2024-03-29 14:16:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015171 4504 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens exportin 6 (XPO6), transcript variant 2, mRNA. ACCESSION NM_015171 VERSION NM_015171.3 GI:401461772 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4504) AUTHORS Dopie,J., Skarp,K.P., Rajakyla,E.K., Tanhuanpaa,K. and Vartiainen,M.K. TITLE Active maintenance of nuclear actin by importin 9 supports transcription JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (9), E544-E552 (2012) PUBMED 22323606 REFERENCE 2 (bases 1 to 4504) AUTHORS Park,S.H., Park,T.J. and Lim,I.K. TITLE Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells JOURNAL Exp. Cell Res. 317 (7), 941-954 (2011) PUBMED 21195711 REMARK GeneRIF: Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation. REFERENCE 3 (bases 1 to 4504) AUTHORS O'Reilly,A.J., Dacks,J.B. and Field,M.C. TITLE Evolution of the karyopherin-beta family of nucleocytoplasmic transport factors; ancient origins and continued specialization JOURNAL PLoS ONE 6 (4), E19308 (2011) PUBMED 21556326 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 4504) AUTHORS Ambs,S., Prueitt,R.L., Yi,M., Hudson,R.S., Howe,T.M., Petrocca,F., Wallace,T.A., Liu,C.G., Volinia,S., Calin,G.A., Yfantis,H.G., Stephens,R.M. and Croce,C.M. TITLE Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer JOURNAL Cancer Res. 68 (15), 6162-6170 (2008) PUBMED 18676839 REFERENCE 5 (bases 1 to 4504) AUTHORS Suzuki,T., Ishigami,Y., Okada,N., Kaneko,A., Fukutomi,R. and Isemura,M. TITLE Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells JOURNAL Biomed. Res. 29 (3), 141-145 (2008) PUBMED 18614847 REFERENCE 6 (bases 1 to 4504) AUTHORS Suzuki,T., Tazoe,H., Taguchi,K., Koyama,Y., Ichikawa,H., Hayakawa,S., Munakata,H. and Isemura,M. TITLE DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells JOURNAL Biomed. Res. 27 (3), 99-109 (2006) PUBMED 16847355 REFERENCE 7 (bases 1 to 4504) AUTHORS Stuven,T., Hartmann,E. and Gorlich,D. TITLE Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes JOURNAL EMBO J. 22 (21), 5928-5940 (2003) PUBMED 14592989 REMARK GeneRIF: identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI465054.1, BX346769.2, AB002368.3, AY026388.1 and AK026172.1. On Aug 16, 2012 this sequence version replaced gi:112293256. Summary: The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]. Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AB002368.3 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-5 BI465054.1 5-9 6-49 BX346769.2 1-44 50-2802 AB002368.3 1-2753 2803-4471 AY026388.1 2276-3944 4472-4504 AK026172.1 3616-3648 FEATURES Location/Qualifiers source 1..4504 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="16" /map="16p11.2" gene 1..4504 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /note="exportin 6" /db_xref="GeneID:23214" /db_xref="HGNC:19733" /db_xref="HPRD:10525" /db_xref="MIM:608411" exon 1..553 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" misc_feature 527..529 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /note="upstream in-frame stop codon" CDS 551..3928 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /note="isoform 2 is encoded by transcript variant 2; exportin-6; ran-binding protein 20" /codon_start=1 /product="exportin-6 isoform 2" /protein_id="NP_055986.1" /db_xref="GI:46049063" /db_xref="CCDS:CCDS42135.1" /db_xref="GeneID:23214" /db_xref="HGNC:19733" /db_xref="HPRD:10525" /db_xref="MIM:608411" /translation="
MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL
" misc_feature 641..838 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /note="Importin-beta N-terminal domain; Region: IBN_N; smart00913" /db_xref="CDD:197981" misc_feature 857..1309 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /note="Exportin 1-like protein; Region: Xpo1; pfam08389" /db_xref="CDD:203927" misc_feature 1145..1147 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1151..1153 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q96QU8.1); phosphorylation site" misc_feature 1151..1153 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1160..1162 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q96QU8.1); phosphorylation site" misc_feature 1160..1162 