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2024-03-28 23:24:46, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014720               5629 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens STE20-like kinase (SLK), mRNA.
ACCESSION   NM_014720
VERSION     NM_014720.2  GI:41281452
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5629)
  AUTHORS   Viswanatha,R., Ohouo,P.Y., Smolka,M.B. and Bretscher,A.
  TITLE     Local phosphocycling mediated by LOK/SLK restricts ezrin function
            to the apical aspect of epithelial cells
  JOURNAL   J. Cell Biol. 199 (6), 969-984 (2012)
   PUBMED   23209304
  REMARK    GeneRIF: It was shown that lymphocyte-oriented and STE20 kinase
            were sufficient to restrict ezrin function to the apical domain.
            Both kinases were enriched in microvilli and locally activated
            there.
REFERENCE   2  (bases 1 to 5629)
  AUTHORS   Cha,P.C., Takahashi,A., Hosono,N., Low,S.K., Kamatani,N., Kubo,M.
            and Nakamura,Y.
  TITLE     A genome-wide association study identifies three loci associated
            with susceptibility to uterine fibroids
  JOURNAL   Nat. Genet. 43 (5), 447-450 (2011)
   PUBMED   21460842
REFERENCE   3  (bases 1 to 5629)
  AUTHORS   Roovers,K., Wagner,S., Storbeck,C.J., O'Reilly,P., Lo,V.,
            Northey,J.J., Chmielecki,J., Muller,W.J., Siegel,P.M. and
            Sabourin,L.A.
  TITLE     The Ste20-like kinase SLK is required for ErbB2-driven breast
            cancer cell motility
  JOURNAL   Oncogene 28 (31), 2839-2848 (2009)
   PUBMED   19525980
  REMARK    GeneRIF: Studies define an interaction between Neu and SLK
            signaling in the regulation of cancer cell motility.
REFERENCE   4  (bases 1 to 5629)
  AUTHORS   Burakov,A.V., Zhapparova,O.N., Kovalenko,O.V., Zinovkina,L.A.,
            Potekhina,E.S., Shanina,N.A., Weiss,D.G., Kuznetsov,S.A. and
            Nadezhdina,E.S.
  TITLE     Ste20-related protein kinase LOSK (SLK) controls microtubule radial
            array in interphase
  JOURNAL   Mol. Biol. Cell 19 (5), 1952-1961 (2008)
   PUBMED   18287541
  REMARK    GeneRIF: Protein kinase LOSK is required for radial microtubule
            organization and for the proper localization of Golgi complex in
            various cell types.
REFERENCE   5  (bases 1 to 5629)
  AUTHORS   Pike,A.C., Rellos,P., Niesen,F.H., Turnbull,A., Oliver,A.W.,
            Parker,S.A., Turk,B.E., Pearl,L.H. and Knapp,S.
  TITLE     Activation segment dimerization: a mechanism for kinase
            autophosphorylation of non-consensus sites
  JOURNAL   EMBO J. 27 (4), 704-714 (2008)
   PUBMED   18239682
REFERENCE   6  (bases 1 to 5629)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res. 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   7  (bases 1 to 5629)
  AUTHORS   Dan,I., Watanabe,N.M. and Kusumi,A.
  TITLE     The Ste20 group kinases as regulators of MAP kinase cascades
  JOURNAL   Trends Cell Biol. 11 (5), 220-230 (2001)
   PUBMED   11316611
REFERENCE   8  (bases 1 to 5629)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   9  (bases 1 to 5629)
  AUTHORS   Yamada,E., Tsujikawa,K., Itoh,S., Kameda,Y., Kohama,Y. and
            Yamamoto,H.
  TITLE     Molecular cloning and characterization of a novel human STE20-like
            kinase, hSLK
  JOURNAL   Biochim. Biophys. Acta 1495 (3), 250-262 (2000)
   PUBMED   10699464
REFERENCE   10 (bases 1 to 5629)
  AUTHORS   Sabourin,L.A., Tamai,K., Seale,P., Wagner,J. and Rudnicki,M.A.
  TITLE     Caspase 3 cleavage of the Ste20-related kinase SLK releases and
            activates an apoptosis-inducing kinase domain and an
            actin-disassembling region
  JOURNAL   Mol. Cell. Biol. 20 (2), 684-696 (2000)
   PUBMED   10611247
  REMARK    Erratum:[Mol Cell Biol 2000 Apr;20(8):2949]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF273048.1.
