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2024-04-20 06:20:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015834 3605 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens adenosine deaminase, RNA-specific, B1 (ADARB1),
transcript variant 3, mRNA.
ACCESSION NM_015834
VERSION NM_015834.3 GI:237681085
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3605)
AUTHORS Galeano,F., Rossetti,C., Tomaselli,S., Cifaldi,L., Lezzerini,M.,
Pezzullo,M., Boldrini,R., Massimi,L., Di Rocco,C.M., Locatelli,F.
and Gallo,A.
TITLE ADAR2-editing activity inhibits glioblastoma growth through the
modulation of the CDC14B/Skp2/p21/p27 axis
JOURNAL Oncogene 32 (8), 998-1009 (2013)
PUBMED 22525274
REMARK GeneRIF: Findings demonstrate that post-transcriptional A-to-I RNA
editing might be crucial for glioblastoma pathogenesis, identify
ADAR2-editing enzyme as a candidate tumor suppressor gene and
provide proof that ADAR2 may represent a suitable target.
REFERENCE 2 (bases 1 to 3605)
AUTHORS Yamashita,T., Hideyama,T., Teramoto,S. and Kwak,S.
TITLE The abnormal processing of TDP-43 is not an upstream event of
reduced ADAR2 activity in ALS motor neurons
JOURNAL Neurosci. Res. 73 (2), 153-160 (2012)
PUBMED 22414730
REMARK GeneRIF: ADAR2 activity does not consistently change due to the
overexpression or knockdown of TDP-43 or the expression of abnormal
TDP-43 in amyotrophic lateral sclerosis (ALS) motor neurons.
REFERENCE 3 (bases 1 to 3605)
AUTHORS Kawahara,Y., Ito,K., Ito,M., Tsuji,S. and Kwak,S.
TITLE Novel splice variants of human ADAR2 mRNA: skipping of the exon
encoding the dsRNA-binding domains, and multiple C-terminal splice
sites
JOURNAL Gene 363, 193-201 (2005)
PUBMED 16297572
REFERENCE 4 (bases 1 to 3605)
AUTHORS Slavov,D. and Gardiner,K.
TITLE Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2
genes and transcripts: conservation and diversity in editing site
sequence and alternative splicing patterns
JOURNAL Gene 299 (1-2), 83-94 (2002)
PUBMED 12459255
REFERENCE 5 (bases 1 to 3605)
AUTHORS Gerber,A., O'Connell,M.A. and Keller,W.
TITLE Two forms of human double-stranded RNA-specific editase 1 (hRED1)
generated by the insertion of an Alu cassette
JOURNAL RNA 3 (5), 453-463 (1997)
PUBMED 9149227
REFERENCE 6 (bases 1 to 3605)
AUTHORS Lai,F., Chen,C.X., Carter,K.C. and Nishikura,K.
TITLE Editing of glutamate receptor B subunit ion channel RNAs by four
alternatively spliced DRADA2 double-stranded RNA adenosine
deaminases
JOURNAL Mol. Cell. Biol. 17 (5), 2413-2424 (1997)
PUBMED 9111310
REFERENCE 7 (bases 1 to 3605)
AUTHORS Yang,J.H., Sklar,P., Axel,R. and Maniatis,T.
TITLE Purification and characterization of a human RNA adenosine
deaminase for glutamate receptor B pre-mRNA editing
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (9), 4354-4359 (1997)
PUBMED 9113993
REFERENCE 8 (bases 1 to 3605)
AUTHORS Mittaz,L., Scott,H.S., Rossier,C., Seeburg,P.H., Higuchi,M. and
Antonarakis,S.E.
TITLE Cloning of a human RNA editing deaminase (ADARB1) of glutamate
receptors that maps to chromosome 21q22.3
JOURNAL Genomics 41 (2), 210-217 (1997)
PUBMED 9143496
REFERENCE 9 (bases 1 to 3605)
AUTHORS O'Connell,M.A., Gerber,A. and Keller,W.
