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2024-04-26 05:52:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016454 1013 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ER membrane protein complex subunit 4 (EMC4), mRNA.
ACCESSION NM_016454
VERSION NM_016454.2 GI:24475963
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1013)
AUTHORS Christianson,J.C., Olzmann,J.A., Shaler,T.A., Sowa,M.E.,
Bennett,E.J., Richter,C.M., Tyler,R.E., Greenblatt,E.J.,
Harper,J.W. and Kopito,R.R.
TITLE Defining human ERAD networks through an integrative mapping
strategy
JOURNAL Nat. Cell Biol. 14 (1), 93-105 (2012)
PUBMED 22119785
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1013)
AUTHORS Ring,G., Khoury,C.M., Solar,A.J., Yang,Z., Mandato,C.A. and
Greenwood,M.T.
TITLE Transmembrane protein 85 from both human (TMEM85) and yeast
(YGL231c) inhibit hydrogen peroxide mediated cell death in yeast
JOURNAL FEBS Lett. 582 (17), 2637-2642 (2008)
PUBMED 18586032
REMARK GeneRIF: TMEM85 is a complex gene that encodes a novel conserved
anti-apoptotic protein.
REFERENCE 3 (bases 1 to 1013)
AUTHORS Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
TITLE A germline-specific class of small RNAs binds mammalian Piwi
proteins
JOURNAL Nature 442 (7099), 199-202 (2006)
PUBMED 16751776
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF151018.1.
On Nov 2, 2002 this sequence version replaced gi:7705996.
##Evidence-Data-START##
Transcript exon combination :: AF151018.1, BC016348.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1013
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q14"
gene 1..1013
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/note="ER membrane protein complex subunit 4"
/db_xref="GeneID:51234"
/db_xref="HGNC:28032"
/db_xref="HPRD:14233"
exon 1..157
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="alignment:Splign:1.39.8"
misc_feature 54..56
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/note="upstream in-frame stop codon"
variation 60
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:200295598"
variation 65
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="t"
/db_xref="dbSNP:376859759"
variation 70
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:150984739"
CDS 72..623
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/note="proliferation-inducing gene 17; cell
proliferation-inducing gene 17 protein; transmembrane
protein 85"
/codon_start=1
/product="ER membrane protein complex subunit 4"
/protein_id="NP_057538.1"
/db_xref="GI:7705997"
/db_xref="CCDS:CCDS10035.1"
/db_xref="GeneID:51234"
/db_xref="HGNC:28032"
/db_xref="HPRD:14233"
/translation="
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL
"
misc_feature 165..167
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 192..194
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 198..200
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 228..590
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/note="Protein of unknown function (DUF1077); Region:
DUF1077; pfam06417"
/db_xref="CDD:219016"
misc_feature 321..383
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5J8M3.2);
transmembrane region"
misc_feature 459..521
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q5J8M3.2);
transmembrane region"
variation 93
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="g"
/replace="t"
/db_xref="dbSNP:1132869"
variation 97
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="g"
/db_xref="dbSNP:139134705"
variation 127
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:371572098"
exon 158..272
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="alignment:Splign:1.39.8"
variation 175
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="g"
/db_xref="dbSNP:140809470"
variation 177
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:145064675"
variation 194
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="g"
/replace="t"
/db_xref="dbSNP:371911554"
variation 235
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:79389628"
variation 263
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="g"
/db_xref="dbSNP:79609466"
exon 273..426
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="alignment:Splign:1.39.8"
variation 296
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="t"
/db_xref="dbSNP:200052989"
variation 302
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/db_xref="dbSNP:11544433"
variation 321
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:11544434"
variation 363
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="g"
/replace="t"
/db_xref="dbSNP:11544437"
variation 406
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/db_xref="dbSNP:181943133"
variation 414
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="g"
/db_xref="dbSNP:11544438"
exon 427..587
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="alignment:Splign:1.39.8"
variation 437
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:377044886"
variation 479
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:371080541"
variation 482
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:376299788"
variation 484
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:116858574"
variation 554
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:368550740"
variation 557
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:375492262"
variation 581
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:375749312"
exon 588..991
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/inference="alignment:Splign:1.39.8"
variation 589
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:138144365"
variation 621
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:372229813"
variation 651
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:201082530"
variation 659
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:374866723"
variation 685
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/db_xref="dbSNP:11544436"
variation 694
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:372247843"
variation 722
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/db_xref="dbSNP:140570424"
variation 723
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:112473788"
variation 742..743
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace=""
/replace="ac"
/db_xref="dbSNP:201968639"
variation 743..744
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace=""
/replace="ct"
/db_xref="dbSNP:71702457"
variation 745
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:201628991"
variation 813
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="c"
/replace="t"
/db_xref="dbSNP:7598"
variation 824
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="c"
/db_xref="dbSNP:16958862"
variation 837
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="t"
/db_xref="dbSNP:16958864"
variation 866
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="g"
/replace="t"
/db_xref="dbSNP:147712898"
variation 894
/gene="EMC4"
/gene_synonym="PIG17; TMEM85"
/replace="a"
/replace="g"
/db_xref="dbSNP:371851468"
ORIGIN
acgctggtgggcctgttgtggagtacgctttggactgagaagcatcgaggctataggacgcagctgttgccatgacggcccaggggggcctggtggctaaccgaggccggcgcttcaagtgggccattgagctaagcgggcctggaggaggcagcaggggtcgaagtgaccggggcagtggccagggagactcgctctacccagtcggttacttggacaagcaagtgcctgataccagcgtgcaagagacagaccggatcctggtggagaagcgctgctgggacatcgccttgggtcccctcaaacagattcccatgaatctcttcatcatgtacatggcaggcaatactatctccatcttccctactatgatggtgtgtatgatggcctggcgacccattcaggcacttatggccatttcagccactttcaagatgttagaaagttcaagccagaagtttcttcagggtttggtctatctcattgggaacctgatgggtttggcattggctgtttacaagtgccagtccatgggactgttacctacacatgcatcggattggttagccttcattgagccccctgagagaatggagttcagtggtggaggactgcttttgtgaacatgagaaagcagcgcctggtccctatgtatttgggtcttatttacatccttctttaagcccagtggctcctcagcatactcttaaactaatcacttatgttaaaaagaaccaaaagactcttttctccatggtggggtgacaggtcctagaaggacaatgtgcatattacgacaaacacaaagaaactataccataacccaaggctgaaaataatgtagaaaactttatttttgtttccagtacagagcaaaacaacaacaaaaaaacataactatgtaaacaagagaataactgctgctaaatcaagaactgttgcagcatctcctttcaataaattaaatggttgagaacaatgcataaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51234 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:51234 -> Cellular component: GO:0016021 [integral to membrane] evidence: IDA
GeneID:51234 -> Cellular component: GO:0072546 [ER membrane protein complex] evidence: IDA
by
@meso_cacase at
DBCLS
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