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2024-04-25 04:36:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016587 2102 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens chromobox homolog 3 (CBX3), transcript variant 2,
mRNA.
ACCESSION NM_016587
VERSION NM_016587.3 GI:325197147
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2102)
AUTHORS Smallwood,A., Hon,G.C., Jin,F., Henry,R.E., Espinosa,J.M. and
Ren,B.
TITLE CBX3 regulates efficient RNA processing genome-wide
JOURNAL Genome Res. 22 (8), 1426-1436 (2012)
PUBMED 22684280
REMARK GeneRIF: Loss of CBX3 results in global RNA processing defect.
REFERENCE 2 (bases 1 to 2102)
AUTHORS Saini,V., Hose,C.D., Monks,A., Nagashima,K., Han,B., Newton,D.L.,
Millione,A., Shah,J., Hollingshead,M.G., Hite,K.M., Burkett,M.W.,
Delosh,R.M., Silvers,T.E., Scudiero,D.A. and Shoemaker,R.H.
TITLE Identification of CBX3 and ABCA5 as putative biomarkers for tumor
stem cells in osteosarcoma
JOURNAL PLoS ONE 7 (8), E41401 (2012)
PUBMED 22870217
REMARK GeneRIF: Identification of CBX3 and ABCA5 as putative biomarkers
for tumor stem cells in osteosarcoma.
Erratum:[PLoS One. 2012;7(11).
doi:10.1371/annotation/8c74aaee-897d-4682-b62d-d95a3506c210]
REFERENCE 3 (bases 1 to 2102)
AUTHORS Ruan,J., Ouyang,H., Amaya,M.F., Ravichandran,M., Loppnau,P., Min,J.
and Zang,J.
TITLE Structural basis of the chromodomain of Cbx3 bound to methylated
peptides from histone h1 and G9a
JOURNAL PLoS ONE 7 (4), E35376 (2012)
PUBMED 22514736
REMARK GeneRIF: The Cbx3 chromodomain binds with comparable affinities to
all of the methylated H3K9, H1K26 and G9aK185 peptides.
REFERENCE 4 (bases 1 to 2102)
AUTHORS Shimura,M., Toyoda,Y., Iijima,K., Kinomoto,M., Tokunaga,K.,
Yoda,K., Yanagida,M., Sata,T. and Ishizaka,Y.
TITLE Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr
causes premature sister chromatid separation
JOURNAL J. Cell Biol. 194 (5), 721-735 (2011)
PUBMED 21875947
REMARK GeneRIF: HIV-1 Vpr displaces heterochromatin protein 1-alpha and
heterochromatin protein 1-gamma from chromatin, resulting in
premature chromatid separation.
REFERENCE 5 (bases 1 to 2102)
AUTHORS Canudas,S., Houghtaling,B.R., Bhanot,M., Sasa,G., Savage,S.A.,
Bertuch,A.A. and Smith,S.
TITLE A role for heterochromatin protein 1gamma at human telomeres
JOURNAL Genes Dev. 25 (17), 1807-1819 (2011)
PUBMED 21865325
REMARK GeneRIF: HP1gamma localizes to telomeres in S phase, where it is
required to establish/maintain cohesion
REFERENCE 6 (bases 1 to 2102)
AUTHORS Lehming,N., Le Saux,A., Schuller,J. and Ptashne,M.
TITLE Chromatin components as part of a putative transcriptional
repressing complex
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (13), 7322-7326 (1998)
PUBMED 9636147
REFERENCE 7 (bases 1 to 2102)
AUTHORS Seeler,J.S., Marchio,A., Sitterlin,D., Transy,C. and Dejean,A.
TITLE Interaction of SP100 with HP1 proteins: a link between the
promyelocytic leukemia-associated nuclear bodies and the chromatin
compartment
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (13), 7316-7321 (1998)
PUBMED 9636146
REFERENCE 8 (bases 1 to 2102)
AUTHORS Lessard,J., Baban,S. and Sauvageau,G.
