Home |
Help |
Advanced search
2024-04-20 00:54:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015225 12602 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens prune homolog 2 (Drosophila) (PRUNE2), mRNA.
ACCESSION NM_015225 XM_041018
VERSION NM_015225.2 GI:162287218
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 12602)
AUTHORS Li,S., Hayakawa-Yano,Y., Itoh,M., Ueda,M., Ohta,K., Suzuki,Y.,
Mizuno,A., Ohta,E., Hida,Y., Wang,M.X. and Nakagawa,T.
TITLE Olfaxin as a novel Prune2 isoform predominantly expressed in
olfactory system
JOURNAL Brain Res. 1488, 1-13 (2012)
PUBMED 23059019
REMARK GeneRIF: We showed that Olfaxin, a novel Prune2 isoform contains a
BCH motif and localizes predominantly to the synaptic cytosol in
the olfactory bulb and layer Ia of the piriform cortex.
REFERENCE 2 (bases 1 to 12602)
AUTHORS Yang,J.L., Cogdell,D., Eddy,J., Trent,J., Price,N. and Zhang,W.
TITLE [Expression of PRUNE2 mRNA and its positive correlation with
non-coding RNA PCA3 in leiomyosarcoma]
JOURNAL Zhonghua Zhong Liu Za Zhi 34 (7), 497-500 (2012)
PUBMED 22967466
REMARK GeneRIF: PRUNE2 expression is correlated with the survival of
leiomyosarcoma patients. Non-coding RNA PCA3 has a significant
positive correlation with PRUNE2 and may play an important role in
the pathogenesis of leiomyosarcoma.
REFERENCE 3 (bases 1 to 12602)
AUTHORS Iwama,E., Tsuchimoto,D., Iyama,T., Sakumi,K., Nakagawara,A.,
Takayama,K., Nakanishi,Y. and Nakabeppu,Y.
TITLE Cancer-related PRUNE2 protein is associated with nucleotides and is
highly expressed in mature nerve tissues
JOURNAL J. Mol. Neurosci. 44 (2), 103-114 (2011)
PUBMED 21234814
REMARK GeneRIF: The nerve tissue-specific and post-development expression
of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the
maintenance of mature nervous systems.
REFERENCE 4 (bases 1 to 12602)
AUTHORS Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
Schreiber,S. and Nebel,A.
TITLE Investigation of genetic susceptibility factors for human longevity
- a targeted nonsynonymous SNP study
JOURNAL Mutat. Res. 694 (1-2), 13-19 (2010)
PUBMED 20800603
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 12602)
AUTHORS Salagierski,M., Verhaegh,G.W., Jannink,S.A., Smit,F.P., Hessels,D.
and Schalken,J.A.
TITLE Differential expression of PCA3 and its overlapping PRUNE2
transcript in prostate cancer
JOURNAL Prostate 70 (1), 70-78 (2010)
PUBMED 19760627
REMARK GeneRIF: The androgen regulation of PRUNE2 expression in prostate
cancer cells was found to not be of any diagnostic value.
REFERENCE 6 (bases 1 to 12602)
AUTHORS Clarke,R.A., Zhao,Z., Guo,A.Y., Roper,K., Teng,L., Fang,Z.M.,
Samaratunga,H., Lavin,M.F. and Gardiner,R.A.
TITLE New genomic structure for prostate cancer specific gene PCA3 within
BMCC1: implications for prostate cancer detection and progression
JOURNAL PLoS ONE 4 (3), E4995 (2009)
PUBMED 19319183
REMARK GeneRIF: the longer BMCC1-1 isoform is upregulated in PCa tissues
and metastases
REFERENCE 7 (bases 1 to 12602)
AUTHORS Soh,U.J. and Low,B.C.
TITLE BNIP2 extra long inhibits RhoA and cellular transformation by Lbc
RhoGEF via its BCH domain
JOURNAL J. Cell. Sci. 121 (PT 10), 1739-1749 (2008)
PUBMED 18445682
REMARK GeneRIF: findings show the BNIP2 & BCH domain of BNIPXL interacts
with specific conformers of RhoA & mediates association with
catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide
exchange factor; BNIPXL inhibits Lbc-induced oncogenic
transformation
REFERENCE 8 (bases 1 to 12602)
AUTHORS Valencia,C.A., Cotten,S.W. and Liu,R.
TITLE Cleavage of BNIP-2 and BNIP-XL by caspases
JOURNAL Biochem. Biophys. Res. Commun. 364 (3), 495-501 (2007)
PUBMED 17961507
REMARK GeneRIF: Our results suggest that the caspase-mediated cleavage of
BNIP-2 and BNIP-XL could result in the release of the BCH domain or
smaller fragments that are crucial for their proapoptotic
activities.
