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2024-04-20 07:14:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016222 2118 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41),
mRNA.
ACCESSION NM_016222
VERSION NM_016222.2 GI:21071031
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2118)
AUTHORS Parvatiyar,K., Zhang,Z., Teles,R.M., Ouyang,S., Jiang,Y.,
Iyer,S.S., Zaver,S.A., Schenk,M., Zeng,S., Zhong,W., Liu,Z.J.,
Modlin,R.L., Liu,Y.J. and Cheng,G.
TITLE The helicase DDX41 recognizes the bacterial secondary messengers
cyclic di-GMP and cyclic di-AMP to activate a type I interferon
immune response
JOURNAL Nat. Immunol. 13 (12), 1155-1161 (2012)
PUBMED 23142775
REMARK GeneRIF: results suggest a mechanism whereby c-di-GMP and c-di-AMP
are detected by DDX41, which forms a complex with STING to signal
to TBK1-IRF3 and activate the interferon response
REFERENCE 2 (bases 1 to 2118)
AUTHORS Zhang,Z., Yuan,B., Bao,M., Lu,N., Kim,T. and Liu,Y.J.
TITLE The helicase DDX41 senses intracellular DNA mediated by the adaptor
STING in dendritic cells
JOURNAL Nat. Immunol. 12 (10), 959-965 (2011)
PUBMED 21892174
REMARK GeneRIF: DDX41 is an additional DNA sensor that depends on STING to
sense pathogenic DNA.
Erratum:[Nat Immunol. 2012 Feb;13(2):196]
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2118)
AUTHORS Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
Jurisica,I. and Li,S.S.
TITLE Systematic identification of SH3 domain-mediated human
protein-protein interactions by peptide array target screening
JOURNAL Proteomics 7 (11), 1775-1785 (2007)
PUBMED 17474147
REFERENCE 4 (bases 1 to 2118)
AUTHORS Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
TITLE Phosphoproteome analysis of the human mitotic spindle
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (14), 5391-5396 (2006)
PUBMED 16565220
REFERENCE 5 (bases 1 to 2118)
AUTHORS Abdul-Ghani,M., Hartman,K.L. and Ngsee,J.K.
TITLE Abstrakt interacts with and regulates the expression of sorting
nexin-2
JOURNAL J. Cell. Physiol. 204 (1), 210-218 (2005)
PUBMED 15690390
REMARK GeneRIF: The N-terminal domain of Abs interacts with the phox
homology (PX) domain of SNX2 suggesting that PX domains may also
participate in protein-protein interaction.
REFERENCE 6 (bases 1 to 2118)
AUTHORS Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
Lamond,A.I. and Mann,M.
TITLE Nucleolar proteome dynamics
JOURNAL Nature 433 (7021), 77-83 (2005)
PUBMED 15635413
REFERENCE 7 (bases 1 to 2118)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
REFERENCE 8 (bases 1 to 2118)
AUTHORS Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
Moore,M.J.
TITLE Purification and characterization of native spliceosomes suitable
for three-dimensional structural analysis
JOURNAL RNA 8 (4), 426-439 (2002)
PUBMED 11991638
REFERENCE 9 (bases 1 to 2118)
AUTHORS Irion,U. and Leptin,M.
TITLE Developmental and cell biological functions of the Drosophila
DEAD-box protein abstrakt
JOURNAL Curr. Biol. 9 (23), 1373-1381 (1999)
PUBMED 10607561
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC015476.1.
On May 22, 2002 this sequence version replaced gi:7705259.
Summary: DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration
of RNA secondary structure, such as translation initiation, nuclear
and mitochondrial splicing, and ribosome and spliceosome assembly.
Based on their distribution patterns, some members of the DEAD box
protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene
encodes a member of this family. The function of this member has
not been determined. Based on studies in Drosophila, the abstrakt
gene is widely required during post-transcriptional gene
expression. [provided by RefSeq, Jul 2008].