            On Jan 25, 2004 this sequence version replaced gi:7661993.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF273048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025086 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..5629
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="STE20-like kinase"
                     /db_xref="GeneID:9748"
                     /db_xref="HGNC:11088"
                     /db_xref="HPRD:11585"
     misc_feature    1..5629
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="sequence similar to KIAA0204in Accession Number
                     D86959 and to partial sequence of chromosome 10 in
                     Accession Number AL138761"
     exon            1..184
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       17
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200364911"
     CDS             35..3742
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /EC_number="2.7.11.1"
                     /note="Long Ste20-like Kinase; Ste20-related
                     serine/threonine kinase; CTCL tumor antigen se20-9; hSLK;
                     STE20-related kinase; serine/threonine-protein kinase 2;
                     STE20-related serine/threonine-protein kinase; SNF1
                     sucrose nonfermenting like kinase; SNF1 (sucrose
                     nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose
                     nonfermenting like kinase"
                     /codon_start=1
                     /product="STE20-like serine/threonine-protein kinase"
                     /protein_id="NP_055535.2"
                     /db_xref="GI:41281453"
                     /db_xref="CCDS:CCDS7553.1"
                     /db_xref="GeneID:9748"
                     /db_xref="HGNC:11088"
                     /db_xref="HPRD:11585"
                     /translation="
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
"
     misc_feature    74..76
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    116..946
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Ste20-like kinase; Region: STKc_SLK; cd06643"
                     /db_xref="CDD:132974"
     misc_feature    134..910
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(152..166,176..178,215..217,221..223,269..271,
                     308..310,350..352,356..367,374..379,386..388,497..499,
                     503..514,518..520,548..553,560..562,602..613,617..619,
                     713..715,740..742)
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="active site"
                     /db_xref="CDD:132974"
     misc_feature    order(152..166,176..178,215..217,221..223,269..271,
                     308..310,350..352,356..367,374..379,386..388,509..514,
                     518..520,548..553)
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:132974"
     misc_feature    order(161..166,497..499,503..511,560..562,602..613,
                     617..619,713..715,740..742)
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:132974"
     misc_feature    548..619
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:132974"
     misc_feature    599..601
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    599..601
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1022..1024
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1052..1054
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1055..1057
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1064..1066
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1064..1066
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1073..1075
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1073..1075
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1076..1078
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1076..1078
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1076..1078
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1094..1096
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1346..1351
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Cleavage, by caspase-3 (By similarity); propagated
                     from UniProtKB/Swiss-Prot (Q9H2G2.1); cleavage site"
     misc_feature    1727..1729
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1745..1747
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    1997..1999
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    2363..2365
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    2369..2371
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    2486..2488
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H2G2.1); phosphorylation site"
     misc_feature    3119..3514
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="Polo kinase kinase; Region: PKK; pfam12474"
                     /db_xref="CDD:204935"
     misc_feature    3323..3325
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q9H2G2.1); phosphorylation site"
     variation       35
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:67005250"
     variation       48
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150455513"
     variation       61
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201104748"
     variation       66
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202109385"
     variation       89
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:137997569"
     variation       133
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149480041"
     variation       183
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201954327"
     exon            185..349
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       204
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113216800"
     exon            350..398
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       383
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11191893"
     variation       398
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:80262674"
     exon            399..548
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       433
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184400051"
     variation       451
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56287824"
     variation       536
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144641250"
     variation       544
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138539059"
     exon            549..621
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       562
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10883960"
     exon            622..816
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       638
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146276432"
     variation       727
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148478778"
     variation       754
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376604412"