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1160..1162 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1172..1174 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1172..1174 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1190..1192 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1220..1222 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q96QU8.1); phosphorylation site" exon 554..644 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 645..757 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 758..955 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 956..1115 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 1116..1193 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" variation 1154 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="c" /replace="g" /db_xref="dbSNP:199701357" exon 1194..1647 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 1648..1774 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 1775..1884 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 1885..1993 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 1994..2086 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" variation 2083 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="a" /replace="t" /db_xref="dbSNP:181760" exon 2087..2156 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 2157..2316 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" STS 2207..2307 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /standard_name="RH125206" /db_xref="UniSTS:162028" exon 2317..2409 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 2410..2554 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 2555..2701 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 2702..2891 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 2892..3047 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" variation 2921 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="c" /replace="g" /db_xref="dbSNP:11557749" variation 2989 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:11557750" exon 3048..3162 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 3163..3334 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" variation 3211 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="a" /replace="g" /db_xref="dbSNP:35178107" exon 3335..3496 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 3497..3595 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" exon 3596..3826 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" variation 3635 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="g" /replace="t" /db_xref="dbSNP:14672" exon 3827..4490 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /inference="alignment:Splign:1.39.8" STS 3876..4480 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /standard_name="XPO6__4913" /db_xref="UniSTS:462949" STS 4232..4368 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /standard_name="RH11596" /db_xref="UniSTS:86526" variation 4272 /gene="XPO6" /gene_synonym="EXP6; RANBP20" /replace="c" /replace="t" /db_xref="dbSNP:11291" polyA_signal 4461..4466 /gene="XPO6" /gene_synonym="EXP6; RANBP20" polyA_site 4490 /gene="XPO6" /gene_synonym="EXP6; RANBP20" ORIGIN
agcgggcggctccagggcgggcgcgcgcaaggatgctctagggggcggcggcagtggccgtgtgggttgaggctgcgaggacagcgcgggcccccgggcctctcccctgagccggccgcctgggccgcgcggtcgaggcctgtcagcctccgcccgttcagcctcggggccggggccgccgccacctctgcccgcggaggccggggagcccctgcctgggcccgcagcctcccccgcgggggtcgggcccgggcgggggtcccgagcagctgccctcctcgccggcatccgagcctcatttcctgctttttcagtttccttggggaggggcgggtgggtctggatgaattgtctcggggtcccccgatgaggcgacccgggcggccctgccctttttagagggtcccctcggggcccggtggggaaggggttgtctttgcatgggtgggggacttcccgagtctgccgggaccatgacctgaactgtgcgagcgggacgtgtccgaagcccaagaaccagctcatctgagccgccccctccccggccagcatggcatctgaagaagcctctctcagggcattggaaagtctgatgacagaattttttcacgattgtacaaccaatgaaagaaaacgtgagatagaggagcttcttaataactttgcccagcaaataggagcctggagattctgcctgtactttctctccagcactaggaatgactatgtaatgatgtacagtttaacagtttttgagaatctgatcaataaaatgtggcttggggtcccatctcaggataagatggaaatccgtagctgtctgcccaaactccttttggctcaccataaaaccttaccttactttatccggaacaagctctgcaaagttattgttgatattggacgtcaggattggcccatgttctaccacgacttttttactaacattttacagttgatccagtcccctgtgacaaccccccttgggctgatcatgttgaagacaacttcagaagagctggcttgtccccgtgaggacctcagtgtggctcggaaggaggagttgcggaagctgctactggaccaggtgcagacagtgcttgggctactgacaggtatcttggagactgtctgggacaaacacagtgttactgctgccactccaccaccatccccgacctcaggagaaagtggtgacttactgagtaacctgttgcagagtcccagttcagccaaactgttgaatcagccaattcccatccttgatgtggagagtgagtatatctgttccctggctttggagtgcctggcccatctcttcagttggattcctctgtctgccagcatcaccccatccctccttaccaccatcttccactttgcacgatttggctgtgacatccgggccagaaagatggcgtcagttaacggcagcagccagaactgtgtctcgggtcaggagcgcggccggctgggggtcctggccatgtcctgcatcaatgaactcatgtccaagaactgtgtgcctatggaatttgaggagtatttactgcgtatgttccagcagactttctacctcctgcagaaaatcaccaaggataacaatgcccacacagtgaagagcaggctagaagagctcgatgagagctatatcgagaagtttactgactttcttcggctctttgtgagtgttcacctaagaagaatcgagtcttactcccagttccctgtggtggagtttttgacacttttgttcaagtacacatttcatcagcctactcatgaaggttacttctcttgtttggatatctggacgctgtttttggactatctgacaagtaaaattaaaagtcgtcttggagacaaggaagcagttctcaacaggtacgaagatgccctggtgctcctgctcacagaggtgttgaatcgaatccagttcagatacaaccaagcccagctggaggagttggatgatgagactctggatgacgatcagcagacggagtggcagcggtacttacggcagagcttggaggtggtggccaaagtgatggagctcctgcccacgcacgccttctccacactgttccctgttcttcaggacaatttagaagtttatttgggattacaacagtttatagtcacttcagggtcaggacacaggttgaacatcacggcggagaacgactgccggcggctgcactgctccctgagagacttgagctccctgctgcaggccgtgggccgcctggccgagtactttatcggggatgtgtttgctgcacggttcaatgatgccctcacagtcgtggaaaggttggtcaaagtcactctgtacggatctcagataaaattgtacaacattgaaactgctgtgccatcagtattgaaacctgacctcattgatgtgcatgctcagtccctggctgcgctgcaggcttactctcactggttagcacagtattgcagtgaagttcaccggcagaacacgcagcagttcgtgacactcatctctactaccatggatgcaatcacacctctaatcagcaccaaggtccaagacaagctgctgctatctgcgtgccacttactggtctcactggccaccaccgtgcggcccgtctttctgatcagcatccctgcagtgcagaaagtattcaacagaatcactgatgcctctgccctgcgacttgtcgataaggcccaggtgttggtgtgccgagccctctctaacatcttgctgcttccgtggccaaaccttccagagaatgagcagcagtggcccgtgcgctccatcaaccacgccagcctcatctctgcactctcccgggactatcgcaacctgaagcccagtgctgttgccccacagagaaagatgccactggatgacaccaaactgattatccaccagacactcagcgtcttagaagatattgtggagaatatctcgggggagtccaccaagtctcgacagatttgctaccagtcgctgcaggaatctgttcaggtctccctggccctctttccagcttttatccatcagtcagatgtgactgatgagatgctgagcttcttcctcactctgtttcgaggccttagagtacagatgggtgtgcctttcactgagcaaatcatacagactttcctcaacatgtttaccagagagcagttagccgagagcatcctccacgagggcagcacaggctgccgggtggtggagaagtttctgaagatcctgcaggtggtggtccaggagccaggccaggtgttcaagcccttcctccccagcatcatcgccctgtgcatggagcaagtgtatcccatcattgccgagcgtccctcccctgatgtgaaggccgagctgtttgagctccttttccggacgctccatcacaactggaggtacttcttcaagtccaccgtgctggccagtgtccagagggggatcgctgaggagcagatggagaatgagccccagttcagtgccatcatgcaggctttcggacagtcctttctccagcccgacatccacctttttaaacaaaatctcttctacttggagactctcaacaccaagcagaagctgtaccacaagaagatcttccggactgccatgctgttccagtttgtgaacgtgctgctccaggtcctggtccacaagtcccatgatcttctgcaggaggagattggcatcgccatctacaacatggcctcagtcgactttgatggcttctttgccgccttcctcccagagttcctgaccagctgtgatggtgtggatgccaaccagaaaagtgtgctggggcggaatttcaagatggatcgggacctgccctcattcacccagaatgtgcacaggctggtcaacgacctgcgctactacagactctgcaacgacagcctgccccctggcactgtgaagctctaggcctgctactgcctggggacacggacttctgctgctgccacctgcgccagccctaccttccaccacagatgtctcccagatgggccttggtcacactccttggcttctcccaccgcaagcaacgctgcctgcctctgccgctcctccacatcttgccgctgcccagcagagctggcttctgggtccacctgagcactggacggtgctcccagggcgttggagcaggcggaggggtgtgtggccaggtactaggaggcaccaggaaatcccgcggggtggcccatgcagaccaggcgcacgtggctcatggggcagaattgccaaggacagctcacgacagtgccaccttctcaccattccagccaaggagagatgtgacgttggaactgctctggcacttctgtcaagcctcccccgccccaattgccttgagatctctgctctttgtcagagatttgcaaagactcacgtttttgttgttttctcatcattccattgtgatactaagaaactaagaagcttaatgaaaagaaataaaatgcctatgttgttgttctagaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:23214 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:23214 -> Molecular function: GO:0008536 [Ran GTPase binding] evidence: IEA GeneID:23214 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IDA GeneID:23214 -> Biological process: GO:0006611 [protein export from nucleus] evidence: IDA GeneID:23214 -> Cellular component: GO:0005634 [nucleus] evidence: IC GeneID:23214 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:23214 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:23214 -> Cellular component: GO:0005737 [cytoplasm] evidence: IC GeneID:23214 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:23214 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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