Home |
Help |
Advanced search
2024-04-26 16:25:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014891 2707 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens PDGFA associated protein 1 (PDAP1), mRNA.
ACCESSION NM_014891
VERSION NM_014891.6 GI:315467839
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2707)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
REFERENCE 2 (bases 1 to 2707)
AUTHORS LaRochelle,W.J., Jeffers,M., McDonald,W.F., Chillakuru,R.A.,
Giese,N.A., Lokker,N.A., Sullivan,C., Boldog,F.L., Yang,M.,
Vernet,C., Burgess,C.E., Fernandes,E., Deegler,L.L., Rittman,B.,
Shimkets,J., Shimkets,R.A., Rothberg,J.M. and Lichenstein,H.S.
TITLE PDGF-D, a new protease-activated growth factor
JOURNAL Nat. Cell Biol. 3 (5), 517-521 (2001)
PUBMED 11331882
REFERENCE 3 (bases 1 to 2707)
AUTHORS Fischer,W.H. and Schubert,D.
TITLE Characterization of a novel platelet-derived growth
factor-associated protein
JOURNAL J. Neurochem. 66 (5), 2213-2216 (1996)
PUBMED 8780057
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BG281467.1, BI460344.1,
BC000684.2, AC004922.2 and BC001578.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 24, 2010 this sequence version replaced gi:51242950.
Summary: The protein encoded by this gene is a phosphoprotein that
may upregulate the PDGFA-stimulated growth of fibroblasts and also
downregulate the mitogenicity of PDGFB. The encoded protein in
rodents has been shown to bind PDGFA with a low affinity. [provided
by RefSeq, Dec 2010].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC000684.2, AL547288.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-62 BG281467.1 1-62
63-88 BI460344.1 55-80
89-1377 BC000684.2 1-1289
1378-2582 AC004922.2 35794-36998
2583-2707 BC001578.1 936-1060
FEATURES Location/Qualifiers
source 1..2707
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.1"
gene 1..2707
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/note="PDGFA associated protein 1"
/db_xref="GeneID:11333"
/db_xref="HGNC:14634"
/db_xref="HPRD:06149"
/db_xref="MIM:607075"
exon 1..147
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
variation 63
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11537951"
CDS 135..680
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/note="PDGF-associated protein"
/codon_start=1
/product="28 kDa heat- and acid-stable phosphoprotein"
/protein_id="NP_055706.1"
/db_xref="GI:7657441"
/db_xref="CCDS:CCDS5662.1"
/db_xref="GeneID:11333"
/db_xref="HGNC:14634"
/db_xref="HPRD:06149"
/db_xref="MIM:607075"
/translation="
MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPKKEKKSLDSDESEDEEDDYQQKRKGVEGLIDIENPNRVAQTTKKVTQLDLDGPKELSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDDATLSGKRMQSLSLNK
"
misc_feature 189..191
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13442.1); phosphorylation site"
misc_feature 303..305
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13442.1); phosphorylation site"
misc_feature 303..305
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 312..314
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13442.1); phosphorylation site"
misc_feature 312..314
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[1]
misc_feature 321..323
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13442.1); phosphorylation site"
misc_feature 321..323
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[1]
misc_feature 321..323
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 384..>572
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/note="Casein kinase substrate phosphoprotein PP28;
Region: PP28; pfam10252"
/db_xref="CDD:204422"
misc_feature 528..530
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13442.1); acetylation site"
misc_feature 660..662
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13442.1); phosphorylation site"
exon 148..239
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
exon 240..347
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
exon 348..469
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
exon 470..621
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
