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2024-04-21 01:10:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015658 2817 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens nucleolar complex associated 2 homolog (S. cerevisiae)
(NOC2L), mRNA.
ACCESSION NM_015658
VERSION NM_015658.3 GI:157694510
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2817)
AUTHORS Wu,J., Zhang,Y., Wang,Y., Kong,R., Hu,L., Schuele,R., Du,X. and
Ke,Y.
TITLE Transcriptional repressor NIR functions in the ribosome RNA
processing of both 40S and 60S subunits
JOURNAL PLoS ONE 7 (2), E31692 (2012)
PUBMED 22363708
REMARK GeneRIF: A transcriptional repressor NIR functions in the rRNA
biogenesis of both the 40S and 60S subunits.
REFERENCE 2 (bases 1 to 2817)
AUTHORS Wu,L., Ma,C.A., Zhao,Y. and Jain,A.
TITLE Aurora B interacts with NIR-p53, leading to p53 phosphorylation in
its DNA-binding domain and subsequent functional suppression
JOURNAL J. Biol. Chem. 286 (3), 2236-2244 (2011)
PUBMED 20959462
REMARK GeneRIF: Aurora B interacts with NIR-p53, leading to p53
phosphorylation in its DNA-binding domain and subsequent functional
suppression.
REFERENCE 3 (bases 1 to 2817)
AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
and Zoghbi,H.Y.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
REFERENCE 4 (bases 1 to 2817)
AUTHORS Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
TITLE Phosphoproteome analysis of the human mitotic spindle
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 103 (14), 5391-5396 (2006)
PUBMED 16565220
REFERENCE 5 (bases 1 to 2817)
AUTHORS Hublitz,P., Kunowska,N., Mayer,U.P., Muller,J.M., Heyne,K., Yin,N.,
Fritzsche,C., Poli,C., Miguet,L., Schupp,I.W., van Grunsven,L.A.,
Potiers,N., van Dorsselaer,A., Metzger,E., Roemer,K. and Schule,R.
TITLE NIR is a novel INHAT repressor that modulates the transcriptional
activity of p53
JOURNAL Genes Dev. 19 (23), 2912-2924 (2005)
PUBMED 16322561
REMARK GeneRIF: Upon recruitment by p53, NIR represses transcription of
both p53-dependent reporters and endogenous target genes
REFERENCE 6 (bases 1 to 2817)
AUTHORS Kim,J.E., Tannenbaum,S.R. and White,F.M.
TITLE Global phosphoproteome of HT-29 human colon adenocarcinoma cells
JOURNAL J. Proteome Res. 4 (4), 1339-1346 (2005)
PUBMED 16083285
REFERENCE 7 (bases 1 to 2817)
AUTHORS Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
TITLE Functional proteomic analysis of human nucleolus
JOURNAL Mol. Biol. Cell 13 (11), 4100-4109 (2002)
PUBMED 12429849
REFERENCE 8 (bases 1 to 2817)
AUTHORS Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
Mann,M. and Lamond,A.I.
TITLE Directed proteomic analysis of the human nucleolus
JOURNAL Curr. Biol. 12 (1), 1-11 (2002)
PUBMED 11790298
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA002961.1, BC003555.1, AW749585.1, AK225239.1 and BX645732.1.
On Sep 27, 2007 this sequence version replaced gi:142373530.
Summary: Histone modification by histone acetyltransferases (HAT)
and histone deacetylases (HDAC) can control major aspects of
transcriptional regulation. NOC2L represents a novel
HDAC-independent inhibitor of histone acetyltransferase (INHAT)
(Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar
2008].
##Evidence-Data-START##
Transcript exon combination :: AK225239.1, BC003555.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-27 DA002961.1 1-27
28-976 BC003555.1 1-949
977-984 AW749585.1 25-32
985-1901 BC003555.1 958-1874
1902-2301 AK225239.1 1857-2256
2302-2695 BC003555.1 2275-2668
2696-2789 BX645732.1 174-267
2790-2817 AK225239.1 2739-2766
FEATURES Location/Qualifiers
source 1..2817
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.33"
gene 1..2817
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/note="nucleolar complex associated 2 homolog (S.
