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2019-03-25 14:30:49, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014677               6420 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens regulating synaptic membrane exocytosis 2 (RIMS2),
            transcript variant 2, mRNA.
ACCESSION   NM_014677 XR_108875
VERSION     NM_014677.4  GI:313482869
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6420)
  AUTHORS   Bello,O.D., Zanetti,M.N., Mayorga,L.S. and Michaut,M.A.
  TITLE     RIM, Munc13, and Rab3A interplay in acrosomal exocytosis
  JOURNAL   Exp. Cell Res. 318 (5), 478-488 (2012)
   PUBMED   22248876
  REMARK    GeneRIF: Here, we report that, like Rab3A, RIM and Munc13 are
            present in human sperm and that they play a functional role in
            acrosomal exocytosis before the acrosomal calcium efflux
REFERENCE   2  (bases 1 to 6420)
  AUTHORS   Nielsen,D.A., Ji,F., Yuferov,V., Ho,A., He,C., Ott,J. and
            Kreek,M.J.
  TITLE     Genome-wide association study identifies genes that may contribute
            to risk for developing heroin addiction
  JOURNAL   Psychiatr. Genet. 20 (5), 207-214 (2010)
   PUBMED   20520587
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 6420)
  AUTHORS   Gebhart,M., Juhasz-Vedres,G., Zuccotti,A., Brandt,N., Engel,J.,
            Trockenbacher,A., Kaur,G., Obermair,G.J., Knipper,M., Koschak,A.
            and Striessnig,J.
  TITLE     Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting
            molecule
  JOURNAL   Mol. Cell. Neurosci. 44 (3), 246-259 (2010)
   PUBMED   20363327
  REMARK    GeneRIF: These data suggest that RIM2beta contributes to the
            stabilization of Ca(v)1.3 gating kinetics in immature cochlear
            inner hair cells.
REFERENCE   4  (bases 1 to 6420)
  AUTHORS   Ellencrona,K., Syed,A. and Johansson,M.
  TITLE     Flavivirus NS5 associates with host-cell proteins zonula
            occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2
            (RIMS2) via an internal PDZ binding mechanism
  JOURNAL   Biol. Chem. 390 (4), 319-323 (2009)
   PUBMED   19199833
  REMARK    GeneRIF: tick-borne encephalitis virus -NS5 has high affinity to
            regulating synaptic membrane exocytosis-2 (RIMS2) and Scribble,
            whereas DENV-NS5 binds primarily to the tight junction protein
            zonula occludens-1 (ZO-1)
REFERENCE   5  (bases 1 to 6420)
  AUTHORS   Weidenhofer,J., Scott,R.J. and Tooney,P.A.
  TITLE     Investigation of the expression of genes affecting cytomatrix
            active zone function in the amygdala in schizophrenia: effects of
            antipsychotic drugs
  JOURNAL   J Psychiatr Res 43 (3), 282-290 (2009)
   PUBMED   18490030
  REMARK    GeneRIF: Western blot analysis shows increased RIMS2 protein
            expression in the amygdala in schizophrenia.
REFERENCE   6  (bases 1 to 6420)
  AUTHORS   Sun,L., Bittner,M.A. and Holz,R.W.
  TITLE     Rim, a component of the presynaptic active zone and modulator of
            exocytosis, binds 14-3-3 through its N terminus
  JOURNAL   J. Biol. Chem. 278 (40), 38301-38309 (2003)
   PUBMED   12871946
REFERENCE   7  (bases 1 to 6420)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J. Biol. Chem. 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 6420)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins(small star, filled)
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
REFERENCE   9  (bases 1 to 6420)
  AUTHORS   Kashima,Y., Miki,T., Shibasaki,T., Ozaki,N., Miyazaki,M., Yano,H.
            and Seino,S.
  TITLE     Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated
            insulin secretion
  JOURNAL   J. Biol. Chem. 276 (49), 46046-46053 (2001)
   PUBMED   11598134
REFERENCE   10 (bases 1 to 6420)
  AUTHORS   Fenster,S.D., Chung,W.J., Zhai,R., Cases-Langhoff,C., Voss,B.,
            Garner,A.M., Kaempf,U., Kindler,S., Gundelfinger,E.D. and
            Garner,C.C.
  TITLE     Piccolo, a presynaptic zinc finger protein structurally related to
            bassoon
  JOURNAL   Neuron 25 (1), 203-214 (2000)
   PUBMED   10707984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP230765.1, BC043144.2, AK126939.1 and AP002849.2.
