2024-03-29 15:55:59, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016509 982 bp mRNA linear PRI 19-MAY-2013 DEFINITION Homo sapiens C-type lectin domain family 1, member B (CLEC1B), transcript variant 1, mRNA. ACCESSION NM_016509 VERSION NM_016509.3 GI:153252028 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 982) AUTHORS Manne,B.K., Getz,T.M., Hughes,C.E., Alshehri,O., Dangelmaier,C., Naik,U.P., Watson,S.P. and Kunapuli,S.P. TITLE Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2) JOURNAL J. Biol. Chem. 288 (11), 7717-7726 (2013) PUBMED 23341451 REMARK GeneRIF: fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway REFERENCE 2 (bases 1 to 982) AUTHORS Hughes,C.E., Sinha,U., Pandey,A., Eble,J.A., O'Callaghan,C.A. and Watson,S.P. TITLE Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2) JOURNAL J. Biol. Chem. 288 (7), 5127-5135 (2013) PUBMED 23264619 REMARK GeneRIF: Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade REFERENCE 3 (bases 1 to 982) AUTHORS Parguina,A.F., Alonso,J., Rosa,I., Velez,P., Gonzalez-Lopez,M.J., Guitian,E., Ebble,J.A., Loza,M.I. and Garcia,A. TITLE A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation JOURNAL Blood 120 (26), E117-E126 (2012) PUBMED 23053573 REMARK GeneRIF: A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation. REFERENCE 4 (bases 1 to 982) AUTHORS Wang,L., Ren,S., Zhu,H., Zhang,D., Hao,Y., Ruan,Y., Zhou,L., Lee,C., Qiu,L., Yun,X. and Xie,J. TITLE Structural and functional conservation of CLEC-2 with the species-specific regulation of transcript expression in evolution JOURNAL Glycoconj. J. 29 (5-6), 335-345 (2012) PUBMED 22740230 REMARK GeneRIF: The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2. REFERENCE 5 (bases 1 to 982) AUTHORS Fei,M., Zhou,L., Xie,J., Ruan,Y., Xu,J., He,S., Shen,H., Hu,Y., Ren,S. and Ruan,C. TITLE The production of soluble C-type lectin-like receptor 2 is a regulated process JOURNAL Glycoconj. J. 29 (5-6), 315-321 (2012) PUBMED 22736279 REMARK GeneRIF: Shedding of CLEC-2 from the cell surface may reflect increased expression of this membrane protein and serve as a marker of disease activity. REFERENCE 6 (bases 1 to 982) AUTHORS Chaipan,C., Soilleux,E.J., Simpson,P., Hofmann,H., Gramberg,T., Marzi,A., Geier,M., Stewart,E.A., Eisemann,J., Steinkasserer,A., Suzuki-Inoue,K., Fuller,G.L., Pearce,A.C., Watson,S.P., Hoxie,J.A., Baribaud,F. and Pohlmann,S. TITLE DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets JOURNAL J. Virol. 80 (18), 8951-8960 (2006) PUBMED 16940507 REMARK GeneRIF: platelets capture and transfer infectious HIV-1 via DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1 dissemination in infected patients REFERENCE 7 (bases 1 to 982) AUTHORS Suzuki-Inoue,K., Fuller,G.L., Garcia,A., Eble,J.A., Pohlmann,S., Inoue,O., Gartner,T.K., Hughan,S.C., Pearce,A.C., Laing,G.D., Theakston,R.D., Schweighoffer,E., Zitzmann,N., Morita,T., Tybulewicz,V.L., Ozaki,Y. and Watson,S.P. TITLE A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 JOURNAL Blood 107 (2), 542-549 (2006) PUBMED 16174766 REFERENCE 8 (bases 1 to 982) AUTHORS Watson,A.A. and O'Callaghan,C.A. TITLE Crystallization and X-ray diffraction analysis of human CLEC-2 JOURNAL Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (PT 12), 1094-1096 (2005) PUBMED 16511244 REMARK GeneRIF: X-ray diffraction analysis of human CLEC-2 REFERENCE 9 (bases 1 to 982) AUTHORS Sobanov,Y., Bernreiter,A., Derdak,S., Mechtcheriakova,D., Schweighofer,B., Duchler,M., Kalthoff,F. and Hofer,E. TITLE A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex JOURNAL Eur. J. Immunol. 31 (12), 3493-3503 (2001) PUBMED 11745369 REFERENCE 10 (bases 1 to 982) AUTHORS Colonna,M., Samaridis,J. and Angman,L. TITLE Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells JOURNAL Eur. J. Immunol. 