REFERENCE 9 (bases 1 to 12602)
AUTHORS Price,N.D., Trent,J., El-Naggar,A.K., Cogdell,D., Taylor,E.,
Hunt,K.K., Pollock,R.E., Hood,L., Shmulevich,I. and Zhang,W.
TITLE Highly accurate two-gene classifier for differentiating
gastrointestinal stromal tumors and leiomyosarcomas
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 104 (9), 3414-3419 (2007)
PUBMED 17360660
REMARK GeneRIF: OBSCN and C9orf65 comprise a highly accurate two-gene
classifier for differentiating gastrointestinal stromal tumors and
leiomyosarcomas.
REFERENCE 10 (bases 1 to 12602)
AUTHORS Machida,T., Fujita,T., Ooo,M.L., Ohira,M., Isogai,E., Mihara,M.,
Hirato,J., Tomotsune,D., Hirata,T., Fujimori,M., Adachi,W. and
Nakagawara,A.
TITLE Increased expression of proapoptotic BMCC1, a novel gene with the
BNIP2 and Cdc42GAP homology (BCH) domain, is associated with
favorable prognosis in human neuroblastomas
JOURNAL Oncogene 25 (13), 1931-1942 (2006)
PUBMED 16288218
REMARK GeneRIF: BMCC1 is a new member of prognostic factors for NBL and
may play an important role in regulating differentiation, survival
and aggressiveness of the tumor cells
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC019095.2, DA410068.1, AB050197.1, AL359314.14 and BQ008420.1.
On Dec 11, 2007 this sequence version replaced gi:62412855.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. This RefSeq lacks full-length transcript
support, but the extent of this transcript is supported by
transcript alignments in human, aligning orthologous transcripts,
and on functional support for the protein in PMID: 16288218.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-877 BC019095.2 1-877
878-936 DA410068.1 494-552
937-5145 AB050197.1 58-4266
5146-5147 AL359314.14 50215-50216 c
5148-7654 AB050197.1 4269-6775
7655-8333 AL359314.14 46368-47046 c
8334-12584 AB050197.1 7440-11690
12585-12602 BQ008420.1 1-18 c
FEATURES Location/Qualifiers
source 1..12602
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q21.2"
gene 1..12602
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="prune homolog 2 (Drosophila)"
/db_xref="GeneID:158471"
/db_xref="HGNC:25209"
/db_xref="MIM:610691"
exon 1..160
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
CDS 125..9391
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="BCH motif-containing molecule at the carboxyl
terminal region 1; BNIP2 motif containing molecule at the
carboxyl terminal region 1; olfaxin; BNIP2
motif-containing molecule at the C-terminal region 1;
truncated PRUNE2"
/codon_start=1
/product="protein prune homolog 2"
/protein_id="NP_056040.2"
/db_xref="GI:162287219"
/db_xref="CCDS:CCDS47982.1"
/db_xref="GeneID:158471"
/db_xref="HGNC:25209"
/db_xref="MIM:610691"
/translation="
MEEFLQRAKSKLNRSKRLEKVHVVIGPKSCDLDSLISTFTYAYFLDKVSPPGVLCLPVLNIPRTEFNYFTETRFILEELNISESFHIFRDEINLHQLNDEGKLSITLVGSSVLASEDKTLESAVVKVINPVEQSDANVEFRESSSSLVLKEILQEAPELITEQLAHRLRGSILFKWMTMESEKISEKQEEILSILEEKFPNLPPREDIINVLQETQFSAQGLSIEQTMLKDLKELSDGEIKVAISTVSMNLENCLFHSNITSDLKAFTDKFGFDVLILFSSYLSEEQQPRRQIAVYSENMELCSQICCELEECQNPCLELEPFDCGCDEILVYQQEDPSVTCDQVVLVVKEVINRRCPEMVSNSRTSSTEAVAGSAPLSQGSSGIMELYGSDIEPQPSSVNFIENPPDLNDSNQAQVDANVDLVSPDSGLATIRSSRSSKESSVFLSDDSPVGEGAGPHHTLLPGLDSYSPIPEGAVAEEHAWSGEHGEHFDLFNFDPAPMASGQSQQSSHSADYSPADDFFPNSDLSEGQLPAGPEGLDGMGTNMSNYSSSSLLSGAGKDSLVEHDEEFVQRQDSPRDNSERNLSLTDFVGDESPSPERLKNTGKRIPPTPMNSLVESSPSTEEPASLYTEDMTQKATDTGHMGPPQTHARCSSWWGGLEIDSKNIADAWSSSEQESVFQSPESWKEHKPSSIDRRASDSVFQPKSLEFTKSGPWESEFGQPELGSNDIQDKNEESLPFQNLPMEKSPLPNTSPQGTNHLIEDFASLWHSGRSPTAMPEPWGNPTDDGEPAAVAPFPAWSAFGKEDHDEALKNTWNLHPTSSKTPSVRDPNEWAMAKSGFAFSSSELLDNSPSEINNEAAPEIWGKKNNDSRDHIFAPGNPSSDLDHTWTNSKPPKEDQNGLVDPKTRGKVYEKVDSWNLFEENMKKGGSDVLVPWEDSFLSYKCSDYSASNLGEDSVPSPLDTNYSTSDSYTSPTFAGDEKETEHKPFAKEEGFESKDGNSTAEETDIPPQSLQQSSRNRISSGPGNLDMWASPHTDNSSEINTTHNLDENELKTEHTDGKNISMEDDVGESSQSSYDDPSMMQLYNETNRQLTLLHSSTNSRQTAPDSLDLWNRVILEDTQSTATISDMDNDLDWDDCSGGAAIPSDGQTEGYMAEGSEPETRFTVRQLEPWGLEYQEANQVDWELPASDEHTKDSAPSEHHTLNEKSGQLIANSIWDSVMRDKDMSSFMLPGSSHITDSEQRELPPEIPSHSANVKDTHSPDAPAASGTSESEALISHLDKQDTERETLQSDAASLATRLENPGYFPHPDPWKGHGDGQSESEKEAQGATDRGHLDEEEVIASGVENASGISEKGQSDQELSSLVASEHQEICIKSGKISSLAVTFSPQTEEPEEVLEYEEGSYNLDSRDVQTGMSADNLQPKDTHEKHLMSQRNSGETTETSDGMNFTKYVSVPEKDLEKTEECNFLEPENVGGGPPHRVPRSLDFGDVPIDSDVHVSSTCSEITKNLDVKGSENSLPGAGSSGNFDRDTISSEYTHSSASSPELNDSSVALSSWGQQPSSGYQEENQGNWSEQNHQESELITTDGQVEIVTKVKDLEKNRINEFEKSFDRKTPTFLEIWNDSVDGDSFSSLSSPETGKYSEHSGTHQESNLIASYQEKNEHDISATVQPEDARVISTSSGSDDDSVGGEESIEEEIQVANCHVAEDESRAWDSLNESNKFLVTADPKSENIYDYLDSSEPAENENKSNPFCDNQQSSPDPWTFSPLTETEMQITAVEKEKRSSPETGTTGDVAWQISPKASFPKNEDNSQLEMLGFSADSTEWWKASPQEGRLIESPFERELSDSSGVLEINSSVHQNASPWGVPVQGDIEPVETHYTNPFSDNHQSPFLEGNGKNSHEQLWNIQPRQPDPDADKFSQLVKLDQIKEKDSREQTFVSAAGDELTPETPTQEQCQDTMLPVCDHPDTAFTHAEENSCVTSNVSTNEGQETNQWEQEKSYLGEMTNSSIATENFPAVSSPTQLIMKPGSEWDGSTPSEDSRGTFVPDILHGNFQEGGQLASAAPDLWIDAKKPFSLKADGENPDILTHCEHDSNSQASDSPDICHDSEAKQETEKHLSACMGPEVESSELCLTEPEIDEEPIYEPGREFVPSNAELDSENATVLPPIGYQADIKGSSQPASHKGSPEPSEINGDNSTGLQVSEKGASPDMAPILEPVDRRIPRIENVATSIFVTHQEPTPEGDGSWISDSFSPESQPGARALFDGDPHLSTENPALVPDALLASDTCLDISEAAFDHSFSDASGLNTSTGTIDDMSKLTLSEGHPETPVDGDLGKQDICSSEASWGDFEYDVMGQNIDEDLLREPEHFLYGGDPPLEEDSLKQSLAPYTPPFDLSYLTEPAQSAETIEEAGSPEDESLGCRAAEIVLSALPDRRSEGNQAETKNRLPGSQLAVLHIREDPESVYLPVGAGSNILSPSNVDWEVETDNSDLPAGGDIGPPNGASKEISELEEEKTIPTKEPEQIKSEYKEERCTEKNEDRHALHMDYILVNREENSHSKPETCEERESIAELELYVGSKETGLQGTQLASFPDTCQPASLNERKGLSAEKMSSKSDTRSSFESPAQDQSWMFLGHSEVGDPSLDARDSGPGWSGKTVEPFSELGLGEGPQLQILEEMKPLESLALEEASGPVSQSQKSKSRGRAGPDAVTLQAVTHDNEWEMLSPQPVQKNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGVLSPSAADMRPEPPNSLDLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTGHDPTANKDSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIEPYRRVISHGGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAEDYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKLDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP
"
misc_feature 194..958
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="Inorganic pyrophosphatase/exopolyphosphatase
[Energy production and conversion]; Region: PPX1; COG1227"
/db_xref="CDD:31420"
misc_feature 449..457
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8WUY3.3);
Region: DHH motif (By similarity)"
misc_feature 785..1081
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="DHHA2 domain; Region: DHHA2; pfam02833"
/db_xref="CDD:202421"
misc_feature 8513..8869
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="Bcl2-/adenovirus E1B nineteen kDa-interacting
protein 2; Region: BNIP2; pfam12496"
/db_xref="CDD:204941"
misc_feature 8819..9259
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="Sec14p-like lipid-binding domain. Found in
secretory proteins, such as S. cerevisiae