     variation       758
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200677132"
     variation       763
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55977639"
     variation       794
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199953246"
     exon            817..898
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       821
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200335070"
     variation       893
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150555883"
     exon            899..1027
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       928
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55893133"
     variation       1000
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139324300"
     variation       1015
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369850873"
     variation       1017
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145464859"
     exon            1028..2383
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       1033
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147685845"
     variation       1047
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201543977"
     variation       1053
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373397561"
     variation       1112
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143489434"
     variation       1133
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201028021"
     variation       1138
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373285860"
     variation       1139
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140715399"
     variation       1151
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199730741"
     variation       1241
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200759996"
     variation       1252
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200580260"
     variation       1254
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201455950"
     variation       1266
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372744623"
     variation       1297
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144609785"
     variation       1299
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199864933"
     variation       1347
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201945425"
     variation       1368
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377170080"
     variation       1398
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368834488"
     variation       1428
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145891003"
     variation       1460
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181201567"
     variation       1505
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:66960104"
     variation       1512
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374158573"
     variation       1538
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200940208"
     variation       1593
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371702036"
     variation       1597
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375320590"
     variation       1600
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369382208"
     variation       1606
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199501020"
     variation       1609
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373232158"
     variation       1636
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185852639"
     variation       1637
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199902178"
     variation       1641
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149001506"
     variation       1671
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143783348"
     variation       1689
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:805657"
     variation       1740
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141030799"
     variation       1741
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:56357599"
     variation       1752
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138561931"
     variation       1778
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202126066"
     variation       1844
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190220654"
     variation       1911
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199510176"
     variation       1934
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375427458"
     variation       2007
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:56400929"
     variation       2020
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74154716"
     variation       2031
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7071400"
     variation       2043
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117017856"
     variation       2048
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375867060"
     variation       2070
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34326537"
     variation       2083
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35389916"
     variation       2113
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144105969"
     variation       2124
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3740469"
     variation       2179
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368294178"
     variation       2224..2225
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:35535114"
     variation       2237
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372263493"
     variation       2276
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142780049"
     variation       2288
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376822140"
     variation       2301
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201226890"
     variation       2370
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187213555"
     variation       2371
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375037120"
     exon            2384..2514
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       2394
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:193020197"
     variation       2396
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376190522"
     variation       2408
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147274773"
     variation       2419
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368748580"
     variation       2434
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371482953"
     variation       2455..2456
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35824206"
     variation       2458..2459
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35910700"
     variation       2492
