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2024-03-28 21:08:13, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_015368               2782 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens pannexin 1 (PANX1), mRNA.
ACCESSION   NM_015368
VERSION     NM_015368.3  GI:39995063
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Lohman,A.W., Weaver,J.L., Billaud,M., Sandilos,J.K., Griffiths,R.,
            Straub,A.C., Penuela,S., Leitinger,N., Laird,D.W., Bayliss,D.A. and
            Isakson,B.E.
  TITLE     S-nitrosylation inhibits pannexin 1 channel function
  JOURNAL   J. Biol. Chem. 287 (47), 39602-39612 (2012)
   PUBMED   23033481
  REMARK    GeneRIF: S-nitrosylation of Panx1 at Cys-40 and Cys-346 inhibits
            Panx1 channel currents and ATP release.
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Xiao,F., Waldrop,S.L., Khimji,A.K. and Kilic,G.
  TITLE     Pannexin1 contributes to pathophysiological ATP release in
            lipoapoptosis induced by saturated free fatty acids in liver cells
  JOURNAL   Am. J. Physiol., Cell Physiol. 303 (10), C1034-C1044 (2012)
   PUBMED   22972801
  REMARK    GeneRIF: These results suggest that panx1 contributes to
            pathophysiological ATP release in lipoapoptosis induced by
            saturated FFA; panx1 may play a role in hepatic inflammation by
            mediating an increase in extracellular ATP concentration in
            lipotoxic liver injury.
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Penuela,S., Gyenis,L., Ablack,A., Churko,J.M., Berger,A.C.,
            Litchfield,D.W., Lewis,J.D. and Laird,D.W.
  TITLE     Loss of pannexin 1 attenuates melanoma progression by reversion to
            a melanocytic phenotype
  JOURNAL   J. Biol. Chem. 287 (34), 29184-29193 (2012)
   PUBMED   22753409
  REMARK    GeneRIF: while Panx1 is present in skin melanocytes it is
            up-regulated during melanoma tumor progression, and tumorigenesis
            can be inhibited by the knockdown of Panx1 raising the possibility
            that Panx1 may be a viable target for the treatment of melanoma.
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Cowan,K.N., Langlois,S., Penuela,S., Cowan,B.J. and Laird,D.W.
  TITLE     Pannexin1 and Pannexin3 exhibit distinct localization patterns in
            human skin appendages and are regulated during keratinocyte
            differentiation and carcinogenesis
  JOURNAL   Cell Commun. Adhes. 19 (3-4), 45-53 (2012)
   PUBMED   22947051
  REMARK    GeneRIF: Panx1 level is modulated during keratinocyte
            differentiation and carcinogenesis and reveal distinct localization
            pattern for Panx1 in human adnexal structures.
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Sandilos,J.K., Chiu,Y.H., Chekeni,F.B., Armstrong,A.J., Walk,S.F.,
            Ravichandran,K.S. and Bayliss,D.A.
  TITLE     Pannexin 1, an ATP release channel, is activated by caspase
            cleavage of its pore-associated C-terminal autoinhibitory region
  JOURNAL   J. Biol. Chem. 287 (14), 11303-11311 (2012)
   PUBMED   22311983
  REMARK    GeneRIF: mechanism of PANX1 channel regulation
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Locovei,S., Bao,L. and Dahl,G.
  TITLE     Pannexin 1 in erythrocytes: function without a gap
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (20), 7655-7659 (2006)
   PUBMED   16682648
  REMARK    GeneRIF: Data show that erythrocytes express the gap junction
            protein pannexin 1.
REFERENCE   7  (bases 1 to 2782)
  AUTHORS   Thompson,R.J., Zhou,N. and MacVicar,B.A.
  TITLE     Ischemia opens neuronal gap junction hemichannels
  JOURNAL   Science 312 (5775), 924-927 (2006)
   PUBMED   16690868
  REMARK    GeneRIF: Pannexin-1 in pyramidal neurons is activated by ischemia
            and may play an important role ionic dysregulation
REFERENCE   8  (bases 1 to 2782)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   9  (bases 1 to 2782)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 100 (23), 13644-13649 (2003)
   PUBMED   14597722
REFERENCE   10 (bases 1 to 2782)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016931.1, AF398509.1,
            AK074897.1, AY359023.1 and CA418094.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 17, 2003 this sequence version replaced gi:29837657.
