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA GeneID:5422 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS GeneID:5422 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA GeneID:5422 -> Molecular function: GO:0003887 [DNA-directed DNA polymerase activity] evidence: IDA GeneID:5422 -> Molecular function: GO:0003887 [DNA-directed DNA polymerase activity] evidence: IMP GeneID:5422 -> Molecular function: GO:0003896 [DNA primase activity] evidence: IDA GeneID:5422 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5422 -> Molecular function: GO:0008408 [3'-5' exonuclease activity] evidence: IBA GeneID:5422 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:5422 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA GeneID:5422 -> Molecular function: GO:0051539 [4 iron, 4 sulfur cluster binding] evidence: IEA GeneID:5422 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:5422 -> Biological process: GO:0000083 [regulation of transcription involved in G1/S phase of mitotic cell cycle] evidence: TAS GeneID:5422 -> Biological process: GO:0000084 [S phase of mitotic cell cycle] evidence: IDA GeneID:5422 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:5422 -> Biological process: GO:0000722 [telomere maintenance via recombination] evidence: TAS GeneID:5422 -> Biological process: GO:0000723 [telomere maintenance] evidence: TAS GeneID:5422 -> Biological process: GO:0000731 [DNA synthesis involved in DNA repair] evidence: IMP GeneID:5422 -> Biological process: GO:0006260 [DNA replication] evidence: IMP GeneID:5422 -> Biological process: GO:0006269 [DNA replication, synthesis of RNA primer] evidence: IDA GeneID:5422 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IDA GeneID:5422 -> Biological process: GO:0006270 [DNA replication initiation] evidence: TAS GeneID:5422 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: IMP GeneID:5422 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS GeneID:5422 -> Biological process: GO:0006272 [leading strand elongation] evidence: IDA GeneID:5422 -> Biological process: GO:0006273 [lagging strand elongation] evidence: IDA GeneID:5422 -> Biological process: GO:0006281 [DNA repair] evidence: IDA GeneID:5422 -> Biological process: GO:0006297 [nucleotide-excision repair, DNA gap filling] evidence: IBA GeneID:5422 -> Biological process: GO:0006303 [double-strand break repair via nonhomologous end joining] evidence: IMP GeneID:5422 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:5422 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:5422 -> Biological process: GO:0019985 [translesion synthesis] evidence: IBA GeneID:5422 -> Biological process: GO:0032201 [telomere maintenance via semi-conservative replication] evidence: TAS GeneID:5422 -> Cellular component: GO:0000785 [chromatin] evidence: IDA GeneID:5422 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:5422 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA GeneID:5422 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA GeneID:5422 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5422 -> Cellular component: GO:0005658 [alpha DNA polymerase:primase complex] evidence: IDA GeneID:5422 -> Cellular component: GO:0005658 [alpha DNA polymerase:primase complex] evidence: TAS GeneID:5422 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:5422 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5422 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IDA GeneID:5422 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_058633 -> EC 2.7.7.7
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