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2024-04-24 15:13:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_016019 2712 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens LUC7-like 2 (S. cerevisiae) (LUC7L2), transcript
variant 1, mRNA.
ACCESSION NM_016019 NM_016007
VERSION NM_016019.4 GI:397174788
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2712)
AUTHORS Webby,C.J., Wolf,A., Gromak,N., Dreger,M., Kramer,H., Kessler,B.,
Nielsen,M.L., Schmitz,C., Butler,D.S., Yates,J.R. III,
Delahunty,C.M., Hahn,P., Lengeling,A., Mann,M., Proudfoot,N.J.,
Schofield,C.J. and Bottger,A.
TITLE Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated
with RNA splicing
JOURNAL Science 325 (5936), 90-93 (2009)
PUBMED 19574390
REFERENCE 2 (bases 1 to 2712)
AUTHORS Kwon,M.J., Oh,E., Lee,S., Roh,M.R., Kim,S.E., Lee,Y., Choi,Y.L.,
In,Y.H., Park,T., Koh,S.S. and Shin,Y.K.
TITLE Identification of novel reference genes using multiplatform
expression data and their validation for quantitative gene
expression analysis
JOURNAL PLoS ONE 4 (7), E6162 (2009)
PUBMED 19584937
REMARK Erratum:[PLoS One. 2009;4(8). doi:
10.1371/annotation/695436c7-3329-4bdc-9832-f427ecc33698]
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2712)
AUTHORS Howell,V.M., Jones,J.M., Bergren,S.K., Li,L., Billi,A.C.,
Avenarius,M.R. and Meisler,M.H.
TITLE Evidence for a direct role of the disease modifier SCNM1 in
splicing
JOURNAL Hum. Mol. Genet. 16 (20), 2506-2516 (2007)
PUBMED 17656373
REFERENCE 4 (bases 1 to 2712)
AUTHORS Puig,O., Bragado-Nilsson,E., Koski,T. and Seraphin,B.
TITLE The U1 snRNP-associated factor Luc7p affects 5' splice site
selection in yeast and human
JOURNAL Nucleic Acids Res. 35 (17), 5874-5885 (2007)
PUBMED 17726058
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY018775.1, BC017163.2 and
AU144525.2.
On Jul 24, 2012 this sequence version replaced gi:347446674.
Summary: This gene encodes a protein that contains a C2H2-type zinc
finger, coiled-coil region and arginine, serine-rich (RS) domain. A
similar protein in mouse interacts with sodium channel modifier 1,
and the encoded protein may be involved in the recognition of
non-consensus splice donor sites in association with the U1 snRNP
spliceosomal subunit. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene.
[provided by RefSeq, Sep 2011].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
##Evidence-Data-START##
Transcript exon combination :: AK001519.1, BC017163.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-83 HY018775.1 1-83
84-2709 BC017163.2 1-2626
2710-2712 AU144525.2 1-3 c
FEATURES Location/Qualifiers
source 1..2712
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34"
gene 1..2712
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/note="LUC7-like 2 (S. cerevisiae)"
/db_xref="GeneID:51631"
/db_xref="HGNC:21608"
/db_xref="MIM:613056"
exon 1..477
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
misc_feature 102..104
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/note="upstream in-frame stop codon"
CDS 417..1595
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/note="isoform 1 is encoded by transcript variant 1;
putative RNA-binding protein Luc7-like 2"
/codon_start=1
/product="putative RNA-binding protein Luc7-like 2 isoform
1"
/protein_id="NP_057103.2"
/db_xref="GI:116812577"
/db_xref="CCDS:CCDS43656.1"
/db_xref="GeneID:51631"
/db_xref="HGNC:21608"
/db_xref="MIM:613056"
/translation="
MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI
"
misc_feature 426..1115
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/note="LUC7 N_terminus; Region: LUC7; pfam03194"
/db_xref="CDD:112027"
misc_feature 429..1100
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/note="U1 snRNP component, mediates U1 snRNP association
with cap-binding complex [RNA processing and
modification]; Region: LUC7; COG5200"
/db_xref="CDD:34799"
misc_feature 465..467
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 468..470
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y383.2); phosphorylation site"
misc_feature 747..749
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9Y383.2); phosphorylation site"
misc_feature 747..749
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1212..1214
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="5-hydroxylysine, by JMJD6; propagated from
UniProtKB/Swiss-Prot (Q9Y383.2); hydroxylation site"
misc_feature 1221..1223
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="5-hydroxylysine, by JMJD6; propagated from
UniProtKB/Swiss-Prot (Q9Y383.2); hydroxylation site"
misc_feature 1455..1457
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1473..1475
