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2024-04-25 15:28:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015322 2583 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens fem-1 homolog b (C. elegans) (FEM1B), mRNA.
ACCESSION NM_015322
VERSION NM_015322.3 GI:52851431
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2583)
CONSRTM GENDEP Investigators; MARS Investigators; STAR*D Investigators
TITLE Common genetic variation and antidepressant efficacy in major
depressive disorder: a meta-analysis of three genome-wide
pharmacogenetic studies
JOURNAL Am J Psychiatry 170 (2), 207-217 (2013)
PUBMED 23377640
REFERENCE 2 (bases 1 to 2583)
AUTHORS Ewens,K.G., Stewart,D.R., Ankener,W., Urbanek,M., McAllister,J.M.,
Chen,C., Baig,K.M., Parker,S.C., Margulies,E.H., Legro,R.S.,
Dunaif,A., Strauss,J.F. III and Spielman,R.S.
TITLE Family-based analysis of candidate genes for polycystic ovary
syndrome
JOURNAL J. Clin. Endocrinol. Metab. 95 (5), 2306-2315 (2010)
PUBMED 20200332
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2583)
AUTHORS Subauste,M.C., Sansom,O.J., Porecha,N., Raich,N., Du,L. and
Maher,J.F.
TITLE Fem1b, a proapoptotic protein, mediates proteasome
inhibitor-induced apoptosis of human colon cancer cells
JOURNAL Mol. Carcinog. 49 (2), 105-113 (2010)
PUBMED 19908242
REMARK GeneRIF: the proapoptotic protein Fem1b is downregulated by the
proteasome in malignant colon cancer cells and mediates proteasome
inhibitor-induced apoptosis of these cells
REFERENCE 4 (bases 1 to 2583)
AUTHORS McGeachie,M., Ramoni,R.L., Mychaleckyj,J.C., Furie,K.L.,
Dreyfuss,J.M., Liu,Y., Herrington,D., Guo,X., Lima,J.A., Post,W.,
Rotter,J.I., Rich,S., Sale,M. and Ramoni,M.F.
TITLE Integrative predictive model of coronary artery calcification in
atherosclerosis
JOURNAL Circulation 120 (24), 2448-2454 (2009)
PUBMED 19948975
REMARK GeneRIF: Observational study of gene-disease association, gene-gene
interaction, gene-environment interaction, and genetic testing.
(HuGE Navigator)
REFERENCE 5 (bases 1 to 2583)
AUTHORS Sun,T.P. and Shieh,S.Y.
TITLE Human FEM1B is required for Rad9 recruitment and CHK1 activation in
response to replication stress
JOURNAL Oncogene 28 (18), 1971-1981 (2009)
PUBMED 19330022
REMARK GeneRIF: FEM1B is required for Rad9 recruitment and CHK1 activation
in response to replication stress.
REFERENCE 6 (bases 1 to 2583)
AUTHORS Nakayama,M., Kikuno,R. and Ohara,O.
TITLE Protein-protein interactions between large proteins: two-hybrid
screening using a functionally classified library composed of long
cDNAs
JOURNAL Genome Res. 12 (11), 1773-1784 (2002)
PUBMED 12421765
REFERENCE 7 (bases 1 to 2583)
AUTHORS Tan,K.M., Chan,S.L., Tan,K.O. and Yu,V.C.
TITLE The Caenorhabditis elegans sex-determining protein FEM-2 and its
human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein
kinase phosphatases that promote apoptosis
JOURNAL J. Biol. Chem. 276 (47), 44193-44202 (2001)
PUBMED 11559703
REFERENCE 8 (bases 1 to 2583)
AUTHORS Chan,S.L., Yee,K.S., Tan,K.M. and Yu,V.C.
TITLE The Caenorhabditis elegans sex determination protein FEM-1 is a
CED-3 substrate that associates with CED-4 and mediates apoptosis
in mammalian cells
JOURNAL J. Biol. Chem. 275 (24), 17925-17928 (2000)
PUBMED 10764728
REFERENCE 9 (bases 1 to 2583)
AUTHORS Ventura-Holman,T. and Maher,J.F.
TITLE Sequence, organization, and expression of the human FEM1B gene
JOURNAL Biochem. Biophys. Res. Commun. 267 (1), 317-320 (2000)
PUBMED 10623617
REFERENCE 10 (bases 1 to 2583)
AUTHORS Chan,S.L., Tan,K.O., Zhang,L., Yee,K.S., Ronca,F., Chan,M.Y. and
Yu,V.C.
TITLE F1Aalpha, a death receptor-binding protein homologous to the
Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase
substrate that mediates apoptosis
JOURNAL J. Biol. Chem. 274 (45), 32461-32468 (1999)
PUBMED 10542291
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC010122.2.