            
            Summary: The protein encoded by this gene belongs to the innexin
            family. Innexin family members are the structural components of gap
            junctions. This protein and pannexin 2 are abundantly expressed in
            central nerve system (CNS) and are coexpressed in various neuronal
            populations. Studies in Xenopus oocytes suggest that this protein
            alone and in combination with pannexin 2 may form cell
            type-specific gap junctions with distinct properties. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016931.1, AK074897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BC016931.1         1-21
            22-174              AF398509.1         20-172
            175-399             AK074897.1         120-344
            400-1676            AY359023.1         161-1437
            1677-2758           AK074897.1         1622-2703
            2759-2782           CA418094.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2782
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /note="pannexin 1"
                     /db_xref="GeneID:24145"
                     /db_xref="HGNC:8599"
                     /db_xref="HPRD:10526"
                     /db_xref="MIM:608420"
     exon            1..566
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="alignment:Splign:1.39.8"
     variation       162..166
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace=""
                     /replace="cccgc"
                     /db_xref="dbSNP:72253125"
     variation       182
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace=""
                     /replace="ccgcc"
                     /db_xref="dbSNP:57120261"
     variation       252
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78409697"
     variation       256
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146477497"
     variation       264
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113788267"
     variation       312
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140930098"
     misc_feature    314..316
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /note="upstream in-frame stop codon"
     variation       352
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201087780"
     variation       353
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376331286"
     variation       362
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370158352"
     variation       365
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77517764"
     variation       368
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370364319"
     CDS             386..1666
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /note="innexin"
                     /codon_start=1
                     /product="pannexin-1"
                     /protein_id="NP_056183.2"
                     /db_xref="GI:39995064"
                     /db_xref="CCDS:CCDS8296.1"
                     /db_xref="GeneID:24145"
                     /db_xref="HGNC:8599"
                     /db_xref="HPRD:10526"
                     /db_xref="MIM:608420"
                     /translation="
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLGQSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQGIDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQRLLDSSC
"
     misc_feature    506..568
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
                     transmembrane region"
     misc_feature    704..766
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
                     transmembrane region"
     misc_feature    1037..1099
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
                     transmembrane region"
     misc_feature    1184..1246
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96RD7.4);
                     transmembrane region"
     variation       387
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374023714"
     variation       391
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200382446"
     variation       395
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17856519"
     variation       400
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1138800"
     variation       436
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375516411"
     variation       466
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143890339"
     variation       467
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147278985"
     variation       493
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74613753"
     variation       532
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140681094"
     exon            567..706
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="alignment:Splign:1.39.8"
     variation       576
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369757341"
     variation       600
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141406306"
     variation       603
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:187445142"
     variation       617
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376684216"
     variation       641
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75339423"
     variation       642
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74961890"
     variation       647
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150832252"
     variation       657
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1138799"
     variation       658
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369787689"
     exon            707..930
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="alignment:Splign:1.39.8"
     variation       731
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139198736"
     variation       735
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184999372"
     variation       756
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199806267"
     variation       757
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376627227"
     variation       766
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200950145"
