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2024-03-29 19:16:20, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014791               2486 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens maternal embryonic leucine zipper kinase (MELK),
            transcript variant 1, mRNA.
ACCESSION   NM_014791
VERSION     NM_014791.3  GI:375493529
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Choi,S. and Ku,J.L.
  TITLE     Resistance of colorectal cancer cells to radiation and 5-FU is
            associated with MELK expression
  JOURNAL   Biochem. Biophys. Res. Commun. 412 (2), 207-213 (2011)
   PUBMED   21806965
  REMARK    GeneRIF: MELK could be associated with increased resistance of
            colorectal cancer cells against radiation and 5-FU.
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Nakano,I., Joshi,K., Visnyei,K., Hu,B., Watanabe,M., Lam,D.,
            Wexler,E., Saigusa,K., Nakamura,Y., Laks,D.R., Mischel,P.S.,
            Viapiano,M. and Kornblum,H.I.
  TITLE     Siomycin A targets brain tumor stem cells partially through a
            MELK-mediated pathway
  JOURNAL   Neuro-oncology 13 (6), 622-634 (2011)
   PUBMED   21558073
  REMARK    GeneRIF: High MELK is associated with brain tumor.
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Pickard,M.R., Green,A.R., Ellis,I.O., Caldas,C., Hedge,V.L.,
            Mourtada-Maarabouni,M. and Williams,G.T.
  TITLE     Dysregulated expression of Fau and MELK is associated with poor
            prognosis in breast cancer
  JOURNAL   Breast Cancer Res. 11 (4), R60 (2009)
   PUBMED   19671159
  REMARK    GeneRIF: MELK expression is increased in breast cancer tissue and
            this is associated with poor survival. The most important factors
            controlling Bcl-G activity are post-translational modification by
            Fau & MELK.
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Marie,S.K., Okamoto,O.K., Uno,M., Hasegawa,A.P., Oba-Shinjo,S.M.,
            Cohen,T., Camargo,A.A., Kosoy,A., Carlotti,C.G. Jr., Toledo,S.,
            Moreira-Filho,C.A., Zago,M.A., Simpson,A.J. and Caballero,O.L.
  TITLE     Maternal embryonic leucine zipper kinase transcript abundance
            correlates with malignancy grade in human astrocytomas
  JOURNAL   Int. J. Cancer 122 (4), 807-815 (2008)
   PUBMED   17960622
  REMARK    GeneRIF: Maternal embryonic leucine zipper kinase transcript
            abundance correlates with malignancy grade in astrocytomas
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Nakano,I., Masterman-Smith,M., Saigusa,K., Paucar,A.A., Horvath,S.,
            Shoemaker,L., Watanabe,M., Negro,A., Bajpai,R., Howes,A.,
            Lelievre,V., Waschek,J.A., Lazareff,J.A., Freije,W.A., Liau,L.M.,
            Gilbertson,R.J., Cloughesy,T.F., Geschwind,D.H., Nelson,S.F.,
            Mischel,P.S., Terskikh,A.V. and Kornblum,H.I.
  TITLE     Maternal embryonic leucine zipper kinase is a key regulator of the
            proliferation of malignant brain tumors, including brain tumor stem
            cells
  JOURNAL   J. Neurosci. Res. 86 (1), 48-60 (2008)
   PUBMED   17722061
  REMARK    GeneRIF: a critical role for MELK in the proliferation of brain
            tumors, including their stem cells, and suggest that MELK may be a
            compelling molecular target for treatment of high-grade brain
            tumors.
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Vulsteke,V., Beullens,M., Boudrez,A., Keppens,S., Van Eynde,A.,
            Rider,M.H., Stalmans,W. and Bollen,M.
  TITLE     Inhibition of spliceosome assembly by the cell cycle-regulated
            protein kinase MELK and involvement of splicing factor NIPP1
  JOURNAL   J. Biol. Chem. 279 (10), 8642-8647 (2004)
   PUBMED   14699119
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
  TITLE     Human pEg3 kinase associates with and phosphorylates CDC25B
            phosphatase: a potential role for pEg3 in cell cycle regulation
  JOURNAL   Oncogene 21 (50), 7630-7641 (2002)
   PUBMED   12400006
  REMARK    GeneRIF: pEg3 is a potential regulator of the G2/M progression and
            may act antagonistically to the CDC25B phosphatase,pEg3 kinase is
            able to specifically phosphorylate CDC25B in vitro. One
            phosphorylation site was identified and corresponded to serine 323
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
  TITLE     Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
            murine protein serine/threonine kinase 38 (MPK38)
  JOURNAL   Biochem. J. 361 (PT 3), 597-604 (2002)
   PUBMED   11802789
REFERENCE   9  (bases 1 to 2486)
  AUTHORS   Gil,M., Yang,Y., Lee,Y., Choi,I. and Ha,H.