phosphatidylinositol transfer protein (Sec14p), and in
lipid regulated proteins such as RhoGAPs, RhoGEFs and
neurofibromin (NF1). SEC14 domain of Dbl is known to...;
Region: SEC14; cd00170"
/db_xref="CDD:29115"
misc_feature order(8882..8884,8888..8890,8900..8902,8981..8983,
9011..9013,9056..9058,9068..9070,9080..9082,9092..9094,
9101..9103,9110..9112,9116..9118,9137..9139,9158..9160,
9194..9196)
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="phospholipid binding pocket [chemical binding];
other site"
/db_xref="CDD:29115"
misc_feature order(9095..9097,9191..9193)
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="salt bridge; other site"
/db_xref="CDD:29115"
exon 161..265
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 266..468
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 469..632
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 633..785
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 786..880
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 881..1039
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 1040..7637
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
misc_feature 3278..3486
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/note="BNIP2-like motif"
variation 4594
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:680729"
variation 4640
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:680775"
STS 5122..5404
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/standard_name="SHGC-143385"
/db_xref="UniSTS:171893"
variation 5246
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:683866"
STS 5751..5891
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/standard_name="RH68047"
/db_xref="UniSTS:69578"
variation 6467
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2077181"
exon 7638..8400
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
variation 7655
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:620552"
variation 7732
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:620985"
variation 8182
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="a"
/replace="g"
/db_xref="dbSNP:560094"
exon 8401..8480
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 8481..8681
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 8682..8852
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 8853..8955
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 8956..9087
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 9088..9174
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 9175..9273
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 9274..9312
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 9313..9360
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
exon 9361..12585
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/inference="alignment:Splign:1.39.8"
variation 10273
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3174373"
variation 10323
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3174372"
STS 12448..12564
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/standard_name="A005S17"
/db_xref="UniSTS:69809"
STS 12448..12564
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/standard_name="G32285"
/db_xref="UniSTS:116882"
STS 12456..12585
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/standard_name="D9S2090"
/db_xref="UniSTS:71410"
variation 12531
