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2024-04-27 08:08:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_015052 6839 bp mRNA linear PRI 29-JUN-2013
DEFINITION Homo sapiens HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 1 (HECW1), mRNA.
ACCESSION NM_015052
VERSION NM_015052.3 GI:94536810
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6839)
AUTHORS Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M. and Green,R.C.
CONSRTM The GENAROADS Consortium, and The Alzheimer's Disease Neuroimaging
Initiative
TITLE Genome-wide association study of the rate of cognitive decline in
Alzheimer's disease
JOURNAL Alzheimers Dement (2013) In press
PUBMED 23535033
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 6839)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 3 (bases 1 to 6839)
AUTHORS Shinada,K., Tsukiyama,T., Sho,T., Okumura,F., Asaka,M. and
Hatakeyama,S.
TITLE RNF43 interacts with NEDL1 and regulates p53-mediated transcription
JOURNAL Biochem. Biophys. Res. Commun. 404 (1), 143-147 (2011)
PUBMED 21108931
REMARK GeneRIF: These findings suggest that RNF43 is associated with
p53-mediated apoptosis in collaboration with NEDL1 in colorectal
carcinogenesis.
REFERENCE 4 (bases 1 to 6839)
AUTHORS Chansard,M., Wang,J., Tran,H.C., Neumayer,G., Shim,S.Y., Park,Y.U.,
Belzil,C., Le,H.T., Park,S.K. and Nguyen,M.D.
TITLE The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity
JOURNAL PLoS ONE 6 (1), E14583 (2011)
PUBMED 21283621
REMARK GeneRIF: Ndel1 regulates Dyn2 GTPase activity and impacts
GluR1-containing membranes distribution in a manner reminiscent of
Dyn2.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 6839)
AUTHORS Zhang,L., Haraguchi,S., Koda,T., Hashimoto,K. and Nakagawara,A.
TITLE Muscle atrophy and motor neuron degeneration in human NEDL1
transgenic mice
JOURNAL J. Biomed. Biotechnol. 2011, 831092 (2011)
PUBMED 20976258
REMARK GeneRIF: These findings suggest that the human NEDL1 transgenic
mice might develop Amyotrophic lateral sclerosis-like symptoms,
showing signs of motor abnormalities, accompanied with significant
reduction in muscle strength.
REFERENCE 6 (bases 1 to 6839)
AUTHORS Li,Y., Ozaki,T., Kikuchi,H., Yamamoto,H., Ohira,M. and
Nakagawara,A.
TITLE A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the
p53-mediated apoptotic cell death in its catalytic
activity-independent manner
JOURNAL Oncogene 27 (26), 3700-3709 (2008)
PUBMED 18223681
REMARK GeneRIF: functional interaction of NEDL1 with p53 might contribute
to the induction of apoptosis in cancerous cells bearing wild-type
p53.
REFERENCE 7 (bases 1 to 6839)
AUTHORS Miyazaki,K., Fujita,T., Ozaki,T., Kato,C., Kurose,Y., Sakamoto,M.,
Kato,S., Goto,T., Itoyama,Y., Aoki,M. and Nakagawara,A.
TITLE NEDL1, a novel ubiquitin-protein isopeptide ligase for
dishevelled-1, targets mutant superoxide dismutase-1
JOURNAL J. Biol. Chem. 279 (12), 11327-11335 (2004)
PUBMED 14684739
REMARK GeneRIF: interaction among misfolded SOD1, NEDL1,
translocon-associated protein-delta, and Dishevelled-1 forms a
ubiquitinated protein complex that is included in potentially
cytotoxic protein aggregates
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AB002320.2, AL079731.1, AL536075.3 and CH236951.1.
On May 4, 2006 this sequence version replaced gi:51702517.