##Evidence-Data-START##
Transcript exon combination :: BC015476.1, AK027768.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..2118
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q35.3"
gene 1..2118
/gene="DDX41"
/gene_synonym="ABS"
/note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 41"
/db_xref="GeneID:51428"
/db_xref="HGNC:18674"
/db_xref="HPRD:10490"
/db_xref="MIM:608170"
exon 1..48
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(12)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:368790564"
CDS 22..1890
/gene="DDX41"
/gene_synonym="ABS"
/EC_number="3.6.4.13"
/note="putative RNA helicase; DEAD-box protein abstrakt;
2900024F02Rik; DEAD box protein 41; DEAD box protein
abstrakt homolog"
/codon_start=1
/product="probable ATP-dependent RNA helicase DDX41"
/protein_id="NP_057306.2"
/db_xref="GI:21071032"
/db_xref="CCDS:CCDS4427.1"
/db_xref="GeneID:51428"
/db_xref="HGNC:18674"
/db_xref="HPRD:10490"
/db_xref="MIM:608170"
/translation="
MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF
"
misc_feature 82..84
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UJV9.2); phosphorylation site"
misc_feature 82..84
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
misc_feature 88..90
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UJV9.2); phosphorylation site"
misc_feature 88..90
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[4]
/citation=[7]
misc_feature 268..270
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 277..279
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 562..648
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJV9.2);
Region: Q motif"
misc_feature 568..1212
/gene="DDX41"
/gene_synonym="ABS"
/note="DEAD-box helicases. A diverse family of proteins
involved in ATP-dependent RNA unwinding, needed in a
variety of cellular processes including splicing, ribosome
biogenesis and RNA degradation. The name derives from the
sequence of the Walker B motif; Region: DEADc; cd00268"
/db_xref="CDD:28928"
misc_feature 703..717
/gene="DDX41"
/gene_synonym="ABS"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:28928"
misc_feature 1051..1062
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UJV9.2);
Region: DEAD box"
misc_feature 1051..1062
/gene="DDX41"
/gene_synonym="ABS"
/note="Mg++ binding site [ion binding]; other site"
/db_xref="CDD:28928"
misc_feature 1144..1152
/gene="DDX41"
/gene_synonym="ABS"
/note="motif III; other site"
/db_xref="CDD:28928"
misc_feature 1246..1626
/gene="DDX41"
/gene_synonym="ABS"
/note="Helicase superfamily c-terminal domain; associated
with DEXDc-, DEAD-, and DEAH-box proteins, yeast
initiation factor 4A, Ski2p, and Hepatitis C virus NS3
helicases; this domain is found in a wide variety of
helicases and helicase related proteins; may...; Region:
HELICc; cd00079"
/db_xref="CDD:28960"
misc_feature order(1339..1350,1408..1413,1486..1494)
/gene="DDX41"
/gene_synonym="ABS"
/note="nucleotide binding region [chemical binding]; other
site"
/db_xref="CDD:28960"
misc_feature order(1510..1512,1573..1575,1585..1587,1594..1596)
/gene="DDX41"
/gene_synonym="ABS"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:28960"
variation complement(24)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:141601766"
variation complement(27)
/gene="DDX41"
/gene_synonym="ABS"
/replace="g"
/replace="t"
/db_xref="dbSNP:138435584"
variation complement(47)
/gene="DDX41"
/gene_synonym="ABS"
/replace=""
/replace="aggt"
/db_xref="dbSNP:77937495"
exon 49..159
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(53)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:144762739"
variation complement(59)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:61736559"
variation complement(80)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:192558384"
variation complement(105)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:369227218"
variation complement(108)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:138939116"
variation complement(111)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:377090308"
variation complement(118)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:150205465"
variation complement(120)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:142331226"
variation complement(134)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555633"
variation complement(147)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:201516083"
exon 160..319
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(163)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:377745714"
variation complement(205)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:368429550"
variation complement(222)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:11555632"
variation complement(243)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:147065982"
variation complement(289)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:199675507"
variation complement(312)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:141619153"
exon 320..394
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(385)
/gene="DDX41"
/gene_synonym="ABS"
/replace="g"
/replace="t"
/db_xref="dbSNP:200567842"
exon 395..455
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(405)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:200841282"
variation complement(436)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:375462407"
exon 456..592
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(483)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:151196255"
variation complement(486)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:199697328"
variation complement(511)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:142143752"
variation complement(532)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:200005940"
