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2024-04-26 21:21:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015493 4966 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens KN motif and ankyrin repeat domains 2 (KANK2),
transcript variant 1, mRNA.
ACCESSION NM_015493 NM_017616
VERSION NM_015493.6 GI:258613874
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4966)
AUTHORS Kakinuma,N., Zhu,Y., Wang,Y., Roy,B.C. and Kiyama,R.
TITLE Kank proteins: structure, functions and diseases
JOURNAL Cell. Mol. Life Sci. 66 (16), 2651-2659 (2009)
PUBMED 19554261
REMARK Review article
REFERENCE 2 (bases 1 to 4966)
AUTHORS Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
TITLE Kank proteins: a new family of ankyrin-repeat domain-containing
proteins
JOURNAL Biochim. Biophys. Acta 1780 (2), 128-133 (2008)
PUBMED 17996375
REFERENCE 3 (bases 1 to 4966)
AUTHORS Zhang,Y., Zhang,H., Liang,J., Yu,W. and Shang,Y.
TITLE SIP, a novel ankyrin repeat containing protein, sequesters steroid
receptor coactivators in the cytoplasm
JOURNAL EMBO J. 26 (11), 2645-2657 (2007)
PUBMED 17476305
REMARK GeneRIF: SIP, a novel ankyrin repeat containing protein, sequesters
steroid receptor coactivators in the cytoplasm.
REFERENCE 4 (bases 1 to 4966)
AUTHORS Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of human RPE/choroid for the
NEIBank Project: over 6000 non-redundant transcripts, novel genes
and splice variants
JOURNAL Mol. Vis. 8, 205-220 (2002)
PUBMED 12107410
REMARK Publication Status: Online-Only
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB282630.1, AY639929.1, DA889034.1, AB040951.2 and BQ007409.1.
On Sep 17, 2009 this sequence version replaced gi:209969810.
Transcript Variant: This variant (1) encodes the longer isoform
(1). This variant may include additional exon structure in the 5'
UTR, but the nature of any additional structure is unclear due to
the lack of 5'-complete transcript data for this variant and the
presence of alternative splicing choices further upstream.
##Evidence-Data-START##
Transcript exon combination :: AY639929.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-79 DB282630.1 113-191
80-891 AY639929.1 1-812
892-979 DA889034.1 354-441
980-2659 AY639929.1 901-2580
2660-4946 AB040951.2 2870-5156
4947-4966 BQ007409.1 1-20 c
FEATURES Location/Qualifiers
source 1..4966
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2"
gene 1..4966
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="KN motif and ankyrin repeat domains 2"
/db_xref="GeneID:25959"
/db_xref="HGNC:29300"
/db_xref="MIM:614610"
exon 1..116
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
misc_feature 2..4
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="upstream in-frame stop codon"
variation 22
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="a"
/replace="g"
/db_xref="dbSNP:754528"
CDS 80..2659
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="isoform 1 is encoded by transcript variant 1;
matrix-remodelling associated 3; ankyrin repeat domain 25;
KN motif and ankyrin repeat domain-containing protein 2;
kidney ankyrin repeat-containing protein 2; SRC-1
interacting protein; SRC1-interacting protein;
SRC-1-interacting protein; matrix-remodeling-associated
protein 3; ankyrin repeat domain-containing protein 25;
SRC-interacting protein"
/codon_start=1
/product="KN motif and ankyrin repeat domain-containing
protein 2 isoform 1"
/protein_id="NP_056308.3"
/db_xref="GI:258613875"
/db_xref="CCDS:CCDS54219.1"
/db_xref="GeneID:25959"
/db_xref="HGNC:29300"
/db_xref="MIM:614610"
/translation="
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTAPPLSSPPGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE
"
misc_feature 80..295
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: Interaction with AIFM1"
misc_feature 134..136
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 173..274
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="KN motif; Region: KN_motif; pfam12075"
/db_xref="CDD:152510"
