2024-03-29 19:16:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014791 2486 bp mRNA linear PRI 08-JUL-2013 DEFINITION Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 1, mRNA. ACCESSION NM_014791 VERSION NM_014791.3 GI:375493529 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2486) AUTHORS Choi,S. and Ku,J.L. TITLE Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JOURNAL Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011) PUBMED 21806965 REMARK GeneRIF: MELK could be associated with increased resistance of colorectal cancer cells against radiation and 5-FU. REFERENCE 2 (bases 1 to 2486) AUTHORS Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D., Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S., Viapiano,M. and Kornblum,H.I. TITLE Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway JOURNAL Neuro-oncology 13 (6), 622-634 (2011) PUBMED 21558073 REMARK GeneRIF: High MELK is associated with brain tumor. REFERENCE 3 (bases 1 to 2486) AUTHORS Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L., Mourtada-Maarabouni,M. and Williams,G.T. TITLE Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JOURNAL Breast Cancer Res. 11 (4), R60 (2009) PUBMED 19671159 REMARK GeneRIF: MELK expression is increased in breast cancer tissue and this is associated with poor survival. The most important factors controlling Bcl-G activity are post-translational modification by Fau & MELK. REFERENCE 4 (bases 1 to 2486) AUTHORS Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M., Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S., Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L. TITLE Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JOURNAL Int. J. Cancer 122 (4), 807-815 (2008) PUBMED 17960622 REMARK GeneRIF: Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas REFERENCE 5 (bases 1 to 2486) AUTHORS Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S., Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A., Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M., Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F., Mischel,P.S., Terskikh,A.V. and Kornblum,H.I. TITLE Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JOURNAL J. Neurosci. Res. 86 (1), 48-60 (2008) PUBMED 17722061 REMARK GeneRIF: a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. REFERENCE 6 (bases 1 to 2486) AUTHORS Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A., Rider,M.H., Stalmans,W. and Bollen,M. TITLE Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JOURNAL J. Biol. Chem. 279 (10), 8642-8647 (2004) PUBMED 14699119 REFERENCE 7 (bases 1 to 2486) AUTHORS Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P. TITLE Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation JOURNAL Oncogene 21 (50), 7630-7641 (2002) PUBMED 12400006 REMARK GeneRIF: pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 REFERENCE 8 (bases 1 to 2486) AUTHORS Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H. TITLE Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JOURNAL Biochem. J. 361 (PT 3), 597-604 (2002) PUBMED 11802789 REFERENCE 9 (bases 1 to 2486) AUTHORS Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H. TITLE Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JOURNAL Gene 195 (2), 295-301 (1997) PUBMED 9305775 REFERENCE 10 (bases 1 to 2486) AUTHORS Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L. TITLE New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JOURNAL Mol. Reprod. Dev. 47 (2), 148-156 (1997) PUBMED 9136115 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP365611.1, D79997.1, AI590871.1 and DB368226.1. On Feb 16, 2012 this sequence version replaced gi:41281490. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D79997.1, BC014039.2 [ECO:0000332] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-14 BP365611.1 3-16 15-1869 D79997.1 1-1855 1870-1870 AI590871.1 619-619 c 1871-2484 D79997.1 1857-2470 2485-2486 DB368226.1 1-2 c FEATURES Location/Qualifiers source 1..2486 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9p13.2" gene 1..2486 /gene="MELK" /gene_synonym="HPK38" /note="maternal embryonic leucine zipper kinase" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="HPRD:06119" /db_xref="MIM:607025" exon 1..146 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 30 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:368403180" variation 35 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:188647479" variation 63 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:73436949" variation 68 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:139108274" variation 84 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:192249789" variation 106..108 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="ctt" /db_xref="dbSNP:143350018" variation 108..110 /gene="MELK" /gene_synonym="HPK38" /replace="" /replace="tct" /db_xref="dbSNP:371278776" exon 147..242 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" misc_feature 167..169 /gene="MELK" /gene_synonym="HPK38" /note="upstream in-frame stop codon" variation 172 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:182440001" CDS 185..2140 /gene="MELK" /gene_synonym="HPK38" /EC_number="2.7.11.1" /EC_number="2.7.10.2" /note="isoform 1 is encoded by transcript variant 1; pEg3 kinase; protein kinase PK38; protein kinase Eg3; tyrosine-protein kinase MELK" /codon_start=1 /product="maternal embryonic leucine zipper kinase isoform 1" /protein_id="NP_055606.1" /db_xref="GI:7661974" /db_xref="CCDS:CCDS6606.1" /db_xref="GeneID:9833" /db_xref="HGNC:16870" /db_xref="HPRD:06119" /db_xref="MIM:607025" /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
" misc_feature 215..973 /gene="MELK" /gene_synonym="HPK38" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 233..970 /gene="MELK" /gene_synonym="HPK38" /note="Catalytic domain of AGC family Protein Serine/Threonine Kinases; Region: STKc_AGC; cd05123" /db_xref="CDD:173660" misc_feature order(233..247,257..259,296..298,302..304,392..394, 440..445,449..451,461..463,467..469,578..580,584..586, 590..595,599..601,629..634,641..643,686..703,785..787, 803..805,812..814) /gene="MELK" /gene_synonym="HPK38" /note="active site" /db_xref="CDD:173660" misc_feature order(233..247,257..259,296..298,302..304,392..394, 443..451,461..463,578..580,584..586,590..595,599..601, 629..634) /gene="MELK" /gene_synonym="HPK38" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173660" misc_feature order(245..247,461..463,467..469,578..580,584..586, 590..592,641..643,686..703,785..787,803..805,812..814) /gene="MELK" /gene_synonym="HPK38" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173660" misc_feature 350..352 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature order(629..646,650..655,683..703) /gene="MELK" /gene_synonym="HPK38" /note="activation loop (A-loop); other site" /db_xref="CDD:173660" misc_feature 671..673 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 683..685 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 695..697 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 941..943 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1028..1147 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q14680.3); Region: UBA-like" misc_feature 1160..2137 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q14680.3); Region: Autoinhibitory region" misc_feature 1190..1192 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1211..1213 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1250..1252 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1283..1285 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1355..1357 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1376..1378 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1403..1405 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1409..1411 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1475..1477 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1616..1618 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1664..1666 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1676..1678 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1697..1699 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1697..1699 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1736..1738 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1769..1771 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, alternate; Phosphoserine, by autocatalysis, alternate; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 1799..1801 /gene="MELK" /gene_synonym="HPK38" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by autocatalysis; propagated from UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site" misc_feature 2000..2137 /gene="MELK" /gene_synonym="HPK38" /note="Kinase associated domain 1; Region: KA1; pfam02149" /db_xref="CDD:190228" variation 220 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:371313222" variation 235 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:202138204" exon 243..328 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 261 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:114617403" variation 287 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:13440297" variation 292 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199697478" variation 323 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201026444" exon 