variation complement(544)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:377695856"
variation complement(559)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:376128262"
variation complement(581)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:185950985"
exon 593..665
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(597)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:375274366"
variation complement(612)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:149122003"
variation complement(618)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:145085939"
variation complement(637)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:373575560"
variation complement(647..648)
/gene="DDX41"
/gene_synonym="ABS"
/replace=""
/replace="c"
/db_xref="dbSNP:34567318"
variation complement(665)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:369566052"
exon 666..819
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(670)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:376867329"
variation complement(674)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:371460149"
variation complement(693)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="c"
/db_xref="dbSNP:367840907"
variation complement(711)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:144003034"
variation complement(733)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:376093707"
variation complement(739)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:139112542"
variation complement(761)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:146175373"
variation complement(762)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:143274979"
variation complement(769)
/gene="DDX41"
/gene_synonym="ABS"
/replace="g"
/replace="t"
/db_xref="dbSNP:200707924"
variation complement(797)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:139780256"
variation complement(798)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:139845884"
variation complement(807)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:181004515"
exon 820..956
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(822)
/gene="DDX41"
/gene_synonym="ABS"
/replace="g"
/replace="t"
/db_xref="dbSNP:150888965"
variation complement(842)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:200122668"
STS 876..1024
/gene="DDX41"
/gene_synonym="ABS"
/standard_name="MARC_24355-24356:1030120548:1"
/db_xref="UniSTS:268896"
variation complement(897)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:367663728"
variation complement(928)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:141982967"
variation complement(947)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:371035635"
exon 957..1119
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(957)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:377107791"
variation complement(966)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:141520272"
variation complement(984)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:200664784"
variation complement(1034)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:148384288"
variation complement(1035)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:201829616"
variation complement(1054)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:370129260"
variation complement(1083)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:199581668"
exon 1120..1251
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1138)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="c"
/db_xref="dbSNP:200003905"
variation complement(1158)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:144382614"
variation complement(1162)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="t"
/db_xref="dbSNP:144057590"
variation complement(1221)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:335438"
exon 1252..1323
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1254)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:147023941"
variation complement(1255)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:367653265"
variation complement(1263)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:201039108"
variation complement(1297)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:376656648"
variation complement(1317)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:201997819"
variation complement(1320)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:61736556"
exon 1324..1420
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1338..1339)
/gene="DDX41"
/gene_synonym="ABS"
/replace=""
/replace="c"
/db_xref="dbSNP:35272017"
variation complement(1368)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:138792438"
variation complement(1375)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:143421709"
variation complement(1389)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:140816118"
exon 1421..1570
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1457)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:200307685"
variation complement(1491)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:151018711"
variation complement(1500)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:148853192"
variation complement(1503)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:374941140"
variation complement(1549)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:199756165"
exon 1571..1642
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1590)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:371427065"
variation complement(1638)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:144162792"
exon 1643..1753
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1663)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:140371153"
variation complement(1664)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:113077379"
