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2024-04-20 03:17:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014352 3013 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens POU class 2 homeobox 3 (POU2F3), transcript variant 1, mRNA. ACCESSION NM_014352 VERSION NM_014352.3 GI:347658962 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3013) AUTHORS Takemoto,H., Tamai,K., Akasaka,E., Rokunohe,D., Takiyoshi,N., Umegaki,N., Nakajima,K., Aizu,T., Kaneko,T., Nakano,H. and Sawamura,D. TITLE Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation JOURNAL J. Dermatol. Sci. 60 (3), 203-205 (2010) PUBMED 21074976 REMARK GeneRIF: It is possible that Skn-1a and the related isoforms have different functions in keratinocyte differentiation and proliferation. REFERENCE 2 (bases 1 to 3013) AUTHORS Lena,A.M., Cipollone,R., Amelio,I., Catani,M.V., Ramadan,S., Browne,G., Melino,G. and Candi,E. TITLE Skn-1a/Oct-11 and DeltaNp63alpha exert antagonizing effects on human keratin expression JOURNAL Biochem. Biophys. Res. Commun. 401 (4), 568-573 (2010) PUBMED 20888799 REMARK GeneRIF: the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene promoter or through an indirect interaction. REFERENCE 3 (bases 1 to 3013) AUTHORS Kukimoto,I., Mori,S., Sato,H., Takeuchi,T. and Kanda,T. TITLE Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin JOURNAL FEBS J. 275 (12), 3123-3135 (2008) PUBMED 18479461 REMARK GeneRIF: Skn-1a enhanced the transient replication of a plasmid containing the HPV16 replication origin in HEK293 cells when co-transfected with a plasmid expressing E1 and E2. REFERENCE 4 (bases 1 to 3013) AUTHORS Nakajima,K., Tamai,K., Yamazaki,T., Toyomaki,Y., Nakano,H., Uitto,J. and Sawamura,D. TITLE Identification of Skn-1n, a splice variant induced by high calcium concentration and specifically expressed in normal human keratinocytes JOURNAL J. Invest. Dermatol. 128 (5), 1336-1339 (2008) PUBMED 17989732 REMARK GeneRIF: splice variant induced in keratinocytes by high calcium REFERENCE 5 (bases 1 to 3013) AUTHORS Zhang,Z., Huettner,P.C., Nguyen,L., Bidder,M., Funk,M.C., Li,J. and Rader,J.S. TITLE Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer JOURNAL Oncogene 25 (39), 5436-5445 (2006) PUBMED 16607278 REMARK GeneRIF: POU2F3 in cervical cancer cells may be CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms. REFERENCE 6 (bases 1 to 3013) AUTHORS Cabral,A., Fischer,D.F., Vermeij,W.P. and Backendorf,C. TITLE Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation JOURNAL J. Biol. Chem. 278 (20), 17792-17799 (2003) PUBMED 12624109 REMARK GeneRIF: the human Skn-1 locus encodes multifunctional protein isotypes, subjected to biochemical cross-talk, which are likely to play a major role in the fine-tuning of keratinocyte terminal differentiation REFERENCE 7 (bases 1 to 3013) AUTHORS Sugihara,T.M., Kudryavtseva,E.I., Kumar,V., Horridge,J.J. and Andersen,B. TITLE The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300 JOURNAL J. Biol. Chem. 276 (35), 33036-33044 (2001) PUBMED 11429405 REFERENCE 8 (bases 1 to 3013) AUTHORS Hildesheim,J., Foster,R.A., Chamberlin,M.E. and Vogel,J.C. TITLE Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor JOURNAL J. Biol. Chem. 274 (37), 26399-26406 (1999) PUBMED 10473598 REFERENCE 9 (bases 1 to 3013) AUTHORS Andersen,B., Weinberg,W.C., Rennekampff,O., McEvilly,R.J., Bermingham,J.R. Jr., Hooshmand,F., Vasilyev,V., Hansbrough,J.F., Pittelkow,M.R., Yuspa,S.H. and Rosenfeld,M.G. TITLE Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation JOURNAL Genes Dev. 11 (14), 1873-1884 (1997) PUBMED 9242494 REFERENCE 10 (bases 1 to 3013) AUTHORS Goldsborough,A.S., Healy,L.E., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Willison,K.R. and Ashworth,A. TITLE Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11 JOURNAL Nucleic Acids Res. 21 (1), 127-134 (1993) PUBMED 8441607 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291993.1, BC101649.1 and AP001150.5. On Sep 24, 2011 this sequence version replaced gi:148664217. Summary: This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133895.1, AF162278.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025082, ERS025084 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-65 AK291993.1 1-65 66-1503 BC101649.1 1-1438 1504-3013 AP001150.5 88084-89593 FEATURES Location/Qualifiers source 1..3013 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11q23.3" gene 1..3013 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /note="POU class 2 homeobox 3" /db_xref="GeneID:25833" /db_xref="HGNC:19864" /db_xref="MIM:607394" exon 1..178 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /inference="alignment:Splign:1.39.8" STS 66..1507 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /db_xref="UniSTS:486948" variation 139 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /replace="c" /replace="g" /db_xref="dbSNP:10790371" STS 144..1511 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /db_xref="UniSTS:481401" CDS 151..1461 /gene="POU2F3" /gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a" /note="isoform 1 is encoded by transcript variant 1; POU domain, class 2, transcription factor 3; octamer-binding protein 11; transcription factor PLA-1; transcription factor Skn-1; octamer-binding transcription factor 11; POU domain transcription factor OCT11a" /codon_start=1 /product="POU domain, class 2, transcription factor 3 isoform 1" /protein_id="NP_055167.2" /db_xref="GI:148664218" /db_xref="CCDS:CCDS8431.1" /db_xref="GeneID:25833" /db_xref="HGNC:19864" /db_xref="MIM:607394" /translation="
MVNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLSDSLQQTLSHRPCHLSQGPAMMSGNQMSGLNASPCQDMASLHPLQQLVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLLPQTGPGLASQAFGHPGLPGSSLEPHLEASQHLPVPKHLPSSGGADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAVNSASSFNSSGSWYRWNHSTYLH
"
misc_feature 697..921
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="Found in Pit-Oct-Unc transcription factors; Region:
POU; smart00352"
/db_xref="CDD:197673"
misc_feature 994..1164
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(994..1008,1012..1014,1063..1065,1081..1083,
1120..1122,1126..1131,1138..1143,1147..1155,1159..1164)
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(1000..1002,1009..1011,1129..1131,1138..1143,
1150..1152)
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
variation 152
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:375627439"
exon 179..247
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 187
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:201301538"
variation 205
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:201020292"
variation 212
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372245806"
variation 213
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:150562013"
variation 220
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:150644971"
exon 248..282
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 257