            On or before Dec 4, 2010 this sequence version replaced
            gi:310120251, gi:154354980.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, and has
            multiple differences in the presence and absence of exons in the 5'
            and mid-coding regions, compared to variant 1. The resulting
            protein (isoform b) is shorter and has a distinct N-terminus,
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043144.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BP230765.1         1-84
            85-576              BC043144.2         1-492
            577-1940            AK126939.1         972-2335
            1941-2240           AK126939.1         2384-2683
            2241-4517           BC043144.2         2157-4433
            4518-6420           AP002849.2         149451-151353
FEATURES             Location/Qualifiers
     source          1..6420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..6420
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="regulating synaptic membrane exocytosis 2"
                     /db_xref="GeneID:9699"
                     /db_xref="HGNC:17283"
                     /db_xref="MIM:606630"
     exon            1..442
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       54
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34191343"
     variation       231
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146278437"
     variation       270
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372767177"
     misc_feature    282..284
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="upstream in-frame stop codon"
     variation       300
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79393780"
     variation       303..304
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:373400839"
     CDS             321..3812
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="isoform b is encoded by transcript variant 2; RAB3
                     interacting protein 3; regulating synaptic membrane
                     exocytosis protein 2; nuclear protein; non-small cell lung
                     cancer RimL3a protein; non-small cell lung cancer RimL3c
                     protein; RIM 2; rab3-interacting molecule 2;
                     rab-3-interacting protein 3; rab-3-interacting molecule 2"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     2 isoform b"
                     /protein_id="NP_055492.3"
                     /db_xref="GI:154354981"
                     /db_xref="CCDS:CCDS43761.1"
                     /db_xref="GeneID:9699"
                     /db_xref="HGNC:17283"
                     /db_xref="MIM:606630"
                     /translation="
MQFETLRQVCNSVLSHFHGVFSSPPNILQNELFGQTLNNARKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS
"
     misc_feature    1521..1766
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="PDZ domain found in a variety of Eumetazoan
                     signaling molecules, often in tandem arrangements. May be
                     responsible for specific protein-protein interactions, as
                     most PDZ domains bind C-terminal polypeptides, and binding
                     to internal (non-C-terminal)...; Region: PDZ_signaling;
                     cd00992"
                     /db_xref="CDD:29049"
     misc_feature    order(1542..1553,1557..1559,1713..1718,1725..1730)
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="protein binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:29049"
     misc_feature    1923..2303
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="C2 domain first repeat contained in
                     Rab3-interacting molecule (RIM) proteins; Region:
                     C2A_RIM1alpha; cd04031"
                     /db_xref="CDD:175997"
     misc_feature    order(2016..2018,2034..2036,2199..2201,2205..2207,
                     2229..2231)
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:175997"
     misc_feature    3300..3737
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="C2 domain second repeat contained in
                     Rab3-interacting molecule (RIM) proteins; Region:
                     C2B_RIM1alpha; cd04028"
                     /db_xref="CDD:175994"
     misc_feature    order(3471..3473,3483..3488,3492..3494,3501..3503,
                     3585..3587,3591..3593,3597..3599,3729..3734)
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /note="homodimer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:175994"
     variation       340
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377178152"
     variation       437
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72681316"
     exon            443..1368
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       456
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201322998"
     variation       459
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190433281"
     variation       476
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369996192"
     variation       485
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374551478"
     variation       523
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146399863"
     variation       536
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34681663"
     variation       540
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373874945"
     variation       542
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139492859"
     variation       577
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17854256"
     variation       578
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:76903489"
     variation       583
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371773136"
     variation       589
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374557980"
     variation       604
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35925435"
     variation       632
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371608826"
     variation       647
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377313890"
     variation       649
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200878422"
     variation       703
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200726457"
     variation       704
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200152573"
     variation       723
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200264682"
     variation       769
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144225573"