variation complement(1665)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:146668975"
variation complement(1704)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:140652745"
variation complement(1746)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:367918756"
exon 1754..2104
/gene="DDX41"
/gene_synonym="ABS"
/inference="alignment:Splign:1.39.8"
variation complement(1761)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:148650463"
variation complement(1809)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:199630434"
variation complement(1863)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:369601583"
variation complement(1887)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:1054860"
variation complement(1891)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:372352153"
variation complement(1893)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:73804364"
variation complement(1908)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="g"
/db_xref="dbSNP:201294859"
variation complement(1911)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:372991865"
variation complement(1918)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:369119236"
variation complement(1932)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/db_xref="dbSNP:192736058"
STS 1942..2056
/gene="DDX41"
/gene_synonym="ABS"
/standard_name="A002K19"
/db_xref="UniSTS:899"
STS 1950..2082
/gene="DDX41"
/gene_synonym="ABS"
/standard_name="RH47489"
/db_xref="UniSTS:19820"
variation complement(1964)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:78923296"
variation complement(1987)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:337395"
variation complement(1998)
/gene="DDX41"
/gene_synonym="ABS"
/replace="c"
/replace="t"
/db_xref="dbSNP:186837776"
variation complement(2001)
/gene="DDX41"
/gene_synonym="ABS"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:28695578"
polyA_signal 2081..2086
/gene="DDX41"
/gene_synonym="ABS"
polyA_site 2104
/gene="DDX41"
/gene_synonym="ABS"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
cgcgcatgcgtgcagcaaagaatggaggagtcggaacccgaacggaagcgggctcgcaccgacgaggtgcctgccggaggaagccgctccgaggcggaagatgaggacgacgaggactacgtgccctatgtgccgttacggcagcgccggcagctactgctccagaagctgctgcagcgaagacgcaagggagctgcggaggaagagcagcaggacagcggtagtgaaccccggggagatgaggacgacatcccgctaggccctcagtccaacgtcagcctcctggatcagcaccagcaccttaaagagaaggctgaagcgcgcaaagagtctgccaaggagaagcagctgaaggaagaagagaagatcctggagagtgttgccgagggccgagcattgatgtcagtgaaggagatggctaagggcattacgtatgatgaccccatcaaaaccagctggactccaccccgttatgttctgagcatgtctgaagagcgacatgagcgcgtgcggaagaaataccacatcctggtggagggagacggtatcccaccacccatcaagagcttcaaggaaatgaagtttcctgcagccatcctgagaggcctgaagaagaaaggcattcaccacccaacacccattcagatccagggcatccccaccattctatctggccgtgacatgataggcatcgctttcacgggttcaggcaagacactggtgttcacgttgcccgtcatcatgttctgcctggaacaagagaagaggttacccttctcaaagcgcgaggggccctatggactcatcatctgcccctcgcgggagctggcccggcagacccatggcatcctggagtactactgccgcctgctgcaggaggacagctcaccactcctgcgctgcgccctctgcattgggggcatgtccgtgaaagagcagatggagaccatccgacacggtgtacacatgatggtggccaccccggggcgcctcatggatttgctgcagaagaagatggtcagcctagacatctgtcgctacctggccctggacgaggctgaccgcatgatcgacatgggcttcgagggtgacatccgtaccatcttctcctacttcaagggccagcgacagaccctgctcttcagtgccaccatgccgaagaagattcagaactttgctaagagtgcccttgtaaagcctgtgaccatcaatgtggggcgcgctggggctgccagcctggatgtcatccaggaggtagaatatgtgaaggaggaggccaagatggtgtacctgctcgagtgcctgcagaagacacccccgcctgtactcatctttgcagagaagaaggcagacgtggacgccatccacgagtacctgctgctcaagggggttgaggccgtagccatccatgggggcaaagaccaggaggaacggactaaggccatcgaggcattccgggagggcaagaaggatgtcctagtagccacagacgttgcctccaagggcctggacttccctgccatccagcacgtcatcaattatgacatgccagaggagattgagaactatgtacaccggattggccgcaccgggcgctcgggaaacacaggcatcgccactaccttcatcaacaaagcgtgtgatgagtcagtgctgatggacctcaaagcgctgctgctagaagccaagcagaaggtgccgcccgtgctgcaggtgctgcattgcggggatgagtccatgctggacattggaggagagcgcggctgtgccttctgcgggggcctgggtcatcggatcactgactgccccaaactcgaggctatgcagaccaagcaggtcagcaacatcggtcgcaaggactacctggcccacagctccatggacttctgagccgacagtcttcccttctctccaagaggcctcagtccccaagactgccaccagtctacacatacagcagccccctggacagaatcagcatttcagctcagctggcctggaatgggccaggctggtcctggctgcctgttccctgtgctcttcagaattactgtttttgtttccttttaccccagctgccattaaagcccaaacctctagcccaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51428 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:51428 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:51428 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:51428 -> Molecular function: GO:0008026 [ATP-dependent helicase activity] evidence: IEA
GeneID:51428 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:51428 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: IC
GeneID:51428 -> Biological process: GO:0006396 [RNA processing] evidence: TAS
GeneID:51428 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:51428 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
GeneID:51428 -> Biological process: GO:0032479 [regulation of type I interferon production] evidence: TAS
GeneID:51428 -> Biological process: GO:0032481 [positive regulation of type I interferon production] evidence: TAS
GeneID:51428 -> Biological process: GO:0035458 [cellular response to interferon-beta] evidence: IEA
GeneID:51428 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:51428 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:51428 -> Biological process: GO:0051607 [defense response to virus] evidence: IEA
GeneID:51428 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:51428 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:51428 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:51428 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:51428 -> Cellular component: GO:0071013 [catalytic step 2 spliceosome] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_057306 -> EC 3.6.4.13
by
@meso_cacase at
DBCLS
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