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2024-04-27 11:44:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014977 4951 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1),
transcript variant 1, mRNA.
ACCESSION NM_014977
VERSION NM_014977.3 GI:190341058
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4951)
AUTHORS Park,H.S., Seong,K.M., Kim,J.Y., Kim,C.S., Yang,K.H., Jin,Y.W. and
Nam,S.Y.
TITLE Chronic low-dose radiation inhibits the cells death by cytotoxic
high-dose radiation increasing the level of AKT and acinus proteins
via NF-kappaB activation
JOURNAL Int. J. Radiat. Biol. 89 (5), 371-377 (2013)
PUBMED 23205493
REMARK GeneRIF: Chronic low-dose radiation increases the levels of AKT and
acinus proteins via NF-kappaB activation
REFERENCE 2 (bases 1 to 4951)
AUTHORS Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
Schreiber,S. and Nebel,A.
TITLE Investigation of genetic susceptibility factors for human longevity
- a targeted nonsynonymous SNP study
JOURNAL Mutat. Res. 694 (1-2), 13-19 (2010)
PUBMED 20800603
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 4951)
AUTHORS Chan,C.B., Liu,X., Jang,S.W., Hsu,S.I., Williams,I., Kang,S.,
Chen,J. and Ye,K.
TITLE NGF inhibits human leukemia proliferation by downregulating cyclin
A1 expression through promoting acinus/CtBP2 association
JOURNAL Oncogene 28 (43), 3825-3836 (2009)
PUBMED 19668232
REMARK GeneRIF: Study shows that transcription corepressor CtBP2 directly
binds acinus, which is regulated by nerve growth factor (NGF),
inhibiting its stimulatory effect on cyclin A1, but not cyclin A2,
expression in leukemia.
REFERENCE 4 (bases 1 to 4951)
AUTHORS Park,H.S., Yun,Y., Kim,C.S., Yang,K.H., Jeong,M., Ahn,S.K.,
Jin,Y.W. and Nam,S.Y.
TITLE A critical role for AKT activation in protecting cells from
ionizing radiation-induced apoptosis and the regulation of acinus
gene expression
JOURNAL Eur. J. Cell Biol. 88 (10), 563-575 (2009)
PUBMED 19615784
REMARK GeneRIF: A critical role for AKT activation in protecting cells
from ionizing radiation-induced apoptosis and the regulation of
acinus gene expression is reported.
REFERENCE 5 (bases 1 to 4951)
AUTHORS Rigou,P., Piddubnyak,V., Faye,A., Rain,J.C., Michel,L., Calvo,F.
and Poyet,J.L.
TITLE The antiapoptotic protein AAC-11 interacts with and regulates
Acinus-mediated DNA fragmentation
JOURNAL EMBO J. 28 (11), 1576-1588 (2009)
PUBMED 19387494
REMARK GeneRIF: The authors report here that AAC-11, a survival protein
whose expression prevents apoptosis that occurs on deprivation of
growth factors, physiologically binds to Acinus and prevents
Acinus-mediated DNA fragmentation.
REFERENCE 6 (bases 1 to 4951)
AUTHORS Joselin,A.P., Schulze-Osthoff,K. and Schwerk,C.
TITLE Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not
chromatin condensation during apoptosis
JOURNAL J. Biol. Chem. 281 (18), 12475-12484 (2006)
PUBMED 16537548
REMARK GeneRIF: Acinus is not involved in DNA condensation but rather has
a role in internucleosomal DNA cleavage during programmed cell
death
REFERENCE 7 (bases 1 to 4951)
AUTHORS Hu,Y., Yao,J., Liu,Z., Liu,X., Fu,H. and Ye,K.
TITLE Akt phosphorylates acinus and inhibits its proteolytic cleavage,
preventing chromatin condensation
JOURNAL EMBO J. 24 (20), 3543-3554 (2005)
PUBMED 16177823
REMARK GeneRIF: Akt phosphorylation of acinus on serine 422 and 573
results in its resistance to caspase cleavage in the nucleus and
the inhibition of acinus-dependent chromatin condensation.