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:66656992"
     variation       2495
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140813954"
     variation       2506
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:116628156"
     exon            2515..2638
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       2521
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56261739"
     variation       2569
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369557083"
     variation       2572
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201110021"
     variation       2580
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373027455"
     variation       2590
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:805662"
     variation       2600
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376478203"
     variation       2601
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138865314"
     variation       2608
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370047288"
     variation       2633
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138028690"
     exon            2639..2818
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       2722
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376977945"
     variation       2741
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139235638"
     variation       2752
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150068060"
     variation       2754
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112147254"
     exon            2819..2911
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       2827
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145383503"
     variation       2853
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371469996"
     variation       2873
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373815490"
     variation       2874
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141355740"
     exon            2912..3041
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       2959
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199577733"
     variation       2967
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143790863"
     variation       3027
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372778251"
     exon            3042..3166
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       3083
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202174450"
     variation       3151
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367939267"
     exon            3167..3355
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       3178
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146708638"
     variation       3186
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373118126"
     variation       3317
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201228187"
     exon            3356..3481
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       3373
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140276120"
     variation       3379
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:55914158"
     variation       3395
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55708299"
     variation       3428
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147985366"
     variation       3463
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377591796"
     variation       3472
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150167438"
     variation       3474
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370580979"
     exon            3482..3595
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       3509
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138622989"
     variation       3510
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201270634"
     variation       3546
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199725906"
     variation       3551
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142839532"
     variation       3561
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147399386"
     variation       3583
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368550353"
     exon            3596..5606
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:1.39.8"
     variation       3656
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61861275"
     variation       3733
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139177471"
     variation       3736
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199817641"
     variation       3739
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143127472"
     variation       3762
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192363594"
     variation       3763
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182458142"
     variation       3766
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184996484"
     variation       3881
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:72044204"
     variation       3918
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143144952"
     variation       4021..4022
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="tgaa"
                     /db_xref="dbSNP:143875505"
     variation       4022..4023
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="tgaa"
                     /db_xref="dbSNP:71717068"
     variation       4177
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11191898"
     variation       4295
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147477212"
     variation       4346
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139919327"
     variation       4400
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41287518"
     variation       4455
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74154720"
     variation       4512
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189872426"
     variation       4562
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:805684"
     variation       4654
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182514725"
     variation       4685
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377187237"
     variation       4712
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374733105"
     variation       4726
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45597434"
     variation       4764
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2902640"
     variation       4807
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:809303"
     variation       4881
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145155087"
     variation       4898
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45559432"
     variation       5030
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75214523"
     variation       5078