cerevisiae)"
/db_xref="GeneID:26155"
/db_xref="HGNC:24517"
/db_xref="MIM:610770"
exon 1..85
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
CDS 60..2309
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/note="novel INHAT (inhibitor of histone
acetyltransferase) repressor; NOC2-like protein; protein
NOC2 homolog; novel INHAT repressor"
/codon_start=1
/product="nucleolar complex protein 2 homolog"
/protein_id="NP_056473.2"
/db_xref="GI:157694511"
/db_xref="CCDS:CCDS3.1"
/db_xref="GeneID:26155"
/db_xref="HGNC:24517"
/db_xref="MIM:610770"
/translation="
MAAAGSRKRRLAELTVDEFLASGFDSESESESENSPQAETREAREAARSPDKPGGSPSASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSDSDSSEEEEGPFHSLPDVLEEASEEEDGAEEGEDGDRVPRGLKGKKNSVPVTVAMVERWKQAAKQRLTPKLFHEVVQAFRAAVATTRGDQESAEANKFQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSSPLWGKLRVDIKAYLGSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVVVWSTGEESLRVLAFLVLSRVCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQLAIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTARFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQEKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQENSAYICSRRQRVSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLEDLNFPEIKRRKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDEEEGEEDSSNSEDGDPDAEAGLAPGELQQLAQGPEDELEDLQLSEDD
"
misc_feature 204..206
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y3T9.4); phosphorylation site"
misc_feature 225..227
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y3T9.4); phosphorylation site"
misc_feature 477..1928
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/note="Uncharacterized conserved protein [Function
unknown]; Region: COG5604"
/db_xref="CDD:35163"
misc_feature 1032..1928
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/note="Noc2p family; Region: Noc2; pfam03715"
/db_xref="CDD:202736"
misc_feature 2073..2075
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y3T9.4); phosphorylation site"
misc_feature 2076..2078
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9Y3T9.4); phosphorylation site"
misc_feature 2091..2093
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9Y3T9.4); phosphorylation site"
exon 86..238
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 239..413
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 414..545
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 546..666
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 667..757
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 758..836
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 837..947
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 948..1061
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1062..1250
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1251..1390
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1391..1502
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1503..1616
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1617..1718
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 1719..1862
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
variation 1726
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace="c"
/replace="t"
/db_xref="dbSNP:35471880"
variation 1737..1738
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace=""
/replace="g"
/db_xref="dbSNP:34516061"
exon 1863..1976
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
misc_feature <1902..>2301
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/product="Nucleolar complex protein 2 homolog"
variation 1902
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace="c"
/replace="t"
/db_xref="dbSNP:2272757"
exon 1977..2112
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 2113..2202
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
exon 2203..2800
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/inference="alignment:Splign:1.39.8"
variation 2631
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace="c"
/replace="t"
/db_xref="dbSNP:1133980"
STS 2639..2770
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/standard_name="SHGC-74122"
/db_xref="UniSTS:63760"
variation 2659
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace="c"
/replace="t"
/db_xref="dbSNP:3196153"
variation 2765
/gene="NOC2L"
/gene_synonym="NET15; NET7; NIR"
/replace="a"
/replace="g"
/db_xref="dbSNP:1134009"