  TITLE     Cloning and expression of a cDNA encoding a novel protein
            serine/threonine kinase predominantly expressed in hematopoietic
            cells
  JOURNAL   Gene 195 (2), 295-301 (1997)
   PUBMED   9305775
REFERENCE   10 (bases 1 to 2486)
  AUTHORS   Heyer,B.S., Warsowe,J., Solter,D., Knowles,B.B. and Ackerman,S.L.
  TITLE     New member of the Snf1/AMPK kinase family, Melk, is expressed in
            the mouse egg and preimplantation embryo
  JOURNAL   Mol. Reprod. Dev. 47 (2), 148-156 (1997)
   PUBMED   9136115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP365611.1, D79997.1, AI590871.1 and DB368226.1.
            On Feb 16, 2012 this sequence version replaced gi:41281490.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D79997.1, BC014039.2 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BP365611.1         3-16
            15-1869             D79997.1           1-1855
            1870-1870           AI590871.1         619-619             c
            1871-2484           D79997.1           1857-2470
            2485-2486           DB368226.1         1-2                 c
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..2486
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="maternal embryonic leucine zipper kinase"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="HPRD:06119"
                     /db_xref="MIM:607025"
     exon            1..146
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       30
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368403180"
     variation       35
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188647479"
     variation       63
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73436949"
     variation       68
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139108274"
     variation       84
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192249789"
     variation       106..108
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="ctt"
                     /db_xref="dbSNP:143350018"
     variation       108..110
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace=""
                     /replace="tct"
                     /db_xref="dbSNP:371278776"
     exon            147..242
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    167..169
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="upstream in-frame stop codon"
     variation       172
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182440001"
     CDS             185..2140
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1; pEg3
                     kinase; protein kinase PK38; protein kinase Eg3;
                     tyrosine-protein kinase MELK"
                     /codon_start=1
                     /product="maternal embryonic leucine zipper kinase isoform
                     1"
                     /protein_id="NP_055606.1"
                     /db_xref="GI:7661974"
                     /db_xref="CCDS:CCDS6606.1"
                     /db_xref="GeneID:9833"
                     /db_xref="HGNC:16870"
                     /db_xref="HPRD:06119"
                     /db_xref="MIM:607025"
                     /translation="
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
"
     misc_feature    215..973
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    233..970
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Catalytic domain of AGC family Protein
                     Serine/Threonine Kinases; Region: STKc_AGC; cd05123"
                     /db_xref="CDD:173660"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     440..445,449..451,461..463,467..469,578..580,584..586,
                     590..595,599..601,629..634,641..643,686..703,785..787,
                     803..805,812..814)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="active site"
                     /db_xref="CDD:173660"
     misc_feature    order(233..247,257..259,296..298,302..304,392..394,
                     443..451,461..463,578..580,584..586,590..595,599..601,
                     629..634)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173660"
     misc_feature    order(245..247,461..463,467..469,578..580,584..586,
                     590..592,641..643,686..703,785..787,803..805,812..814)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173660"
     misc_feature    350..352
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    order(629..646,650..655,683..703)
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173660"
     misc_feature    671..673
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    683..685
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    695..697
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    941..943
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1028..1147
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14680.3);
                     Region: UBA-like"
     misc_feature    1160..2137
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14680.3);
                     Region: Autoinhibitory region"
     misc_feature    1190..1192
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1211..1213
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1250..1252
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1283..1285
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1355..1357
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1376..1378
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1403..1405
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1409..1411
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1475..1477
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1616..1618
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1664..1666
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1676..1678
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q14680.3); phosphorylation site"
     misc_feature    1697..1699
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1697..1699
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1736..1738
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1769..1771
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, alternate; Phosphoserine, by
                     autocatalysis, alternate; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    1799..1801
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (Q14680.3); phosphorylation site"
     misc_feature    2000..2137
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /note="Kinase associated domain 1; Region: KA1; pfam02149"
                     /db_xref="CDD:190228"
     variation       220
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371313222"
     variation       235
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202138204"
     exon            243..328
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       261
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114617403"
     variation       287
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:13440297"
     variation       292