exon 622..2689
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/inference="alignment:Splign:1.39.8"
variation 1203
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044101"
variation 1225
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1044111"
STS 1350..1587
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/standard_name="STS-W92745"
/db_xref="UniSTS:73284"
polyA_signal 1356..1361
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
polyA_site 1377
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
STS 1471..1741
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/standard_name="STS-W92745"
/db_xref="UniSTS:15756"
variation 1572
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3201781"
STS 1875..2564
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/standard_name="PDAP1_9266"
/db_xref="UniSTS:468102"
STS 2020..2108
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
polyA_site 2396
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
variation 2583
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3087868"
polyA_signal 2665..2670
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
polyA_site 2689
/gene="PDAP1"
/gene_synonym="HASPP28; PAP; PAP1"
ORIGIN
ggtccttgcggccactgcggccactgaagcggcggcggcggctggcccaggaggaagaagtcgagcccaagctatttccggttccggtgtcagttcgaggcgccgccgccgccgccgcagccgccggagccgcaatgcctaaaggaggaagaaagggaggccacaaaggccgggcgaggcagtatacaagccctgaggagatcgacgcgcagctgcaggctgagaagcagaaggccagggaagaagaggagcaaaaagaaggtggagatggggctgcaggtgaccccaaaaaggagaagaaatctctagactcagatgagagtgaggatgaagaagatgactaccagcaaaagcgcaaaggcgttgaagggctcatcgacatcgagaaccccaaccgggtggcacagacaaccaaaaaggtcacacaactggatctggacgggccaaaggagctttcgaggagagaacgagaagagattgagaagcagaaggcaaaagagcgttacatgaaaatgcacttggccgggaagacagagcaagccaaggctgacctggcccggctggccatcatccggaaacagcgggaggaggctgcccggaagaaggaagaggaaaggaaagcaaaagacgatgccacattgtcaggaaaacgaatgcagtcactctccctgaataagtaactgcgacccgtgggaggagatgccggggacctgggccgcgctgccaggacctctgctgtgtctcgcccaccctgtgccctggcgccgctgcaacagcccctcatggccaggagccccccatggcctggggcctcctcttcatcttggcacagaaattgtttgggggatggggggggggactgggggaggggtagctgctatctttgagacagaaagatgcaggacagcatttcatatgtaaccatttgaatgtttttgctgtttttagaattcagagcccttgctggggggtgcctgggagatggggtaagaagagctttcatttgtctggtagatagatagcatgtaagggggtggttgtcccaggaggcagctgctgacaggtttgctacacacagccccggactgtgttgcctgggtgctcattcagagaggggctatcatctgggagcctgtgcccctgggtcctcgagggtcatggcttgtccctggtcagtcctgtctgactgacctcagggcctcacctctctgcccttccctgcccggttcctactcacctggctagggccagtgcccattttcagccctacccattgatcatttcaagaaacctctgtttactgtgtggcacccaggcaaaacatgctccacaaattcaacttgtatatttggcagattaaacttgacattatcgtaatctttgttttggcaatccatcctttggcttccgtgctcgagccgtttttacccagctgggtacggtgccacgttcaggcacgtgcacccggcaaggttcagggcacatacctacctggggcatgacatctgtcaggtggcaccgagcaggatgcggggatggaccctagataccacagcctgccccctcccctcctttagccaagtcaggatcttaggcctcagcaggcagggacccttccaggccacagtaggctgaagcagcaccaggatcctggcctggcctggcctgtaggtgtcccctggtggttataattctgtaactctaggggagaaggggaatagcactagcattggatgtcgccaaggcccacattttcctgagagaagccacaaaagatgtgcaaatgcccttcagcacaggacctggtgacatgacataaactccaagacagaacctcagtttacagcacacgaaaaaaatatcttgccaacattgtaatgacaaaataaattcccgtgaagttccacaaccaggccgggcatggtggctcatgcctgtaatcccagcactttgggaggtgaggtgggtggatcatctgaggtcaggagttcaagaccagcctggccaacatggagaaactccgtctctactaaaaatacaaaaattaaccaggcttggtggtgtatgcctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgatcccaggaaggcagaggtggcagtgagctgagaacgcacaactgcactccagcctgggtgacgagcaaaactccatctcaaaacaaaagttccacaaccagcctggagtgtgtagcccctttgtccaggaatttgactagtcaatcagtgacacctggtactggcagttttgggagtggcagcccaggatggacagcagtggggagggaaccatttggcataaggccgttgggcttcaggatcaattttgttggcaagcagtaaaaataagctatctacctatggccgtgcaaacaccaatctctccctggagtcccagctacttgggaggctgaggcagaaggattgctcccacgagttctagtgcagcctggaaaacttagcaagaccccaaggaaataacaaaaaacctctccttccacataggcaagcatgtccataattacttttttttttttttttttttttacacagttgcattttattacctccacattttgaagcagttcatgaccagcatagtgctttgggggcattttttttttttttcaataaatgaaagcatttaagaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11333 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:11333 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.