     variation       768
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200209193"
     variation       772
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371008778"
     variation       773
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201108551"
     variation       812
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202058238"
     variation       839
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111535626"
     variation       844
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377364972"
     variation       850
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149967628"
     variation       857
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145987256"
     variation       864
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371181159"
     variation       865
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201582998"
     variation       929
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374405472"
     exon            931..1586
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="alignment:Splign:1.39.8"
     variation       941
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181188850"
     variation       985
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374632686"
     variation       1034
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139920522"
     variation       1035
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143240087"
     variation       1065
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201905685"
     variation       1066
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372150104"
     variation       1084
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146698723"
     variation       1093
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140305953"
     variation       1099
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200067953"
     variation       1112
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142497626"
     variation       1150
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74832612"
     variation       1176
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:185625556"
     variation       1193
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375463776"
     variation       1197
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:189649511"
     variation       1199
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12793348"
     variation       1253
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372103195"
     variation       1267
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375539925"
     variation       1269
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150484412"
     variation       1312
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138457061"
     variation       1313
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372606410"
     variation       1347
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201625424"
     variation       1362
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376071442"
     variation       1423
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369193430"
     variation       1429
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142555858"
     variation       1465
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373415904"
     variation       1468
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:180948414"
     variation       1475
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185167261"
     variation       1477
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376644296"
     variation       1499
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371006077"
     variation       1501
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191847249"
     variation       1518
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148324299"
     variation       1555
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74549886"
     variation       1572
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115773754"
     variation       1573
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369648726"
     variation       1581
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202124256"
     variation       1584
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199948423"
     variation       1585
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79692921"
     exon            1587..2769
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /inference="alignment:Splign:1.39.8"
     variation       1589
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182654100"
     variation       1595
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200926531"
     variation       1622
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375269852"
     variation       1637
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187308377"
     variation       1638
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368311655"
     variation       1681
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202182737"
     variation       1683
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372065089"
     variation       1760
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12800562"
     variation       1977
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72972552"
     variation       2074
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4453199"
     variation       2082
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1046805"
     variation       2109
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:13655"
     variation       2264
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141960320"
     variation       2340
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1046812"
     variation       2412
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368833550"
     STS             2554..2704
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /standard_name="WIAF-1483"
                     /db_xref="UniSTS:22488"
     variation       2587
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1070"