##Evidence-Data-START##
Transcript exon combination :: BC151227.1, AB002320.2 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1814 AB002320.2 1-1814
1815-2179 AL079731.1 1-365 c
2180-4201 AB002320.2 2180-4201
4202-4393 AL536075.3 497-688
4394-6514 AB002320.2 4394-6514
6515-6839 CH236951.1 8335915-8336239
FEATURES Location/Qualifiers
source 1..6839
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7p13"
gene 1..6839
/gene="HECW1"
/gene_synonym="NEDL1"
/note="HECT, C2 and WW domain containing E3 ubiquitin
protein ligase 1"
/db_xref="GeneID:23072"
/db_xref="HGNC:22195"
/db_xref="MIM:610384"
exon 1..339
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 198
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371891485"
variation 202
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:58294963"
variation 227
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:6950443"
variation 252
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144009401"
variation 287
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:139919755"
exon 340..574
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 452
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:187321344"
variation 487
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192070374"
variation 554
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73690252"
exon 575..632
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
misc_feature 579..581
/gene="HECW1"
/gene_synonym="NEDL1"
/note="upstream in-frame stop codon"
variation 585
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368562868"
variation 586
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199936484"
variation 587
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201510541"
CDS 606..5426
/gene="HECW1"
/gene_synonym="NEDL1"
/note="NEDD4-like ubiquitin-protein ligase 1; HECT type E3
ubiquitin ligase; NEDD4-like E3 ubiquitin-protein ligase
1; HECT, C2 and WW domain-containing protein 1"
/codon_start=1
/product="E3 ubiquitin-protein ligase HECW1"
/protein_id="NP_055867.3"
/db_xref="GI:94536811"
/db_xref="CCDS:CCDS5469.2"
/db_xref="GeneID:23072"
/db_xref="HGNC:22195"
/db_xref="MIM:610384"
/translation="
MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVSELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
"
misc_feature 1218..1628
/gene="HECW1"
/gene_synonym="NEDL1"
/note="C2 domain present in NEDL1 (NEDD4-like ubiquitin
protein ligase-1); Region: C2_NEDL1-like; cd08691"
/db_xref="CDD:176073"
misc_feature 3099..3188
/gene="HECW1"
/gene_synonym="NEDL1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(3141..3143,3174..3176)
/gene="HECW1"
/gene_synonym="NEDL1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 3666..3758
/gene="HECW1"
/gene_synonym="NEDL1"
/note="Two conserved tryptophans domain; also known as the
WWP or rsp5 domain; around 40 amino acids; functions as an
interaction module in a diverse set of signalling
proteins; binds specific proline-rich sequences but at low
affinities compared to other...; Region: WW; cd00201"
/db_xref="CDD:29258"
misc_feature order(3708..3710,3741..3743)
/gene="HECW1"
/gene_synonym="NEDL1"
/note="binding pocket"
/db_xref="CDD:29258"
misc_feature 4353..5417
/gene="HECW1"
/gene_synonym="NEDL1"
/note="HECT domain; C-terminal catalytic domain of a
subclass of Ubiquitin-protein ligase (E3). It binds
specific ubiquitin-conjugating enzymes (E2), accepts
ubiquitin from E2, transfers ubiquitin to substrate lysine
side chains, and transfers additional...; Region: HECTc;
cd00078"
/db_xref="CDD:28959"
misc_feature order(4371..4373,4464..4466,4497..4499,4680..4682,
5202..5204,5307..5312,5319..5333,5391..5393,5412..5414)
/gene="HECW1"
/gene_synonym="NEDL1"
/note="catalytic cleft [active]"
/db_xref="CDD:28959"
misc_feature 4425..5414
/gene="HECW1"
/gene_synonym="NEDL1"
/note="Domain Homologous to E6-AP Carboxyl Terminus with;
Region: HECTc; smart00119"
/db_xref="CDD:197523"
misc_feature order(4764..4766,4773..4778,4782..4787,4794..4796,
4812..4814,4818..4820,4830..4835,4839..4841,4854..4856,
4869..4871,4920..4922,4932..4934)
/gene="HECW1"
/gene_synonym="NEDL1"
/note="E2 interaction site; other site"
/db_xref="CDD:28959"
exon 633..957
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 651
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201086058"
variation 674
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201182663"
variation 681
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:73689977"
variation 683
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200089893"
variation 727
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200159423"
variation 766
/gene="HECW1"
/gene_synonym="NEDL1"
/replace=""
/replace="g"
/db_xref="dbSNP:35544162"
variation 770
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370542628"
variation 798
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374211011"
variation 805
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201089900"
variation 819
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202230638"
variation 829
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368244752"
variation 885
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370846695"
variation 902
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:199717525"
variation 926