     variation       782
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3824117"
     variation       808
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369681508"
     variation       845
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202004651"
     variation       859
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199895069"
     variation       890
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:184923024"
     variation       909
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:188155434"
     variation       925
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377106907"
     variation       957
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200980523"
     variation       958
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201468621"
     variation       967
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376489252"
     variation       979
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371072647"
     variation       991
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199608093"
     variation       996
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376752812"
     variation       1012
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371004236"
     variation       1051
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374105959"
     variation       1126
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367984365"
     variation       1142
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371755249"
     variation       1194
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201466149"
     variation       1204
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17854255"
     variation       1229
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200495823"
     variation       1236
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374794052"
     variation       1254
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200408676"
     variation       1257
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200234707"
     variation       1266
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376615886"
     variation       1316
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199716894"
     exon            1369..1436
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     exon            1437..1556
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1473
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141316868"
     variation       1474
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201351103"
     variation       1479
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370702839"
     variation       1504
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375138135"
     variation       1521
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200160054"
     variation       1533
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370262056"
     variation       1539
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:61760869"
     variation       1542
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200587950"
     variation       1545
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200151905"
     STS             1556..1786
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /standard_name="Syt3-rs"
                     /db_xref="UniSTS:144532"
     exon            1557..1656
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1581
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201686148"
     variation       1613
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369114535"
     exon            1657..1780
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1687
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370047208"
     variation       1764
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76852437"
     variation       1770
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:184595178"
     exon            1781..1827
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1789
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373806828"
     variation       1790
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377538488"
     exon            1828..1940
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1838
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138369781"
     variation       1869
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374131367"
     variation       1888
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202126935"
     variation       1890
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199861708"
     exon            1941..2071
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       1941
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201336825"
     variation       1949
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370086876"
     variation       2002
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61753731"
     variation       2008
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376434557"
     variation       2021
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370828971"
     variation       2027
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183274467"
     exon            2072..2243
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2072
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372179479"
     variation       2075
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373835551"
     variation       2128
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199836073"
     variation       2135
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199544053"
     variation       2150
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367730974"
     variation       2160
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371602210"
     variation       2240
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17854257"
     exon            2244..2397
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2253
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199576216"
     variation       2283
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200856053"
     variation       2306
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201827334"
     variation       2352
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202000083"
     variation       2364
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374100372"
     variation       2386
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376486274"
     variation       2391
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367967716"
