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2024-04-20 00:03:14, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015477 6697 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SIN3 transcription regulator homolog A (yeast)
(SIN3A), transcript variant 2, mRNA.
ACCESSION NM_015477
VERSION NM_015477.2 GI:223941787
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6697)
AUTHORS Icardi,L., Mori,R., Gesellchen,V., Eyckerman,S., De Cauwer,L.,
Verhelst,J., Vercauteren,K., Saelens,X., Meuleman,P.,
Leroux-Roels,G., De Bosscher,K., Boutros,M. and Tavernier,J.
TITLE The Sin3a repressor complex is a master regulator of STAT
transcriptional activity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (30), 12058-12063 (2012)
PUBMED 22783022
REMARK GeneRIF: The Sin3a complex acts as a context-dependent ISGF3/STAT3
transcriptional switch.
REFERENCE 2 (bases 1 to 6697)
AUTHORS Bartholomew,C.R., Suzuki,T., Du,Z., Backues,S.K., Jin,M.,
Lynch-Day,M.A., Umekawa,M., Kamath,A., Zhao,M., Xie,Z., Inoki,K.
and Klionsky,D.J.
TITLE Ume6 transcription factor is part of a signaling cascade that
regulates autophagy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (28), 11206-11210 (2012)
PUBMED 22733735
REMARK GeneRIF: Ume6 is a negative regulator of ATG8 transcription, which
acts along with a histone deacetylase complex including Sin3 and
Rpd3 to regulate Atg8 levels
REFERENCE 3 (bases 1 to 6697)
AUTHORS Lu,P., Hankel,I.L., Hostager,B.S., Swartzendruber,J.A.,
Friedman,A.D., Brenton,J.L., Rothman,P.B. and Colgan,J.D.
TITLE The developmental regulator protein Gon4l associates with protein
YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates
transcriptional repression
JOURNAL J. Biol. Chem. 286 (20), 18311-18319 (2011)
PUBMED 21454521
REMARK GeneRIF: Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that
Gon4l may function as a platform for the assembly of complexes that
regulate gene expression.
REFERENCE 4 (bases 1 to 6697)
AUTHORS Cheng,P.Y., Lin,Y.P., Chen,Y.L., Lee,Y.C., Tai,C.C., Wang,Y.T.,
Chen,Y.J., Kao,C.F. and Yu,J.
TITLE Interplay between SIN3A and STAT3 mediates chromatin conformational
changes and GFAP expression during cellular differentiation
JOURNAL PLoS ONE 6 (7), E22018 (2011)
PUBMED 21779366
REMARK GeneRIF: Interplay between SIN3A and STAT3 mediates chromatin
conformational changes and GFAP expression during cellular
differentiation.(
REFERENCE 5 (bases 1 to 6697)
AUTHORS Aouizerat,B.E., Vittinghoff,E., Musone,S.L., Pawlikowska,L.,
Kwok,P.Y., Olgin,J.E. and Tseng,Z.H.
TITLE GWAS for discovery and replication of genetic loci associated with
sudden cardiac arrest in patients with coronary artery disease
JOURNAL BMC Cardiovasc Disord 11, 29 (2011)
PUBMED 21658281
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 6697)
AUTHORS Laherty,C.D., Yang,W.M., Sun,J.M., Davie,J.R., Seto,E. and
Eisenman,R.N.
TITLE Histone deacetylases associated with the mSin3 corepressor mediate
mad transcriptional repression
JOURNAL Cell 89 (3), 349-356 (1997)
PUBMED 9150134
REMARK GeneRIF: mSin3A interacts with HDAC2 via the HDAC-interacting
domain (HID) of mSin3A.
GeneRIF: The transcriptional repressor mSin3A associates with
histone deacetylase 1 forming a co-repressor complex. See also PMID
(PubMed identifier) 9150133.
REFERENCE 7 (bases 1 to 6697)
AUTHORS Hassig,C.A., Fleischer,T.C., Billin,A.N., Schreiber,S.L. and
Ayer,D.E.
TITLE Histone deacetylase activity is required for full transcriptional
repression by mSin3A
JOURNAL Cell 89 (3), 341-347 (1997)
PUBMED 9150133
REFERENCE 8 (bases 1 to 6697)
AUTHORS Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
TITLE Mad3 and Mad4: novel Max-interacting transcriptional repressors
that suppress c-myc dependent transformation and are expressed
during neural and epidermal differentiation
JOURNAL EMBO J. 14 (22), 5646-5659 (1995)
PUBMED 8521822
REMARK Erratum:[EMBO J. 1996 Apr 15;15(8):2030. PMID: 8617250]
REFERENCE 9 (bases 1 to 6697)
AUTHORS Halleck,M.S., Pownall,S., Harder,K.W., Duncan,A.M., Jirik,F.R. and
Schlegel,R.A.