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375404889"
variation 927
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186064841"
exon 958..1065
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 971
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201545934"
variation 1018
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367924457"
variation 1051
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200226327"
exon 1066..1160
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1097
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372011835"
variation 1101
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375316956"
variation 1151
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369654096"
exon 1161..1236
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1190
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374959981"
variation 1191
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201771274"
variation 1217
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375753925"
exon 1237..1406
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1259
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201174011"
variation 1313
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:202123661"
variation 1331
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200458933"
variation 1378
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371180560"
variation 1383
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201297726"
exon 1407..1549
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1409
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368494869"
variation 1413
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371361987"
variation 1424
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376228341"
variation 1451
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188917781"
variation 1510
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371439876"
variation 1517
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375986974"
exon 1550..1650
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1581
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:373341777"
variation 1598
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375464510"
variation 1610
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186034589"
STS 1617..1721
/gene="HECW1"
/gene_synonym="NEDL1"
/standard_name="MARC_17638-17639:1019144663:1"
/db_xref="UniSTS:268363"
variation 1646
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372616325"
exon 1651..3003
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 1718
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200043164"
variation 1731
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199805512"
variation 1746
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148732222"
variation 1747
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375948910"
variation 1813
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199787620"
variation 1815
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:61756574"
variation 1816
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370379725"
variation 1831
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373792271"
variation 1833
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367947817"
variation 1881
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371781370"
variation 1932
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374061853"
variation 1955
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187285315"
variation 1970
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61756575"
variation 1982
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371948423"
variation 2030
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201974973"
variation 2031
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375279794"
variation 2033
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371806516"
variation 2052
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200135192"
variation 2101
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112942689"
variation 2109
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:61756576"
variation 2132
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375038744"
variation 2144
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:73098706"
variation 2321
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201984876"
variation 2332
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202172981"
variation 2395
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377574727"
variation 2408
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369433003"
variation 2425
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200427298"
variation 2434
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:377717656"
variation 2465
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371190628"
variation 2466
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144554534"
variation 2485
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201389596"
variation 2509
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376075834"
variation 2534
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201515538"
variation 2623
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370448181"
variation 2644