     variation       2396
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200894680"
     exon            2398..2466
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2416
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374496599"
     variation       2457
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377340659"
     exon            2467..2623
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2479
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199624235"
     variation       2482
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372815457"
     variation       2487
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200437104"
     variation       2503
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368660775"
     variation       2505
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371994550"
     variation       2507
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199696831"
     variation       2538
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35099196"
     variation       2578
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148823573"
     variation       2600
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:34236346"
     exon            2624..2740
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2626
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368813886"
     variation       2634
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187532798"
     variation       2647
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376934485"
     variation       2667
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147193181"
     variation       2688
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201715496"
     variation       2711
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199654709"
     variation       2719
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75811370"
     exon            2741..2806
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2772
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375700279"
     variation       2773
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368600067"
     variation       2799
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182266368"
     exon            2807..2986
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2817
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369055191"
     variation       2849
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201345102"
     variation       2861
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76323676"
     variation       2862
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61743841"
     variation       2908
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199562210"
     variation       2917
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369842078"
     exon            2987..3096
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       2998
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377554442"
     variation       3021
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146646525"
     variation       3030
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199718726"
     variation       3057
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201593154"
     exon            3097..3238
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       3122
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200842041"
     variation       3131
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187159461"
     variation       3139
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145791616"
     variation       3149
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191216972"
     variation       3150
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182290714"
     variation       3155
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372897311"
     variation       3156
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377163259"
     variation       3177
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369122734"
     exon            3239..3351
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       3252
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376745301"
     variation       3302
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369558186"
     variation       3334
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370979244"
     exon            3352..3453
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       3355
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199721614"
     variation       3362..3363
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:59975412"
     variation       3362
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2028945"
     variation       3396
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188939341"
     variation       3436
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372761966"
     exon            3454..3593
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     variation       3458
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143698299"
     variation       3461
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1134949"
     variation       3506
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368801298"
     exon            3594..6420
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /inference="alignment:Splign:1.39.8"
     STS             3606..3847
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /standard_name="D8S1580"
                     /db_xref="UniSTS:34726"
     variation       3611
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200958268"
     variation       3619
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200286153"
     variation       3634
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:61997186"
     STS             3679..3763
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /standard_name="D17S1777"
                     /db_xref="UniSTS:154156"
     variation       3692
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61753732"
     variation       3736
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:181950889"
     variation       3743
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10461"
     variation       3786
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201106079"
     variation       3809
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:138693244"
     variation       3846
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370269591"
     variation       3851..3852