misc_feature 1145..1147
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 1202..1204
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 1493..1495
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q63ZY3.1); phosphorylation site"
misc_feature 1985..2410
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 2084..2479
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 2099..2191
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: ANK 1"
misc_feature 2108..2608
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: Interaction with NCOA1"
misc_feature 2330..2587
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 2399..>2587
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
variation 106
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:754529"
exon 117..1328
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1329..1496
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1497..1623
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1624..1863
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1864..1951
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1952..2171
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2172..2314
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2315..2515
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2516..2605
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2606..4950
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
variation 3149
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:892112"
STS 3412..3595
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/standard_name="RH45741"
/db_xref="UniSTS:16416"
variation 3959
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="a"
/replace="c"
/db_xref="dbSNP:892113"
variation 4051
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:3185010"
variation 4080..4081
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace=""
/replace="ca"
/db_xref="dbSNP:16423"
variation 4635
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:7187"
STS 4689..4861
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/standard_name="STS-W84522"
/db_xref="UniSTS:53506"
variation 4754
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="g"
/replace="t"
/db_xref="dbSNP:7188"
ORIGIN
gtaagcctcagccggtgctgcaggcagtctgactcgcagtccctcaagtgacttccaaggagcatctgtagaaaagaagatggcccaggtcctgcacgtgcctgctcccttcccagggacccctggcccagcctccccacctgccttccctgccaaggaccccgatccaccctactccgtggagaccccctatggctaccgcctggacctggacttcctcaagtacgtggatgacatcgagaagggccacacgctgcgacgcgtggcagtgcagcgccgcccccgcctgagctcgctgccccgtggccctggctcctggtggacgtccactgagtcgctgtgctccaatgccagtggggacagccgccactcagcctattcctactgcggccgtggcttctaccctcagtatggtgctctggagacccgcggtggcttcaatccgcgggtggagcgcacgctgctggatgcccgtcgccgtctcgaggaccaggcggccacacccaccggcctgggctccctgacccccagtgcggccggctcgacagcctccctggtgggcgtggggttgccacccccgacaccacggagttcaggactgtccacaccggtgcctcccagtgccgggcacctggcccacgtgcgggagcagatggcgggtgccctgcggaagctgcggcagctggaggagcaggtgaagctgatccctgtgctccaggtgaagctctcggtgctccaggaggaaaagcggcagctcacagtacaacttaagagccagaagttcctgggccaccccacagcgggccggggtcgcagcgagctctgcctggacctccccgatcccccagaggacccagtggcactggagacccggagtgtgggcacctgggttcgagaacgggacttgggcatgcctgatggggaggctgccctcgccgccaaggtcgctgtgctggagacccagctcaagaaggcgctgcaggagctgcaggcagctcaggcccggcaggctgacccccagccccaggcctggccaccgccggacagcccggtccgcgtggatacagtccgggtggtagaagggccacgggaggtggaggtggtggccagcacagccgctggcgcccccgcacagcgggcccagagcctggagccttacggcacagggctgagggccctggcaatgcctggtaggcctgagagcccacctgtgttccgcagccaggaggtggtggagacaatgtgcccagtgcccgctgcagctaccagcaacgtccatatggtgaagaagattagcatcacagagcgaagctgcgatggagcagcaggcctcccagaagttcctgccgaatcgtcttcgtcacccccggggtccgaggtagcctcccttacacagcctgagaagagcacaggccgagtgcccacccaggagcccacccacagggagcccaccaggcaagcagcctcccaagagtccgaggaggccgggggcaccgcacctccgctgtcctcccctccaggcgggcccccggcaggcgtgcgatctatcatgaaacggaaagaggaggttgcagaccccacggcccaccggaggagcctccagttcgtgggggtcaacggcgggtatgagtcgtcatccgaggactccagcacagcagagaacatctcagacaacgacagcacagagaacgaggccccagagccgagggagagggttccgagtgtggccgaagccccccagctcaggcctgcagggacggcagcggccaagaccagccggcaggagtgtcagctgtctcgagaatctcagcacatacccactgctgagggggcatcaggatcaaacacggaggaggagatcaggatggagctaagccctgacctcatctcagcctgcttggccctggaaaagtacctggacaatcccaacgccctcacagagcgggagctgaaagtggcctacaccacagtgctgcaggagtggctgcgcctggcctgccgcagcgacgcacaccccgagctggtgcggcggcacctggtcacgttccgggccatgtctgcgcggctgctggactacgtggtcaacatcgccgacagcaacggcaacacagccctgcactactccgtgtctcatgccaacttccccgtggtgcagcagctgctcgacagcggtgtctgcaaggtggacaaacagaaccgtgctggctacagccctattatgctcaccgccctggccaccctgaagacccaggacgacatcgagactgtccttcagctcttccggcttggcaacatcaatgccaaagccagccaggcaggacagacggccctgatgctggccgtcagccacgggcgggtggacgttgtcaaagccctgctggcctgtgaggcagatgtcaacgtgcaagatgatgacggctccacggccctcatgtgcgcctgtgagcacggccacaaggagatcgcggggctgctgctggccgtgcccagctgtgacatctcactcacagatcgcgatgggagcacagctctgatggtggccttggacgcagggcagagtgagattgcgtccatgctgtattcccgcatgaacatcaagtgctcgtttgccccaatgtcagatgacgagagccctacatcatcctcggcagaagagtagccgtgagggaggcggggaccagccagaccgggagcaaaccgtcccttgtccccgtctcctccctgttcccgttcctccctggcccaccccactcacactccccaaggcccacggctcaaaggcaagcgagctctccctctgcttccctgggggagccccgacggccacaggactccagctccaagtgggttttcttggctcccctgttcaaagtggccacagcgcagaccgaagcaaaattcttgtatacattggcgccagggctgatgctggggtgtgggttttatgaagaacattgagaacaatcagctggtaattatggatggaggaagagggagaggaaaaaaatattgtatttttgaatcattgttgcaggagggggtgggaatcttaggatttgttgccagatttgaaagtcactggaacttgcatattttcattttaatcctaagtgttattacgcaccagttggggttcacccttcatcccccacatttaattgtctgatatagaatagtgttgtgtccactgccccgctagacggctttcttaggggaattttcttctggttgtttcacaagacagattctgtccttgtcacccgggacagaaaactcagtcttttcaccctcattcagatgaagggactcaggacaggctctgtgacttacagggacccaatcaattcacaatgagaaattaccggccaggcgtggtgactcacgtctgtaatcccagcactttgggagggcaaggcaagagcttgagcttgagcctagacgttaaagaccagcctgggcaacacagcaagacccatctctacaagaaatttaaaaactagccaggcgtggtggtgcgcgcctgtagtcccagctacttgggaggctgagccctggaggtcgaggctacagtgagctatgatcacaccattgcacttcagcctgggcgacacagcgagaccctgtctcaagaaagaaaagaaaaagagacaaattacccagaaacccctcccttccccacatggaggccttggcaaatgttaattttcctagaaaatccttcagacctgaagacgcaggaaaagaatctggctctcagggtggcttctgcgtccccgccgccaggccccagactatggtcacagggccgtcctgttcctccccgggactccagaatttctctcctcaaaggaaagaaaacagggcatgcgcttgttggcaaaacgcagggccggctcccaaaaaccccatgtgtgtacgattaaaagttggccgtccccaggcctcccagcgcaaacttaaagagacagggctttgctgaaaaccaaacatgggccagctgggctttttaacaacctagagactttccggagctgcctggaacagagcctgcgggaaacggggcttgccagagacactcacagtttccttcatggcctgttttggtcccctaagaatctccacatcattgtctttcttgtgccttttccttggtgagcaacagaaagggaagggttccaagcctctaaaaatgtgctttgtgatcaggagtgcgctccaaaccaaatacgcgcgctgccctttcgaggccagtgagctcagcctccaaggctttaaagccacatttcagcaagagaaagcgctgagagctcgcaggttcattaaagaaggcaaagcactggtttctctccttagaaaagtaggtttcttggcttgatgtagactggcttgctttgatttttagtgaagggaatgtacgtaaaacaaaatagggcttggctggtcaaaggagacaagcaggatggatggatggatggatggatggatggatggatggatggatggatgaatagatagatggtgtttgcatgtaaattgcagagaaaacaaaaccaaagctgattggaaacaattaattgtgggtgtctgagggggaaggtcgcagctttgggcagctttgagaagcggtacaagagttctgtgcctgtgtgtccagccctggagccagccagtgcatttattttaagctcttagaagcaactccttggcccaggaatgcgtgacccctgagatgggtccacgcatctctctacacttccttctctccgtgggatactggactcgtgcctctgcgcccattctcttctcacgcatatccatgagctttaatttcactttctgatcacggtacgtccataaagccagtattacacttaaatgaagtattcttttttgtaatcgttttttttagaaggtaaacaaatttaataaagctaccaataatgttgatgaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25959 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25959 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:25959 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:25959 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:25959 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:25959 -> Biological process: GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway] evidence: IDA
GeneID:25959 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IDA
GeneID:25959 -> Biological process: GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:25959 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:25959 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
by
@meso_cacase at
DBCLS
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