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2024-04-19 19:24:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016848 9768 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SHC (Src homology 2 domain containing) transforming
protein 3 (SHC3), mRNA.
ACCESSION NM_016848
VERSION NM_016848.5 GI:302393565
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9768)
AUTHORS Ortensi,B., Osti,D., Pellegatta,S., Pisati,F., Brescia,P.,
Fornasari,L., Levi,D., Gaetani,P., Colombo,P., Ferri,A.,
Nicolis,S., Finocchiaro,G. and Pelicci,G.
TITLE Rai is a new regulator of neural progenitor migration and
glioblastoma invasion
JOURNAL Stem Cells 30 (5), 817-832 (2012)
PUBMED 22311806
REMARK GeneRIF: Rai (ShcC/N-Shc), a member of the family of Shc-like
adaptor proteins, as a new regulator of migration of normal and
cancer stem/progenitor cells.
REFERENCE 2 (bases 1 to 9768)
AUTHORS Chasman,D.I., Giulianini,F., MacFadyen,J., Barratt,B.J., Nyberg,F.
and Ridker,P.M.
TITLE Genetic determinants of statin-induced low-density lipoprotein
cholesterol reduction: the Justification for the Use of Statins in
Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
trial
JOURNAL Circ Cardiovasc Genet 5 (2), 257-264 (2012)
PUBMED 22331829
REMARK Erratum:[Circ Cardiovasc Genet. 2012 Jun;5(3):e27]
REFERENCE 3 (bases 1 to 9768)
AUTHORS Vangsted,A.J., Klausen,T.W., Gimsing,P., Abildgaard,N.,
Andersen,N.F., Gregersen,H., Nexo,B.A. and Vogel,U.B.
TITLE The importance of a sub-region on chromosome 19q13.3 for prognosis
of multiple myeloma patients after high-dose treatment and stem
cell support: a linkage disequilibrium mapping in RAI and CD3EAP
JOURNAL Ann. Hematol. 90 (6), 675-684 (2011)
PUBMED 21046104
REMARK GeneRIF: Polymorphism in RAI and CD3EAP are associated with outcome
of myeloma patients treated with high dose treatment.
REFERENCE 4 (bases 1 to 9768)
AUTHORS Magrassi,L., Marziliano,N., Inzani,F., Cassini,P., Chiaranda,I.,
Skrap,M., Pizzolito,S., Arienta,C. and Arbustini,E.
TITLE EDG3 and SHC3 on chromosome 9q22 are co-amplified in human
ependymomas
JOURNAL Cancer Lett. 290 (1), 36-42 (2010)
PUBMED 19748727
REMARK GeneRIF: amplification of SHC3 and EDG3 genes suggests that the two
proteins co-operate and are important for ependymomas in vivo.
REFERENCE 5 (bases 1 to 9768)
AUTHORS Miyake,I., Ohira,M., Nakagawara,A. and Sakai,R.
TITLE Distinct role of ShcC docking protein in the differentiation of
neuroblastoma
JOURNAL Oncogene 28 (5), 662-673 (2009)
PUBMED 18997821
REMARK GeneRIF: ShcC is a therapeutic target that might induce
differentiation in the aggressive type of neuroblastomas.
REFERENCE 6 (bases 1 to 9768)
AUTHORS Wang,J.F., Ganju,R.K., Liu,Z.Y., Avraham,H., Avraham,S. and
Groopman,J.E.
TITLE Signal transduction in human hematopoietic cells by vascular
endothelial growth factor related protein, a novel ligand for the
FLT4 receptor
JOURNAL Blood 90 (9), 3507-3515 (1997)
PUBMED 9345034
REFERENCE 7 (bases 1 to 9768)
AUTHORS Nakamura,T., Sanokawa,R., Sasaki,Y., Ayusawa,D., Oishi,M. and
Mori,N.
TITLE N-Shc: a neural-specific adapter molecule that mediates signaling
from neurotrophin/Trk to Ras/MAPK pathway
JOURNAL Oncogene 13 (6), 1111-1121 (1996)
PUBMED 8808684
REFERENCE 8 (bases 1 to 9768)
AUTHORS Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
Cesareni,G. and Pelicci,P.G.