ORIGIN
gtgcgcagccgcgcggcattctggggccggaagtggggtgcacgcttcgggttggtgtcatggcagctgcggggagccgcaagaggcgcctggcggagctgacggtggacgagttcctagcttcgggctttgactccgagtccgaatccgagtccgaaaattctccacaagcggagacacgggaagcacgcgaggctgcccggagtccggataagccgggcgggagcccctcggccagccggcgtaaaggccgtgcctctgagcacaaagaccagctctctcggctgaaggacagagaccccgagttctacaagttcctgcaggagaatgaccagagcctgctaaacttcagcgactcggacagctctgaggaggaagaggggccgttccactccctgccagatgtgctggaggaagccagtgaggaggaggatggagcggaggaaggagaagatggggacagagtccccagagggctgaaggggaagaagaattctgttcctgtgaccgtcgccatggttgagagatggaagcaggcagcaaagcaacgcctcactccaaagctgttccatgaagtggtacaggcgttccgagcagctgtggccaccacccgaggggaccaggaaagtgctgaggccaacaaattccaggtcacggacagtgctgcattcaatgctctggttaccttctgcatcagagacctcattggctgtctccagaagctgctgtttggaaaggtggcaaaggatagcagcaggatgctgcagccgtccagcagcccgctctgggggaagcttcgtgtggacatcaaggcttacctgggctcggccatacagctggtgtcctgtctgtcggagacgacggtgttggcggccgtgctgcggcacatcagcgtgctggtgccctgcttcctgaccttccccaagcagtgccgcatgctgctcaagagaatggtggtcgtatggagcactggggaagagtctctgcgggtgctggctttcctggtcctcagcagagtctgccggcacaagaaggacactttccttggccccgtcctcaagcaaatgtacatcacgtatgtgaggaactgcaagttcacctcgcctggtgccctccccttcatcagtttcatgcagtggaccttgacggagctgctggccctggagccgggtgtggcctaccagcacgccttcctctacatccgccagctcgccatacacctgcgcaacgccatgaccacccgcaagaaggaaacataccagtctgtgtacaactggcagtatgtgcactgcctcttcctgtggtgccgggtcctgagcactgcgggccccagcgaagccctccagcccttggtctacccccttgcccaagtcatcattggctgtatcaagctcatccccactgcccgcttctacccgctgcgaatgcactgcatccgtgccctgacgctgctctcggggagctcgggggccttcatcccggtgctgcctttcatcctggagatgttccagcaggtcgacttcaacaggaagccagggcgcatgagctccaagcccatcaacttctccgtgatcctgaagctgtccaatgtcaacctgcaggagaaggcgtaccgggacggcctggtggagcagctgtacgacctcaccctggagtacctgcacagccaggcacactgcatcggcttcccggagctggtgctgcctgtggtcctgcagctgaagtcgttcctccgggagtgcaaggtggccaactactgccggcaggtgcagcagctgcttgggaaggttcaggagaactcggcatacatctgcagccgccgccagagggtttccttcggcgtctctgagcagcaggcagtggaagcctgggagaagctgacccgggaagaggggacacccctgaccttgtactacagccactggcgcaagctgcgtgaccgggagatccagctggagatcagtggcaaagagcggctggaagacctgaacttccctgagatcaaacgaaggaagatggctgacaggaaggatgaggacaggaagcaatttaaagacctctttgacctgaacagctctgaagaggacgacaccgagggattctcggagagagggatactgaggcccctgagcactcggcatggggtggaagacgatgaagaggacgaggaggagggcgaggaggacagcagcaactcggaggatggagacccagacgcagaggcggggctggcccctggggagctgcagcagctggcccaggggccggaggacgagctggaggatctgcagctctcagaggacgactgaggcagcccatctggggggcctgtaggggctgccgggctggtggccagtgtttccacctccctggcagtcaggcctagaggctggcgtctgtgcagttgggggaggcagtagacacgggacaggctttattatttatttttcagcatgaaagaccaaacgtatcgagagctgggctgggctgggctggtgtggctgctgaagccccacagctgtgggctgctgaagtcagctccgcgggggagctgaccctgacgtcagcagaccgagaccagtcccagttccagggggaggcctgcaggcccctggccccttccaccacctctgccctccgtctgcagacctcgtccatctgcaccaggctctgccttcactcccccaagtctttgaaaatttgttcctttcctttgaagtcacattttcttttaaaattttttgttttgcatccgaaaccgaaagaaataaagcggtgggaggcagggccattgtgttgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:26155 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
GeneID:26155 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
GeneID:26155 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:26155 -> Molecular function: GO:0031491 [nucleosome binding] evidence: IDA
GeneID:26155 -> Molecular function: GO:0042393 [histone binding] evidence: IDA
GeneID:26155 -> Molecular function: GO:0070491 [repressing transcription factor binding] evidence: IDA
GeneID:26155 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:26155 -> Biological process: GO:0002903 [negative regulation of B cell apoptotic process] evidence: IMP
GeneID:26155 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:26155 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:26155 -> Biological process: GO:0031497 [chromatin assembly] evidence: IDA
GeneID:26155 -> Biological process: GO:0032066 [nucleolus to nucleoplasm transport] evidence: IDA
GeneID:26155 -> Biological process: GO:0034644 [cellular response to UV] evidence: IDA
GeneID:26155 -> Biological process: GO:0035067 [negative regulation of histone acetylation] evidence: IDA
GeneID:26155 -> Biological process: GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] evidence: IMP
GeneID:26155 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:26155 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
GeneID:26155 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
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