     variation       2601
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:191846383"
     variation       2621
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1071"
     variation       2717
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183658061"
     variation       2719
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146290949"
     variation       2725
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8830"
     variation       2735
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117849903"
     polyA_signal    2738..2743
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
     variation       2765
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:72972556"
     polyA_site      2769
                     /gene="PANX1"
                     /gene_synonym="MRS1; PX1; UNQ2529"
ORIGIN      
gggcggcgcggaggggcagggccagagggaagcgctttgttccgcgcgtggttcccgcgcctgggggtgcgcgggagaggcgcgaatccgagtgccgcgcgcggcccggggacttgcacgggcgtgcggggtggaaccgcaggaagcggagctctcgggttcccgccccgccccgccccgccggcggcggaggcagcgagcgcgagagcccagcggagtcgctgggagcctgaggcaccgagacacaaaggcaggcgggatgcgggagcaggcaaagggaaagcgaaagccgcgcgcccggccggtgactgggtgaaggcgccgcgcagctttcccgacgccggctgtacccggacctcctggtcgagcctggcgcgccgcagccatggccatcgctcaactggccacggagtacgtgttctcggatttcttgctgaaggagcccacggagcccaagttcaaggggctgcgactggagctggctgtggacaagatggtcacgtgcattgcggtggggctgcccctgctgctcatctcgctggccttcgcgcaggagatctcgattggtacacagataagctgtttctctccaagttctttctcctggcgtcaggctgcctttgtggattcatattgctgggcggctgttcagcagaagaactcactgcagagcgagtctggaaacctcccactgtggctgcataagtttttcccctacatcctgctgctctttgcgatcctcctgtacctgcccccgctgttctggcgtttcgcagctgctcctcatatttgctcagacttgaagtttatcatggaagaacttgacaaagtttacaaccgtgcaattaaggctgcaaagagtgcgcgtgaccttgacatgagagatggagcctgctcagttccaggtgttaccgagaacttagggcaaagtttgtgggaggtatctgaaagccacttcaagtacccaattgtggagcagtacttgaagacaaagaaaaattctaataatttaatcatcaagtacattagctgccgcctgctgacactcatcattatactgttagcgtgtatctacctgggctattacttcagcctctcctcactctcagacgagtttgtgtgcagcatcaaatcagggatcctgagaaacgacagcaccgtgcccgatcagtttcagtgcaaactcattgccgtgggcatcttccagttgctcagtgtcattaaccttgtggtttatgtcctgctggctcccgtggttgtctacacgctgtttgttccattccgacagaagacagatgttctcaaagtgtacgaaatcctccccacttttgatgttctgcatttcaaatctgaagggtacaacgatttgagcctctacaatctcttcttggaggaaaatataagtgaggtcaagtcatacaagtgtcttaaggtactggagaatattaagagcagtggtcaggggatcgacccaatgctactcctgacaaaccttggcatgatcaagatggatgttgttgatggcaaaactcccatgtctgcagagatgagagaggagcaggggaaccagacggcagagctccaaggtatgaacatagacagtgaaactaaagcaaataatggagagaagaatgcccgacagagacttctggattcttcttgctgatgatttttttccttgagctgtaaatctgtgacttctgcgacatgggatttaatttggctaaagcacccctgttggtttcacagctggtttgcaataaatggttcttggtggagatactgagcatgtcttattgagtccctaatggaaatggtgatcaacaaaaggttatggaagaatggtttatgaacttcccataggaagcacctgagagatagtaaactgcagcaagtaactatgtgtaagtcctcatcaaatgaaaagcagaaagacaagaacaattagtcaagagcagtagccctgtcagagcctcggagcaatacctttctgtacccgtggtgagacaagacccagagctactggaaaacaagcactttggaagatttgttttgttttcatggaataataatatgtcagggtataatttaacgtgagtttcttatgtgcccttaaagactgttagacaagaaaagcattcactggctaataatccataggtcgacctatgtcctaagttaggtgtaaggtccgatgccttggcccacactcgagctctctttacattgttagttgtcaaccttggctgatggaaatcccgtaaccactatttgttgcactgtgccttgaagggcagcaggcccaagtgctgctctgactgaaaactgagttaacaagatgaaatctaaaggatattcacagtgacttcaattcaggaagaatgcttccaaaagagcccagtggggaaatctgacatcacagaagacattaattcagtcactttcaaagagtttgtctacaggcggtttctctgttatcaaaggcatttgaaataggattttacttaaacaataatggaacacaggagtatttaaagtgaagaacactttgcctgaatgtgatcagggcacataagtgacattggcatgcttcatatggcgtgcttggagccagaaaaacttagcggtttattttgtttatatttaagcacagctttaaaaaattcattatcgtttattcagtgtccgaattgaggccatttgggaagaaaattctagcactggtggagaattatagaataaagattataaatggttggataagacaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:24145 -> Molecular function: GO:0002020 [protease binding] evidence: IEA
            GeneID:24145 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
            GeneID:24145 -> Molecular function: GO:0005262 [calcium channel activity] evidence: IMP
            GeneID:24145 -> Molecular function: GO:0022840 [leak channel activity] evidence: IMP
            GeneID:24145 -> Molecular function: GO:0044325 [ion channel binding] evidence: IEA
            GeneID:24145 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
            GeneID:24145 -> Molecular function: GO:0051015 [actin filament binding] evidence: IEA
            GeneID:24145 -> Molecular function: GO:0055077 [gap junction hemi-channel activity] evidence: IDA
            GeneID:24145 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IEA
            GeneID:24145 -> Biological process: GO:0002931 [response to ischemia] evidence: IEA
            GeneID:24145 -> Biological process: GO:0006812 [cation transport] evidence: IDA
            GeneID:24145 -> Biological process: GO:0006816 [calcium ion transport] evidence: IMP
            GeneID:24145 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
            GeneID:24145 -> Biological process: GO:0033198 [response to ATP] evidence: IEA
            GeneID:24145 -> Biological process: GO:0034214 [protein hexamerization] evidence: IDA
            GeneID:24145 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
            GeneID:24145 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:24145 -> Biological process: GO:0050717 [positive regulation of interleukin-1 alpha secretion] evidence: IEA
            GeneID:24145 -> Biological process: GO:0050718 [positive regulation of interleukin-1 beta secretion] evidence: IDA
            GeneID:24145 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
            GeneID:24145 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
            GeneID:24145 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:24145 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:24145 -> Cellular component: GO:0005921 [gap junction] evidence: IEA
            GeneID:24145 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:24145 -> Cellular component: GO:0032059 [bleb] evidence: IDA
            GeneID:24145 -> Cellular component: GO:0043234 [protein complex] evidence: IEA

by @meso_cacase at DBCLS
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