TITLE A family of Shc related proteins with conserved PTB, CH1 and SH2
regions
JOURNAL Oncogene 13 (3), 633-641 (1996)
PUBMED 8760305
REFERENCE 9 (bases 1 to 9768)
AUTHORS O'Bryan,J.P., Songyang,Z., Cantley,L., Der,C.J. and Pawson,T.
TITLE A mammalian adaptor protein with conserved Src homology 2 and
phosphotyrosine-binding domains is related to Shc and is
specifically expressed in the brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (7), 2729-2734 (1996)
PUBMED 8610109
REFERENCE 10 (bases 1 to 9768)
AUTHORS Waters,S.B., Yamauchi,K. and Pessin,J.E.
TITLE Insulin-stimulated disassociation of the SOS-Grb2 complex
JOURNAL Mol. Cell. Biol. 15 (5), 2791-2799 (1995)
PUBMED 7739560
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC026314.1, D84361.1, AL353150.25 and AL772202.14.
On Aug 10, 2010 this sequence version replaced gi:224586792.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC026314.1, D84361.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-479 BC026314.1 2-480
480-1644 D84361.1 353-1517
1645-1967 BC026314.1 1646-1968
1968-6605 AL353150.25 2001-6638 c
6606-9768 AL772202.14 52794-55956 c
FEATURES Location/Qualifiers
source 1..9768
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q22.1"
gene 1..9768
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="SHC (Src homology 2 domain containing) transforming
protein 3"
/db_xref="GeneID:53358"
/db_xref="HGNC:18181"
/db_xref="MIM:605263"
exon 1..781
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
misc_feature 134..136
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="upstream in-frame stop codon"
CDS 308..2092
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="neuronal Shc; src homology 2 domain-containing
transforming protein C3; protein Rai; SH2 domain protein
C3; SHC-transforming protein C; src homology 2
domain-containing-transforming protein C3"
/codon_start=1
/product="SHC-transforming protein 3"
/protein_id="NP_058544.3"
/db_xref="GI:224586793"
/db_xref="CCDS:CCDS6681.1"
/db_xref="GeneID:53358"
/db_xref="HGNC:18181"
/db_xref="MIM:605263"
/translation="
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
"
misc_feature 734..1231
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="SHC phosphotyrosine-binding (PTB) domain; Region:
SHC; cd01209"
/db_xref="CDD:176285"
misc_feature order(761..790,971..1024,1037..1045,1055..1081,1100..1126,
1139..1165,1181..1222)
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="PTB core; other site"
/db_xref="CDD:176285"
misc_feature order(815..817,821..823,1067..1072,1076..1078,1121..1123,
1139..1141,1187..1189,1196..1198,1202..1204,1208..1210,
1229..1231)
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="peptide binding site [polypeptide binding]; other
site"
/db_xref="CDD:176285"
misc_feature order(815..817,1067..1069,1121..1123,1139..1141)
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="phosphotyrosine binding site [chemical binding];
other site"
/db_xref="CDD:176285"
misc_feature 1310..1801
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q92529.1);
Region: CH1"
misc_feature 1781..2089
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="Src homology 2 (SH2) domain found in SH2 adaptor
protein C (SHC); Region: SH2_SHC; cd09925"