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:111854045"
variation 2646
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373899022"
variation 2657
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147766038"
variation 2658
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371914325"
variation 2675
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:191603508"
variation 2692
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374384580"
variation 2703
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:368768711"
variation 2718
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:372217151"
variation 2719
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:376772391"
variation 2720
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368888011"
variation 2726
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371663336"
variation 2765
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183902396"
variation 2768
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201225073"
variation 2790
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369348156"
variation 2819
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374095777"
variation 2822
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201575281"
variation 2833
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375621126"
variation 2855
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369845470"
variation 2936
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200544206"
variation 2937
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373326288"
variation 2943
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377512268"
variation 2971
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:370000752"
variation 2975
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372665438"
exon 3004..3105
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3013
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374067266"
variation 3015
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199597438"
variation 3040
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368269884"
variation 3060
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371238353"
variation 3064
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374435338"
exon 3106..3256
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3107
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142991713"
variation 3181
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368974637"
variation 3202
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201757499"
variation 3203
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376661071"
variation 3246
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367930122"
exon 3257..3396
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3316
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369474916"
variation 3317
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373646359"
variation 3324
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185512708"
variation 3330
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370723063"
variation 3348
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200817273"
variation 3351
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372874591"
variation 3369
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:71540534"
variation 3382
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369965476"
exon 3397..3518
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3404
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111254619"
variation 3410
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2304329"
variation 3464
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138489968"
variation 3467
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370783862"
variation 3488
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149605998"
variation 3494
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200118170"
variation 3509
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2304328"
variation 3518
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115118985"
exon 3519..3704
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3531
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369598569"
variation 3601
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372121389"
variation 3607
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199913481"
variation 3615
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:113884072"
variation 3617
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150631717"
variation 3620
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:191580199"
variation 3644
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376467156"
variation 3656
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200234231"
variation 3688
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:374098288"
variation 3699
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373090671"
exon 3705..3839
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3770
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:370199372"
variation 3775
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374489291"
variation 3780
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368011857"
variation 3784