REFERENCE 8 (bases 1 to 4951)
AUTHORS Sordet,O., Rebe,C., Plenchette,S., Zermati,Y., Hermine,O.,
Vainchenker,W., Garrido,C., Solary,E. and Dubrez-Daloz,L.
TITLE Specific involvement of caspases in the differentiation of
monocytes into macrophages
JOURNAL Blood 100 (13), 4446-4453 (2002)
PUBMED 12393560
REFERENCE 9 (bases 1 to 4951)
AUTHORS Zermati,Y., Garrido,C., Amsellem,S., Fishelson,S., Bouscary,D.,
Valensi,F., Varet,B., Solary,E. and Hermine,O.
TITLE Caspase activation is required for terminal erythroid
differentiation
JOURNAL J. Exp. Med. 193 (2), 247-254 (2001)
PUBMED 11208865
REFERENCE 10 (bases 1 to 4951)
AUTHORS Sahara,S., Aoto,M., Eguchi,Y., Imamoto,N., Yoneda,Y. and
Tsujimoto,Y.
TITLE Acinus is a caspase-3-activated protein required for apoptotic
chromatin condensation
JOURNAL Nature 401 (6749), 168-173 (1999)
PUBMED 10490026
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF124726.1, AL117258.4 and
BC032770.1.
This sequence is a reference standard in the RefSeqGene project.
On Jun 13, 2008 this sequence version replaced gi:142377385.
Summary: Apoptosis is defined by several morphologic nuclear
changes, including chromatin condensation and nuclear
fragmentation. This gene encodes a nuclear protein that induces
apoptotic chromatin condensation after activation by caspase-3,
without inducing DNA fragmentation. This protein has also been
shown to be a component of a splicing-dependent multiprotein exon
junction complex (EJC) that is deposited at splice junctions on
mRNAs, as a consequence of pre-mRNA splicing. It may thus be
involved in mRNA metabolism associated with splicing. Alternatively
spliced transcript variants encoding different isoforms have been
described for this gene. [provided by RefSeq, Oct 2011].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1), also known as
ACINUS-L.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF124726.1, AB014570.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-76 AF124726.1 1-76
77-78 AL117258.4 149543-149544
79-4935 AF124726.1 78-4934
4936-4951 BC032770.1 3010-3025
FEATURES Location/Qualifiers
source 1..4951
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q11.2"
gene 1..4951
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="apoptotic chromatin condensation inducer 1"
/db_xref="GeneID:22985"
/db_xref="HGNC:17066"
/db_xref="HPRD:05191"
/db_xref="MIM:604562"
exon 1..640
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
misc_feature 317..319
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="upstream in-frame stop codon"
CDS 329..4354
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="isoform 1 is encoded by transcript variant 1;
apoptotic chromatin condensation inducer in the nucleus;
functional spliceosome-associated protein 152"
/codon_start=1
/product="apoptotic chromatin condensation inducer in the
nucleus isoform 1"
/protein_id="NP_055792.1"
/db_xref="GI:7662238"
/db_xref="CCDS:CCDS9587.1"
/db_xref="GeneID:22985"
/db_xref="HGNC:17066"
/db_xref="HPRD:05191"
/db_xref="MIM:604562"
/translation="
MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR
"
misc_feature 542..646
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="SAP domain; Region: SAP; pfam02037"
/db_xref="CDD:202100"
misc_feature 824..826
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 833..835
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 893..895
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 896..898
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 923..925
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 950..952
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 956..958
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 974..976
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 974..976
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1046..1048
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1046..1048
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1055..1057
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1055..1057
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1088..1090
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 1133..1135
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 1211..1213
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1304..1306
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 1310..1312
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1310..1312
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1349..1351
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1421..1423
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1421..1423