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199697478"
     variation       323
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201026444"
     exon            329..445
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       351
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35233455"
     variation       373
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200697039"
     variation       408
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147513197"
     variation       412
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148574125"
     variation       417
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115531852"
     exon            446..589
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       448
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142987107"
     variation       475
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377591615"
     variation       478
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370732572"
     variation       512
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150500682"
     variation       525
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370963407"
     variation       550
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375693491"
     exon            590..658
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       625
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146379072"
     variation       631
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374766454"
     variation       655
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:139481227"
     exon            659..751
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       661
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374077047"
     variation       662
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199834356"
     variation       716
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149686898"
     variation       725
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:115586289"
     exon            752..850
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       755
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199880240"
     variation       763
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374075415"
     variation       769
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146709588"
     variation       792
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369063583"
     variation       840
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35142210"
     variation       841
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144075335"
     exon            851..919
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       883
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111341110"
     variation       891
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376164595"
     variation       912
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112003774"
     exon            920..1018
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       942
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201211316"
     variation       944
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146486300"
     exon            1019..1105
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1030
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56115025"
     variation       1042
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374946247"
     variation       1043
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374744271"
     variation       1051
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190200350"
     exon            1106..1237
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1125
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116620621"
     variation       1132
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368444354"
     variation       1160
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148081976"
     variation       1161
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146185715"
     variation       1175
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140963190"
     variation       1176
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146537035"
     variation       1182
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34655121"
     variation       1183
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372595506"
     variation       1192
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1137377"
     variation       1227
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55845414"
     variation       1236
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369940373"
     exon            1238..1360
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1245
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147502395"
     variation       1246
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138281295"
     variation       1267
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:55637735"
     variation       1268
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377133091"
     variation       1290
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370552987"
     variation       1293
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144405877"
     variation       1303
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148610937"
     variation       1350
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147684393"
     variation       1354
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200203253"
     exon            1361..1592
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1402
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56223064"
     variation       1441
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369328430"
     variation       1450
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371627417"
     variation       1462
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201838679"
     variation       1490
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374730094"
     variation       1494
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139147189"
     variation       1563
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144052967"
     variation       1564
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369059064"
     exon            1593..1689
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1594
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377540320"
     variation       1605
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150974354"
     variation       1627
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56176668"
     variation       1642
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149745317"
     variation       1660
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145670187"
     variation       1672
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200256801"
     variation       1688
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148905986"
     exon            1690..1858