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:34085789"
     variation       3851
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78110727"
     variation       3851
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:376818345"
     variation       3852..3853
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="aaa"
                     /db_xref="dbSNP:372192764"
     variation       3863..3864
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:367714696"
     variation       3868..3869
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:370350019"
     variation       3869..3870
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="aaa"
                     /db_xref="dbSNP:34750742"
     variation       3917
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79468299"
     variation       4029
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185724163"
     variation       4058
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376587640"
     STS             4081..4647
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /standard_name="RIMS2_8980"
                     /db_xref="UniSTS:468122"
     variation       4151
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149242528"
     variation       4203
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:190532813"
     variation       4209
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112773352"
     variation       4238
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181040862"
     variation       4380
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1060441"
     variation       4432
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144512653"
     variation       4442
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79796539"
     variation       4456
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373797577"
     variation       4519..4520
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34435746"
     variation       4519
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200942509"
     variation       4520
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74456116"
     variation       4521
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75938964"
     variation       4534
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201729090"
     variation       4627
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186528326"
     variation       4765
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367554661"
     variation       4823
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77012762"
     variation       4922
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373490788"
     variation       4971
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190998614"
     variation       4984
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182712473"
     variation       5120
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188976120"
     variation       5125
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191875491"
     variation       5215
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148422757"
     variation       5237
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141099590"
     variation       5580
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183455401"
     variation       5581
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187390673"
     variation       5682
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146111359"
     variation       5777
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192327925"
     variation       5822
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184115197"
     variation       5855
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188108691"
     variation       5939
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:116500812"
     variation       5981
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2511592"
     variation       6111..6113
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="att"
                     /db_xref="dbSNP:143954005"
     variation       6135
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:57490000"
     variation       6137
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140185293"
     variation       6196..6198
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="t"
                     /replace="tt"
                     /db_xref="dbSNP:33923607"
     variation       6196
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200838311"
     variation       6205..6206
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="t"
                     /replace="tt"
                     /db_xref="dbSNP:10701383"
     variation       6206..6207
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace=""
                     /replace="t"
                     /replace="tt"
                     /db_xref="dbSNP:67441588"
     variation       6226
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2511593"
     variation       6268
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192634080"
     variation       6351
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372531775"
     variation       6406
                     /gene="RIMS2"
                     /gene_synonym="OBOE; RAB3IP3; RIM2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143857184"
ORIGIN      
atgagtagagtacatgaaagcagctcagcttcacacttcagctgggaatgcccaaaaagcttactgctgtttagaattcttgctacagtcaggagaaagccgaaagctgcacgggtactgaatcttctacgactgaattagaagaataatgactgtacaattaactatcaacctctgttcatttaagcacagtttttacagagctcaggagaaatatggaacttgattggcgtgtttttatttgatggtgtcagcaaatagatgattttaaagacaggtggtagggaaaaataagagaaggggaaaaaaaaagaaagaaaatgcaatttgagacattgcgccaggtctgcaattctgttttatctcattttcatggggttttttcatccccaccaaatatcttacaaaatgagctttttggacaaacactgaacaatgcaaggaaaagaagcccatctgtgtccagagatcagaatagaagatacgaccaaagggaagaaagagaggaatattcacagtatgctacttcggataccgcaatgcctagatctccatcagattatgctgataggcgatctcaacatgaacctcagttttatgaagactctgatcatttaagttatagggactccaacaggagaagtcataggcattccaaagaatatattgtagatgatgaggatgtggaaagcagagatgaatacgaaaggcaaaggagagaggaagagtaccagtcacgctaccgaagtgatccgaatttggcccgttatccagtaaagccacaaccctatgaagaacaaatgcggatccatgctgaagtgtcccgagcacggcatgagagaaggcatagtgatgtttctttggcaaatgctgatctggaagattccaggatttctatgctaaggatggatcgaccatcaaggcaaagatctatatcagaacgtagagctgccatggaaaatcagcgatcttattcaatggaaagaactcgagaggctcagggaccaagttcttatgcacaaaggaccacaaaccatagtcctcctacccccaggaggagtccactacccatagatagaccagacttgaggcgtactgactcactacggaaacagcaccacttagatcctagctctgctgtaagaaaaacaaaacgggaaaaaatggaaacaatgttaaggaatgattctctcagttcagaccagtcagagtcagtgagacctccaccaccaaagcctcataaatcaaagaaaggcggtaaaatgcgccagatttcgttgagcagttcagaggaggaattggcttccacgcctgaatatacaagttgtgatgatgttgagattgaaagtgagagtgtaagtgaaaaaggagacatggattacaactggttggatcatacgtcttggcatagcagtgaggcatccccaatgtctttgcaccctgtaacctggcaaccatctaaagatggagatcgtttaattggtcgcattttattaaataagcgtctaaaagatggaagtgtacctcgagattcaggagcaatgcttggcttgaaggttgtaggaggaaagatgactgaatcaggtcggctttgtgcatttattactaaagtaaaaaaaggaagtttagctgatactgtaggacatcttagaccaggtgatgaagtattagaatggaatggaagactactgcaaggagccacatttgaggaagtgtacaacatcattctagaatccaaacctgaaccacaagtagaacttgtagtttcaaggcctattggagatataccgcgaatacctgatagcacacatgcacaactggagtccagttctagctcctttgaatctcaaaaaatggatcgtccttctatttctgttacctctcccatgagtcctggaatgttgagggatgtcccacagttcttatcaggacaactttcaataaaactatggtttgacaaggttggtcaccaattaatagttacaattttgggagcaaaagatctcccttccagggaagatgggaggccaaggaatccttatgttaaaatttactttcttccagacagaagtgataaaaacaagagaagaactaaaacagtaaagaaaacattggaacccaaatggaaccaaacattcatttattctccagtccaccgaagagaatttcgggaacgaatgctagagattaccctttgggatcaagctcgtgttcgagaggaagaaagtgaattcttaggcgagattttaattgaattagaaacagcattattagatgatgagccacattggtacaaacttcagacgcatgatgtctcttcattgccacttccccacccttctccatatatgccacgaagacagctccatggagagagcccaacacggaggttgcaaaggtcaaagagaataagtgatagtgaagtctctgactatgactgtgatgatggaattggtgtagtatcagattatcgacatgatggtcgagatcttcaaagctcaacattatcagtgccagaacaagtaatgtcatcaaaccactgttcaccatcagggtctcctcatcgagtagatgttataggaaggactagatcatggtcacccagtgtccctcctccacaaagtcggaatgtggaacaggggcttcgagggacccgcactatgaccggacattataatacaattagccgaatggacagacatcgtgtcatggatgaccattattctccagatagagacagtcattttcttactctacctcgctccagatacagtcagaccattgaccatcatcacagggatggcagggattgtgaagcagcagatagacagccatatcacagatccagatcaacagaacaacggcctctccttgagcggaccaccacccgctccagatccactgaacgtcctgatacaaacctcatgaggtcgatgccttcattaatgactggaagatctgcccctccttcacctgccttatcgaggtctcatcctcgtactgggtctgtccagacaagcccatcaagtactccagtcgcaggacgaaggggccgacagcttccacagcttccaccaaagggaacgttggatagaaaagcaggaggtaaaaaactaaggagcactgtccaaagaagtacagaaacaggcctggccgtggaaatgaggaactggatgactcgacaggcaagccgagagtctacagatggtagcatgaacagctacagctcagaaggaaatctgattttccctggtgttcgcttggcctctgatagccagttcagtgatttcctggatggccttggccctgctcagctagtgggacgccagactctggcaacacctgcaatgggtgacattcaggtaggaatgatggacaaaaagggacagctggaggtagaaatcatccgggcccgtggccttgttgtaaaaccaggttccaagacactgccagcaccgtatgtaaaagtgtatctattagataacggagtctgcatagccaaaaagaaaacaaaagtggcaagaaaaacgctggaacccctttaccagcagctattatctttcgaagagagtccacaaggaaaagttttacagatcatcgtctggggagattatggccgcatggatcacaaatcttttatgggagtggcccagatacttttagatgaactagagctatccaatatggtgatcggatggttcaaacttttcccaccttcctccctagtagatccaaccttggcccctctgacaagaagagcttcccaatcatctctggaaagttcaactggaccttcttactctcgttcatagcagctgtaaaaaaattgttgtcacagcaaccagcgttacaaaaaaaaaaaaaaaaatcacaggttgcaaaccctggtaacactgcatgcttaatgttgtgtcttctgagcctgtttctagggatacaaagcaatcctgtgttctcagaggaagttgcacacattgtgccctaaagaaggccctcaggtgaaagagcagagctgtgaagaactatcagatttggaattcaatgacactcgagttctggtccaatctgaagccatggattaatctcaaagaatcagtcagtttcatgcaacagaagcccttttcaatggcacctttatatttttatcattcctttttcttcatttatctaaccccaaagccctgatatgccacagaaatggagctatacagccatgaagcggtgttacaggtgaggagtgtaatcctaggaagcatcaggtgaaaagcaggagaccaaagaagtggtcaggaacaatcatcagccctcctctgggcgggaatcagagcagtcagtccagcaggaagagtggcagactttgtagctccatgggcacgtcaattactaatgctaagatgtgttggactctgaaaaacaaaattctgtggctacactgtactgaatgaaattaaagaaactttttttgcatggacacagattagctgaatacttaaattattttcttggggctgcaacttgcaaaaaaaaaaaaaagaataaaaatcagccattttcaacaatttatattatttttaaaaataaatttcactagtgcatggttttaaaaaggagagagaatgcaacagggtgatacaaagatacaccatgtttattctttaatcatagtctgtgttttggcagacattacaaatggaaatactttctagaagatacttaaaattctctttatgtgacaaataagtataatatattcaatttatttccatgttaaatatacaaatcttatgaagttcaatatgtgcaaatttttcacatctttctccttctctcactttacctcttctccctcttttaaacttttctttctccctgccagagtgaaccttatactaaaaaattacaagttttgatctgatcctctctcataccccatgtttgattcagagctgtagatgcctctgaatttgcgaatttctcaagggaaaattaactttaagagctttctttatttcaagcatgttgaaaaggattttgcaacatgacttgggagtacattaaagtaagtcagcatgtatttgacgaagaagatatttgaacttttgcagtttattgtacagtgcatggtaattttttcacctttaaaattcagtttacaggaaaattctaaaatcatgttgccattgtgatgtccaataaatttgtttttagcaccagcattattcatacaggggttaaagtattatttgtagaaggtcttaggttttgtttgttttttaatcatttaaagcaatttctttagccagtttccatttactatgtgaatagaagcactgctaaaaattgggaaccctgaaacacagggctgtttattaattcatttttctgtagtaaaattcaatttttcacaaattatatttctaaagaaatatagtaaacataaatttgcaacaattttaaagctccagtttttaggtgactcaaagaaagtcattatgcctattaatagttatttgatgccatcaccaaaagtctatgtgaaaatctcctaaagtcaaaacccctgcctttggttttacagacggttattaccattgggtggagctgcaaggtcaaatttctcctaagttcccctatttagaggaaaagtcactggttattgtaataaaccacccatggttctttatgtacattttgataacacattattatagcttgattttaattttttgcattaatttttgaaatccacatacatctcatttgtttaaattaaggccatgcacaaatattttttttagttcagtgctgaccattaaaaactatcatgcttgatacggtgcaaaagttaaaatgagtatcactaaaaatgccttctttttatgtggtgcaatatgaaatacaccaagactgtgtcttgacattctgatggacccaggtaaagttgttaaaagaacgaataaaactttattaaaataatttagacacctgtgtaccagcaacaattgatttaatagacctatagtgtctatactatcccttagaataaaggtttatgattttcctgatactaagatgcagtcacataatcttttgtgcatattcctatacaaattatttctaattttaataagaaggacgtgactacggaatatttgtacatacttgtcattatgcagtatttatttaaaagttggtgtttttttttaattttcacatctgcacctcgacttgtggtttagtcatgtaactagcactatgccagtgaccgttgttgccctgtacatagtatgtttgaaaagtaaagggaattccagttgggaaaaaagggcagattagtcctgtaatgaacaccaactaatgtaaatcaaattcattctggtgatggtatttaacactttaaataaaacattttctttacag
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9699 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9699 -> Molecular function: GO:0017137 [Rab GTPase binding] evidence: IEA
            GeneID:9699 -> Molecular function: GO:0044325 [ion channel binding] evidence: IEA
            GeneID:9699 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:9699 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
            GeneID:9699 -> Biological process: GO:0017156 [calcium ion-dependent exocytosis] evidence: IEA
            GeneID:9699 -> Biological process: GO:0017157 [regulation of exocytosis] evidence: IEA
            GeneID:9699 -> Biological process: GO:0019933 [cAMP-mediated signaling] evidence: IEA
            GeneID:9699 -> Biological process: GO:0030073 [insulin secretion] evidence: IEA
            GeneID:9699 -> Biological process: GO:0042391 [regulation of membrane potential] evidence: IEA
            GeneID:9699 -> Biological process: GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] evidence: IEA
            GeneID:9699 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:9699 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
            GeneID:9699 -> Cellular component: GO:0042734 [presynaptic membrane] evidence: IEA

by @meso_cacase at DBCLS
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