TITLE Stage-specific expression of polycomb group genes in human bone
marrow cells
JOURNAL Blood 91 (4), 1216-1224 (1998)
PUBMED 9454751
REFERENCE 9 (bases 1 to 2102)
AUTHORS Ye,Q., Callebaut,I., Pezhman,A., Courvalin,J.C. and Worman,H.J.
TITLE Domain-specific interactions of human HP1-type chromodomain
proteins and inner nuclear membrane protein LBR
JOURNAL J. Biol. Chem. 272 (23), 14983-14989 (1997)
PUBMED 9169472
REFERENCE 10 (bases 1 to 2102)
AUTHORS Ye,Q. and Worman,H.J.
TITLE Interaction between an integral protein of the nuclear envelope
inner membrane and human chromodomain proteins homologous to
Drosophila HP1
JOURNAL J. Biol. Chem. 271 (25), 14653-14656 (1996)
PUBMED 8663349
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CD514780.1, BX648807.1 and
DB565723.1.
On Mar 4, 2011 this sequence version replaced gi:20544150.
Summary: At the nuclear envelope, the nuclear lamina and
heterochromatin are adjacent to the inner nuclear membrane. The
protein encoded by this gene binds DNA and is a component of
heterochromatin. This protein also can bind lamin B receptor, an
integral membrane protein found in the inner nuclear membrane. The
dual binding functions of the encoded protein may explain the
association of heterochromatin with the inner nuclear membrane.
This protein binds histone H3 tails methylated at Lys-9 sites. This
protein is also recruited to sites of ultraviolet-induced DNA
damage and double-strand breaks. Two transcript variants encoding
the same protein but differing in the 5' UTR, have been found for
this gene.[provided by RefSeq, Mar 2011].
Transcript Variant: This variant (2) contains an alternate 5' exon
but encodes the same protein as transcript variant 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX648807.1, AF136630.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-45 CD514780.1 12-56
46-1846 BX648807.1 2-1802
1847-2102 DB565723.1 209-464
FEATURES Location/Qualifiers
source 1..2102
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p15.2"
gene 1..2102
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="chromobox homolog 3"
/db_xref="GeneID:11335"
/db_xref="HGNC:1553"
/db_xref="HPRD:05130"
/db_xref="MIM:604477"
exon 1..123
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
variation 41..42
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tga"
/db_xref="dbSNP:370625470"
variation 57
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:200192216"
exon 124..175
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
variation 126
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:369210080"
variation 135
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:372876793"
variation 143
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:370877360"
misc_feature 146..148
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="upstream in-frame stop codon"
variation 147
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:200166027"
CDS 152..703
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="heterochromatin protein HP1 gamma; chromobox
homolog 3 (HP1 gamma homolog, Drosophila);
heterochromatin-like protein 1; modifier 2 protein;
heterochromatin protein 1 homolog gamma"
/codon_start=1
/product="chromobox protein homolog 3"
/protein_id="NP_057671.2"
/db_xref="GI:20544151"
/db_xref="CCDS:CCDS5398.1"
/db_xref="GeneID:11335"
/db_xref="HGNC:1553"
/db_xref="HPRD:05130"
/db_xref="MIM:604477"
/translation="
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
"
misc_feature 179..181
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13185.4); acetylation site"
misc_feature 257..385
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="Chromatin organization modifier (chromo) domain is
a conserved region of around 50 amino acids found in a
variety of chromosomal proteins, which appear to play a
role in the functional organization of the eukaryotic
nucleus. Experimental evidence...; Region: CHROMO;
cd00024"
/db_xref="CDD:237991"
misc_feature 281..283
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13185.4); acetylation site"
misc_feature order(296..298,302..304,311..313,323..325,335..337,
347..352)
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="histone binding site; other site"
/db_xref="CDD:237991"
misc_feature 299..301
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13185.4); acetylation site"
misc_feature 428..430
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13185.4); phosphorylation site"
misc_feature 428..430
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 434..436
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13185.4); phosphorylation site"
misc_feature 434..436
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 440..442
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13185.4); phosphorylation site"
misc_feature 440..442
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 446..448
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13185.4); phosphorylation site"
misc_feature 446..448
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 455..457