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3177384"
variation 12552
/gene="PRUNE2"
/gene_synonym="A214N16.3; bA214N16.3; BMCC1; BNIPXL;
C9orf65; KIAA0367; RP11-58J3.2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1045994"
ORIGIN
ggagggagcagtcggtcgctgcgccccggcgggccactttcccgggaccccgctcgtcttccttgggccgagattttccactgcgcccctccgagtacccgggttccaaacccctagccacgacatggaagaatttttgcaacgcgccaaatctaaactgaatcgaagcaaacgcttggagaaggtccatgtggttattgggcctaaatcgtgtgacttggattctctcatttctaccttcacatatgcttactttctagacaaggtcagtccaccaggggttctgtgtttaccagtgctgaacataccaagaactgaattcaactacttcaccgagacgaggtttattttagaagagctaaatatttccgaatcattccacatattccgggatgaaattaacctgcatcagctaaatgatgaagggaagttatcgataacacttgttggcagcagtgtgctggcgagtgaagacaaaactttagaatcagcagttgtcaaagtcattaatccggttgagcagagcgatgccaacgttgagttccgagagtcttcctcttctctcgtgctaaaggagattctccaagaggctcctgagctcatcaccgagcaactggctcatcgcctcagaggtagcattcttttcaagtggatgaccatggaatcagagaagatctcagagaagcaggaggaaattctttctatcctggaagaaaaatttcctaacttgcctccaagagaggacatcatcaacgtcctacaggagacccagttcagtgctcagggtttaagtattgaacagacaatgttgaaagatctaaaggagctgtcagatggagaaataaaagtggccattagtactgtgagcatgaaccttgagaattgtctatttcacagcaatattaccagtgacttgaaagcatttacagacaagtttggttttgatgtcctcatcctgttctccagctatctgtcagaggagcagcagccgagacgacagattgctgtgtactcagaaaacatggagctgtgcagtcagatttgctgtgagctggaagagtgtcagaacccttgcctagaactggagccctttgactgtggctgtgatgagatcctggtgtaccaacaagaggacccttcagtgacttgtgatcaggtggttctcgttgtcaaggaagtcatcaacaggaggtgtccagagatggtctccaatagccggacatcctcaacagaagccgtggcaggcagtgcccccctctcccaggggtcttctgggattatggaattgtatggttctgacatagagccacaacccagctctgtgaatttcatagagaaccctccagatctcaatgattctaaccaggctcaggtggatgccaatgtagaccttgttagcccagacagcggactggctaccattaggagcagccgctcatccaaggagagctctgttttcctcagtgacgacagccccgtgggagaaggtgctgggcctcaccacacccttctcccagggcttgactcctacagccccatccctgaaggggcggtggcggaggaacatgcatggtctggagaacacggtgagcacttcgacctcttcaattttgacccagcacccatggcttctgggcagtcccagcaatcttctcattctgcagactactccccagcagatgacttcttccccaacagtgacctgtcagaaggacagctccccgctgggcctgaaggacttgatggcatgggaaccaacatgtctaattattcatccagttcacttttgtcaggggctggcaaagatagccttgtggaacatgatgaggagtttgtccagagacaagacagtcccagagataactctgaaagaaatttgagcctgacagattttgtgggagatgaatccccttccccagaaaggctaaaaaatactggaaagaggatcccaccaacacccatgaatagtttagtagaaagctcgccatccactgaagaaccagcctcactctatacagaagatatgacccaaaaagcaactgacacaggtcacatggggccacctcagacccatgcacggtgcagcagctggtggggtggtttggaaattgactccaaaaatattgcagatgcgtggagttccagtgaacaggaatctgttttccagagccctgaatcatggaaagagcataagccaagctccattgataggagagcctcagattctgtatttcaaccaaagagcctcgaatttacaaagtcaggtccctgggagtctgaatttggtcagcctgaactgggtagcaatgatattcaagacaaaaatgaggaaagcttgccgttccagaacctgcccatggagaagtcacctttgccaaatacatctccccaaggaacaaaccacctgatagaagactttgcttctttgtggcattctggtcgctctcccacagccatgcccgagccctggggaaatcctacagatgatggtgaaccagcagctgtggcgccattcccagcctggagtgcatttggtaaagaagatcatgatgaagctttaaaaaatacctggaatttgcacccaacaagcagcaagacaccttctgttagggacccgaatgagtgggccatggcaaaaagtgggtttgccttttcttcttcagaactactggacaattcacccagtgagataaacaatgaagcagctccagaaatctggggcaagaaaaacaatgactccagggatcacatctttgcacctggaaatcccagttctgatctggatcacacatggactaattctaagccaccaaaagaagatcagaatggtttagtggatcctaaaactaggggcaaggtatatgaaaaggtagattcctggaacctttttgaggagaatatgaagaaaggagggtcagatgtcctagttccttgggaagattccttcttatcttacaaatgttctgattacagtgcatccaacctaggagaagattcggtgccttcccccttagataccaattattccacctcagactcttacacatcaccaacatttgctggagacgaaaaggaaactgaacacaagccatttgctaaagaggaaggttttgagtcaaaagatggtaactccacggcagaggagactgacattcctcctcagtcactgcaacagtcatctcgaaatcgaatcagttcaggtcctgggaacctagacatgtgggcttcacctcatacagataacagttctgaaataaataccactcacaacctggatgaaaatgaactcaagacagagcacacagatggtaagaatatctccatggaggatgacgtcggggaaagcagccagtccagttacgacgaccccagcatgatgcaactgtacaatgaaacaaaccgacaactcacacttttgcacagcagcaccaactcccggcagacggcccctgacagtctcgacttgtggaacagagtgattttggaggatactcagtccactgcaacgatctcagatatggacaatgatttggactgggatgactgcagtgggggtgcggcaatccccagtgatggtcaaacagaaggatacatggctgaaggttccgagccggaaacccgatttacagtgagacagctggaaccctggggcttggagtatcaggaagcaaatcaggtagattgggagctccctgcctctgatgagcataccaaggacagtgctcccagtgaacatcacacattgaatgagaaaagtgggcagctaattgcaaacagtatttgggattctgtcatgagagataaagacatgtcatcattcatgttaccaggctcctcacatatcacagattcagagcaaagggaattgcctcctgaaatccccagccattcagcaaatgttaaagacactcattccccagatgcgccagcagcctctggaaccagtgaatcagaggcacttatatctcatcttgacaagcaggacacagagagggaaaccctgcaaagtgatgcagcatccttggcgactaggcttgagaatccagggtattttccacacccagatccatggaaaggtcatggcgatggacaaagtgaaagtgagaaggaagcccagggagccactgacagggggcaccttgatgaagaggaggtgatcgcctctggtgtggagaatgcctcagggatttctgaaaaagggcagagtgaccaggaactgtcttctctggttgcatctgaacatcaggaaatctgcattaaatcaggcaaaatcagctctcttgctgtcactttcagtcctcaaaccgaggaaccagaggaagttttagagtatgaggaggggtcttacaatctagactcccgtgatgtgcaaacagggatgtccgcagataacctgcagccaaaagatacccatgaaaaacacctcatgagtcaaagaaattcaggtgaaactactgagacttcagatgggatgaatttcacaaaatatgtatctgtacctgaaaaggatcttgagaaaactgaagaatgtaactttctagagccagagaacgtgggtggagggccacctcacagagttccccgaagtcttgattttggggacgtccctatagacagtgatgtgcatgtcagcagcacatgttctgagataaccaaaaatcttgacgttaaggggtctgaaaatagccttccaggagccggttcgtctggaaattttgacagagatactatttctagtgagtatactcattcaagtgcatcaagtcctgagttaaatgactcttcagttgcactgtcctcctggggccagcaacccagttctgggtatcaagaagaaaaccaaggcaactggagtgaacagaatcaccaagaatctgaactaattaccactgatggccaagtagaaatagttaccaaagtgaaggatttagagaaaaacagaataaatgagtttgaaaagagctttgatcgcaaaactcctacatttttagagatctggaatgactcagttgatggtgattccttttcctctttatccagtcctgaaacaggcaaatattctgaacattcagggacacatcaggaaagcaatctaattgctagctaccaggagaaaaatgaacatgacatttctgcaactgtgcagccagaggatgccagggtcatttcaacaagctcaggttctgatgatgacagtgtcggtggtgaagagtcaatagaggaagagatccaggtggccaactgccacgttgctgaggatgaatccagagcttgggattcattgaatgaatctaataagttcttggtcacagctgatcctaagtctgaaaatatttatgactacctagacagctcagagccagcagagaatgagaataagtcaaacccattctgtgacaatcaacaaagcagccctgatccctggactttctcaccattaacggagactgaaatgcagattacagcagtggagaaggagaagagatcttctccagaaacagggacaacaggagatgttgcatggcaaatatctcccaaagcttcgttcccaaagaacgaagataattctcaactggaaatgctgggcttctcagctgatagcactgagtggtggaaggcctcaccccaggaagggagactaattgaaagtccatttgaaagggagctgtctgactccagtggtgtgttggagataaattcttcagtacaccaaaatgccagtccctggggagtaccagttcagggtgatattgagcccgtggaaacacactatactaatccttttagtgacaaccatcagtcaccctttctggaaggtaatgggaagaactcccatgagcaactctggaacattcaaccaaggcagccagacccagatgctgacaagttcagccagcttgtaaaattagaccaaattaaagaaaaggactcaagagagcaaacctttgtgtctgctgctggtgatgagctgactcctgaaacacctacccaagagcagtgtcaggacaccatgctgccagtctgtgatcatccggacacagcctttactcacgcagaggaaaatagttgtgttacatctaatgtttcaactaatgaaggtcaagaaacaaatcagtgggaacaagaaaaatcatacctaggtgagatgacaaattcaagcattgccacagaaaattttcctgctgtcagttctcccacccaactgataatgaagccaggctctgaatgggatggctctaccccaagtgaggactcccgaggtacctttgtgccagatattttacatggcaactttcaagagggtgggcagctggcctctgccgcgcctgacttgtggatagatgctaagaagcccttcagtttgaaagcagatggtgagaatcctgatatcctgacgcactgcgaacatgacagcaattctcaggcttccgacagccctgatatatgtcacgattctgaagcaaagcaagagactgagaagcacctcagtgcttgcatgggacctgaagtggaatccagtgagctttgtctcactgagccagagatagatgaagaacccatttatgagcctggacgggagtttgtcccatccaatgcagaactcgattctgaaaacgcaactgtgctgcctccaattggctatcaagcagacataaagggctcctctcagcccgcctctcataaaggttcacctgaaccttctgaaataaacggtgacaacagtacaggtttacaagtatcagaaaaaggagccagcccagatatggcaccaattttggaaccagttgacagaagaatcccaaggattgaaaatgtggcaactagcatttttgtaactcaccaagagccaactccagaaggtgacggttcttggatatcagacagcttttctcctgaaagtcagcctggtgcaagagctttgtttgatggtgatccacatttatccacagagaatcctgccttggttcctgatgctttgctagcctcagacacttgtctggatataagcgaagctgcctttgaccacagtttcagcgatgcctcaggtctcaacacatccacgggaacaatagatgacatgagtaaactgacattatccgaaggccatccggaaacgccagttgatggggacctagggaagcaagatatctgctcatctgaagcctcgtggggtgattttgaatatgatgtaatgggccagaatatcgatgaagatttactgagagagcctgaacacttcctgtatggtggtgaccctcctttggaggaagattctctgaagcagtcgctggcaccgtacacacctccctttgatttgtcttatctcacagaacctgcccagagtgctgaaacaatagaggaagctgggtctccagaggatgaatctctgggatgcagagcagcagagatagtgctttctgcacttcctgatcgaagaagtgagggaaaccaggctgagaccaaaaacagactgcctggatcccagctggctgtgctgcatattcgtgaagaccctgagtccgtttatttgccggtaggagcaggctccaacattttgtctccatcaaacgttgactgggaagtagaaacagataattctgatttaccagcaggtggagacataggaccaccaaatggtgccagcaaggaaatatcagaattggaagaagaaaaaacaattcctaccaaagagcctgagcagataaaatcagaatacaaggaagaaagatgtacagagaagaatgaagatcgtcatgcactacacatggattacatacttgtaaaccgtgaagaaaattcacactcaaagccagagacctgtgaagaaagagaaagcatagctgaattagaattgtatgtaggttccaaagaaacagggctgcagggaactcagttagcaagcttcccagacacatgtcagccagcctccttaaatgaaagaaaaggtctctctgcagagaaaatgtcttctaaaagcgatacgagatcatcttttgaaagccctgcacaagaccagagttggatgttcttgggccatagtgaggttggtgatccatcactggatgccagggactcagggcctgggtggtctggcaagactgtggagccgttctctgaactcggcttgggtgagggtccccagctgcagattctggaagaaatgaagcctctagaatctttggcactagaggaagcctctggtccagtcagccaatcacagaagagtaagagccgaggcagggctggcccggatgcagttacgttgcaggctgtcacccatgacaatgaatgggaaatgctttcaccacagcctgttcagaaaaacatgatccctgacacggaaatggaggaggagacagagttccttgagctcggaaccaggatatcaagaccaaatggactactgtcagaggatgtaggaatggacatcccctttgaagagggcgtgctgagtcccagtgctgcagacatgaggcctgaacctcctaattctctggatcttaatgacactcatcctcggagaatcaagctcacagccccaaatatcaatctttctctggaccaaagtgaaggatctattctctctgatgataacttggacagtccagatgaaattgacatcaatgtggatgaacttgatacccccgatgaagcagattcttttgagtacactggccatgatcccacagccaacaaagattctggccaagagtcagagtctattccagaatatacggccgaagaggaacgggaggacaaccggctttggaggacagtggtcattggagaacaagagcagcgcattgacatgaaggtcatcgagccctacaggagagtcatttctcacggaggatactatggggacggtctaaatgccatcattgtgtttgccgcctgttttctgccagacagcagtcgggcggattaccactatgtcatggaaaatcttttcctatatgtaataagtactttagagttgatggtagctgaagactatatgattgtgtacttgaatggtgcaaccccaagaaggaggatgccagggctaggctggatgaagaaatgctaccagatgattgacagacggttgaggaagaatttgaaatcattcatcattgttcatccatcttggttcatcagaacaatccttgctgtgacacgaccttttataagttcaaaattcagcagtaaaattaaatatgtcaatagcttatcagaactcagtgggctgatcccaatggattgcatccacattccagagagcatcatcaaactggatgaagaactgagggaagcatcagaggcagctaaaactagctgcctttacaatgatccagaaatgtcttctatggagaaggatattgacttgaagctgaaagaaaagccttagttggccatgctggaagaagaggatgcttttctggttcatggttctgttgaaacatatctacctgaaagagacagggctgatgttacctttttccactttgcactacctggtgccattctaaatttctaaggggaaaaatagaaagtttgtttactcttaagatattttatgaaattgtgtgtactttcctattttgccaattatgtgcctcaaagattttagttgagccttagcaagaaagtaggaccttccatttcaatacttcattaacacggtgtagtgatactttgtcccttagactggtgtttaccagtaagatacctttaatccactgttaagtatgagtggatttgtttccatagattagctggatttccttttggtgattgcattaggtttaaagtacacaggtctcaactctccccaggaaagtttcccctgtttgactccacctttaaaatcctaagcctgactaggacagccacaaaccacacaaggtgtaaaaccatcatcagctaagtgcccgttttgttcttgtttaccagaatctcctttaacttctcaaagggaagccgggctttctaatccacgtcaactttattttagttgtcaaattgggcattatattttatgtaaattggtcttttaacatcattttcctgatgaatgttggtgaccaccacattgtgaaatttaagaatccgtgttgcatgtttggtagctctctgagtttcaggccataaactcagctccagaggttaccttttaagtgccaagaactcaagtgcaaggtggcctactcaaaaatcatttggtagcattcagttattcatgaattcctctctcgcatgcattataaaaagtgatctgctttaaaacaccgtaatctgatcataggcttaaaattaaatatgagtattactttcatgtacaaaatatttcctttatagtcttcatatgccctttaaaatgccaacaagatttcaagtctgtaggcctctagtgaggtggggtggcaaaccacagctaagtctcgctcaccactgcaagctaagaatggtttttacattttgggttggaaaaattttttttgaatatttcatgacacatgaaaattattcaaatgttagtgccgataaataaagtggtactgaaacacagccacacaaacttgtttttgtactgtctacagctactttcacactacagccgcagagctgagcagttcagcagaccgtatgtcccacaatgcctaaaacattgactatgtttacagaaaaagtttgctgacccctgctctagcaaacgcatcctttcctactccaccccaatttgtatttagatagtttctctaacagaacggacaaatgaggctgcaaactaatttatttttgtcaaaaatcaatgttttgacatccacagacagtgaaataaaagaaatggcttgctgaaaaacatgaggagtcctagccacaaaatcactgcttaggttgcaattgccaaaatgaagccttcttagaagcacttctttagtatatacaggtgttggctgaagtccgtgcctcactctgggaaccattcttagtctccagtgtctcctattacaaagaagctggcagaaataaaaatgaaggggtgagagcggttccaccctagtctcatggtggaaaattcattggggagagctgtccaggatatttggagtcctgggtagaaggagcttgtaactactttaaagtcgacatctttgcacaggtgattgagtttctctgacctcattgcttcacctctgtctcctcccgtccttccgcacgtgcccacacacacgcagttcagccctctttcctccataagcctccatcgttttctcttttctcctcttgatcctttcaagcgagtatcttgttgaattgtatgttctgttggatctcctccttcataacatctggcttgttggacagaaaaaccctacagcccaccccctcccacagcccacctccacttttgaaagcccaaattacacctctcccagaacacagtgttgacgtaaatacagttacccaatattcctgtttgttcacctatttgctactttcactcagtagcatcccattttgtaaaatgaattccatggtcaccctgtcacaggaagtaatgaaaaatccagtgttcagtgtagtggtgcaaacctgagggcatagagctgttcatagagggctcttgttatagccaaacagacacagcaacaatctcaccatttatatatatatttttaacttgtccagctcatctatggaaaactactcaggtggtatgctgtttgaagcctcatcttcctacatgaaaattatgggcatttgtcccaatgattttgtttcagctgttctgtaggctgcataaccactctgatatttaggtatctgctattttattatcttaaaagacaaattaatttaattgcatgtgctagggaaaagctaccatgtacattcaccccaagtaaatagaatcctagatgaatcctagaaaaataatccctaagcagataggtagacagaggtaaacattcacatgatttagctctctagctcttgcactctgaacattcttgctttggttctgacttctgggaactgctttgcatttctcctatagatctgtagttaagggaaccaaggggtcattggggcaaaagcattgtttctcaaagctccttgattaagagaaagaacagaaatttgcacagaagatagtgtcaaggagtgagaaagtttgtttgagggcagtagctcagtgtggaagaaaatcctgaagtttctgttgaagccatacaatgttctatggggttactctctaagacattctctgaggtgtgtgaggaagtcactactcctagcctttgttaagatgtaattttaaatattcagttatggtactatgtttgcaactctcgtcttatcacaatgcctcagtagtttgttcccttagaaacatttagatgtgcacaaattaatcttttatatatctaaaggtttttctatcatgcattggattgctcagaataaagtgtctgttagacttcgttttggtaaataaattctccataatgtagattaataatataaaagtctttaatgacacaatatatctatatagcctcactgtataattcagaaataaaaattgattctgcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:158471 -> Molecular function: GO:0016462 [pyrophosphatase activity] evidence: IEA
GeneID:158471 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:158471 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:158471 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:158471 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:158471 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.