On Sep 30, 2004 this sequence version replaced gi:20070258.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC010122.2, AK290167.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2583
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q22"
gene 1..2583
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="fem-1 homolog b (C. elegans)"
/db_xref="GeneID:10116"
/db_xref="HGNC:3649"
/db_xref="HPRD:16889"
/db_xref="MIM:613539"
exon 1..863
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/inference="alignment:Splign:1.39.8"
variation 18
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="g"
/replace="t"
/db_xref="dbSNP:116529867"
variation 20
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:146502335"
variation 26
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:55941639"
variation 59
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139474050"
variation 147
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:35599421"
variation 151
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:149657294"
variation 153
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:193261445"
variation 367
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374792610"
variation 394
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:145530056"
variation 398
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:74521321"
variation 449
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:185418232"
variation 469
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:188776003"
variation 478
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace=""
/replace="t"
/db_xref="dbSNP:373528730"
variation 500..501
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace=""
/replace="c"
/db_xref="dbSNP:35278866"
variation 529
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:368483635"
misc_feature 532..534
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="upstream in-frame stop codon"
variation 593
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:200735664"
variation 609
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:147100682"
variation 611
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:375373890"
variation 613
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="g"
/replace="t"
/db_xref="dbSNP:372561452"
CDS 616..2499
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="FEM-1-like death receptor binding protein;
FEM1-beta; fem-1-like death receptor-binding protein
alpha; fem-1-like in apoptotic pathway protein alpha"
/codon_start=1
/product="protein fem-1 homolog B"
/protein_id="NP_056137.1"
/db_xref="GI:7657265"
/db_xref="CCDS:CCDS10228.1"
/db_xref="GeneID:10116"
/db_xref="HGNC:3649"
/db_xref="HPRD:16889"
/db_xref="MIM:613539"
/translation="
MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH
"
misc_feature 640..1038
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 748..837
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 1"
misc_feature 751..939
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="Ankyrin repeats (many copies); Region: Ank_4;
pfam13637"
/db_xref="CDD:205814"
misc_feature 874..1236
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 874..963
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 2"
misc_feature 889..1164
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 973..1062
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 3"
misc_feature 1072..1161
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 4"
misc_feature 1087..1356
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 1171..1260
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 5"
misc_feature 1267..1359
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 6"
misc_feature 1639..1644
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by a caspase-3-like protease; propagated
from UniProtKB/Swiss-Prot (Q9UK73.1); cleavage site"
misc_feature 1645..1746
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: TPR"
misc_feature <2026..2349
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 2062..2196
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 7"
misc_feature 2167..2349
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/note="Ankyrin repeats (many copies); Region: Ank_5;
pfam13857"
/db_xref="CDD:206028"
misc_feature 2206..2319
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UK73.1);
Region: ANK 8"
variation 647..648
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace=""
/replace="a"
/db_xref="dbSNP:35987978"
variation 654
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:35606342"
variation 714
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:376316886"
variation 724
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199722163"
variation 744
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199906667"
variation 755
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:370707411"
variation 760
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:140096080"
variation 762
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150312899"
variation 777
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:137978210"
variation 814
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:147717192"
exon 864..2559
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/inference="alignment:Splign:1.39.8"
variation 952
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:147134863"
variation 984
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:201703543"
variation 987
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:35525989"
variation 991
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:146114767"
variation 1053
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375170532"
variation 1163
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:140441270"
variation 1243
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:138980106"
variation 1244
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:142755987"
variation 1251
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="t"
/db_xref="dbSNP:372323856"
variation 1278
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:34917142"
variation 1302
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:148495013"
variation 1316
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:111558288"
variation 1317
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:142803256"
variation 1332
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:144468787"
variation 1339
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139755237"
variation 1348
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:375920632"
variation 1351
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:148564851"
variation 1352
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:142905378"
