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2019-03-25 14:57:06, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_016848               9768 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens SHC (Src homology 2 domain containing) transforming
            protein 3 (SHC3), mRNA.
ACCESSION   NM_016848
VERSION     NM_016848.5  GI:302393565
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9768)
  AUTHORS   Ortensi,B., Osti,D., Pellegatta,S., Pisati,F., Brescia,P.,
            Fornasari,L., Levi,D., Gaetani,P., Colombo,P., Ferri,A.,
            Nicolis,S., Finocchiaro,G. and Pelicci,G.
  TITLE     Rai is a new regulator of neural progenitor migration and
            glioblastoma invasion
  JOURNAL   Stem Cells 30 (5), 817-832 (2012)
   PUBMED   22311806
  REMARK    GeneRIF: Rai (ShcC/N-Shc), a member of the family of Shc-like
            adaptor proteins, as a new regulator of migration of normal and
            cancer stem/progenitor cells.
REFERENCE   2  (bases 1 to 9768)
  AUTHORS   Chasman,D.I., Giulianini,F., MacFadyen,J., Barratt,B.J., Nyberg,F.
            and Ridker,P.M.
  TITLE     Genetic determinants of statin-induced low-density lipoprotein
            cholesterol reduction: the Justification for the Use of Statins in
            Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)
            trial
  JOURNAL   Circ Cardiovasc Genet 5 (2), 257-264 (2012)
   PUBMED   22331829
  REMARK    Erratum:[Circ Cardiovasc Genet. 2012 Jun;5(3):e27]
REFERENCE   3  (bases 1 to 9768)
  AUTHORS   Vangsted,A.J., Klausen,T.W., Gimsing,P., Abildgaard,N.,
            Andersen,N.F., Gregersen,H., Nexo,B.A. and Vogel,U.B.
  TITLE     The importance of a sub-region on chromosome 19q13.3 for prognosis
            of multiple myeloma patients after high-dose treatment and stem
            cell support: a linkage disequilibrium mapping in RAI and CD3EAP
  JOURNAL   Ann. Hematol. 90 (6), 675-684 (2011)
   PUBMED   21046104
  REMARK    GeneRIF: Polymorphism in RAI and CD3EAP are associated with outcome
            of myeloma patients treated with high dose treatment.
REFERENCE   4  (bases 1 to 9768)
  AUTHORS   Magrassi,L., Marziliano,N., Inzani,F., Cassini,P., Chiaranda,I.,
            Skrap,M., Pizzolito,S., Arienta,C. and Arbustini,E.
  TITLE     EDG3 and SHC3 on chromosome 9q22 are co-amplified in human
            ependymomas
  JOURNAL   Cancer Lett. 290 (1), 36-42 (2010)
   PUBMED   19748727
  REMARK    GeneRIF: amplification of SHC3 and EDG3 genes suggests that the two
            proteins co-operate and are important for ependymomas in vivo.
REFERENCE   5  (bases 1 to 9768)
  AUTHORS   Miyake,I., Ohira,M., Nakagawara,A. and Sakai,R.
  TITLE     Distinct role of ShcC docking protein in the differentiation of
            neuroblastoma
  JOURNAL   Oncogene 28 (5), 662-673 (2009)
   PUBMED   18997821
  REMARK    GeneRIF: ShcC is a therapeutic target that might induce
            differentiation in the aggressive type of neuroblastomas.
REFERENCE   6  (bases 1 to 9768)
  AUTHORS   Wang,J.F., Ganju,R.K., Liu,Z.Y., Avraham,H., Avraham,S. and
            Groopman,J.E.
  TITLE     Signal transduction in human hematopoietic cells by vascular
            endothelial growth factor related protein, a novel ligand for the
            FLT4 receptor
  JOURNAL   Blood 90 (9), 3507-3515 (1997)
   PUBMED   9345034
REFERENCE   7  (bases 1 to 9768)
  AUTHORS   Nakamura,T., Sanokawa,R., Sasaki,Y., Ayusawa,D., Oishi,M. and
            Mori,N.