TITLE A widely distributed putative mammalian transcriptional regulator
containing multiple paired amphipathic helices, with similarity to
yeast SIN3
JOURNAL Genomics 26 (2), 403-406 (1995)
PUBMED 7601471
REFERENCE 10 (bases 1 to 6697)
AUTHORS Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
TITLE Mad-Max transcriptional repression is mediated by ternary complex
formation with mammalian homologs of yeast repressor Sin3
JOURNAL Cell 80 (5), 767-776 (1995)
PUBMED 7889570
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF418569.1, BC041047.1,
AC068338.14 and BM676304.1.
On Feb 21, 2009 this sequence version replaced gi:23397665.
Summary: The protein encoded by this gene is a transcriptional
regulatory protein. It contains paired amphipathic helix (PAH)
domains, which are important for protein-protein interactions and
may mediate repression by the Mad-Max complex. [provided by RefSeq,
Jul 2008].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1, 2 and 3 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF418569.1, BC137098.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3998 AF418569.1 1-3998
3999-5130 BC041047.1 642-1773
5131-6217 AC068338.14 4815-5901
6218-6697 BM676304.1 1-480 c
FEATURES Location/Qualifiers
source 1..6697
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q24.2"
gene 1..6697
/gene="SIN3A"
/note="SIN3 transcription regulator homolog A (yeast)"
/db_xref="GeneID:25942"
/db_xref="HGNC:19353"
/db_xref="HPRD:09690"
/db_xref="MIM:607776"
exon 1..226
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 227..448
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
misc_feature 233..235
/gene="SIN3A"
/note="upstream in-frame stop codon"
CDS 260..4081
/gene="SIN3A"
/note="transcriptional co-repressor Sin3A; histone
deacetylase complex subunit Sin3a; transcriptional
corepressor Sin3a; transcriptional regulator, SIN3A; SIN3
homolog A, transcription regulator"
/codon_start=1
/product="paired amphipathic helix protein Sin3a"
/protein_id="NP_056292.1"
/db_xref="GI:23397666"
/db_xref="CCDS:CCDS10279.1"
/db_xref="GeneID:25942"
/db_xref="HGNC:19353"
/db_xref="HPRD:09690"
/db_xref="MIM:607776"
/translation="
MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTPSYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
"
misc_feature 281..>2725
/gene="SIN3A"
/note="Histone deacetylase complex, SIN3 component
[Chromatin structure and dynamics]; Region: SIN3; COG5602"
/db_xref="CDD:35161"
misc_feature 287..289
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 614..847
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with HCFC1"
misc_feature 680..820
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 872..1699
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with REST (By similarity)"
misc_feature 1088..1090
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 1223..1402
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 1631..1834
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with SAP30 (By similarity)"
misc_feature 1664..1666
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q96ST3.2); acetylation site"
misc_feature 1691..1828
/gene="SIN3A"
/note="Paired amphipathic helix repeat; Region: PAH;
pfam02671"
/db_xref="CDD:202341"
misc_feature 1826..2809
/gene="SIN3A"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with NCOR1 (By similarity)"
misc_feature 1829..2236
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with SUDS3 and SAP130"
misc_feature 1907..2209
/gene="SIN3A"
/note="Sin3 family co-repressor; Region: Sin3_corepress;
pfam08295"
/db_xref="CDD:191990"
misc_feature 2318..2746
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with HDAC1 and ARID4B"
misc_feature 2753..2755
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 2753..2755
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2837..2839
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 2837..2839
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2921..3160
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96ST3.2);
Region: Interaction with OGT"
misc_feature 3077..3079