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187023559"
     variation       5106
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192820921"
     variation       5227
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1803467"
     STS             5237..5356
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /standard_name="RH25417"
                     /db_xref="UniSTS:88178"
     variation       5276
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183728611"
     variation       5367
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:147186541"
     variation       5503
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188657821"
ORIGIN      
cttaagtgcaaggaactctgtgttgggaggaaaaatgtccttcttcaatttccgtaagatcttcaagttggggagcgagaagaagaagaagcagtacgaacacgtgaagagggacctgaaccccgaagacttttgggagattataggagaactgggcgacggagcctttgggaaagtgtacaaggcccagaataaagagaccagtgttttagctgctgcaaaagtgattgacactaaatctgaagaagaacttgaagattacatggtagagattgacatattagcatcttgtgatcacccaaatatagtcaagcttctagatgccttctattatgagaacaatctttggatcctcattgaattttgtgcaggtggagcagtagatgctgtgatgcttgaacttgagagaccattaactgagtcccaaatacaagtagtttgcaagcagactttagatgcattgaactacttacatgataataagatcatccacagagatctgaaggctggcaacattctctttaccttagatggagatatcaaattggcggattttggagtatcagctaaaaacacgaggacaattcaaagaagagattcctttattggtacaccatattggatggctcctgaagtagtcatgtgtgaaacatctaaggacagaccctatgactacaaagctgatgtttggtccctgggtatcactttaatagaaatggctgagatagaaccacctcatcatgaattaaatccaatgcgagtgctgctaaaaatagcaaaatctgagccacctacattagcacagccatccagatggtcttcaaattttaaggactttctaaagaaatgcttagaaaagaatgtggatgccaggtggactacatctcagctgctgcagcatccctttgttactgttgattccaacaaacccatccgagaattgattgcagaggcgaaggctgaagtaacagaagaagttgaagatggcaaagaggaagatgaagaggaggaaacagaaaattctctgccaatacctgcaagtaagcgtgcatcttctgaccttagtatcgccagctctgaagaagataaactttcacaaaatgcttgtattttggagtctgtctcagaaaaaacagaacgtagtaactctgaagataaactcaacagcaaaattcttaatgaaaaacccaccactgatgaacctgaaaaggctgtggaggatattaatgaacatattaccgatgctcagttagaagcaatgactgaactccatgacagaacagcagtaatcaaggagaatgaaagagagaagaggcccaagcttgaaaatctgcctgacacagaagaccaagaaactgtggacattaattcagtcagtgaaggaaaagagaataatataatgataaccttagaaacaaatattgaacataatctaaaatctgaggaagaaaaggatcaggaaaagcaacagatgtttgaaaataagcttataaaatctgaagaaattaaagatactattttgcaaacagtagatttagtttctcaagagactggagaaaaagaggcaaatattcaggcagttgatagtgaagttgggcttacaaaggaagacacccaagagaaattgggggaagacgacaaaactcaaaaagatgtgatcagcaatacaagtgatgtgataggaacatgtgaggcagcagatgtggctcagaaagtggatgaagacagtgctgaggatacgcagagtaatgatgggaaagaagtggtcgaagtaggccagaaattaattaataagcccatggtgggtcctgaggctggtggtactaaggaagttcctattaaagaaatagttgaaatgaatgaaatagaagaaggtaaaaataaggaacaagcaataaacagttcagagaacataatggacatcaatgaggaaccaggaacaactgaaggtgaagaaatcactgagtcaagtagcactgaagaaatggaggtcagaagtgtggtggctgatactgaccaaaaggctttaggaagtgaagttcaggatgcttctaaagtcactactcagatagataaagagaaaaaagaaattccagtgtcaattaaaaaagagcctgaagttactgtagtttcacagcccactgaacctcagcctgttctaatacccagtattaatatcaactctgacagtggagaaaataaagaagaaataggttctttatcaaaaactgaaactattctgccaccagaatctgagaatccaaaggaaaatgataatgattcaggcactggttccactgctgatactagcagtattgacttgaatttatccatctctagctttctaagtaaaactaaagacagtggatcgatatctttacaagaaacaagaagacaaaagaaaacattgaagaaaacacgcaaatttattgttgatggtgtagaagtgagtgtaacaacatcaaagatagttacagatagtgattccaaaactgaagaattgcggtttcttagacgtcaggaacttcgggaattaagatttcttcagaaagaagagcaaagagcccaacaacagctcaatagcaaactacagcaacaacgagaacaaattttccggcgctttgagcaggaaatgatgagtaaaaagcgacaatatgaccaggaaattgagaatctagaaaaacagcagaaacagactatcgaacgcctggaacaagagcacacaaatcgcttgcgagatgaagccaaacgcatcaaaggagaacaagagaaagagttgtccaaatttcagaatatgctgaagaaccgaaagaaggaggttataaatgaagtggagaaagcacccaaagagctgagaaaagagctcatgaaacgcaggaaagaggagcttgcacaaagccagcatgctcaggaacaagagtttgttcagaaacaacagcaagaattagatggctctctgaaaaagatcatccagcagcagaaggcagagttagctaatattgagagagagtgcctgaataacaagcaacagctcatgagagctcgagaagctgcaatttgggagctcgaagaacgacacttacaagaaaaacaccagctgctcaaacagcagcttaaagatcagtatttcatgcaaagacatcagctacttaagcgccacgagaaggaaacagagcaaatgcagcgttacaatcaaagacttattgaggaattgaaaaacagacagactcaagaaagagcaagactgcccaagattcagcgcagtgaagccaagactcgaatggccatgtttaagaagagtttgagaattaactcaacagccacaccagatcaggaccgtgataaaattaaacagtttgctgcacaagaagaaaagaggcagaaaaatgagagaatggctcagcatcagaaacatgagaatcaaatgcgagatcttcagttgcagtgtgaagccaatgtccgcgaactgcatcagctgcagaatgaaaaatgccacttgttggttgagcatgagactcagaaactgaaggagttagatgaggaacatagccaagaattaaaggagtggagagagaaattgagacctaggaaaaagacactggaagaagagtttgccaggaaactacaggaacaggaagtattctttaaaatgactggggagtctgaatgccttaacccatcaacacagagccggatttccaaattttatcctattcccagcttgcattccaccggatcataacaaagggaagcattctgtgcgtgggtttggctctttcagtatgtcattctgttctcatcttctgccacagtctctcagatagctcatgaagacaatcacctgcctcaccttctaggtgttttccttttttgttttttttgttttgttttgtttttaagcaaagatgaagggaaaacgaactaagacagacgctaggccatgttggcaaagtagcatcttggtgactaaggtgactttgtatattcatcttaaaaattatgttctttagacactgctacctgaaaactgttggagaaataatgtttaaagttatttaagaaaaactgttacatcactaagtattaataaattcttcttacctgacgtaacttctcaatgcctaaattctgtagttgaagctctgctgcagagagttgggataattttcttttggtggatcagctctcataaaaaagctatgatttgctcaaatatgctgttgactcagtaaatgaatatatttttttctttaaataggaacaacctcttttaaaagagaaaaattatttcagtgatttgtcaaaacgaattacctcttttggcatgagctaataattgagggtgctaattttcttaagatagtgcctaaaacactaaatttcagtcaagtcgtaagtaggattttctttttgatcaacagggacaaaaacatctttagaattaaaaacatggttgttttggaatttttgcttctcttaccgtttgatagaaattttcatcctaaaatacatgtacaaagtttggaaagatgaaaaaaagaggtagcttttagattgcaaattggaaatgtaaaactcatgaaatttaagcaatataggtttagctatctgtgtttattttctaaaataatacctgagctggttaaatgatttctctccatcttagctaattctgtttaaaactctgtcagaggcctgcaggctgtgagttatatttataaatatatcttcagaaattaatcttaaaagaggcattagttcagaatacttttttaaaagtttaaattaaatatttaggcacgtcagaaattacttttccttattttgaaatgaggctacttatgtcttggttttattttgttccatgtttaaatcattcactttgatttgagtgggaaaagcctgaagcctttatcatgtggttgctggtgtgtgtaattattaatgaaatgttcactcctagtcccttatgaggcttagaatttcaaccacgtgtcaggtcagacagtattataaactgtactttgctgtctgagacagcacatttgtgaatgatgcttgctgcctgccattttcaacctattctctcttaagagtgctaggtaccaaattgtgaaagtttgttttcagttatattacttttgaggctggtgaaaaatttaaatgtaactttgtgggaacactgattcatatttagaaaatgtaaatgtctgtagcactttcttgcagttaatttgaaaactttggatgctgaaccttgtttgtcagtgatttagatgatttaaaaatgcatgtgtgatttgaattttataattgttttgacaagcataatttacttggacaacttcgtaggtagccttaacttctggccaagtttgttttttatataaatatatatacatatatacatattatgtatggttgtaaattcatacacttatcacatgaatgtgttactgtatacaaaactcttaatgctttattctcaaatgctgggttgaaaaatgttttgaaagccttttaaaatatatatctttataaagtaatattcaggatgatgataaaaattgtttatattgttatgataaaaatgacagtataatgttaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9748 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9748 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9748 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:9748 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:9748 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:9748 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:9748 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_055535 -> EC 2.7.11.1

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.