  TITLE     N-Shc: a neural-specific adapter molecule that mediates signaling
            from neurotrophin/Trk to Ras/MAPK pathway
  JOURNAL   Oncogene 13 (6), 1111-1121 (1996)
   PUBMED   8808684
REFERENCE   8  (bases 1 to 9768)
  AUTHORS   Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
            Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
            Cesareni,G. and Pelicci,P.G.
  TITLE     A family of Shc related proteins with conserved PTB, CH1 and SH2
            regions
  JOURNAL   Oncogene 13 (3), 633-641 (1996)
   PUBMED   8760305
REFERENCE   9  (bases 1 to 9768)
  AUTHORS   O'Bryan,J.P., Songyang,Z., Cantley,L., Der,C.J. and Pawson,T.
  TITLE     A mammalian adaptor protein with conserved Src homology 2 and
            phosphotyrosine-binding domains is related to Shc and is
            specifically expressed in the brain
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (7), 2729-2734 (1996)
   PUBMED   8610109
REFERENCE   10 (bases 1 to 9768)
  AUTHORS   Waters,S.B., Yamauchi,K. and Pessin,J.E.
  TITLE     Insulin-stimulated disassociation of the SOS-Grb2 complex
  JOURNAL   Mol. Cell. Biol. 15 (5), 2791-2799 (1995)
   PUBMED   7739560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026314.1, D84361.1, AL353150.25 and AL772202.14.
            On Aug 10, 2010 this sequence version replaced gi:224586792.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026314.1, D84361.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               BC026314.1         2-480
            480-1644            D84361.1           353-1517
            1645-1967           BC026314.1         1646-1968
            1968-6605           AL353150.25        2001-6638           c
            6606-9768           AL772202.14        52794-55956         c
FEATURES             Location/Qualifiers
     source          1..9768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..9768
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="SHC (Src homology 2 domain containing) transforming
                     protein 3"
                     /db_xref="GeneID:53358"
                     /db_xref="HGNC:18181"
                     /db_xref="MIM:605263"
     exon            1..781
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    134..136
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="upstream in-frame stop codon"
     CDS             308..2092
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="neuronal Shc; src homology 2 domain-containing
                     transforming protein C3; protein Rai; SH2 domain protein
                     C3; SHC-transforming protein C; src homology 2
                     domain-containing-transforming protein C3"
                     /codon_start=1
                     /product="SHC-transforming protein 3"
                     /protein_id="NP_058544.3"
                     /db_xref="GI:224586793"
                     /db_xref="CCDS:CCDS6681.1"
                     /db_xref="GeneID:53358"
                     /db_xref="HGNC:18181"
                     /db_xref="MIM:605263"
                     /translation="
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
"
     misc_feature    734..1231
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="SHC phosphotyrosine-binding (PTB) domain; Region:
                     SHC; cd01209"
                     /db_xref="CDD:176285"
     misc_feature    order(761..790,971..1024,1037..1045,1055..1081,1100..1126,
                     1139..1165,1181..1222)
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="PTB core; other site"
                     /db_xref="CDD:176285"
     misc_feature    order(815..817,821..823,1067..1072,1076..1078,1121..1123,
                     1139..1141,1187..1189,1196..1198,1202..1204,1208..1210,
                     1229..1231)
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176285"
     misc_feature    order(815..817,1067..1069,1121..1123,1139..1141)
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="phosphotyrosine binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176285"
     misc_feature    1310..1801
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92529.1);
                     Region: CH1"
     misc_feature    1781..2089
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="Src homology 2 (SH2) domain found in SH2 adaptor
                     protein C (SHC); Region: SH2_SHC; cd09925"
                     /db_xref="CDD:198179"
     misc_feature    order(1823..1825,1871..1873,1877..1879,1892..1894,
                     1907..1909,1934..1942)
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198179"
     misc_feature    order(1904..1906,1937..1939,1943..1945,1949..1951,
                     1964..1972,1985..1987,2003..2005,2036..2044)
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198179"
     exon            782..852
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            853..916
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            917..1036
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1037..1090
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1091..1142
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1143..1269
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1270..1420
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1421..1508
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1509..1667
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     exon            1668..1963
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     variation       1846
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2282124"
     exon            1964..9768
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:1.39.8"
     STS             2247..2370
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /standard_name="SHGC-36196"
                     /db_xref="UniSTS:25981"
     variation       2372
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12519"
     STS             2452..2587
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /standard_name="D9S981E"
                     /db_xref="UniSTS:473328"
     variation       3012
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2316282"
     variation       6643
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1125467"
     STS             9484..9679
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /standard_name="RH11756"
                     /db_xref="UniSTS:32236"
     STS             9533..9757
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /standard_name="D9S1143"
                     /db_xref="UniSTS:7907"
     STS             9622..9744
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /standard_name="D9S1758"
                     /db_xref="UniSTS:33397"
ORIGIN      