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 518..676
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="Chromo Shadow Domain, found in association with
N-terminal chromo (CHRromatin Organization MOdifier)
domain; Chromo domains mediate the interaction of the
heterochromatin with other heterochromatin proteins,
thereby affecting chromatin structure (e.g; Region: ChSh;
cd00034"
/db_xref="CDD:237998"
misc_feature order(536..538,557..559,620..622,644..646,653..655,
665..667)
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:237998"
misc_feature order(644..646,653..655)
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/note="potential binding pit; other site"
/db_xref="CDD:237998"
misc_feature 668..670
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 677..679
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13185.4); phosphorylation site"
misc_feature 677..679
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 176..318
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
variation 215
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:371590498"
variation 310
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:192881539"
exon 319..481
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
variation 368
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:199646600"
variation 404
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:11554895"
variation 412
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:148438009"
variation 445
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:142550836"
variation 454
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:372035189"
exon 482..576
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
STS 489..686
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/standard_name="CBX3"
/db_xref="UniSTS:503620"
variation 505
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:376630956"
variation 538
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:200410047"
variation 568
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:200791010"
exon 577..2102
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/inference="alignment:Splign:1.39.8"
variation 623
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:372760990"
variation 625
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:372183110"
variation 653
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:151101852"
variation 686..687
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="a"
/db_xref="dbSNP:34210465"
variation 718
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:9768418"
variation 735
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:191976883"
variation 746
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:145395285"
variation 795
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:184267440"
variation 842
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:376832373"
variation 933
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:189467571"
variation 1038
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:182369741"
variation 1041
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:9768454"
variation 1073..1074
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tt"
/db_xref="dbSNP:368752748"
variation 1074..1079
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tttgtgtg"
/db_xref="dbSNP:150882395"
variation 1074..1077
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tttgtg"
/db_xref="dbSNP:150158222"
variation 1075..1088
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="ttgtgtgtgtgtgtgt"
/db_xref="dbSNP:56362406"
variation 1076..1081
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tgtgtgtg"
/db_xref="dbSNP:199895382"
variation 1076..1077
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tgt"
/db_xref="dbSNP:78265643"
variation 1076..1077
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tgtg"
/db_xref="dbSNP:202216295"
variation 1076
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tg"
/db_xref="dbSNP:200992022"
variation 1077
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:9769357"
variation 1078..1080
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:70943279"
variation 1079
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:12532361"
variation 1081
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:200128779"
variation 1087
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:201652043"
variation 1089
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:201093455"
variation 1140
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:111871239"
variation 1198
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:184550155"
variation 1257
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:10156063"
variation 1332
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:3735554"
variation 1391
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:189258793"
variation 1487
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:374505442"
variation 1544
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:11554894"
STS 1572..1815