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372005698"
variation 3833
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2304327"
exon 3840..3945
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3865
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371345945"
variation 3875
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375914979"
variation 3877
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201511376"
variation 3900
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:61756577"
variation 3938
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371372725"
exon 3946..4042
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 3946
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377720223"
variation 4038
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371604134"
variation 4040
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:181114904"
exon 4043..4126
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4063
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201521619"
variation 4079
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187653529"
exon 4127..4236
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4142
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375910588"
variation 4154
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367579167"
variation 4155
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117557838"
variation 4156
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:116945469"
variation 4179
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371633447"
variation 4201
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201959497"
variation 4202
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:17339479"
exon 4237..4357
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4286
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369643434"
STS 4326..4411
/gene="HECW1"
/gene_synonym="NEDL1"
/standard_name="MARC_8191-8192:996688382:1"
/db_xref="UniSTS:269922"
variation 4350
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:62458257"
exon 4358..4471
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4369
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200076235"
variation 4399
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200912368"
variation 4413
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142279539"
variation 4418
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370521844"
variation 4420
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367661051"
variation 4433
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:17172219"
variation 4435
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150833111"
variation 4469
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368235881"
exon 4472..4624
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4559
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:77786939"
variation 4589
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371606271"
variation 4590
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376669273"
variation 4598
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200822928"
variation 4599
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200973212"
variation 4607
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:78404575"
variation 4613
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141017471"
exon 4625..4723
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4637
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61756578"
variation 4665
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143683073"
variation 4685
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373271990"
variation 4694
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2304320"
exon 4724..4853
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4743
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370202350"
exon 4854..5000
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 4859
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199970050"
variation 4884
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369426934"
variation 4925
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371997052"
variation 4930
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375289259"
variation 4937
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:35927018"
variation 4951
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76552943"
variation 4959
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374397852"
exon 5001..5115
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 5012
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56111512"
variation 5019
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:367572727"
variation 5025
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371652643"
variation 5042
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:62461064"
variation 5068
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:192568048"
variation 5069
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374730956"
variation 5092
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368182508"
variation 5099
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200324723"
exon 5116..5314
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 5120
