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2024-04-25 20:16:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016521 1680 bp mRNA linear PRI 29-APR-2013
DEFINITION Homo sapiens transcription factor Dp family, member 3 (TFDP3),
mRNA.
ACCESSION NM_016521
VERSION NM_016521.2 GI:26024208
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1680)
AUTHORS Sun,H.X., Xu,Y., Yang,X.R., Wang,W.M., Bai,H., Shi,R.Y.,
Nayar,S.K., Devbhandari,R.P., He,Y.Z., Zhu,Q.F., Sun,Y.F., Hu,B.,
Khan,M., Anders,R.A. and Fan,J.
TITLE Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma
growth through the transcription factor dimerization partner 3/ E2F
transcription factor 1-dependent apoptotic pathway
JOURNAL Hepatology 57 (3), 1088-1097 (2013)
PUBMED 23212661
REMARK GeneRIF: Data gathered from cell lines, tumorigenicity studies, and
primary hepatocellular carcinoma samples demonstrate a negative
role of HIF-2alpha in tumors, which is mediated by the TFDP3/E2F1
pathway.
REFERENCE 2 (bases 1 to 1680)
AUTHORS Ren,L.F., Ma,Y.Y., Yue,Q.H., Su,M.Q. and Hao,X.K.
TITLE [Effects of TFDP3 on regulating the autophagy and apoptosis of
LNCaP cells]
JOURNAL Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28 (4), 347-349 (2012)
PUBMED 22482402
REMARK GeneRIF: Data show that TFDP3 upregulates the expression of
autophagy gene LC3B and inhibits E2F1-induced apoptosis, and may
play an important role in prostate cancer.
REFERENCE 3 (bases 1 to 1680)
AUTHORS Ingram,L., Munro,S., Coutts,A.S. and La Thangue,N.B.
TITLE E2F-1 regulation by an unusual DNA damage-responsive DP partner
subunit
JOURNAL Cell Death Differ. 18 (1), 122-132 (2011)
PUBMED 20559320
REMARK GeneRIF: DP-4 downregulating E2F-1 activity and contributes to a
new pRb-independent mechanism for regulating cell cycle
progression.
REFERENCE 4 (bases 1 to 1680)
AUTHORS Tian,C., Lv,D., Qiao,H., Zhang,J., Yin,Y.H., Qian,X.P., Wang,Y.P.,
Zhang,Y. and Chen,W.F.
TITLE TFDP3 inhibits E2F1-induced, p53-mediated apoptosis
JOURNAL Biochem. Biophys. Res. Commun. 361 (1), 20-25 (2007)
PUBMED 17632080
REFERENCE 5 (bases 1 to 1680)
AUTHORS Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
TITLE Human TFDP3, a novel DP protein, inhibits DNA binding and
transactivation by E2F
JOURNAL J. Biol. Chem. 282 (1), 454-466 (2007)
PUBMED 17062573
REMARK GeneRIF: TFDP3, a novel DP protein, inhibits DNA binding and
transactivation by E2F
REFERENCE 6 (bases 1 to 1680)
AUTHORS Milton,A., Luoto,K., Ingram,L., Munro,S., Logan,N., Graham,A.L.,
Brummelkamp,T.R., Hijmans,E.M., Bernards,R. and La Thangue,N.B.
TITLE A functionally distinct member of the DP family of E2F subunits
JOURNAL Oncogene 25 (22), 3212-3218 (2006)
PUBMED 16418725
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF219119.2.
This sequence is a reference standard in the RefSeqGene project.
On Dec 4, 2002 this sequence version replaced gi:7706068.
Summary: This gene encodes a member of the DP family of
transcription factors. These factors heterodimerize with E2F
proteins to enhance their DNA-binding activity and promote
transcription from E2F target genes. This protein functions as a
negative regulator and inhibits the DNA binding and transcriptional
activities of E2F factors.[provided by RefSeq, May 2010].