TITLE Purification of human double-stranded RNA-specific editase 1
(hRED1) involved in editing of brain glutamate receptor B pre-mRNA
JOURNAL J. Biol. Chem. 272 (1), 473-478 (1997)
PUBMED 8995285
REFERENCE 10 (bases 1 to 3605)
AUTHORS Melcher,T., Maas,S., Herb,A., Sprengel,R., Seeburg,P.H. and
Higuchi,M.
TITLE A mammalian RNA editing enzyme
JOURNAL Nature 379 (6564), 460-464 (1996)
PUBMED 8559253
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC030663.1, U76422.1 and BU726292.1.
On May 16, 2009 this sequence version replaced gi:75709171.
Summary: This gene encodes the enzyme responsible for pre-mRNA
editing of the glutamate receptor subunit B by site-specific
deamination of adenosines. Studies in rat found that this enzyme
acted on its own pre-mRNA molecules to convert an AA dinucleotide
to an AI dinucleotide which resulted in a new splice site.
Alternative splicing of this gene results in several transcript
variants, some of which have been characterized by the presence or
absence of an ALU cassette insert and a short or long C-terminal
region. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3), also known as DRADA2c, lacks
an alternate segment in the 3' coding region, compared to variant
2. The resulting isoform (3) has a shorter and distinct C-terminus,
compared to isoform 2, and contains the ALU cassette insert and the
short C-terminal region.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U76422.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085, ERS025090 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
undergoes RNA editing :: PMID: 11717408, 12045112
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-22 BC030663.1 10-31
23-2922 U76422.1 1-2900
2923-3203 U76422.1 2902-3182
3204-3584 U76422.1 3184-3564
3585-3605 BU726292.1 1-21 c
FEATURES Location/Qualifiers
source 1..3605
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="21"
/map="21q22.3"
gene 1..3605
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="adenosine deaminase, RNA-specific, B1"
/db_xref="GeneID:104"
/db_xref="HGNC:226"
/db_xref="HPRD:06777"
/db_xref="MIM:601218"
exon 1..216
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
exon 217..388
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
misc_feature 259..261
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="upstream in-frame stop codon"
variation 284
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190895413"
exon 389..463
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
CDS 436..2580
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="isoform 3 is encoded by transcript variant 3;
adenosine deaminase, RNA-specific, B1 (RED1 homolog rat);
adenosine deaminase, RNA-specific, B1 (homolog of rat
RED1); RNA editase; double-stranded RNA-specific editase
1; RNA editing deaminase 1; RNA-editing enzyme 1;
RNA-editing deaminase 1; dsRNA adenosine deaminase DRADA2"
/codon_start=1
/product="double-stranded RNA-specific editase 1 isoform
3"
/protein_id="NP_056649.1"
/db_xref="GI:7669479"
/db_xref="CCDS:CCDS42970.1"
/db_xref="GeneID:104"
/db_xref="HGNC:226"
/db_xref="HPRD:06777"
/db_xref="MIM:601218"
/translation="
MDIEDEENMSSSSTDVKENRNLDNVSPKDGSTPGPGEGSQLSNGGGGGPGRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYTLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKAEPPFYVGSNGDDSFSSSGDLSLSASPVPASLAQPPLPVLPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALAAIFNLHLDQTPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARIFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPNVYHESKLAAKEYQAAKVH
"
misc_feature 511..513
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P78563.1); phosphorylation site"
misc_feature 511..513
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 670..>813
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature 682..699
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78563.1);
Region: Interaction with substrate RNA (By similarity)"
misc_feature order(685..690,808..813)
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 745..750
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78563.1);
Region: Interaction with substrate RNA (By similarity)"
misc_feature 1138..>1275
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(1138..1140,1156..1161,1270..1275)
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 1144..1161
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78563.1);
Region: Interaction with substrate RNA (By similarity)"
misc_feature 1210..1212
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P78563.1);
Region: Interaction with substrate RNA (By similarity)"
misc_feature 1399..2571
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/note="tRNA-specific and double-stranded RNA adenosine
deaminase (RNA-specific editase); Region: ADEAMc;
smart00552"
/db_xref="CDD:128825"
exon 464..1398
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 493
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142180298"
variation 494
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:375341807"
variation 511
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201653105"
variation 528
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370431644"
variation 538
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141594032"
variation 563
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200269366"
variation 569
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144363543"
