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2024-04-26 05:38:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014828 4538 bp mRNA linear PRI 21-APR-2013
DEFINITION Homo sapiens TOX high mobility group box family member 4 (TOX4),
mRNA.
ACCESSION NM_014828 XM_375045
VERSION NM_014828.2 GI:99077116
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4538)
AUTHORS Li,W.L. and Gao,Q.
TITLE [Mig-7 enhances vasculogenic mimicry in gastric cancer cells]
JOURNAL Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28 (11), 1142-1145 (2012)
PUBMED 23127401
REMARK GeneRIF: The formation of vasculogenic mimicry is inhibited by
reducing the expression of Mig-7 in gastric cancer cells.
REFERENCE 2 (bases 1 to 4538)
AUTHORS Tessema,M., Yingling,C.M., Grimes,M.J., Thomas,C.L., Liu,Y.,
Leng,S., Joste,N. and Belinsky,S.A.
TITLE Differential epigenetic regulation of TOX subfamily high mobility
group box genes in lung and breast cancers
JOURNAL PLoS ONE 7 (4), E34850 (2012)
PUBMED 22496870
REMARK GeneRIF: Compared with TOX4, expression of TOX1, TOX2 and TOX3 in
normal lung was 25, 44, and 88%lower, respectively, supporting the
premise that reduced promoter activity confers increased
susceptibility to methylation during lung carcinogenesis.
REFERENCE 3 (bases 1 to 4538)
AUTHORS Bounaix Morand du Puch,C., Barbier,E., Kraut,A., Coute,Y.,
Fuchs,J., Buhot,A., Livache,T., Seve,M., Favier,A., Douki,T.,
Gasparutto,D., Sauvaigo,S. and Breton,J.
TITLE TOX4 and its binding partners recognize DNA adducts generated by
platinum anticancer drugs
JOURNAL Arch. Biochem. Biophys. 507 (2), 296-303 (2011)
PUBMED 21184731
REMARK GeneRIF: interaction between TOX4 and platinated DNA
REFERENCE 4 (bases 1 to 4538)
AUTHORS Lee,J.H., You,J., Dobrota,E. and Skalnik,D.G.
TITLE Identification and characterization of a novel human PP1
phosphatase complex
JOURNAL J. Biol. Chem. 285 (32), 24466-24476 (2010)
PUBMED 20516061
REMARK GeneRIF: mammalian Wdr82 functions in a variety of cellular
processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1)
has a role in the regulation of chromatin structure during the
transition from mitosis into interphase
REFERENCE 5 (bases 1 to 4538)
AUTHORS Lee,S.J., Lee,J.K., Maeng,Y.S., Kim,Y.M. and Kwon,Y.G.
TITLE Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus:
implications for this complex in transcriptional regulation
JOURNAL Exp. Mol. Med. 41 (3), 189-200 (2009)
PUBMED 19293638
REMARK GeneRIF: the coordinated spatial and temporal regulation of LCP1
and PNUTS may be a novel mechanism to control the expression of
genes that are critical for certain physiological and pathological
processes.
REFERENCE 6 (bases 1 to 4538)
AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
and Zoghbi,H.Y.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
REFERENCE 7 (bases 1 to 4538)
AUTHORS Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
TITLE Functional proteomics mapping of a human signaling pathway
JOURNAL Genome Res. 14 (7), 1324-1332 (2004)
PUBMED 15231748
REFERENCE 8 (bases 1 to 4538)
AUTHORS Lehner,B. and Sanderson,C.M.
TITLE A protein interaction framework for human mRNA degradation
JOURNAL Genome Res. 14 (7), 1315-1323 (2004)
PUBMED 15231747
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA334895.1, BC013689.1, BQ676957.1, AB018280.1 and BU677026.1.
On May 22, 2006 this sequence version replaced gi:7662273.