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1694
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200746617"
     variation       1703
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2068826"
     variation       1717
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376763778"
     variation       1728
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375073240"
     variation       1732
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370585219"
     variation       1752
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202227041"
     variation       1762
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375455193"
     variation       1803
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62637654"
     variation       1818
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:147882939"
     variation       1832
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141614983"
     variation       1840
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115242044"
     variation       1841
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370307671"
     exon            1859..1962
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       1870
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2274473"
     variation       1879
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375021615"
     variation       1903
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372375679"
     variation       1925
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117713820"
     variation       1932
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141986091"
     variation       1956
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199547857"
     variation       1960
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150268458"
     exon            1963..2486
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /inference="alignment:Splign:1.39.8"
     variation       2032
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200440363"
     variation       2129
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113044021"
     variation       2135
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138922465"
     variation       2141
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142248586"
     variation       2154
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201409152"
     variation       2163
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201509530"
     STS             2164..2336
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /standard_name="RH25391"
                     /db_xref="UniSTS:52302"
     variation       2164
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374341087"
     variation       2186
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368962453"
     variation       2227
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12685407"
     variation       2268
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375359642"
     variation       2295
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138890476"
     variation       2414
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12347708"
     variation       2451
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189562435"
     variation       2481
                     /gene="MELK"
                     /gene_synonym="HPK38"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141466859"
ORIGIN      
gagatttgattcccttggcgggcggaagcggccacaacccggcgatcgaaaagattcttaggaacgccgtaccagccgcgtctctcaggacagcaggcccctgtccttctgtcgggcgccgctcagccgtgccctccgcccctcaggttctttttctaattccaaataaacttgcaagaggactatgaaagattatgatgaacttctcaaatattatgaattacatgaaactattgggacaggtggctttgcaaaggtcaaacttgcctgccatatccttactggagagatggtagctataaaaatcatggataaaaacacactagggagtgatttgccccggatcaaaacggagattgaggccttgaagaacctgagacatcagcatatatgtcaactctaccatgtgctagagacagccaacaaaatattcatggttcttgagtactgccctggaggagagctgtttgactatataatttcccaggatcgcctgtcagaagaggagacccgggttgtcttccgtcagatagtatctgctgttgcttatgtgcacagccagggctatgctcacagggacctcaagccagaaaatttgctgtttgatgaatatcataaattaaagctgattgactttggtctctgtgcaaaacccaagggtaacaaggattaccatctacagacatgctgtgggagtctggcttatgcagcacctgagttaatacaaggcaaatcatatcttggatcagaggcagatgtttggagcatgggcatactgttatatgttcttatgtgtggatttctaccatttgatgatgataatgtaatggctttatacaagaagattatgagaggaaaatatgatgttcccaagtggctctctcccagtagcattctgcttcttcaacaaatgctgcaggtggacccaaagaaacggatttctatgaaaaatctattgaaccatccctggatcatgcaagattacaactatcctgttgagtggcaaagcaagaatccttttattcacctcgatgatgattgcgtaacagaactttctgtacatcacagaaacaacaggcaaacaatggaggatttaatttcactgtggcagtatgatcacctcacggctacctatcttctgcttctagccaagaaggctcggggaaaaccagttcgtttaaggctttcttctttctcctgtggacaagccagtgctaccccattcacagacatcaagtcaaataattggagtctggaagatgtgaccgcaagtgataaaaattatgtggcgggattaatagactatgattggtgtgaagatgatttatcaacaggtgctgctactccccgaacatcacagtttaccaagtactggacagaatcaaatggggtggaatctaaatcattaactccagccttatgcagaacacctgcaaataaattaaagaacaaagaaaatgtatatactcctaagtctgctgtaaagaatgaagagtactttatgtttcctgagccaaagactccagttaataagaaccagcataagagagaaatactcactacgccaaatcgttacactacaccctcaaaagctagaaaccagtgcctgaaagaaactccaattaaaataccagtaaattcaacaggaacagacaagttaatgacaggtgtcattagccctgagaggcggtgccgctcagtggaattggatctcaaccaagcacatatggaggagactccaaaaagaaagggagccaaagtgtttgggagccttgaaagggggttggataaggttatcactgtgctcaccaggagcaaaaggaagggttctgccagagacgggcccagaagactaaagcttcactataacgtgactacaactagattagtgaatccagatcaactgttgaatgaaataatgtctattcttccaaagaagcatgttgactttgtacaaaagggttatacactgaagtgtcaaacacagtcagattttgggaaagtgacaatgcaatttgaattagaagtgtgccagcttcaaaaacccgatgtggtgggtatcaggaggcagcggcttaagggcgatgcctgggtttacaaaagattagtggaagacatcctatctagctgcaaggtataattgatggattcttccatcctgccggatgagtgtgggtgtgatacagcctacataaagactgttatgatcgctttgattttaaagttcattggaactaccaacttgtttctaaagagctatcttaagaccaatatctctttgtttttaaacaaaagatattattttgtgtatgaatctaaatcaagcccatctgtcattatgttactgtcttttttaatcatgtggttttgtatattaataattgttgactttcttagattcacttccatatgtgaatgtaagctcttaactatgtctctttgtaatgtgtaatttctttctgaaataaaaccatttgtgaatatag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9833 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
            GeneID:9833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9833 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9833 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
            GeneID:9833 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
            GeneID:9833 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
            GeneID:9833 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0030097 [hemopoiesis] evidence: ISS
            GeneID:9833 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: ISS
            GeneID:9833 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:9833 -> Biological process: GO:0061351 [neural precursor cell proliferation] evidence: ISS
            GeneID:9833 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:9833 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_055606 -> EC 2.7.10.2
            NP_055606 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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