variation 603
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201038678"
variation 605
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:147822904"
variation 614
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141269164"
variation 629
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201786934"
variation 631
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143795052"
variation 632
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150318827"
variation 663
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2838798"
variation 670
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148374145"
variation 713..714
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="t"
/db_xref="dbSNP:36102117"
variation 741..742
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="g"
/db_xref="dbSNP:35259738"
variation 741
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150871717"
variation 744
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115658841"
variation 753
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201356458"
variation 778
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:78867942"
variation 792
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:146833412"
variation 796
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199805536"
variation 803
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143261942"
variation 849
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374872814"
variation 853
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367618294"
variation 892
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143826821"
variation 921
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148155796"
variation 968
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142958161"
variation 993
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146135960"
variation 1008
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61735850"
variation 1024..1025
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="g"
/db_xref="dbSNP:34030195"
variation 1066
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:78152471"
variation 1070
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200222908"
variation 1102
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145235270"
variation 1106
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199697177"
variation 1128
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377458378"
variation 1158
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139706517"
variation 1188
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:73384785"
variation 1194
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200567642"
variation 1212
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150844459"
variation 1224
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139263374"
variation 1243
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370937062"
variation 1265
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149552510"
variation 1266
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201273628"
variation 1278
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61735851"
variation 1294
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142476560"
variation 1305
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200806468"
variation 1317
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140656510"
variation 1354
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147692665"
variation 1366
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145945840"
variation 1376
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370266307"
exon 1399..1513
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1410
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114027650"
variation 1413
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112127672"
variation 1464..1465
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="c"
/db_xref="dbSNP:35834898"
variation 1509
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147573765"
exon 1514..1682
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1521
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199843457"
variation 1563
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370335315"
variation 1627
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200625156"
exon 1683..1831
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1707
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:139637757"
variation 1719
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142574659"
variation 1740
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150188818"
variation 1792
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138735662"
exon 1832..1951
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
exon 1952..2120
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 1995
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace=""
/replace="a"
/db_xref="dbSNP:34353015"
variation 1996
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183960739"
variation 2010
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190183213"
variation 2036
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201477864"
variation 2045
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150948356"
variation 2058
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:151225586"
variation 2064
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140716415"