329..445 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 351 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:35233455" variation 373 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200697039" variation 408 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:147513197" variation 412 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:148574125" variation 417 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115531852" exon 446..589 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 448 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142987107" variation 475 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377591615" variation 478 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370732572" variation 512 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:150500682" variation 525 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370963407" variation 550 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375693491" exon 590..658 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 625 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146379072" variation 631 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374766454" variation 655 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:139481227" exon 659..751 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 661 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:374077047" variation 662 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199834356" variation 716 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:149686898" variation 725 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:115586289" exon 752..850 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 755 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:199880240" variation 763 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:374075415" variation 769 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146709588" variation 792 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:369063583" variation 840 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:35142210" variation 841 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144075335" exon 851..919 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 883 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:111341110" variation 891 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:376164595" variation 912 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:112003774" exon 920..1018 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 942 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201211316" variation 944 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146486300" exon 1019..1105 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1030 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:56115025" variation 1042 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:374946247" variation 1043 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374744271" variation 1051 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:190200350" exon 1106..1237 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1125 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:116620621" variation 1132 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:368444354" variation 1160 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:148081976" variation 1161 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146185715" variation 1175 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:140963190" variation 1176 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:146537035" variation 1182 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:34655121" variation 1183 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372595506" variation 1192 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:1137377" variation 1227 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55845414" variation 1236 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369940373" exon 1238..1360 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1245 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147502395" variation 1246 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:138281295" variation 1267 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:55637735" variation 1268 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:377133091" variation 1290 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:370552987" variation 1293 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:144405877" variation 1303 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148610937" variation 1350 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:147684393" variation 1354 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:200203253" exon 1361..1592 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1402 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56223064" variation 1441 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369328430" variation 1450 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:371627417" variation 1462 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:201838679" variation 1490 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374730094" variation 1494 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:139147189" variation 1563 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:144052967" variation 1564 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:369059064" exon 1593..1689 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1594 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:377540320" variation 1605 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:150974354" variation 1627 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:56176668" variation 1642 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:149745317" variation 1660 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:145670187" variation 1672 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200256801" variation 1688 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:148905986" exon 1690..1858 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1694 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:200746617" variation 1703 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:2068826" variation 1717 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:376763778" variation 1728 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375073240" variation 1732 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370585219" variation 1752 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:202227041" variation 1762 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375455193" variation 1803 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:62637654" variation 1818 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="t" /db_xref="dbSNP:147882939" variation 1832 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141614983" variation 1840 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:115242044" variation 1841 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:370307671" exon 1859..1962 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 1870 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:2274473" variation 1879 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:375021615" variation 1903 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:372375679" variation 1925 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:117713820" variation 1932 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:141986091" variation 1956 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:199547857" variation 1960 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:150268458" exon 1963..2486 /gene="MELK" /gene_synonym="HPK38" /inference="alignment:Splign:1.39.8" variation 2032 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /db_xref="dbSNP:200440363" variation 2129 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:113044021" variation 2135 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138922465" variation 2141 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:142248586" variation 2154 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201409152" variation 2163 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:201509530" STS 2164..2336 /gene="MELK" /gene_synonym="HPK38" /standard_name="RH25391" /db_xref="UniSTS:52302" variation 2164 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:374341087" variation 2186 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:368962453" variation 2227 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="c" /db_xref="dbSNP:12685407" variation 2268 /gene="MELK" /gene_synonym="HPK38" /replace="c" /replace="t" /db_xref="dbSNP:375359642" variation 2295 /gene="MELK" /gene_synonym="HPK38" /replace="g" /replace="t" /db_xref="dbSNP:138890476" variation 2414 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:12347708" variation 2451 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:189562435" variation 2481 /gene="MELK" /gene_synonym="HPK38" /replace="a" /replace="g" /db_xref="dbSNP:141466859" ORIGIN
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_055606 -> EC 2.7.10.2 NP_055606 -> EC 2.7.11.1
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