##Evidence-Data-START##
Transcript exon combination :: AB018280.1, BC013689.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-61 DA334895.1 1-61
62-1142 BC013689.1 1-1081
1143-1300 BQ676957.1 295-452
1301-2337 BC013689.1 1240-2276
2338-4245 AB018280.1 2267-4174
4246-4538 BU677026.1 1-293 c
FEATURES Location/Qualifiers
source 1..4538
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q11.2"
gene 1..4538
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/note="TOX high mobility group box family member 4"
/db_xref="GeneID:9878"
/db_xref="HGNC:20161"
/db_xref="HPRD:12661"
/db_xref="MIM:614032"
exon 1..109
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
misc_feature 77..79
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/note="upstream in-frame stop codon"
CDS 104..1969
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/note="migration-inducing protein 7; epidermal Langerhans
cell protein LCP1"
/codon_start=1
/product="TOX high mobility group box family member 4"
/protein_id="NP_055643.1"
/db_xref="GI:7662274"
/db_xref="CCDS:CCDS32043.1"
/db_xref="GeneID:9878"
/db_xref="HGNC:20161"
/db_xref="HPRD:12661"
/db_xref="MIM:614032"
/translation="
MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPAPPSQTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLSSYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPSPETICEMITDVVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKHCRDVFLAWVASRNSNTVVFVK
"
misc_feature 623..625
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 626..628
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 629..631
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 635..637
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O94842.1); phosphorylation site"
misc_feature 635..637
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 644..646
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 647..649
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O94842.1); phosphorylation site"
misc_feature 740..757
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O94842.1);
Region: Nuclear localization signal (Potential)"
misc_feature 770..>928
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/note="High Mobility Group (HMG)-box is found in a variety
of eukaryotic chromosomal proteins and transcription
factors. HMGs bind to the minor groove of DNA and have
been classified by DNA binding preferences. Two
phylogenically distinct groups of Class I...; Region:
HMG-box; cd00084"
/db_xref="CDD:28965"
misc_feature order(776..778,782..787,791..796,803..808,815..817,
827..829,866..868,875..877,884..886)
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28965"
misc_feature 1040..1042
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (O94842.1); phosphorylation site"
misc_feature 1046..1048
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O94842.1); phosphorylation site"
exon 110..178
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 179..421
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 422..682
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 683..913
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 914..994
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 995..1744
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 1745..1908
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
exon 1909..4524
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/inference="alignment:Splign:1.39.8"
STS 2143..2289
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="RH25501"
/db_xref="UniSTS:87640"
STS 2895..3044
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="PMC156606P4"
/db_xref="UniSTS:271411"
STS 2904..3044
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="PMC156606P3"
/db_xref="UniSTS:271410"
STS 2904..3034
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="PMC156606P2"
/db_xref="UniSTS:271409"
STS 2973..3102
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="D15S1477"
/db_xref="UniSTS:474482"
STS 3325..3434
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="RH44762"
/db_xref="UniSTS:32768"
variation complement(3641)
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/replace="g"
/replace="t"
/db_xref="dbSNP:1802004"
STS 4088..4178
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
/standard_name="SHGC-64027"
/db_xref="UniSTS:31045"
polyA_signal 4493..4498
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
polyA_site 4524
/gene="TOX4"
/gene_synonym="C14orf92; KIAA0737; LCP1; MIG7"
ORIGIN