variation 2091
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149878224"
exon 2121..2302
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2127
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139203173"
variation 2133
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201987444"
variation 2137
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146201109"
variation 2164
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367731799"
variation 2184
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372954828"
variation 2196
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146663117"
variation 2211
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370522638"
variation 2212
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183042891"
variation 2232
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377171441"
variation 2234
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187662077"
variation 2255
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192150622"
variation 2272
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142974408"
variation 2274
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:141463450"
exon 2303..2481
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2305
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202213478"
variation 2313
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371862858"
variation 2334
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374114165"
variation 2370
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200514838"
variation 2386
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143903410"
variation 2395
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188207954"
variation 2405
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148687014"
variation 2425
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:145150920"
variation 2426
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138974538"
variation 2427
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202057345"
variation 2448
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149395488"
exon 2482..2571
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2487
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367997843"
variation 2509
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143716305"
variation 2517
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1051367"
variation 2542
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201552994"
variation 2547
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:141891675"
exon 2572..3588
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/inference="alignment:Splign:1.39.8"
variation 2577
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368699178"
variation 2590
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374500062"
variation 2596
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144075386"
variation 2656
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370941785"
variation 2664
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187657496"
variation 2825
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:4819035"
variation 2836
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146517855"
variation 2842
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141163172"
variation 2859
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804760"
variation 2867
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:144872642"
variation 2903
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146796369"
variation 2992
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192150217"
variation 3079
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77712126"
variation 3090
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:79322398"
variation 3108
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:185670032"
variation 3115
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2838820"
variation 3123
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="t"
/db_xref="dbSNP:116146935"
variation 3182
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111308125"
variation 3223
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370390751"
variation 3285
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375264198"
STS 3326..3539
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="Cda0pa11"
/db_xref="UniSTS:74782"
variation 3374
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051385"
STS 3386..3557
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="D21S1720E"
/db_xref="UniSTS:150776"
variation 3400
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140433470"
variation 3405
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73386760"
STS 3447..3570
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/standard_name="G23228"
/db_xref="UniSTS:83279"
variation 3456
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="c"
/db_xref="dbSNP:11537553"
variation 3471
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377315991"
variation 3527
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:188985880"
variation 3530
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150434591"
variation 3587
/gene="ADARB1"
/gene_synonym="ADAR2; DRABA2; DRADA2; RED1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192378418"
ORIGIN