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/standard_name="RH24974"
/db_xref="UniSTS:85612"
STS 1643..1823
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/standard_name="HSC11F052"
/db_xref="UniSTS:60487"
STS 1649..1750
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/standard_name="D7S2103E"
/db_xref="UniSTS:151124"
variation 1664
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="g"
/db_xref="dbSNP:375726042"
variation 1677
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:7186"
variation 1751
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:78619479"
variation 1808..1810
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="tgg"
/db_xref="dbSNP:144437057"
variation 1810..1812
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace=""
/replace="gtg"
/db_xref="dbSNP:377589440"
variation 1834
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:13247806"
variation 1841
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:28407029"
variation 1846
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="c"
/db_xref="dbSNP:142267744"
variation 1852
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:373262978"
variation 1860
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="c"
/replace="t"
/db_xref="dbSNP:181300726"
variation 1880
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="g"
/db_xref="dbSNP:369134863"
variation 1943
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="a"
/replace="t"
/db_xref="dbSNP:111891412"
variation 1944
/gene="CBX3"
/gene_synonym="HECH; HP1-GAMMA; HP1Hs-gamma"
/replace="g"
/replace="t"
/db_xref="dbSNP:115829318"
ORIGIN
tccccccggcggccccgcgcgcagctcccggctccctcccccttcggatgtggcttgagctgtaggcgcggagggccggagacgctgcagacccgcgacccggagcagctcggaggcggtgaataatagctcttcaagtctgcaataaaaaatggcctccaacaaaactacattgcaaaaaatgggaaaaaaacagaatggaaagagtaaaaaagttgaagaggcagagcctgaagaatttgtcgtggaaaaagtactagatcgacgtgtagtgaatgggaaagtggaatatttcctgaagtggaagggatttacagatgctgacaatacttgggaacctgaagaaaatttagattgtccagaattgattgaagcgtttcttaactctcagaaagctggcaaagaaaaagatggtacaaaaagaaaatctttatctgacagtgaatctgatgacagcaaatcaaagaagaaaagagatgctgctgacaaaccaagaggatttgccagaggtcttgatcctgaaagaataattggtgccacagacagcagtggagaattgatgtttctcatgaaatggaaagattcagatgaggcagacttggtgctggcgaaagaggcaaatatgaagtgtcctcaaattgtaattgctttttatgaagagagactaacttggcattcttgtccagaagatgaagctcaataattgttcacattgttcttttatatatatttatatatatatataaaaattgggtcttagattttgatttactagtgtgacaaaataactacatcctaatgaaaatcaagtttgatatgtttgttttgaaagtagcgttggaagagttgttgggggttttttgcatccatagcactggttactttgaacaaataaataaaagctttctgtagttgcttcctttatcagaaaagaacatttgataccatggtatatcatttcctcttcattaaagaacagcttttctaaatgttgggggaaatgtccatagtcattactcagtcaaaacttgtgttctcatgagcctaaggaccattctagatttattacgtgttttttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatccataaaatgcatatgtaaatttttttttgtttttaagcattcacccaaacaaaaaaatcacaggtaaacccatgtttctgagatgccattattccaagcaaaataagagataatcccttcaagttaaattgaaaattttcctgaaaccatacatttcaagtgaaataagtaattctagataggacaatttaaattggataattttaaagtgtctataattgcagtggtttatttgcaaaattcctaaaaggaaaaattttatcactgccatcacagcaggtttcctcatccagatgaggaaactagacaaatgctagtgtgttttaactagctaaacaaaactaagttaaatgaacatttaaaagtttccctagcgggccattccttagcaaaatgttggaatccctgttgctacattgactaaaaggtcatgatgaatggaatatgtaagacttggctcatagaaacctaatcagatggttagaggtgttggcagtttaggacctgctgtcataaatgtgtgaacaaccttttgtaacctaacctattgacctgcatgttttttctttaccccaattcattacatggaggctcaatcttgagtttgctttactggttcagcaaaagccaggaagaacaactttgtagtaatcaaaatgttatccaactgtatattgtttactttattgtaaatactggtgaacagtggttaataaatagttttatattcctttatgcaattattagacttttttctttatttgatatgcctttacagtagaaatagaaatgcccacactcattggattatctttgtttataagttagatgataccagtaaggcattacagtacatatcctagatcttttgagcttacgagttttaaacttgaatatgtatttccacaggaatgtttccacagttgggaaataaaagtttcatgtgatgcctagggtcaattgtctcattaaaatgaggttttaaattctg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11335 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:11335 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:11335 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:11335 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:11335 -> Biological process: GO:0006338 [chromatin remodeling] evidence: NAS
GeneID:11335 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:11335 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:11335 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP
GeneID:11335 -> Cellular component: GO:0000779 [condensed chromosome, centromeric region] evidence: ISS
GeneID:11335 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:11335 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:11335 -> Cellular component: GO:0005635 [nuclear envelope] evidence: ISS
GeneID:11335 -> Cellular component: GO:0005637 [nuclear inner membrane] evidence: NAS
GeneID:11335 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA
GeneID:11335 -> Cellular component: GO:0005720 [nuclear heterochromatin] evidence: IDA
GeneID:11335 -> Cellular component: GO:0005819 [spindle] evidence: IDA
GeneID:11335 -> Cellular component: GO:0031618 [nuclear centromeric heterochromatin] evidence: ISS
by
@meso_cacase at
DBCLS
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