/db_xref="CDD:198179"
misc_feature order(1823..1825,1871..1873,1877..1879,1892..1894,
1907..1909,1934..1942)
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198179"
misc_feature order(1904..1906,1937..1939,1943..1945,1949..1951,
1964..1972,1985..1987,2003..2005,2036..2044)
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198179"
exon 782..852
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 853..916
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 917..1036
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1037..1090
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1091..1142
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1143..1269
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1270..1420
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1421..1508
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1509..1667
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
exon 1668..1963
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
variation 1846
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/replace="a"
/replace="g"
/db_xref="dbSNP:2282124"
exon 1964..9768
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/inference="alignment:Splign:1.39.8"
STS 2247..2370
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/standard_name="SHGC-36196"
/db_xref="UniSTS:25981"
variation 2372
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/replace="a"
/replace="g"
/db_xref="dbSNP:12519"
STS 2452..2587
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/standard_name="D9S981E"
/db_xref="UniSTS:473328"
variation 3012
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/replace="c"
/replace="g"
/db_xref="dbSNP:2316282"
variation 6643
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/replace="c"
/replace="t"
/db_xref="dbSNP:1125467"
STS 9484..9679
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/standard_name="RH11756"
/db_xref="UniSTS:32236"
STS 9533..9757
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/standard_name="D9S1143"
/db_xref="UniSTS:7907"
STS 9622..9744
/gene="SHC3"
/gene_synonym="N-Shc; NSHC; RAI; SHCC"
/standard_name="D9S1758"
/db_xref="UniSTS:33397"
ORIGIN
tgcttttgctgtgagcagccccaagcagctgggcgctccatcagaggcaactatgacttttgcaaagcaaacgtgcaaccccaagcagcggtctcccgggccggggctgcgcggccgccgctgtgctggcttttaacggtgggagggcaccatcctcttgctctgctctcgttctccagaaggctgtcccggggcccccactctccgtcccgctccggggacagtggctcgcctgctatgcgcggcagcccgcgccggggccggcaccagcagcgcccgggcggatgcagcgagcccacggaggggcatgcttccacgcaccaagtataaccgcttcaggaatgactcggtgacatcggtcgatgaccttctccacagcctgtcggtgagcggcggcggaggcaaggtttcggcggcgcgcgcgaccccggcggcggctccctacttggtgtccggcgaggcgctgcgcaaggcgcccgacgatgggcccggcagcctgggccacctgctccacaaggtgtcccacctgaaactctccagctcgggcctccgcggcctgtcgtcggccgcccgggagcgggcgggcgcgcggctctcgggcagctgcagcgcgcccagcctggccgccccggacggcagtgcgccctcggcgccccgcgccccggccatgagcgccgccaggaagggccggcccggcgacgagccgctgcccaggccccctcggggggcgccgcacgccagcgaccaggtgctggggcccggagtcacctacgtggtcaagtacttggggtgcattgaagttctgcgctcaatgaggtctcttgacttcagtacaagaacacaaattaccagggaagccatcagccgcgtctgtgaagctgtgcctggtgcgaagggagccttcaagaagagaaagcctccaagcaaaatgctgtccagcatcttgggaaagagcaacctccagtttgcgggaatgagcatctctctgaccatctccacggccagtctgaacctgcgaactccggactccaaacagatcatagcgaatcaccacatgcggtccatctccttcgcctctgggggagacccggacacaactgactatgttgcatatgtggctaaggaccctgttaatcgcagagcttgtcacattttggaatgctgtgatgggctggcccaggatgtcatcggctccatcggacaagcctttgagctccggtttaagcaatatttacagtgtcctaccaagattcccgctctccatgatcgaatgcagagtctggatgagccatggacggaagaggagggagatggctcagaccacccatactacaacagcatcccaagcaagatgcctcctccagggggctttcttgatactagactgaaacccagaccccatgctcctgacacagcccagtttgcaggaaaagagcagacttattaccagggaagacacttaggagacacttttggcgaagactggcagcaaacacctttaaggcaagggtcctcggacatctacagcacgccagaagggaaactgcacgtggcccccacgggagaagcacccacctacgtcaacactcagcagatcccaccacaggcctggccggctgcggtcagcagtgctgagagcagcccaaggaaagacctctttgacatgaaaccttttgaagatgctctcaagaaccagcccttggggcccgtgttaagcaaggcagcctccgtggagtgcatcagccctgtgtcacctagagccccagatgccaagatgctggaggaactgcaagccgagacttggtaccaaggagagatgagcaggaaggaggcagaggggctgctggagaaagacggagacttcctggtcaggaagagcaccaccaacccgggctcctttgtcctcacgggcatgcacaatggccaggccaagcacctgctgctcgtggacccagaaggcacgatccggacaaaggacagagtctttgacagtatcagccacctcatcaaccaccacctagaaagcagcctgcccattgtctctgcagggagtgagctgtgtctccagcagccagtggagaggaagcagtgacctggccagcactgctcccagcactgcgcaccaggtcaggaggacctggagtggactagaatcggggctgctggaactgggacagctgcctgtggctcagagccttcttcaaaagcttcaaaaggaaggcttcctttaaggtcaagtttcataaacttggttctgaatttctcatatgcatattaaaggtgtacatacctatacatcctgtacaaattatccctctatatttatattttttaagactaagaaagatgtaagactaatgttctgtgctgtatgtttttaatgaaaaaaaaaaataagtttaactgtagttgtccaggcaaaaatttaattcaactgacccatcccaccgggaaatgccactaggaaggtgtagcctgcagttttacctaataagcacaactggaggggaatagaaacacagaattgtgagggaatcgcaaggcatgctgctcagagcatgcctagccctgcactgaaagctatgagatactggttctgaggcatggctgtgcttgctggtgggagcgggcatcctcccttggcctccctgggacacctcctgtgctccctgcactgcactccacgtgcctggggtgtctacacaactcgctgcagcttcactaaagaacaggtggcactccagcttctccgggtcctgctgagcacagggccccgccacccttgaccccagttgtgcgaggagtacttgggaattcatttcatgccaaaatggcacaaaataagcttcaccaaccaagattttgattgacaagtgcttccctgttctcatgtatctaatgctaaaatgggtatttgtagaagggtggtcggggcaaattcctggtttgtgtctccctctagtcagcggttgactacaggctgcttatggtaattgctagtaaagtcccccgcccgccttatacaataggggagaagcctgtgtgacagcaagagcaggcacccatcccagagctcagtcccgaagactcaggtattgaggcttctggggctgcatgtgccagaaacccaggagtcactggaatccatttgaggtactgcctctggcatgagggatgggggaaaggcctgctgtcccaacaacaaggtttctccgttgctgcagggaagagcatgtgcctgcccccactctttgtcttgactccctttcttccaggtaaaatactgtcatttcctgaggagtcatttggtgttagaaagctggcaatgtttatacctttcaaatactatctgggctgagattgccctgtgattttcacagatgccctttaaagaatagatggatccatttgcttgctggcagcgtggctcttgttctggtgagaccccacagggtacagcaccctgtagggtatgggtcagcagaacagaaagacacactaaacacgcttagagttggatagtgataaatctgatcctgtaaggagagttatgaggagactgaaaaatctggcagataataatactgctaagttctaatgccaatggtatgagccccatttctgccttggggtgtgcgtgtggccagatggaaggacaggttagagctaaccagtgaggatgagtcagggcaggccccagccttcatacatggccttctagggagtctttgcctttgagggtccagtgaatttgagatgacagtgaagtcagtgttctagaatgttctgcagtggattgaaactctggagagtctgacactactgtagactgcactgctgttttctgaaatggttttggcttcaggcatcatgtggatactctgcttagtgatccagaagcagacggctccacggggttgctggcagcagctgcatcaggctcctgccccaagacagcatagacttgggtgctctgagagctgccctgcacatctgtcctctgggaggctgggagccctggagagacacacacagctctgacccacctgtgcatgaatgtgcaccacatagaaaaatgtgcgaaatgaccttctttctacattcatgcattccccacttgtgaaaggtcaaaatgctattataacattcagggacaatagcaaagtaggaaatgcaagttaggagctgtgaatgctgtaacatttgatttactttatttttctcttggggggacttgaatggtaacctgcagctttagtagctcttgctgtgaagtcagtgtctagttcgatggtgatagaaaatatatatattttttgcatgagaatcaatttagaaaatttaaagtattggagtcgaattttttctttttaatattaattcaaaatatacatttttaagctcagattatatattggttacactagaatagtgccagtgaagtgagcaggcttcagacatagcagatggcagcgattttctaatctttgttccctcccatttgtaaagtgggttagagcacacattagttatcccaactcttccctccagcactgtgtggtgggccattcctgtgagcctcacagacacatggggaaagtgaggctggggctggtgccacaccttcctggaggccatgttgtcatctggctgcagagctcttctgctcactcagcatttcgtgagccctgctgtgtgccagcctgtgctttgagctcaggattccaaggcaaaagcaatggaggctcctccctgtctagcctgggcccctcttccccacactttctcaggccacatctctgcctgggcagggcagggaagctgaacaatgaacgcagcgggaatggcattaggccttgcgttccagggcctcaggcttccagggcacagtcgctgctgctgtgctgggccaccctggtcctgcagagtgcacctgggccctgctgtccctccaatgggcacccccaacacttaaccccaaactctatgtcttctgggagtacaaggtgggggccagcagtcctaaaacggcccctctgcccttaccgagtggccctagagacccccacccacctcccctaaccccacgaatgaatcagctgtgcttcaaatgacatctctgtcccacggaggccggctgggcctctcatgggggtgctcattgtggtttaagtcagctttgattcttgacctccaaggctgcctctgagtagctaaccggagaatcgggtggggaggtgaaaaacaccgcagtcaaatgactcaatctttaatcctgtgcttaagacaccactgttgctgttttttatatttgaagcacccaaagactgggcgtccgctcagccttgatgagcgagcagctattttgtcaggccatctatgatgttgggataatggacaaaggcctgattgggccatatatggccttctttagggcctcctggaggtggaggaagttgtgggtaatttctaataaagacgggaaatgacaagccgtgtgtgtaggtaaagtcctaacttaaaaggaaggacaggcctagggaagggtggaccctaaagggcccatgtgccaggggaacagtggacatgtgtgtccagcccaacctccatgtctggtgctgggattctgaaggtggcccccagctcccaaaataaagctttccttttcagtagcgtccgacacttgggtagcttctttctataagcaatgcttgaagatggacgtctgggtcctcatttcctccaaactggctgctacctgaaggcagtcacacatttcttttctgttgggctgagctgggcagaagcctcggactataggcctttccagggcagaggcaatgcgggccacgagtagatacctccatccagcctccaccctggcacacccagaacggcgtggactcaggcgggttgctggatttctctgagccttggcgtgctctacactgcagggctatacatgttcccagcttgagggcgtgctggggattgacaaatatatgaaacatataagcgcaatgattttctaaaattgtgcattcccagcgtgcccattggttctctctcgctggcccaactttgtgtgctgtccataaatccctttctgtggacggtgacagtaggattgggagtgagtgggaagattgtggaaagattgcaaagaggtcattgcaggactcagacagaccttgcagtgggtttcagagtaatactcaggttctcccatggaactttcaaagctggctctaagaaagatgaagaggacaaacccactcctggacatagtgccaacctagaactgtcagctccacacaggatcacagggaagggagcttggtaagacagcccagtagggggccctgcttttcagaagaggaaactggagccatgcaagggcctggggatcaacttagaaaagagcacaggactcacagtcctgggcctgcacgtaaagctagccccctgccccacggaaatggcaagcagtgcttccctccaggggttctacatctgtgctccatctcaaaatgcataaaagcctgagtcattcagatgggagagacagtgtttctacttcctcttagttggggttcctccagaaggagaccctgagagaggacttgaggttatgtagtttatttgagtgaagatcccggaagtagggagagaaggaagctgacggggaaggcgtgcattatcaagtaagttaccgtcatgtgcacaactggagctgaatcccaccggggaaccccgagagacagagctgacaccccagagttcacccagcaaggcggggagacagctggggtatttattcaccaagtctatcacttatgaaaggctgtttctggaaacaatttctgactggccctgcacacacctgagcatacttcctaagccggggatgtccctgagctgagacaggcgttcgtgacaagcagacttcgagtggaaggcaggcatcagaaccaccctgtgagctggttcagacaaagattgcaggcccttccacccccctggccccgccaagttcctgactccctaggtctggagtggggcccgggaatttgcatttcaaaaaatctcgaggtgatgctggtgcagctgctctgaagtcttgactttgagaaccactcactagtgagagtttccagcccttacctgtctcttattgatggctttcccccctctaatttataattatgctttcacaccacttcatgtcacagatcccagggtccgtgctgtgaatttaaaagtggagaattaataagcatttataactccatgcaaccattgctggcagcttaaatgccatctgccagccataatttatttataatggggtttatacatatttataagtttgcaagcaacaaatgcacagttttaaaactggcacattttatagcagccagaaaaattgcaactttataccaggacttgtgaatgtgaattgcatatgtatatacatatacgcatatacttacattgattaaaaacggatctgcatctctgtacacacgcagattggctctgtgttgtgcaccttgggactcctccctgggctttggttttacagctaagtaggaagtcaaacaaacgtgaagaatttgggaattggcaggctgtggcatcagccatggaggatggtcctggatgctgtaggatgtgagatccagcacaaagagaacaagaacaggacatgaggaccacagggattgggggaacccactgtgggaaatgacagagaagccagtgggggaagacaaagaaagaagaaggtggaggcagaataaaggtgagaagaagggaaggggaggataaaacaagtccagatttagatcttccttcatgcagccatgcatagctgtctgaggccagcagggaaggaggagaaagggaaggtgtggtggaggaggctgtgctcgtgatgtcatgctttcgtgtattcccaggtgcagctgcatatacttggcacagtttcttgggatttctagccagtttcttggcctcatttgtgcattagttaatatgtggctggccctgtactgggatggtgggatagagaagtgaatgtatgaggcctctgcctgagtttataacctagaaagaaataaagacacacacacacaaaggtgttggagtgtgacaagccttaaggtacccgtgtgtccaagtaaagtagaaccagcaagggtggagtgcccaggtcagtctggggactctggaggcttcgcactgcaggcgtcagatactgagtgttagtggcacggagaagagtgtggaaggctcaggatgggggtggacagcctggagttgtcactctcagtagagatgctagaaggggcgggaggtgatcccagcctcccttctttcctcctcctggctgtcacagatgctctgaattgatgaatccttcaggccaaaaacacacaggctccttccctaggtctggaaaaatggttctcgctgaaaaagcaccaggaataaaatctcatacaattttaggtgtctattttgttgtctcaccttgaaatactgcagacagaaaaacatgcacatggggagctgtggtcctgagctttgaggtaatgaattcccactcatgtgatcatttttaccataaccaaagtttctaaccatcaaaatcaagtgacaattaaaacaggcattaatggataaatccgtctttaaatattaatggggttaattttgttaacagctatgtgttggttgcaagtggaatgttctctgttcatttgacttttgaatataacttgttccagaatattgtaaaattaagtatgtgaatgtttctttgtattcagaattaaacatttggtgttaaaatcccaggattaggagacaactccatgtaaatttaatgtgtaataataagataataactttttaaaaagcatttggatggcaaattatacatactgacaaatgaatattatctgaaagttgttttgtttccattaacttttgtgaaacaaaaagaattactgtaacagtctatgtcttggcgtattgccaattcaccactttctactttgtgctggaacagaactggcttttttgacatccctgaggagtggaaatgcaaaacgaatttcaagttctctaatctttgttctatgacaaatgaaaaaacctaagttatctggtgttttggagatttgagaatacagcaggtgaagagaattagcttaaattccctcctcccttttgataaatccacagggattccttcactctgtcaggaaatggtgtggtttccaagcattagcccttcatgatctgtctggtgcatttctgtgctcctgggatcgccaagtgcaggcacggcatcgcatccccaggtgtcatcctgtgacccaggaggggaagatgacacacccaatttaggtaatgctgcacttcttgttataattggttattggaaaatgtgcctttattatcagaacagtggtgtgcgcatttctgattatggagctaacttttggatatctgacttagatactaaaaacatttgggtgttgcagttttgcacttgtagatacaacttaaaagcatgaaactggtgatttaattagatgttttctataaaatgcaccttgttacatttctgtgaaagggtcttaccagcgtggaataactggctcaagggttgagagaaacaaccattttctaaacagttaattgtttaaaggactatacatgtaagtctgcaggcaataaaggctgttgtgaaaagta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:53358 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:53358 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:53358 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: TAS
GeneID:53358 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:53358 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
GeneID:53358 -> Biological process: GO:0007417 [central nervous system development] evidence: TAS
GeneID:53358 -> Biological process: GO:0007611 [learning or memory] evidence: IEA
GeneID:53358 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
GeneID:53358 -> Biological process: GO:0035249 [synaptic transmission, glutamatergic] evidence: IEA
GeneID:53358 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: NAS
GeneID:53358 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:53358 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:53358 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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