30 (2), 697-704 (2000) PUBMED 10671229 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC029554.1, AY358599.1 and AC091814.10. On Jul 24, 2007 this sequence version replaced gi:56711305. Summary: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358599.1, AF124841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-137 BC029554.1 71-207 138-257 AY358599.1 119-238 258-258 AC091814.10 11405-11405 259-269 AY358599.1 240-250 270-270 AC091814.10 12073-12073 271-390 AY358599.1 252-371 391-391 AC091814.10 13196-13196 392-982 AY358599.1 373-963 FEATURES Location/Qualifiers source 1..982 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12p13.2" gene 1..982 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /note="C-type lectin domain family 1, member B" /db_xref="GeneID:51266" /db_xref="HGNC:24356" /db_xref="MIM:606783" exon 1..264 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" misc_feature 135..137 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /note="upstream in-frame stop codon" CDS 201..890 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /note="isoform a is encoded by transcript variant 1; C-type lectin-like receptor-2; CLEC-2; C-type lectin-like receptor 2" /codon_start=1 /product="C-type lectin domain family 1 member B isoform a" /protein_id="NP_057593.3" /db_xref="GI:153252029" /db_xref="CCDS:CCDS41752.1" /db_xref="GeneID:51266" /db_xref="HGNC:24356" /db_xref="MIM:606783" /translation="
MQDEDGYITLNIKTRKPALISVGSASSSWWRVMALILLILCVGMVVGLVALGIWSVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP
" misc_feature 219..221 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine; propagated from UniProtKB/Swiss-Prot (Q9P126.2); phosphorylation site" misc_feature 300..362 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9P126.2); transmembrane region" misc_feature 504..854 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /note="C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs); Region: CLECT_NK_receptors_like; cd03593" /db_xref="CDD:153063" misc_feature order(666..668,750..752,804..806,810..815) /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /note="ligand binding surface [chemical binding]; other site" /db_xref="CDD:153063" variation 258 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /replace="a" /replace="g" /db_xref="dbSNP:612593" exon 265..363 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" variation 270 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /replace="c" /replace="t" /db_xref="dbSNP:2273986" variation 283 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /replace="c" /replace="t" /db_xref="dbSNP:2273987" exon 364..483 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" variation 391 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /replace="a" /replace="g" /db_xref="dbSNP:583903" exon 484..638 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" exon 639..745 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" exon 746..972 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /inference="alignment:Splign:1.39.8" variation 901 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" /replace="a" /replace="t" /db_xref="dbSNP:15635" polyA_signal 936..941 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" polyA_site 958 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" polyA_site 972 /gene="CLEC1B" /gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384; QDED721" ORIGIN
gtccatgtatctctgagcagctatgaagaagcttcctggaaaacaataagcaaaggaaaacaaatgtgtcccatctcacatggttctaccctactaaagacaggaagatcataaactgacagatactgaaattgtaaagttggaaactacattttgcaaagtcattgaactctgagctcagttgcagtactcgggaagccatgcaggatgaagatggatacatcaccttaaatattaaaactcggaaaccagctctcatctccgttggctctgcatcctcctcctggtggcgtgtgatggctttgattctgctgatcctgtgcgtggggatggttgtcgggctggtggctctggggatttggtctgtcatgcagcgcaattacctacaaggtgagaatgaaaatcgcacaggaactctgcaacaattagcaaagcgcttctgtcaatatgtggtaaaacaatcagaactaaagggcactttcaaaggtcataaatgcagcccctgtgacacaaactggagatattatggagatagctgctatgggttcttcaggcacaacttaacatgggaagagagtaagcagtactgcactgacatgaatgctactctcctgaagattgacaaccggaacattgtggagtacatcaaagccaggactcatttaattcgttgggtcggattatctcgccagaagtcgaatgaggtctggaagtgggaggatggctcggttatctcagaaaatatgtttgagtttttggaagatggaaaaggaaatatgaattgtgcttattttcataatgggaaaatgcaccctaccttctgtgagaacaaacattatttaatgtgtgagaggaaggctggcatgaccaaggtggaccaactaccttaatgcaaagaggtggacaggataacacagataagggctttattgtacaataaaagatatgtatgaatgcatcagtagctgaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:51266 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS GeneID:51266 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:51266 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: IEA GeneID:51266 -> Biological process: GO:0006952 [defense response] evidence: TAS GeneID:51266 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS GeneID:51266 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
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