variation 1411
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:367887087"
variation 1440
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:151125509"
variation 1464
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="g"
/replace="t"
/db_xref="dbSNP:369950571"
variation 1634
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:144468118"
variation 1654
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199982589"
variation 1680
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:375949403"
variation 1738
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:77594247"
variation 1743
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:140169831"
variation 1745
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:368926800"
variation 1797
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:375876991"
variation 1807
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:148913869"
variation 1817
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:201133680"
variation 1878
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:112285240"
variation 1879
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:373504463"
variation 1880
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="t"
/db_xref="dbSNP:376986851"
variation 1916
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="t"
/db_xref="dbSNP:143444897"
variation 2091
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:143637660"
variation 2094
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:6494729"
variation 2126
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:200910706"
variation 2130
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:142144377"
variation 2133
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:181515066"
variation 2175
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="g"
/db_xref="dbSNP:371624753"
variation 2301
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:34021140"
variation 2367
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:149652183"
variation 2378
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:112963437"
variation 2388
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:111662065"
variation 2398
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:201268065"
variation 2412
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:186758386"
variation 2432
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="g"
/db_xref="dbSNP:199597830"
variation 2451
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374580566"
variation 2519
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369702955"
variation 2547
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="t"
/db_xref="dbSNP:373846418"
variation 2557
/gene="FEM1B"
/gene_synonym="F1A-ALPHA; FIAA"
/replace="a"
/replace="c"
/db_xref="dbSNP:1043378"
ORIGIN
cgctcttgcgggagcgttccgcatcgccccgggggcccctacgcgaggatctccggggccgttggcagcgcctggcacttctgagctcggcggacgagagcctgcaggtttcctccagtcagggacggcgaagggcggaaagcgcaggaggaggcagtgttaggccttaggccgggtgggccgggtcaggagagacgcgcccatctttcgccatccggggtgcgcgaggtcctctcgggacccggccggcgacccgtagctcgggcacgcgcctgtcgcatcccgcaggaaggaggggtccggcctgaggcccggggcggcgtccgccatggagatcccctcggtccagggccggcgcctgggacctggcgggcggccctgaccgccttcctccctgcgcgggctgggtcgcggacgtgcccttcgcggcactcggcctcctctgcgtctccgccttccctgggccgcactgctgcctgggcgcggcggcggcgacggcgccctgttgaatgggctgtgagggcccaggtttaaagcgctggcgaacgcggcctccgggggcgcacggcagctgcagcggtggcgaccaaacgggtgttggagttggcggcggccatggagggcctggctggctatgtatacaaggcggccagcgagggcaaggtgctgactctggccgccttgcttctcaaccggtctgaaagcgacatccgctatctgcttggctatgtcagccagcagggagggcagcgctccacgcccctcatcatcgcagcccgcaatggacacgcaaaggtggtacgcttgctcttagaacattaccgggtgcagactcagcagactggcaccgtccgcttcgacgggtatgtcattgatggtgccactgctctttggtgtgcagctggagcaggacattttgaagttgttaaacttctagtcagccatggagccaacgtgaaccataccacagtaactaattcaacccccctgcgggcagcatgctttgatggcagactggacattgtgaaatacttggttgaaaataatgccaacatcagcattgccaacaaatatgacaacacctgcctaatgattgcggcatataagggacacactgatgtggtcagataccttttagaacaacgtgctgatcccaatgccaaagcacattgtggagccacagcattgcactttgcagctgaagctgggcacatagatattgtgaaagagctgataaaatggcgtgctgctatagtagtgaatggccatgggatgacgccattgaaagtagctgccgaaagctgtaaagctgatgtcgtagaactgttactctctcatgctgattgcgaccgaagaagtcggattgaagctttggaactcttgggtgcctcctttgcaaatgaccgtgagaactatgacatcataaagacataccactatctatatttagccatgttagagaggttccaagatggtgataacattctcgaaaaagaggttcttccaccaatccatgcttatgggaatagaactgaatgtagaaatcctcaggaactggagtccattcggcaagacagagatgctcttcatatggaaggccttatagttcgggaacggattttaggtgctgacaatattgatgtttctcatcccatcatttacagaggagctgtttatgcggataatatggaatttgagcagtgtatcaagttgtggcttcatgccctgcacctcagacaaaaaggtaacaggaacacccacaaggatcttcttcgatttgctcaagttttctcacaaatgatacatttgaatgaaactgtgaaggccccagacatagaatgtgttttgagatgcagtgttttggaaatagaacaaagtatgaacagagtgaaaaatatttcagatgctgatgtccacaatgctatggacaattatgaatgtaatctctatacctttctgtatttagtgtgcatctctaccaaaacacagtgcagcgaagaagatcagtgcaaaattaacaagcagatctacaacctgattcaccttgatcccagaactcgtgaaggtttcaccttgctgcatctggctgtcaactccaatactccagttgatgatttccacaccaatgacgtctgcagctttccaaatgcacttgtcacaaagctcctgctggactgtggtgctgaggtgaatgccgtggacaatgagggaaacagtgcccttcatattatcgttcagtacaacaggcccatcagtgattttttgaccttgcactccatcatcattagcctagttgaagccggagctcacactgacatgacgaataaacagaataagactccgctagacaaaagtacaactggggtatctgaaatactgcttaaaactcaaatgaagatgagtctcaagtgcctggctgcccgagcagttcgggctaatgacattaactaccaagaccagatccccagaactcttgaagagtttgttggatttcattaagtgactggatatgtaaagtcgtttaatgtggtgctaaaaagtaaaggacttttaatcacaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10116 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IMP
GeneID:10116 -> Molecular function: GO:0005123 [death receptor binding] evidence: IMP
GeneID:10116 -> Molecular function: GO:0005123 [death receptor binding] evidence: NAS
GeneID:10116 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10116 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10116 -> Biological process: GO:0006917 [induction of apoptosis] evidence: NAS
GeneID:10116 -> Biological process: GO:0051438 [regulation of ubiquitin-protein ligase activity] evidence: IMP
GeneID:10116 -> Biological process: GO:0060442 [branching involved in prostate gland morphogenesis] evidence: IEA
GeneID:10116 -> Biological process: GO:0060743 [epithelial cell maturation involved in prostate gland development] evidence: IEA
GeneID:10116 -> Biological process: GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
GeneID:10116 -> Biological process: GO:2000001 [regulation of DNA damage checkpoint] evidence: IMP
GeneID:10116 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10116 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:10116 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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DBCLS
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