##Evidence-Data-START##
Transcript is intronless :: AF219119.2 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1680 AF219119.2 1-1680
FEATURES Location/Qualifiers
source 1..1680
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq26.2"
gene 1..1680
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/note="transcription factor Dp family, member 3"
/db_xref="GeneID:51270"
/db_xref="HGNC:24603"
/db_xref="MIM:300772"
exon 1..1680
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/inference="alignment:Splign:1.39.8"
misc_feature 63..65
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/note="upstream in-frame stop codon"
CDS 90..1307
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/note="E2F-like protein; cancer/testis antigen 30;
hepatocellular carcinoma-associated antigen 661"
/codon_start=1
/product="transcription factor Dp family member 3"
/protein_id="NP_057605.3"
/db_xref="GI:189409125"
/db_xref="CCDS:CCDS14636.2"
/db_xref="GeneID:51270"
/db_xref="HGNC:24603"
/db_xref="MIM:300772"
/translation="
MAKYVSLTEANEELKVLMDENQTSRPVAVHTSTVNPLGKQLLPKTFGQSSVNIDQQVVIGMPQRPAASNIPVVGSPNPPSTHFASQNQHSYSSPPWAGQHNRKGEKNGMGLCRLSMKVWETVQRKGTTSCQEVVGELVAKFRAASNHASPNESAYDVKNIKRRTYDALNVLMAMNIISREKKKIKWIGLTTNSAQNCQNLRVERQKRLERIKQKQSELQQLILQQIAFKNLVLRNQYVEEQVSQRPLPNSVIHVPFIIISSSKKTVINCSISDDKSEYLFKFNSSFEIHDDTEVLMWMGMTFGLESGSCSAEDLKMARNLVPKALEPYVTEMAQGTFGGVFTTAGSRSNGTWLSASDLTNIAIGMLATSSGGSQYSGSRVETPAVEEEEEEDNNDDDLSENDEDD
"
misc_feature 405..653
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/note="E2F/DP family winged-helix DNA-binding domain;
Region: E2F_TDP; pfam02319"
/db_xref="CDD:202203"
misc_feature 450..452
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/experiment="experimental evidence, no additional details
recorded"
/note="Critical for repression of E2F activity; propagated
from UniProtKB/Swiss-Prot (Q5H9I0.1); other site"
misc_feature 477..479
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/experiment="experimental evidence, no additional details
recorded"
/note="Critical for repression of E2F activity; propagated
from UniProtKB/Swiss-Prot (Q5H9I0.1); other site"
misc_feature 480..482
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/experiment="experimental evidence, no additional details
recorded"
/note="Critical for repression of E2F activity; propagated
from UniProtKB/Swiss-Prot (Q5H9I0.1); other site"
misc_feature 507..509
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/experiment="experimental evidence, no additional details
recorded"
/note="Critical for repression of E2F activity; propagated
from UniProtKB/Swiss-Prot (Q5H9I0.1); other site"
misc_feature 555..659
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5H9I0.1);
Region: DEF box (By similarity)"
misc_feature 612..1007
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5H9I0.1);
Region: Involved in negatively regulating E2F activity"
misc_feature 672..1103
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/note="Transcription factor DP; Region: DP; pfam08781"
/db_xref="CDD:192151"
misc_feature 714..812
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5H9I0.1);
Region: DCB1 (By similarity)"
misc_feature 849..1019
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5H9I0.1);
Region: DCB2 (By similarity)"
STS 205..1602
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/db_xref="UniSTS:486219"
STS 242..1335
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/db_xref="UniSTS:481962"
variation 674
/gene="TFDP3"
/gene_synonym="CT30; DP4; HCA661"
/replace="g"
/replace="t"
/db_xref="dbSNP:35745873"
ORIGIN
cacggcagccctacactcggcctggaagaattgtttttcttctctggaaaggtgaacatttatagcatttatttcccaaatctgttaacatggcaaaatatgtcagtctcactgaagctaacgaagaactcaaggtcttaatggacgagaaccagaccagccgccccgtggccgttcacacctccaccgtgaacccgctcgggaagcagctcttgccgaaaacctttggacagtccagtgtcaacattgaccagcaagtggtaattggtatgcctcagagaccagcagcatcaaacatccctgtggtaggaagcccaaacccacccagcactcactttgcctctcagaaccagcattcctactcctcacctccttgggccgggcagcacaacaggaaaggagagaagaatggcatgggcctgtgccgtctttccatgaaggtctgggagacggtgcagaggaaagggaccacttcctgccaggaagtggtgggcgagctggtcgccaagttcagagctgccagcaaccacgcctcaccaaacgagtcagcttatgacgtgaaaaacataaaacggcgcacctacgatgccttaaacgtgctgatggccatgaatatcatctccagggagaaaaagaagatcaagtggattggtctgaccaccaactcggctcagaactgtcagaacttacgggtggaaagacagaagagacttgaaagaataaagcagaaacagtctgaacttcaacaacttattctacagcaaattgctttcaagaacctggtgctgagaaaccagtatgtggaggagcaggtcagccagcggccgctgcccaactcagtcatccacgtgcccttcatcatcatcagcagtagcaagaagaccgtcatcaactgcagcatctccgacgacaaatcagaatatctgtttaagtttaacagctcctttgaaatccacgatgacacagaagtgctgatgtggatgggcatgacttttgggctagagtccgggagctgctctgccgaagaccttaaaatggccagaaatttggtcccaaaggctctggagccgtacgtgacagaaatggctcagggaacttttggaggtgtgttcacgacggcaggttccaggtctaatggcacgtggctttctgccagtgacctgaccaacattgcgattgggatgctggccacaagctccggtggatctcagtacagtggctccagggtggagaccccagcagtcgaggaggaagaggaggaggacaacaacgatgacgacctcagtgagaatgacgaggatgactgacgtcctctcgccttaagattcagcttcaggaaaacatttagggaaaagaaactttttttttttttttaatgtgaggttttctgtttcttttttgcctactcccaagaagatattggtaagctatagaatttagatatgcacctctgataagcaaggattgtttcccgtatgattaagacgtgctgttgatgtgtgttttgataccagtgtgctgacacagaatctttatttactttttaggattttgtgttttcattttctatttttctttaaatgcagagttcattgttgccccttaacagtttttcctgagtttactgaagaaattgtacttcatccacatccatgaaaataaaatgctctccttttgtgc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51270 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:51270 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:51270 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IDA
GeneID:51270 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:51270 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:51270 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
GeneID:51270 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:51270 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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