agcagagagaacacacgtccttgcggaagtgacggcagttccgagtccagtgggggcggtgggagcgatgagggtctgagacggtgggagcggttgtgtgaagatggagtttcccggaggaaatgacaattacctgacgatcacagggccttcgcaccccttcctgtcaggggccgagacattccatacaccaagcttgggtgatgaggaatttgaaatcccacctatctccttggattctgatccctcattggctgtctcagatgtggttggccactttgatgacctggcagacccttcctcttcacaggatggcagtttttcagcccagtatggggtccagacattggacatgcctgtgggcatgacccatggcttgatggagcagggcggggggctcctgagtgggggcttgaccatggacttggaccactctataggaactcagtatagtgccaacccacctgttacaattgatgtaccaatgacagacatgacatctggcttgatggggcatagccagttgaccaccattgatcagtcagaactgagttcccagctgggtttgagcctagggggtggcaccatcctgccacctgcccagtcacctgaagatcgtctttcaaccaccccttcacctactagttcacttcacgaggatggtgttgaggatttccggaggcaacttcccagccagaagacagtcgtggtggaagcagggaaaaagcagaaggccccaaagaagagaaaaaagaaagatcctaatgaacctcagaaaccagtttcagcatatgctttattctttcgtgatacacaggctgccatcaagggacagaatcctaatgccacttttggtgaggtttcaaaaattgtggcctccatgtgggatagtcttggagaggagcaaaaacaggtatataagaggaaaactgaggctgccaagaaagagtatctgaaggcactggctgcttacaaagacaaccaggagtgtcaggccactgtggaaacagtggaattggatccagcaccaccatcacaaactccttctccacctcctatggctactgttgacccagcatctccagcaccagcttcaatagagccccctgccctgtccccatccattgttgttaactccaccctttcatcctatgtggcaaaccaggcatcttctggagctgggggtcagcccaatatcaccaagttgattattaccaaacaaatgttgccctcttctattactatgtctcaaggagggatggttactgttatcccagccacagtggtgacctcccgggggctccaactaggccaaaccagtacagctactatccagcccagtcaacaagcccagattgtcactcggtcagtgttgcaggcagcagcagctgctgctgctgctgcttctatgcaactgcctccaccccgactacagccccctccattacaacagatgccacagcccccgactcagcagcaagttaccattctgcagcagcctcctccactccaggccatgcaacagcctccacctcagaaagttcgaatcaatttacagcaacagcctcctcctctgcagatcaagagtgtgcctctacccactttgaaaatgcagactaccttagtcccaccaactgtggaaagtagtcctgagcggcctatgaacaacagccctgaggcccatacagtggaggcaccttctcctgagactatctgtgagatgatcacagatgtagttcctgaggttgagtctccttctcagatggatgttgaattggtgagtgggtctcctgtggcactctcaccccagcctcgatgtgtgaggtctggttgtgagaaccctcccattgtgagtaaggactgggacaatgaatactgcagcaatgagtgtgtggtgaagcactgcagggatgtattcttggcctgggtagcctctagaaattcaaacacagtggtgtttgtgaaatagtccttcctgttctccaagccagtgaagagttatctgctgggaaagtgtccaagagcctgtttttgaaacacaagctgggcttctggtagtgcctcatcacaacccatgatggctgttcatgtttcaccccttttcttccttcagcagaggccaggctatggagcagggccactgaatttgctgtaatctggagatgctttttactttcaaccataagcggtaatagcagaggaaagggtgaagggagtctgggcaagcaaagcatagagatggtggggtggtggtggggttgaagaaacttgttggtataattgtcataggacttgcctaaaatattattaaaattacgggagtgtactcagctttgagcctaggagaaaatgccactgtgtgcatccattttaaagggttccctcataaaaaaatgttattccccattatcacatcagtacactgctttgaaaacaaaacttttcaacatgggcatactgggctacatggaaaatgacatcacccaggagtgatttctctttatatatattatttctgcagttaccatccttatctgagttatcacagttcatgaatctaagaggcggaactctacatcattagtaagaggttccaccaaagtctaaagttgtattcacttgtgtttgatgaactatctttaaaagaccataggtctatcattatttcttagacataatctaaagaaaaacagactagagaagccacctggttgtaacagaataagcagaagtttacagcatgatagtccaagtggtgataactttaaataaaactcaaatttttactgtttgtagacaggaatgctgtcctagagaacctcctcctcaaccagctacgtacatagttttatcctatgcattcctgttttctgtgttttttgttttttttttttgagacagagtctcgctctgtcacccaggctggagtgcagtggtgcgacctcagctcactgaaacctctgcctcccgggttcaagcgattctcctgcatcagcctcccgagtagctaggattacaggcgcccgccactacgcccagctaatttgtggtatttttagtagagacagggtttcaccatgttggccaggctggtctcgaactcctgacctcatgatccgcccgccttgacctcccaaagtgctgggattacaggcatgagccaccgcacccagcctgcattcctgtttttttaatggttttggagggtagcagtagagatggggtctcactatgttgcccagtctagtcttgaactcctgggctacagttaccctcctacctcggcttcccaaagtgctcggattacaggtgtgagccactgtgcctagcctataatgatcattttaatgtttcccatgcactcatttagtttgaaccttcacagcaacccaatgaggtaatactcccatttcacatataatactgagagatgagttgcacaagattatacactgttaagtagcagagccagaatggacttcagaatcccaactacaatacaaatgtttatttaaataaagaagaaagctattgtacaaatatcactcttcaggtttagcttacagagccatggctatggattcttagctctgtaaggaagtgcttctataaattcttaggtttagagatgataccatctgggtacctttgcttgaaccgtgcaaccacatctgggtctagtaggtggatcccatccagttggtttccaagggtgatcctgaaacagtgtaaaaggaggggcaaaccagaaatcctggaattagagggtttaatattgttaaaaaatgcataccaaatgaagactgcctatcatcatatcaaatatgccaattctaaaaagagcttaacattagaatagtatatggtagaattactagttcagaattggcatagattctggtgttaaaatagactggatctgtattatctgagggttagtaactaatgcttagccaggcctgcttcacagagttgctaccagggagtattctttggataagcaaaatgctagcagcatgtgttttaagctctgttaaggggtgaaagatgtaattattgacagattaaatagataacttcgtaaccaccagggggcagattcaatacatcacagaatggctgaggaagatccttgggttgtgaagagagtagaaaccctagggagcagtgcttttgggtcctagaacctgttgagtttctaatgaatatttgtagaatctcataaaacagtttaaatacaagcttaagtggcttatgaatcctgtgaagctcatttatggactagtgtaaaacaatgtgaagctctactaagttctgtccttaatcataaataatagccccttgaggactagcctgttctctggtcaccttaccagttgggttgcacattgtgtggtcgtccaaataactcaatcttgcgagtgccaggagatagtctttcaatcatgccatagatttcatctggtttatgactggtggaacgaacctaggaaataaaaactagctgctttttaagttacacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9878 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:9878 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9878 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:9878 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9878 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:9878 -> Cellular component: GO:0072357 [PTW/PP1 phosphatase complex] evidence: IDA
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