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 3593..3595
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96ST3.2); phosphorylation site"
misc_feature 3593..3595
/gene="SIN3A"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 449..625
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 626..732
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 733..1015
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
variation 906
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:199949593"
exon 1016..1267
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1268..1420
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1421..1576
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1577..1666
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1667..1785
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1786..1996
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 1997..2113
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2114..2352
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2353..2536
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 2537..3110
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3111..3280
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3281..3454
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3455..3547
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3548..3642
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3643..3850
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
exon 3851..6681
/gene="SIN3A"
/inference="alignment:Splign:1.39.8"
STS 4139..4330
/gene="SIN3A"
/standard_name="D15S735E"
/db_xref="UniSTS:151629"
STS 4211..4363
/gene="SIN3A"
/standard_name="RH101985"
/db_xref="UniSTS:96319"
STS 4251..5143
/gene="SIN3A"
/standard_name="SIN3A_8019"
/db_xref="UniSTS:471761"
variation 4960
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551123"
polyA_signal 5100..5105
/gene="SIN3A"
polyA_signal 5104..5109
/gene="SIN3A"
polyA_site 5130
/gene="SIN3A"
variation 5387
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11551122"
polyA_signal 6663..6668
/gene="SIN3A"
variation 6672
/gene="SIN3A"
/replace="c"
/replace="t"
/db_xref="dbSNP:16967090"
polyA_site 6681
/gene="SIN3A"
ORIGIN
ccagtctgggcaccggagcctgtgaccgcttcgttagtggagaggtagctggcagtccgcttcggcgggcctgtgccccgcgccgttctcggggcctccctgctgagctcgcggctcacgctgagagggacacgcagtgacgagcggccgaagcagctttgcggtgagagcacgctgggccgggggccgggcgggagcctggtggcgggtaacgccggactcgagggttttgtagtgcatccctgagcatgagcacagaatgaagcggcgtttggatgaccaggagtcaccggtgtatgcagcccagcagcgtcggatccctggcagcacagaggcttttcctcaccagcaccgggtgcttgcccctgcccctcctgtgtatgaagcagtgtctgagaccatgcagtcagctacgggaattcagtactctgtaacacccagctaccaggtttcagccatgccacagagctccggcagtcatgggcccgctatagcagcagttcatagcagccatcatcacccaacagcggtgcagccccacggaggccaggtggtccagagtcatgctcatccagccccaccagttgcaccagtgcagggacagcagcaatttcagaggctgaaggtggaggatgcgctatcttatcttgaccaggtgaagctgcagtttggtagtcagcctcaggtctacaatgatttccttgacatcatgaaggaatttaaatctcagagcatcgacaccccaggagtgattagtcgtgtgtcccagctattcaaaggccaccccgatctgataatgggattcaacaccttcttgccccctggctacaaaattgaggtgcaaaccaatgacatggtgaatgtgacaactcctggccaggttcatcagattcccacccatggcatccagccacagcctcaaccaccaccccaacatccttcccagccttcagcccagtcagccccagctcctgcccagccagctcctcagcccccacctgccaaagtcagcaagccctcccaactgcaagcacatactccggccagtcagcagactcccccacttccaccgtatgcatccccacgttctccgccggtccagcctcacacaccagtgacaatctcgttgggaacggccccatccttgcagaacaatcaacctgtggagtttaatcatgccatcaactatgttaataagatcaagaacagatttcagggccaaccagacatctacaaagcattcctggagattttgcacacatatcagaaagagcagagaaatgccaaggaagctggaggaaactacactccagcattgacagagcaggaggtgtatgcccaggttgctcgtctctttaaaaaccaggaagatttgttgtcagagtttggacaattcctaccagatgccaacagctccgtgcttttaagcaaaacaactgctgagaaggttgattctgtgagaaatgatcatggaggcactgtcaagaagccccaactgaacaacaagccgcagaggcccagccagaatggctgccagatccgcagacatcctacaggaaccacccctccagttaagaagaaacccaaactgctcaatctgaaggattcttctatggcagatgccagcaaacatggtggtggaacagaatcgttattttttgataaggtccgaaaggctcttcggagtgcagaagcctacgaaaatttcctacgctgtcttgttatttttaaccaggaggtgatctctcgtgctgagcttgtgcaactagtctctcctttcctggggaaattccctgagttgtttaattggtttaaaaactttctgggctataaggagtctgtacatctggaaacttatccaaaggagcgagccacagagggcattgctatggagatagattatgcttcttgtaaacgattgggctccagctatcgagccttaccaaagagttaccagcagcccaagtgtacaggacggactcctctctgtaaagaggttttaaatgatacctgggtttccttcccttcgtggtctgaggactctacctttgtgagttccaagaagactcaatatgaagaacatatttatcgttgtgaagatgaacgctttgagcttgatgtagttttagagaccaatctggcaacaatccgggttctggaagcaatacagaagaagctttcccgcttgtctgctgaagaacaagccaaatttcgcttggacaacacccttgggggcacatcagaagtcatccatagaaaagcactccagaggatatatgctgataaagcagctgacatcattgatggtctgagaaagaatccctccattgctgttccaattgtccttaaaaggttgaagatgaaagaggaagaatggcgagaagctcagagaggctttaacaaagtatggcgagaacaaaatgagaaatactacttgaagtctctggaccaccaggggatcaactttaaacagaatgacaccaaggtcctgaggtctaagagcttactcaatgagattgagagtatctatgatgagaggcaagagcaggctacggaggagaatgctggtgtacctgttggcccacacctctcacttgcgtatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagaggcagacaggcattcagaaggaggacaaatataagataaaacaaatcatgcatcattttattccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaagagatggatgtagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagtccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaagaggaatggatgaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccagattctctgcctgaggctgctacggatttgttcccaagccgaacggcaaattgaagaagaaaaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagccctgccattcagctacgtctcaaagaacctatggatgttgatgtagaagattattacccagctttcctggacatggtgcggagcctgctggatggcaacatagactcatcacagtatgaagattcactgagagagatgttcaccattcatgcctacattgcctttaccatggacaaactgatccagagcattgtcagacagctgcagcatatcgtgagtgatgagatctgtgtgcaggtgactgacctttacctggcagaaaataataatggggccaccggaggccagctgaacacacagaactcaaggagcctcctggagtcaacgtatcagcggaaagctgagcagctaatgtcagatgagaattgctttaagcttatgtttattcagagccaaggccaggtccagctgactattgagcttctggacacagaagaggagaattcggatgaccctgtggaagcagagcgctggtcagactacgtggagcgatacatgaattcagatactacctcgcctgagcttcgtgaacatctagcacagaaaccagtatttctccccaggaatctacggcggatccggaagtgtcaacgtggtcgagagcagcaggaaaaggaagggaaggaaggaaacagcaagaagaccatggagaatgtggatagtctggataagctggagtgtagattcaagctgaattcctacaagatggtgtatgtgatcaaatcagaggactatatgtatcggaggaccgccctgctccgggctcatcagtcccatgagcgtgtaagcaagcgtctacatcagagattccaggcctgggtagataaatggaccaaggagcatgtgccccgtgaaatggcagcagagaccagcaagtggctcatgggtgaggggctggagggcctggtgccctgtaccaccacctgtgatacagagaccctgcattttgtgagcattaacaagtatcgtgtcaaatacggcacagtattcaaagccccttaactgcaaagccagagcagataacttggggtgtgtgtggggatgtgtgtgtgggcctatgcactcacacactgaagaaacaaggaagatgcctttcaagcctcactgggcctctctgggacatggccacctgacctgtgtgtggctggtgcagcctggcaccaagtgggctacctgttaggaacatgaataccttacaaagctgaagctggaacttttcccaaagggttttgggtatagcctgccctggaggggaaggaagtccatgcaagcaaagacatgcagtttgcttgcacacaccagcagagctaagactggagtctcctgtggcctaactttcaatgagggaaccggatgctgttcacactttgactggatggagatgcatttacaaaacagactggagaaggacttaatactcagatggattggaactatcatggtcactgctcctctcccctccccacaaaaggaaaaaaaagctggatttgattttttttttctggtcactcgagcacatctaagatcacccattaggttttatctgggacctgcagtttggctttgggattgatcatcttgtggattttattcctgacgattcccttgctgcctacccttttctctcctctggttctcaacctcaacgagttcaaatcagttgtcctttttagctcccgtggaactgttttgtatctgcctctttactagtctaccttagtgccatccaccagctttactctctgacacacacacgcacacacacacacaattttaacttgtttttttgtacataatgtacatactgtcaattttttattaaaagaaatatgctttgatgtgctagcataactgctctagcttcttgtgtaccatagtactgtggcttcagatttagtacctatgaacagatgtacaagacatttattacactttttaccaaagggagttaccattgtagtacttttgtgtaaaacttgtcttcccctttgcccccaacttttttttttttttttttgtaaataaataaagcttggttcttacttaaggaataaactctcaacccacgtcccttgtcctcaccagaaaatactgtgaagcagggattttgacttcagttccttatccagggtagaaacaggattttgcttaaaatacttgttacttgtcccaaatcaaaatattccaaaatcttagaatacttaagtcttttagtacgtgtttttttcccttgttcaaataatctgaaaatattttatatttgggtaagttgtcaagctatgtagtttgtatttctatatattttttcttattcacattggtgatggatgggggtgagcaacttaaataccaaaccagtgtttgaaaaaaaagtgtgcataaggcatgtggtataccttataaatggagttgggagggagagaatttgaaatgggatacctatttttttaattacataaatttaaactagcagacatttaaacatgaatgattaggatttttctatgtggttaacctggactttctgaacaaagaccaactgagcccctcccagtactctggtggatttttcttcagcaaccattacgcaagtcttagttgtaaccagcaatgttctgtgtgttttatgtttgctttttagttaaaaatcaccaccaccaccaaaaagaaaaacaaaattttttggctcctggattttcaaaacacatggtagacctctctgattttaggcttttattgtttaaagacagtgtctcgctttatgacccacactggagtgcagtgccacgatcatagctcactgcaggcttgacctcccaggctcaagcagtcctcccacctcggcctcctgagtagctgcatgccaccacgcccagctaattttttaactttttgtagagacagggtcttgctatgctgcccaggttggtctcaaactcctggcctcaagctgtcctcccacctcggcctcgcaaagtgctgagattacaggtgtgagccaccctggcctgattttaggctttttttgtactggggagaagagactgtgagccaaagtgtagggtgccaaaaagagctttgtgggatgagattttagggcaaagctggggcagtgtctgacttggcggtggtcatgtgtactgatttaggggaaagatcttgaggttttctcaaataattcacctatccccgtgttccctcaagaaaggtcatgttgacctggaaccataggggaaattggtggggtgtgatcagggtcagccccagctgttgctgcccctgcagtgttttgtccagagcacttgcctgcaggtcaggataggatttcaaggccagttcaggagaaagtcccaacccaccagtgcaaccaacaaaagagtaagttttacctacagcctgggttttcacaagtagcatttttattcctcctgctgtctgacatctgagctccaagctctaaacccaacctgtattatatgcagcagcaggttatctttgttttaaatcacatttgttattctgtacttagtcacctttccgtgtgatctgcatttgaaatgttgtaaacttggtcagtatttccattaaaatatcagggctaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25942 -> Molecular function: GO:0001102 [RNA polymerase II activating transcription factor binding] evidence: IPI
GeneID:25942 -> Molecular function: GO:0001103 [RNA polymerase II repressing transcription factor binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0001106 [RNA polymerase II transcription corepressor activity] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:25942 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: RCA
GeneID:25942 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25942 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:25942 -> Molecular function: GO:0033558 [protein deacetylase activity] evidence: IMP
GeneID:25942 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:25942 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:25942 -> Biological process: GO:0002218 [activation of innate immune response] evidence: IMP
GeneID:25942 -> Biological process: GO:0002230 [positive regulation of defense response to virus by host] evidence: IMP
GeneID:25942 -> Biological process: GO:0006260 [DNA replication] evidence: IEA
GeneID:25942 -> Biological process: GO:0006476 [protein deacetylation] evidence: IMP
GeneID:25942 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:25942 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:25942 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
GeneID:25942 -> Biological process: GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:25942 -> Biological process: GO:0031937 [positive regulation of chromatin silencing] evidence: IMP
GeneID:25942 -> Biological process: GO:0034613 [cellular protein localization] evidence: IEA
GeneID:25942 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:25942 -> Biological process: GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] evidence: IEA
GeneID:25942 -> Biological process: GO:0044255 [cellular lipid metabolic process] evidence: TAS
GeneID:25942 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:25942 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:25942 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:25942 -> Biological process: GO:0051595 [response to methylglyoxal] evidence: IEA
GeneID:25942 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:25942 -> Biological process: GO:1900181 [negative regulation of protein localization to nucleus] evidence: IMP
GeneID:25942 -> Biological process: GO:1901675 [negative regulation of histone H3-K27 acetylation] evidence: IMP
GeneID:25942 -> Biological process: GO:2000678 [negative regulation of transcription regulatory region DNA binding] evidence: IMP
GeneID:25942 -> Cellular component: GO:0000776 [kinetochore] evidence: IEA
GeneID:25942 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:25942 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:25942 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:25942 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:25942 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:25942 -> Cellular component: GO:0016580 [Sin3 complex] evidence: IDA
GeneID:25942 -> Cellular component: GO:0016580 [Sin3 complex] evidence: NAS
GeneID:25942 -> Cellular component: GO:0017053 [transcriptional repressor complex] evidence: IEA
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