tgcttttgctgtgagcagccccaagcagctgggcgctccatcagaggcaactatgacttttgcaaagcaaacgtgcaaccccaagcagcggtctcccgggccggggctgcgcggccgccgctgtgctggcttttaacggtgggagggcaccatcctcttgctctgctctcgttctccagaaggctgtcccggggcccccactctccgtcccgctccggggacagtggctcgcctgctatgcgcggcagcccgcgccggggccggcaccagcagcgcccgggcggatgcagcgagcccacggaggggcatgcttccacgcaccaagtataaccgcttcaggaatgactcggtgacatcggtcgatgaccttctccacagcctgtcggtgagcggcggcggaggcaaggtttcggcggcgcgcgcgaccccggcggcggctccctacttggtgtccggcgaggcgctgcgcaaggcgcccgacgatgggcccggcagcctgggccacctgctccacaaggtgtcccacctgaaactctccagctcgggcctccgcggcctgtcgtcggccgcccgggagcgggcgggcgcgcggctctcgggcagctgcagcgcgcccagcctggccgccccggacggcagtgcgccctcggcgccccgcgccccggccatgagcgccgccaggaagggccggcccggcgacgagccgctgcccaggccccctcggggggcgccgcacgccagcgaccaggtgctggggcccggagtcacctacgtggtcaagtacttggggtgcattgaagttctgcgctcaatgaggtctcttgacttcagtacaagaacacaaattaccagggaagccatcagccgcgtctgtgaagctgtgcctggtgcgaagggagccttcaagaagagaaagcctccaagcaaaatgctgtccagcatcttgggaaagagcaacctccagtttgcgggaatgagcatctctctgaccatctccacggccagtctgaacctgcgaactccggactccaaacagatcatagcgaatcaccacatgcggtccatctccttcgcctctgggggagacccggacacaactgactatgttgcatatgtggctaaggaccctgttaatcgcagagcttgtcacattttggaatgctgtgatgggctggcccaggatgtcatcggctccatcggacaagcctttgagctccggtttaagcaatatttacagtgtcctaccaagattcccgctctccatgatcgaatgcagagtctggatgagccatggacggaagaggagggagatggctcagaccacccatactacaacagcatcccaagcaagatgcctcctccagggggctttcttgatactagactgaaacccagaccccatgctcctgacacagcccagtttgcaggaaaagagcagacttattaccagggaagacacttaggagacacttttggcgaagactggcagcaaacacctttaaggcaagggtcctcggacatctacagcacgccagaagggaaactgcacgtggcccccacgggagaagcacccacctacgtcaacactcagcagatcccaccacaggcctggccggctgcggtcagcagtgctgagagcagcccaaggaaagacctctttgacatgaaaccttttgaagatgctctcaagaaccagcccttggggcccgtgttaagcaaggcagcctccgtggagtgcatcagccctgtgtcacctagagccccagatgccaagatgctggaggaactgcaagccgagacttggtaccaaggagagatgagcaggaaggaggcagaggggctgctggagaaagacggagacttcctggtcaggaagagcaccaccaacccgggctcctttgtcctcacgggcatgcacaatggccaggccaagcacctgctgctcgtggacccagaaggcacgatccggacaaaggacagagtctttgacagtatcagccacctcatcaaccaccacctagaaagcagcctgcccattgtctctgcagggagtgagctgtgtctccagcagccagtggagaggaagcagtgacctggccagcactgctcccagcactgcgcaccaggtcaggaggacctggagtggactagaatcggggctgctggaactgggacagctgcctgtggctcagagccttcttcaaaagcttcaaaaggaaggcttcctttaaggtcaagtttcataaacttggttctgaatttctcatatgcatattaaaggtgtacatacctatacatcctgtacaaattatccctctatatttatattttttaagactaagaaagatgtaagactaatgttctgtgctgtatgtttttaatgaaaaaaaaaaataagtttaactgtagttgtccaggcaaaaatttaattcaactgacccatcccaccgggaaatgccactaggaaggtgtagcctgcagttttacctaataagcacaactggaggggaatagaaacacagaattgtgagggaatcgcaaggcatgctgctcagagcatgcctagccctgcactgaaagctatgagatactggttctgaggcatggctgtgcttgctggtgggagcgggcatcctcccttggcctccctgggacacctcctgtgctccctgcactgcactccacgtgcctggggtgtctacacaactcgctgcagcttcactaaagaacaggtggcactccagcttctccgggtcctgctgagcacagggccccgccacccttgaccccagttgtgcgaggagtacttgggaattcatttcatgccaaaatggcacaaaataagcttcaccaaccaagattttgattgacaagtgcttccctgttctcatgtatctaatgctaaaatgggtatttgtagaagggtggtcggggcaaattcctggtttgtgtctccctctagtcagcggttgactacaggctgcttatggtaattgctagtaaagtcccccgcccgccttatacaataggggagaagcctgtgtgacagcaagagcaggcacccatcccagagctcagtcccgaagactcaggtattgaggcttctggggctgcatgtgccagaaacccaggagtcactggaatccatttgaggtactgcctctggcatgagggatgggggaaaggcctgctgtcccaacaacaaggtttctccgttgctgcagggaagagcatgtgcctgcccccactctttgtcttgactccctttcttccaggtaaaatactgtcatttcctgaggagtcatttggtgttagaaagctggcaatgtttatacctttcaaatactatctgggctgagattgccctgtgattttcacagatgccctttaaagaatagatggatccatttgcttgctggcagcgtggctcttgttctggtgagaccccacagggtacagcaccctgtagggtatgggtcagcagaacagaaagacacactaaacacgcttagagttggatagtgataaatctgatcctgtaaggagagttatgaggagactgaaaaatctggcagataataatactgctaagttctaatgccaatggtatgagccccatttctgccttggggtgtgcgtgtggccagatggaaggacaggttagagctaaccagtgaggatgagtcagggcaggccccagccttcatacatggccttctagggagtctttgcctttgagggtccagtgaatttgagatgacagtgaagtcagtgttctagaatgttctgcagtggattgaaactctggagagtctgacactactgtagactgcactgctgttttctgaaatggttttggcttcaggcatcatgtggatactctgcttagtgatccagaagcagacggctccacggggttgctggcagcagctgcatcaggctcctgccccaagacagcatagacttgggtgctctgagagctgccctgcacatctgtcctctgggaggctgggagccctggagagacacacacagctctgacccacctgtgcatgaatgtgcaccacatagaaaaatgtgcgaaatgaccttctttctacattcatgcattccccacttgtgaaaggtcaaaatgctattataacattcagggacaatagcaaagtaggaaatgcaagttaggagctgtgaatgctgtaacatttgatttactttatttttctcttggggggacttgaatggtaacctgcagctttagtagctcttgctgtgaagtcagtgtctagttcgatggtgatagaaaatatatatattttttgcatgagaatcaatttagaaaatttaaagtattggagtcgaattttttctttttaatattaattcaaaatatacatttttaagctcagattatatattggttacactagaatagtgccagtgaagtgagcaggcttcagacatagcagatggcagcgattttctaatctttgttccctcccatttgtaaagtgggttagagcacacattagttatcccaactcttccctccagcactgtgtggtgggccattcctgtgagcctcacagacacatggggaaagtgaggctggggctggtgccacaccttcctggaggccatgttgtcatctggctgcagagctcttctgctcactcagcatttcgtgagccctgctgtgtgccagcctgtgctttgagctcaggattccaaggcaaaagcaatggaggctcctccctgtctagcctgggcccctcttccccacactttctcaggccacatctctgcctgggcagggcagggaagctgaacaatgaacgcagcgggaatggcattaggccttgcgttccagggcctcaggcttccagggcacagtcgctgctgctgtgctgggccaccctggtcctgcagagtgcacctgggccctgctgtccctccaatgggcacccccaacacttaaccccaaactctatgtcttctgggagtacaaggtgggggccagcagtcctaaaacggcccctctgcccttaccgagtggccctagagacccccacccacctcccctaaccccacgaatgaatcagctgtgcttcaaatgacatctctgtcccacggaggccggctgggcctctcatgggggtgctcattgtggtttaagtcagctttgattcttgacctccaaggctgcctctgagtagctaaccggagaatcgggtggggaggtgaaaaacaccgcagtcaaatgactcaatctttaatcctgtgcttaagacaccactgttgctgttttttatatttgaagcacccaaagactgggcgtccgctcagccttgatgagcgagcagctattttgtcaggccatctatgatgttgggataatggacaaaggcctgattgggccatatatggccttctttagggcctcctggaggtggaggaagttgtgggtaatttctaataaagacgggaaatgacaagccgtgtgtgtaggtaaagtcctaacttaaaaggaaggacaggcctagggaagggtggaccctaaagggcccatgtgccaggggaacagtggacatgtgtgtccagcccaacctccatgtctggtgctgggattctgaaggtggcccccagctcccaaaataaagctttccttttcagtagcgtccgacacttgggtagcttctttctataagcaatgcttgaagatggacgtctgggtcctcatttcctccaaactggctgctacctgaaggcagtcacacatttcttttctgttgggctgagctgggcagaagcctcggactataggcctttccagggcagaggcaatgcgggccacgagtagatacctccatccagcctccaccctggcacacccagaacggcgtggactcaggcgggttgctggatttctctgagccttggcgtgctctacactgcagggctatacatgttcccagcttgagggcgtgctggggattgacaaatatatgaaacatataagcgcaatgattttctaaaattgtgcattcccagcgtgcccattggttctctctcgctggcccaactttgtgtgctgtccataaatccctttctgtggacggtgacagtaggattgggagtgagtgggaagattgtggaaagattgcaaagaggtcattgcaggactcagacagaccttgcagtgggtttcagagtaatactcaggttctcccatggaactttcaaagctggctctaagaaagatgaagaggacaaacccactcctggacatagtgccaacctagaactgtcagctccacacaggatcacagggaagggagcttggtaagacagcccagtagggggccctgcttttcagaagaggaaactggagccatgcaagggcctggggatcaacttagaaaagagcacaggactcacagtcctgggcctgcacgtaaagctagccccctgccccacggaaatggcaagcagtgcttccctccaggggttctacatctgtgctccatctcaaaatgcataaaagcctgagtcattcagatgggagagacagtgtttctacttcctcttagttggggttcctccagaaggagaccctgagagaggacttgaggttatgtagtttatttgagtgaagatcccggaagtagggagagaaggaagctgacggggaaggcgtgcattatcaagtaagttaccgtcatgtgcacaactggagctgaatcccaccggggaaccccgagagacagagctgacaccccagagttcacccagcaaggcggggagacagctggggtatttattcaccaagtctatcacttatgaaaggctgtttctggaaacaatttctgactggccctgcacacacctgagcatacttcctaagccggggatgtccctgagctgagacaggcgttcgtgacaagcagacttcgagtggaaggcaggcatcagaaccaccctgtgagctggttcagacaaagattgcaggcccttccacccccctggccccgccaagttcctgactccctaggtctggagtggggcccgggaatttgcatttcaaaaaatctcgaggtgatgctggtgcagctgctctgaagtcttgactttgagaaccactcactagtgagagtttccagcccttacctgtctcttattgatggctttcccccctctaatttataattatgctttcacaccacttcatgtcacagatcccagggtccgtgctgtgaatttaaaagtggagaattaataagcatttataactccatgcaaccattgctggcagcttaaatgccatctgccagccataatttatttataatggggtttatacatatttataagtttgcaagcaacaaatgcacagttttaaaactggcacattttatagcagccagaaaaattgcaactttataccaggacttgtgaatgtgaattgcatatgtatatacatatacgcatatacttacattgattaaaaacggatctgcatctctgtacacacgcagattggctctgtgttgtgcaccttgggactcctccctgggctttggttttacagctaagtaggaagtcaaacaaacgtgaagaatttgggaattggcaggctgtggcatcagccatggaggatggtcctggatgctgtaggatgtgagatccagcacaaagagaacaagaacaggacatgaggaccacagggattgggggaacccactgtgggaaatgacagagaagccagtgggggaagacaaagaaagaagaaggtggaggcagaataaaggtgagaagaagggaaggggaggataaaacaagtccagatttagatcttccttcatgcagccatgcatagctgtctgaggccagcagggaaggaggagaaagggaaggtgtggtggaggaggctgtgctcgtgatgtcatgctttcgtgtattcccaggtgcagctgcatatacttggcacagtttcttgggatttctagccagtttcttggcctcatttgtgcattagttaatatgtggctggccctgtactgggatggtgggatagagaagtgaatgtatgaggcctctgcctgagtttataacctagaaagaaataaagacacacacacacaaaggtgttggagtgtgacaagccttaaggtacccgtgtgtccaagtaaagtagaaccagcaagggtggagtgcccaggtcagtctggggactctggaggcttcgcactgcaggcgtcagatactgagtgttagtggcacggagaagagtgtggaaggctcaggatgggggtggacagcctggagttgtcactctcagtagagatgctagaaggggcgggaggtgatcccagcctcccttctttcctcctcctggctgtcacagatgctctgaattgatgaatccttcaggccaaaaacacacaggctccttccctaggtctggaaaaatggttctcgctgaaaaagcaccaggaataaaatctcatacaattttaggtgtctattttgttgtctcaccttgaaatactgcagacagaaaaacatgcacatggggagctgtggtcctgagctttgaggtaatgaattcccactcatgtgatcatttttaccataaccaaagtttctaaccatcaaaatcaagtgacaattaaaacaggcattaatggataaatccgtctttaaatattaatggggttaattttgttaacagctatgtgttggttgcaagtggaatgttctctgttcatttgacttttgaatataacttgttccagaatattgtaaaattaagtatgtgaatgtttctttgtattcagaattaaacatttggtgttaaaatcccaggattaggagacaactccatgtaaatttaatgtgtaataataagataataactttttaaaaagcatttggatggcaaattatacatactgacaaatgaatattatctgaaagttgttttgtttccattaacttttgtgaaacaaaaagaattactgtaacagtctatgtcttggcgtattgccaattcaccactttctactttgtgctggaacagaactggcttttttgacatccctgaggagtggaaatgcaaaacgaatttcaagttctctaatctttgttctatgacaaatgaaaaaacctaagttatctggtgttttggagatttgagaatacagcaggtgaagagaattagcttaaattccctcctcccttttgataaatccacagggattccttcactctgtcaggaaatggtgtggtttccaagcattagcccttcatgatctgtctggtgcatttctgtgctcctgggatcgccaagtgcaggcacggcatcgcatccccaggtgtcatcctgtgacccaggaggggaagatgacacacccaatttaggtaatgctgcacttcttgttataattggttattggaaaatgtgcctttattatcagaacagtggtgtgcgcatttctgattatggagctaacttttggatatctgacttagatactaaaaacatttgggtgttgcagttttgcacttgtagatacaacttaaaagcatgaaactggtgatttaattagatgttttctataaaatgcaccttgttacatttctgtgaaagggtcttaccagcgtggaataactggctcaagggttgagagaaacaaccattttctaaacagttaattgtttaaaggactatacatgtaagtctgcaggcaataaaggctgttgtgaaaagta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:53358 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
            GeneID:53358 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:53358 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: TAS
            GeneID:53358 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:53358 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
            GeneID:53358 -> Biological process: GO:0007417 [central nervous system development] evidence: TAS
            GeneID:53358 -> Biological process: GO:0007611 [learning or memory] evidence: IEA
            GeneID:53358 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:53358 -> Biological process: GO:0035249 [synaptic transmission, glutamatergic] evidence: IEA
            GeneID:53358 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: NAS
            GeneID:53358 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:53358 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
            GeneID:53358 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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