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1478..1480
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1478..1480
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1478..1480
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1484..1486
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1484..1486
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1490..1492
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1490..1492
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1490..1492
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1505..1507
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 1505..1507
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1526..1528
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1550..1552
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1556..1558
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1556..1558
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1568..1570
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 1568..1570
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1598..1600
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1601..1603
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1628..1630
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1685..1687
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1697..1699
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1709..1711
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1760..1762
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1796..1798
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 1796..1798
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1862..1864
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 2009..2011
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2288..2290
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="N6,N6,N6-trimethyllysine, by EHMT2, alternate;
N6,N6-dimethyllysine, by EHMT2, alternate; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); methylation site"
misc_feature 2291..2293
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2291..2293
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2297..2299
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2297..2299
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2297..2299
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2309..2311
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2354..2356
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2372..2374
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 2372..2374
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2456..2458
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2456..2458
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2456..2458
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2468..2470
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2477..2479
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); acetylation site"
misc_feature 2486..2488
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation site"
misc_feature 2513..2515
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2513..2515
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2801..2803
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 2840..2842
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3011..3013
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3020..3022
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3287..3289
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3296..3298
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3338..3340
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKV3.2); phosphorylation site"
misc_feature 3338..3340
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3338..3340
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3368..3547
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(3371..3373,3479..3481,3485..3487)
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 3605..3610
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q9UKV3.2); cleavage site"
misc_feature 3605..3607
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/citation=[10]
/db_xref="HPRD:02799"
misc_feature 3854..3856
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3860..3862
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3866..3868
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by SRPK2 and PKB/AKT1; propagated
from UniProtKB/Swiss-Prot (Q9UKV3.2); phosphorylation
site"
misc_feature 4178..4180
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4313..4315
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4319..4321
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4322..4324
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 641..706
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 707..818
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 819..938
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
variation 870
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:201254054"
exon 939..1027
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 1028..2290
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
STS 1074..1177
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/standard_name="D14S791"
/db_xref="UniSTS:153528"
variation 1098
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="a"
/replace="g"
/db_xref="dbSNP:11555803"
variation 1165..1167
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace=""
/replace="gga"
/db_xref="dbSNP:3841035"
variation 1261
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="a"
/replace="g"
/db_xref="dbSNP:3811182"
exon 2291..2509
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 2510..2625
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 2626..2767
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 2768..2810
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 2811..2944
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
variation 2859
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="a"
/replace="g"
/db_xref="dbSNP:1052671"
exon 2945..3097
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 3098..3239
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 3240..3385
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 3386..3493
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 3494..3601
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
STS 3555..3654
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/standard_name="MARC_15355-15356:1013456014:1"
/db_xref="UniSTS:267824"
exon 3602..3926
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
STS 3654..3813
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/standard_name="RH44611"
/db_xref="UniSTS:68317"
exon 3927..4027
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
exon 4028..4938
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/inference="alignment:Splign:1.39.8"
STS 4586..4835
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/standard_name="WI-20153"
/db_xref="UniSTS:16489"
variation 4792
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052881"
variation 4794
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052884"
variation 4833
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="a"
/replace="c"
/db_xref="dbSNP:1052904"
variation 4844
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
/replace="a"
/replace="c"
/db_xref="dbSNP:1052922"
polyA_signal 4914..4919
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
polyA_site 4938
/gene="ACIN1"
/gene_synonym="ACINUS; ACN; fSAP152"
ORIGIN
cttttctctcgaagggcacccgaagattgtcacgagtccttagactccaactactgcggcagcttccaaatttcctgaaaaccctaagctgggccagcccggcagcccacgcacttccggcctcggacccgccccaaacacccaagcgccccagcgcctcatctctaggtccggaaataaacgaacatctccgattatggttataccagggtcgagggtttccgaatatattcgattcaaagcttcggcaagacgaagaaaaccgagcctgaaagcagggcgagaaaaggggcgctgcagggcggatggaaagaattgattggtaacgatgtggagacggaaacatccgaggacatccggaggaacccggggagttctgagtggtaatcgaggggtagagtatggcagtgggcggggtcatctcggtacgttcgaagggcgttggcggaaattaccgaagatgcccgaagccgtcgggacggacccgagtacctcacgcaagatggcggagctggaggaggtgactctggacgggaagcctcttcaggcgctgcgggtgaccgacctgaaggccgcactggagcagcgaggcctagccaagagcgggcagaagagtgccctggtcaagcggctcaaaggggctctaatgctagaaaatttacagaaacactcaacaccccatgctgcattccagccaaattcccagattggtgaggaaatgagccagaacagtttcataaaacagtatctggaaaagcagcaggagctacttaggcagcgtctggaacgtgaagctcgagaagctgcagaacttgaagaagcttcagctgagtcggaggacgagatgatccatcctgagggagtggcttccctgctgcctcctgactttcagagcagcctggagagaccagagctggagctcagcagacattcgcccagaaaaagctcctcaatttctgaagagaaaggtgactctgatgatgagaaaccaaggaaaggagaaagacgatcatctagggtcagacaggcaagagcagctaaactgtctgagggcagccaacctgctgaggaggaagaggatcaagaaacaccttccagaaacctaagggtcagagcagatcgaaatttgaaaacagaggaggaagaagaggaggaggaggaggaggaagaagatgatgaagaagaggaaggtgatgatgagggacaaaaatctagggaggcaccaatcctgaaagagtttaaggaagaaggggaagagatacctagagtaaaaccagaggagatgatggatgagagacccaaaacaagatcccaggaacaggaggtgttagagagaggagggagatttacaagatcccaggaagaggctagaaaaagtcatctggccagacagcagcaggagaaggaaatgaaaacaacatctccccttgaggaggaagaaagagaaataaaatcttcacaaggcttaaaggaaaaatcgaagtctccttcccctcctcgactgactgaagatcgaaagaaggcctcacttgtagcgctgccagagcaaactgccagcgaggaggagactcctccacctttactaacaaaggaagcatcttctccaccacctcatccacagctccatagcgaagaagaaatagagcccatggaaggcccagccccccctgtcctcattcagttatctcctcctaatacagatgctgacaccagggagctattagtatctcagcatactgtccagttggtaggaggcctgtctcctttgtcaagtccttcagacaccaaagcagaatctccagcagagaaagtgccagaggagagtgtcctgcctctggttcagaaaagcacactggctgactactcagcccagaaggatcttgaacctgagtcagacagatctgctcagcccctccctctaaaaattgaggaattagcactggccaaaggaatcactgaagaatgtctgaaacagccatctttggaacagaaggaaggcagaagagcttctcatacccttctcccaagccacagattgaaacagtcagctgattcatcctctagccggtcctcctcatcttcctcctccagttctagatcaagatctcgctctcctgacagttcaggttctcggtctcattcaccgctcagatccaagcagagagatgtagcccaggcacgtactcatgccaaccctcgtggtagacccaagatgggctccagatcaacatcagagtccagatcaaggtcacgttcacgttctcgttcagcatcaagcaacagcagaaaatctctgagccctggagtctccagggacagcagcaccagctatactgaaaccaaagatccctcttctggtcaggaggttgcaactccaccagtgccacaactgcaggtctgtgagccaaaggagaggacttccacctcctcatcctctgtccaagcaaggcgtctgagtcagcctgaatcagctgaaaagcatgtgacccagaggttacagcctgagcgggggagcccaaagaagtgtgaagctgaagaggcagagccaccagctgccacacagccccaaacctcagagactcagacctctcatctgccagaatcagaaagaattcatcacactgttgaggagaaggaggaagtgaccatggacacaagtgaaaacagacctgaaaatgatgttccagaacctcccatgcctattgcagaccaagtcagcaatgatgaccgcccggagggcagtgttgaagatgaggagaagaaagagagctcgctgcccaaatcattcaagaggaagatctccgttgtctcagctaccaagggggtgccagctggaaacagtgacacagaggggggccagcctggtcggaaacgacgctggggagccagcacagccaccacacagaagaaaccttccatcagtatcaccactgaatcactaaagagcctcatccccgacatcaaacccctggcggggcaggaggctgttgtggatcttcatgctgatgactctcgcatctctgaggatgagacagagcgtaatggcgatgatgggacccatgacaaggggctgaaaatatgccggacagtcactcaggtagtacctgcagagggccaggagaatgggcagagggaagaagaggaagaagagaaggaacctgaagcagaacctcctgtacctccccaggtgtcagtagaggtggccttgcccccacctgcagagcatgaagtaaagaaagtgactttaggagataccttaactcgacgttccattagccagcagaagtccggagtttccattaccattgatgacccagtccgaactgcccaggtgccctccccaccccggggcaagattagcaacattgtccatatctccaatttggtccgtcctttcactttaggccagctaaaggagttgttggggcgcacaggaaccttggtggaagaggccttctggattgacaagatcaaatctcattgctttgtaacgtactcaacagtagaggaagctgttgccacccgcacagctctgcacggggtcaaatggccccagtccaatcccaaattcctttgtgctgactatgccgagcaagatgagctggattatcaccgaggcctcttggtggaccgtccctctgaaactaagacagaggagcagggaataccacggcccctgcaccccccacccccacccccggtccagccaccacagcacccccgggcagagcagcgggagcaggaacgggcagtgcgggaacagtgggcagaacgggaacgggaaatggagcggcgggagcggactcgatcagagcgtgaatgggatcgggacaaagttcgagaagggccccgttcccgatcaaggtcccgtgaccgccgccgcaaggaacgtgcgaagtctaaagaaaagaagagtgagaagaaagagaaagcccaggaggaaccacctgccaagctgctggatgaccttttccgaaagaccaaggcagctccctgcatctattggctcccactgactgacagccagatcgttcagaaagaggcagagcgggccgaacgggccaaggagcgggagaagcggcgaaaggagcaagaagaagaagagcaaaaggagcgggagaaggaagccgagcgggaacggaaccgacagctggagcgagagaaacgtcgggagcacagtcgggagagggacagggagagagagagagaaagggagcgggacaggggggaccgagatcgggatagggaaagggaccgagaacgaggcagggaaagggatcgcagggacaccaagcgccacagcagaagccggagtcggagcacacctgtgcgggaccggggtgggcgccgctagctgggaaaacactagagctgcaggtaccagccactcggccccagggggttatggccacagagggataggcacagtctccaccaccctggagccaagggtctttcacatcacctatccctacatacataccaaatggaaaagtggccatccttttccccccaaacacacccccttaacctatctcttgggacttagcccgaccctccctctcatttcccattaagtctgagaggcaagagctaggttaggcaaggaggtggttggccagagatggggaacagccaggtgccccagtcctctgatttttcctccatcctgcttaccacctccctgggtacttacagccttctcttgggaacagccggggccaggactgggtcacctatgagctgaatcagcatctcctcctgagtcccagggcccctgcagttcccagtctcttctgtcctgcagcccttgcctctttcccacaggttccactttatatccaccttttccttttgttcaatttttatttttattttttttattattaaatgatgtggtctatggaaaaaaaaataaaaatctgacttagttttaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:22985 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:22985 -> Molecular function: GO:0003676 [nucleic acid binding] evidence: NAS
GeneID:22985 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:22985 -> Molecular function: GO:0016887 [ATPase activity] evidence: NAS
GeneID:22985 -> Molecular function: GO:0019899 [enzyme binding] evidence: NAS
GeneID:22985 -> Biological process: GO:0006200 [ATP catabolic process] evidence: NAS
GeneID:22985 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:22985 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:22985 -> Biological process: GO:0030218 [erythrocyte differentiation] evidence: IEP
GeneID:22985 -> Biological process: GO:0030263 [apoptotic chromosome condensation] evidence: IDA
GeneID:22985 -> Biological process: GO:0045657 [positive regulation of monocyte differentiation] evidence: IEP
GeneID:22985 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:22985 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:22985 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:22985 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:22985 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA
by
@meso_cacase at
DBCLS
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