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1476..1478
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1563..1565
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y383.2); phosphorylation site"
misc_feature 1566..1568
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y383.2); phosphorylation site"
misc_feature 1566..1568
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 478..572
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 573..671
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 672..782
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 783..926
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
variation 872
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/replace="c"
/replace="t"
/db_xref="dbSNP:267601312"
variation 873
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/replace="c"
/replace="t"
/db_xref="dbSNP:267601313"
exon 927..1103
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 1104..1195
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 1196..1225
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 1226..1417
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
exon 1418..2712
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/inference="alignment:Splign:1.39.8"
polyA_signal 2385..2390
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
polyA_site 2403
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
STS 2569..2693
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
/standard_name="SGC30686"
/db_xref="UniSTS:83282"
polyA_signal 2686..2691
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
polyA_site 2709
/gene="LUC7L2"
/gene_synonym="CGI-59; CGI-74; LUC7B2"
ORIGIN
agttggtggagcccccgcgggaaacgactgagcgcgaggagcgtgcgcgctcccgtcgtggcgacggtggcggcgagcggcgtcagagcttgagggggggttgacggcttctggcgggtggcggtgttgaaggcgagagcttgcttggcccgtgtcgcttctgtcccaagaaccggacggagagtgagggcacgagggtcgctgtcgggggctgtcgtcttccacgtacacgtcgtcgtgaggagcgcagtccggactcttcccgcaacccctccggctccctttccgcacgcctcgaggcggcggcggccaccgagacagcagcgcaccttcccccatcccttccccttatcccccagcccaaaagggcccggtctgcgccccacccccgcccgtccgcccgctacgccgccgccatgtcggcgcaggcccagatgcgcgcgatgctggaccagttgatgggcacctcccgggacggagatacaactcgtcaacgaatcaaattcagtgatgacagagtatgcaagagtcaccttctcaactgttgtcctcatgatgtcctttctggaactagaatggatcttggagaatgtctgaaagtccatgacctggctttaagagcggattatgaaattgcatccaaagaacaagattttttctttgaacttgatgccatggatcatctgcagtcattcattgcagattgtgatcgtagaacagaagtggccaagaaaagattagcagaaactcaagaagagattagtgctgaagtagcagcaaaggcagaacgtgttcatgagttaaatgaagaaattggtaaattgttagccaaggtggaacaactaggagctgaagggaatgtggaggaatcccagaaagtaatggatgaagtagagaaagcacgggcaaagaaaagagaagcagaggaagtttatcggaattctatgccagcttccagttttcagcagcagaaacttcgagtctgtgaagtctgctctgcctatttaggacttcatgataatgacagacgactggctgatcattttgggggtaaactgcacctgggatttattgaaataagagagaagcttgaagaattaaagagagtcgtagctgagaagcaggagaaaagaaaccaggaacggctgaaacgaagagaagagagagagagagaagaaagggagaagctgaggaggtcccgatcacacagcaagaatccaaaaagatccaggtccagagagcatcgcagacatcgatctcgctccatgtcacgtgaacgcaagaggagaactcgatccaaatctcgggagaaacgccatcgccacaggtcccgctccagcagccgtagccgcagccgtagccaccagagaagtcggcacagttctagagataggagcagagaacgatccaagaggagatcctcaaaagaaagattcagagaccaagacttagcatcatgtgacagagacaggagttcaagagacagatcacctcgtgacagagatcggaaagataagaagcggtcctatgagagtgctaatggcagatcagaagacaggaggagctctgaagagcgcgaagcaggggagatctaactagctgtgtacatttcttcagtccttaagcttcctacggagttacgtactattgtttagttcacagctgttcagggtgacagtgagcagatccagacaccagatccagctaggctagatgtacagtatctaacttgatctgaactgaacctgttttccttgatgatgcctaaaactacatccatagtttctggtgaacctgtaatacagttctgaaagtacagttttatataataagatgctgatctctttattctttcaagtaagagtgctagtgaacaaattgtgttacttgccttgggattttttgaacgtttgtaaaatgctgtcttcctagtccaaacagctgcagctttgggcatttttctttttaattattcttcctctgactttgtatcccttaatacctacactctccaattgtaagagaaagggggcagggaagcaatatagcttccattctaaggctgtattcccgttatgaattactagctgattacagttcagagcattgatcctggaatgtgtgctggagaaatttaaaatactggggttttttgtttaatggtgcctatttagagttggaagttgaacagctgttgcattacatacttttgcttttttattgaaattttgaaatcaaacgtcttgatttttctgttctgttgaattgctatgttcaggatgttctagggggtgggggcagggactcttttcgtaataagcacttgttttattttgtgtgtgtggagtataaaggctacacccttattgtaaaaaaataataataataaaatgaaagaaacaatcaccaccaccattattaaactgtaacttgtctagtaaattgtcactagaactatttgctgtgggcatttcctctattctgttacgtcattaacagtgccttactgtgcaaggcaccaaaggacataaatacgtacttgcaaagattccagatgagctgttcatgtgggccccttgctgactatattccagccacttcagggttgtttgtaatgaccgttatagagaagggctcgacctgcagaagaaactggggtgtttttattctcattcaacaaacccaaataaaaacagtatatgtaaccaacat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51631 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:51631 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:51631 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA
by
@meso_cacase at
DBCLS
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