ctgaggcgctgaggcggccgtggcggcggcggcggcggcggcggcagcggcggccaagcggccaggttggcggccggggctccgggccgcgcgaggccacggccacgccgcgccgctgcgcacaaccaacgaggcagagcgccgcccggcgcgagactgcggccgaagcgtggggcgcgcgtgcggaggaccaggcgcggcgcggctgcggctgagagtggagcctttcaggctggcatggagagcttaaggggcaactgaaggagacacactggccaagcgcggagttctgcttacttcagtcctgctgagatactctctcagtccgctcgcaccgaaggaagctgccttgggatcagagcagacataaagctagaaaaatttcaagacagaaacagtctccgccagtcaagaaaccctcaaaagtattttgccatggatatagaagatgaagaaaacatgagttccagcagcactgatgtgaaggaaaaccgcaatctggacaacgtgtcccccaaggatggcagcacacctgggcctggcgagggctctcagctctccaatgggggtggtggtggccccggcagaaagcggcccctggaggagggcagcaatggccactccaagtaccgcctgaagaaaaggaggaaaacaccagggcccgtcctccccaagaacgccctgatgcagctgaatgagatcaagcctggtttgcagtacacactcctgtcccagactgggcccgtgcacgcgcctttgtttgtcatgtctgtggaggtgaatggccaggtttttgagggctctggtcccacaaagaaaaaggcaaaactccatgctgctgagaaggccttgaggtctttcgttcagtttcctaatgcctctgaggcccacctggccatggggaggaccctgtctgtcaacacggacttcacatctgaccaggccgacttccctgacacgctcttcaatggttttgaaactcctgacaaggcggagcctcccttttacgtgggctccaatggggatgactccttcagttccagcggggacctcagcttgtctgcttccccggtgcctgccagcctagcccagcctcctctccctgtcttaccaccattcccacccccgagtgggaagaatcccgtgatgatcttgaacgaactgcgcccaggactcaagtatgacttcctctccgagagcggggagagccatgccaagagcttcgtcatgtctgtggtcgtggatggtcagttctttgaaggctcggggagaaacaagaagcttgccaaggcccgggctgcgcagtctgccctggccgccatttttaacttgcacttggatcagacgccatctcgccagcctattcccagtgagggtcttcagctgcatttaccgcaggttttagctgacgctgtctcacgcctggtcctgggtaagtttggtgacctgaccgacaacttctcctcccctcacgctcgcagaaaagtgctggctggagtcgtcatgacaacaggcacagatgttaaagatgccaaggtgataagtgtttctacaggaacaaaatgtattaatggtgaatacatgagtgatcgtggccttgcattaaatgactgccatgcagaaataatatctcggagatccttgctcagatttctttatacacaacttgagctttacttaaataacaaagatgatcaaaaaagatccatctttcagaaatcagagcgaggggggtttaggctgaaggagaatgtccagtttcatctgtacatcagcacctctccctgtggagatgccagaatcttctcaccacatgagccaatcctggaagggtctcgctcttacacccaggctggagtgcagtggtgcaatcatggctcactgcagcctcgacctcctgggctcttaagcgatccttccacctcaaccttccaaggagctgggactacagaaccagcagatagacacccaaatcgtaaagcaagaggacagctacggaccaaaatagagtctggtgaggggacgattccagtgcgctccaatgcgagcatccaaacgtgggacggggtgctgcaaggggagcggctgctcaccatgtcctgcagtgacaagattgcacgctggaacgtggtgggcatccagggatccctgctcagcattttcgtggagcccatttacttctcgagcatcatcctgggcagcctttaccacggggaccacctttccagggccatgtaccagcggatctccaacatagaggacctgccacctctctacaccctcaacaagcctttgctcagtggcatcagcaatgcagaagcacggcagccagggaaggcccccaacttcagtgtcaactggacggtaggcgactccgctattgaggtcatcaacgccacgactgggaaggatgagctgggccgcgcgtcccgcctgtgtaagcacgcgttgtactgtcgctggatgcgtgtgcacggcaaggttccctcccacttactacgctccaagattaccaagcccaacgtgtaccatgagtccaagctggcggcaaaggagtaccaggccgccaaggtacactgaggaggggacggctccgtcttcacattgtgcacagatctgaggatgggattagcgaagctgtggagactgcacatccggacctgcccatgtctcaaaacaaacacatgtacagtggctctttttccttctcaaacactttaccccagaagcaggtggtctgccccaggcataaagaaggaaaattggccatctttcccacctctaaattctgtaaaattatagacttgctcaaaagattcctttttatcatccccacgctgtgtaagtggaaagggcattgtgttccgtgtgtgtccagtttacagcgtctctgccccctagcgtgttttgtgacaatctccctgggtgaggagtgggtgcacccagccccgaggccagtggttgctcggggccttccgtgtgagttctagtgttcacttgatgccggggaatagaattagagaaaactctgacctgccgggttccagggactggtggaggtggatggcaggtccgactcgaccatgacttagttgtaagggtgtgtcggctttttcagtctcatgtgaaaatcctcctgtctctggcagcactgtctgcactttcttgtttactgtttgaagggacgagtaccaagccacaagaacacttcttttggccacagcataagctgatggtatgtaaggaaccgatgggccattaaacatgaactgaacggttaaaagcacagtctatggaacgctaatggagtcagcccctaaagctgtttgctttttcaggctttggattacatgcttttaatttgattttagaatctggacactttctatgaatgtaattcggctgagaaacatgttgctgagatgcaatcctcagtgttctctgtatgtaaatctgtgtatacaccacacgttacaactgcatgagcttcctctcgcacaagaccagctggaactgagcatgagacgctgtcaaatacagacaaaggatttgagatgttctcaataaaaagaaaatgtttcactactcaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:104 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
GeneID:104 -> Molecular function: GO:0003725 [double-stranded RNA binding] evidence: IDA
GeneID:104 -> Molecular function: GO:0003726 [double-stranded RNA adenosine deaminase activity] evidence: IDA
GeneID:104 -> Molecular function: GO:0003729 [mRNA binding] evidence: TAS
GeneID:104 -> Molecular function: GO:0004000 [adenosine deaminase activity] evidence: IEA
GeneID:104 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:104 -> Biological process: GO:0006382 [adenosine to inosine editing] evidence: IDA
GeneID:104 -> Biological process: GO:0006382 [adenosine to inosine editing] evidence: TAS
GeneID:104 -> Biological process: GO:0006396 [RNA processing] evidence: IDA
GeneID:104 -> Biological process: GO:0006397 [mRNA processing] evidence: IEA
GeneID:104 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:104 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:104 -> Biological process: GO:0016553 [base conversion or substitution editing] evidence: IC
GeneID:104 -> Biological process: GO:0016556 [mRNA modification] evidence: TAS
GeneID:104 -> Biological process: GO:0030336 [negative regulation of cell migration] evidence: IDA
GeneID:104 -> Biological process: GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation] evidence: IDA
GeneID:104 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: IMP
GeneID:104 -> Biological process: GO:0045087 [innate immune response] evidence: IEA
GeneID:104 -> Biological process: GO:0051607 [defense response to virus] evidence: IEA
GeneID:104 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IDA
GeneID:104 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:104 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:104 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
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