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113348394"
variation 5123
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200208944"
variation 5142
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202048147"
variation 5143
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139970379"
variation 5209
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202007423"
variation 5210
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373576994"
variation 5231
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376684730"
variation 5232
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370997480"
variation 5240
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375902111"
exon 5315..6839
/gene="HECW1"
/gene_synonym="NEDL1"
/inference="alignment:Splign:1.39.8"
variation 5329
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76196235"
variation 5343
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370262468"
variation 5350
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373779591"
variation 5359
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367929468"
variation 5367
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371612774"
variation 5433
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374811661"
STS 5436..5598
/gene="HECW1"
/gene_synonym="NEDL1"
/standard_name="RH11865"
/db_xref="UniSTS:11349"
variation 5585
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187241787"
variation 5586
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:190465842"
variation 5716
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="c"
/db_xref="dbSNP:183059413"
variation 5789
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:117445746"
variation 5810
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:736997"
variation 5890
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76050353"
variation 5936
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:187685077"
variation 5972
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="g"
/db_xref="dbSNP:3735072"
variation 5981
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="g"
/replace="t"
/db_xref="dbSNP:117889829"
variation 6008
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112198088"
variation 6116
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:113837549"
variation 6176
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:193290357"
variation 6179
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149818761"
variation 6293
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182441179"
variation 6357
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145837806"
variation 6493..6494
/gene="HECW1"
/gene_synonym="NEDL1"
/replace=""
/replace="t"
/db_xref="dbSNP:140721439"
variation 6493
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:78472786"
variation 6502
/gene="HECW1"
/gene_synonym="NEDL1"
/replace=""
/replace="t"
/db_xref="dbSNP:72182378"
variation 6506..6507
/gene="HECW1"
/gene_synonym="NEDL1"
/replace=""
/replace="t"
/db_xref="dbSNP:200680129"
variation 6559
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187869343"
variation 6832
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115530424"
variation 6836
/gene="HECW1"
/gene_synonym="NEDL1"
/replace="a"
/replace="t"
/db_xref="dbSNP:369265302"
ORIGIN
ggggatgcaagcgggaggataaagcgatgaagtgtgctgcgttaccgcgcatcaggcgctgttgttggagccggaacaccgtgcgactctgaccgaaccggccccctcctcgcgcacacactcgccgagccgcgcgcgcccctccgccgtgacagtggccgtggcctccgctctctcggggcacccggcagccagagcgcagcgagagcgggcggtcgccagggtcccctccccagccagtcccaggcgcccggtgcactatgcggggcacgtgcgccccccagctctaatctgcgcgctgacaggagcatgatctgtgcccaggccagggctgccaagatatcaatgctatgttcagcagaaacggatacagcaagagcagcatagttcaaaaattgagggaggcatcttctctcttttcctgggatttaaacgcgatttaggagggcagatgccctacccgaaaaggccaaccgttaaagaccccggcagtgttgtggtccaaggcgtctcaaagcaggtggccagatctgcgtttctcatcagcagactcactccggctgtggctattacggaattgatgcgcgtacacgtggtgggtcattatgctgctgcacctgtgtagtgtgaagaatctgtaccagaacaggtttttaggcctggccgccatggcgtctccttctagaaactcccagagccgacgccggtgcaaggagccgctccgatacagctacaaccccgaccagttccacaacatggacctcaggggcggcccccacgatggcgtcaccattccccgctccaccagcgacactgacctggtcacctcggacagccgctccacgctcatggtcagcagctcctactattccatcgggcactctcaggacctggtcatccactgggacataaaggaggaagtggacgctggggactggattggcatgtacctcattgatgaggtcttgtccgaaaactttctggactataaaaaccgtggagtcaatggttctcatcggggccagatcatctggaagatcgatgccagctcgtactttgtggaacctgaaactaagatctgcttcaaatactaccatggagtgagtggggccctgcgagcaaccacccccagtgtcacggtcaaaaactcggcagctcctatttttaaaagcattggtgctgatgagaccgtccaaggacaaggaagtcggaggctgatcagcttctctctctcagatttccaagccatggggttgaagaaagggatgtttttcaacccagacccttatctgaagatttccattcagcctgggaaacacagcatcttccccgccctccctcaccatggacaggagaggagatccaagatcataggcaacaccgtgaaccccatctggcaggccgagcaattcagttttgtgtccttgcccactgacgtgctggaaattgaggtgaaggacaagtttgccaagagccgccccatcatcaagcgcttcttgggaaagctgtcgatgcccgttcaaagactcctggagagacacgccataggggatagggtggtcagctacacacttggccgcaggcttccaacagatcatgtgagtggacagctgcaattccgatttgagatcacttcctccatccacccagatgatgaggagatttccctgagtaccgagcctgagtcagcccaaattcaggacagccccatgaacaacctgatggaaagcggcagtggggaacctcggtctgaggcaccagagtcctctgagagctggaagccagagcagctgggtgagggcagtgtccccgatggtccagggaaccaaagcatagagctttccagaccagctgaggaagcagcagtcatcacggaggcaggagaccagggcatggtctctgtgggacctgaaggggctggggagctcctggcccaggtgcaaaaggacatccagcctgcccccagtgcagaagagctggccgagcagctggacctgggtgaggaggcatcagcactgctgctggaagacggtgaagccccagccagcaccaaggaggagcccttggaggaggaagcaacgacccagagccgggctggaagggaagaagaggagaaggagcaggaggaggagggagatgtgtctaccctggagcagggagagggcaggctgcagctgcgggcctcggtgaagagaaaaagcaggccctgctccttgcctgtgtccgagctggagacggtgatcgcgtcagcctgcggggaccccgagaccccgcggacacactacatccgcatccacaccctgctgcacagcatgccctccgcccagggcggcagcgcggcagaggaggaggacggcgcggaggaggagtccaccctcaaggactcctcggagaaggatgggctcagcgaggtggacacggtggccgctgacccgtctgccctggaagaggacagagaagagcccgagggggctactccaggcacggcgcaccctggccactccgggggccacttccccagcctggccaatggcgcggcccaggatggcgacacgcaccccagcaccgggagcgagagcgactccagccccaggcaaggcggggaccacagttgcgagggctgtgacgcgtcctgctgcagcccctcgtgctacagctcctcgtgctacagcacgtcctgctacagcagctcgtgctacagcgcctcgtgctacagcccctcctgctacaacggcaacaggttcgccagccacacgcgcttctcctccgtggacagcgccaagatctccgagagcacggtcttctcctcgcaagacgacgaggaggaggagaacagcgcgttcgagtcggtacccgactccatgcagagccctgagctggacccggagtccacgaacggcgctgggccgtggcaagacgagctggccgcccctagcgggcacgtggaaagaagcccggaaggtctggaatcccccgtggcaggtccaagcaatcggagagaaggtgaatgtcctatactccataattcccagccagtaagccagcttccttccctgaggcctgaacatcatcactacccaacaatcgatgagcctcttccaccaaactgggaagctcgaattgacagccacgggcgggtcttttatgtggaccacgtgaaccgcacaaccacctggcagcgtccgacggcagcagccaccccggatggcatgcggagatcggggtccatccagcagatggagcaactcaacaggcggtatcaaaacattcagcgaaccattgcaacagagaggtccgaagaagattctggcagccaaagctgcgagcaagccccagcaggaggaggcggaggtggagggagtgactcagaagccgaatcttcccagtccagcttagatctaaggagagaggggtcactttctccagtgaactcacaaaaaatcaccttgctgctgcagtccccagcggtcaagttcatcaccaaccccgagttcttcactgtgctacatgccaattatagtgcctaccgagtcttcaccagtagcacctgcttaaagcacatgattctgaaagtccgacgggatgctcgcaattttgaacgctaccagcacaaccgggacttggtgaatttcatcaacatgttcgcagacactcggctggaactgccccggggctgggagatcaaaacggaccagcagggaaagtcttttttcgtggaccacaacagtcgagctaccactttcattgacccccgaatccctcttcagaacggtcgtcttcccaatcatctaactcaccgacagcacctccagaggctccgaagttacagcgctggagaggcctcagaagtttctagaaacagaggagcctctttactggccaggccaggacacagcttagtagctgctattcgaagccaacatcaacatgagtcattgccactggcatataatgacaagattgtggcatttcttcgccagccaaacatttttgaaatgctgcaagagcgtcagccaagcttagcaagaaaccacacactcagggagaaaatccattacattcggactgagggtaatcacgggcttgagaagttgtcctgtgatgcggatctggtcattttgctgagtctctttgaagaagagattatgtcctacgtccccctgcaggctgccttccaccctgggtatagcttctctccccgatgttcaccctgttcttcacctcagaactccccaggtttacagagagccagtgcaagagccccttccccctaccgaagagactttgaggccaagctccgcaatttctacagaaaactggaagccaaaggatttggtcagggtccggggaaaattaagctcattattcgccgggatcatttgttggagggaaccttcaatcaggtgatggcctattcgcggaaagagctccagcgaaacaagctctacgtcacctttgttggagaggagggcctggactacagtggcccctcgcgggagttcttcttccttctgtctcaggagctcttcaacccttactatggactctttgagtactcggcaaatgatacttacacggtgcagatcagccccatgtccgcatttgtagaaaaccatcttgagtggttcaggtttagcggtcgcatcctgggtctggctctgatccatcagtaccttcttgacgctttcttcacgaggcccttctacaaggcactcctgagactgccctgtgatttgagtgacctggaatatttggatgaggaattccaccagagtttgcagtggatgaaggacaacaacatcacagacatcttagacctcactttcactgttaatgaagaggtttttggacaggtcacggaaagggagttgaagtctggaggagccaacacacaggtgacggagaaaaacaagaaggagtacatcgagcgcatggtgaagtggcgggtggagcgcggcgtggtacagcagaccgaggcgctggtgcgcggcttctacgaggttgtagactcgaggctggtgtccgtgtttgatgccagggagctggagctggtgatagctggcaccgcggaaatcgacctaaatgactggcggaataacactgagtaccggggaggttaccacgatgggcatcttgtgatccgctggttctgggctgcggtggagcgcttcaataatgagcagaggctgagattactgcagtttgtcacgggaacatccagcgtgccctacgaaggcttcgcagccctccgtgggagcaatgggcttcggcgcttctgcatagagaaatgggggaaaattacttctctccccagggcacacacatgcttcaaccgactggatcttccaccgtatccctcgtactccatgttgtatgaaaagctgttaacagcagtagaggaaaccagcacctttggacttgagtgaggacatggaacctcgcctgacattttcctggccagtgacatcacccttcctgggatgatccccttttccctttcccttaatcaactctcctttgattttggtattccatgatttttattttcaaaccaaatcaggattgacaaaagctgtgcatgaagaactgccttcttctaagatctaaccttcaggcttctctcctctgttttcaatgaactgctagcctgtatgcaatattaaaaaacagctgtctcaaggtctgtgtatatctccacatacctccattactaacaatgaaatatgaatgcaagttaagctacacttgaccaaatggtaataaatgtttacttccatttctatcattgaagggaaaatgtgagcattaagcactccaggctttcatatgcccatgtcttctgagcagagccaccattttttataatttctaataaccaactccagaactaggagctgatcaactctttgttttcctctccatctacttttccctgtgcataatatccatccaaaggacaacagtggcaaagctgaaatttttatacattcaactcatgattcacatgtggcatcagtcccatcagccggaactagcctagacatacggtgcaaatatgacacttctaacgattaacaacagcaagaaaacacctgctgctgatgcaatgcaatgcatcccaatggttgtggggattgtgggctcaactcaagagaagtttaggagggggagcatccctagtgaatactcacaccacaagaaggacaaacttgtgcacatgtccaagaaagaaagcttcttgattgaggtagcatgaaggatgaggcttcagcccccattgtcttatgtagaatgtggcaatgccaactggagaaagggaagaaggacatattaccttggtttgaatccctgagttctgtactgttctgttttgtttagtctagccacagttcttcacaaaggaaaaaaaaatgtgtagatgataccatgacttttgttaaagccatgacttttgtttgcttggcagacaaaccctttttttaaaactttgatatttttttttcacatttttttttccttttcctttcttaatcatggagttcaagttcctttgcattcgattgtccatcgggaccacactaggaagctgcagagagtgatggtgcttgttagggatcaagggcaacatagtacttctccttcacccatagtaatcctcctggggcagaaacataacaccccaaaggcacgttgatttgtatcaaaataaatatccagtttcttttagcattcagtgaaaacatatctcagaaaacttcatgttgtcagaaaaacagctgcaggctccaaagacagcctaacctctcaactacatttgaaataaacccaaccataatggt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23072 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IBA
GeneID:23072 -> Biological process: GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IBA
GeneID:23072 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:23072 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:23072 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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