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200756719"
variation 279
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:374278692"
exon 283..408
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 291
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:139585451"
variation 307
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="g"
/replace="t"
/db_xref="dbSNP:149689245"
variation 331
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:372543314"
variation 361
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:145496153"
variation 369
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:113447905"
variation 393
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:370189714"
exon 409..511
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 428
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:199908870"
variation 501
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369163466"
variation 509
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:139221088"
variation 510
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:143953974"
exon 512..594
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 526
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:146425412"
variation 552
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:367755083"
variation 553
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200455762"
variation 585
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:140710784"
variation 589
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:143843036"
variation 593
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376782432"
exon 595..777
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 596
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201145362"
variation 599
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:151083714"
variation 604
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:202027996"
variation 605
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:7110845"
variation 654
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:150249219"
variation 665
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:139093583"
variation 696
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201298803"
variation 714
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:370431541"
exon 778..919
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 797
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:371408943"
variation 885
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:374712708"
exon 920..1056
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 928
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201865274"
variation 930
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:377762447"
variation 947
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:371185538"
variation 1004
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:143121284"
variation 1009
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:147033976"
variation 1015
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:373394231"
variation 1028
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:138343985"
variation 1043
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:149531239"
exon 1057..1218
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 1074
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376467328"
variation 1083
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:376184076"
variation 1098
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:35602880"
variation 1106
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:377205553"
variation 1116
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:148695404"
variation 1149
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372281815"
variation 1162
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:202225394"
variation 1190
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:149496403"
variation 1194
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:146242937"
variation 1198
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375346340"
variation 1211
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201319590"
variation 1214
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:77550935"
exon 1219..1285
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
exon 1286..1421
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 1290
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:144064421"
variation 1312
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:113676807"
variation 1319
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:2282537"
variation 1320
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:139827446"
variation 1347
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:147219684"
variation 1371
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:377039236"
variation 1399
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:150057507"
exon 1422..3013
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/inference="alignment:Splign:1.39.8"
variation 1433
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:370231426"
variation 1464
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="c"
/db_xref="dbSNP:190020776"
variation 1467
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376587998"
variation 1498
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:376715195"
variation 1540
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:375456701"
variation 1566
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:140667393"
variation 1604
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369925673"
variation 1621
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:61898346"
variation 1719
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:144375055"
variation 1772..1773
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="tt"
/db_xref="dbSNP:3832733"
variation 1773
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:200541107"
variation 1932
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375085577"
variation 1963
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="t"
/db_xref="dbSNP:112050659"
variation 2062
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:75477342"
variation 2063
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:146080572"
variation 2124
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="g"
/replace="t"
/db_xref="dbSNP:112894319"
STS 2154..2337
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="RH69888"
/db_xref="UniSTS:27428"
variation 2225
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:151121242"
variation 2243
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:73578283"
variation 2287..2288
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="g"
/db_xref="dbSNP:35061338"
variation 2316
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:373224204"
variation 2420
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="g"
/db_xref="dbSNP:141117331"
variation 2434..2435
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="g"
/db_xref="dbSNP:201098205"
variation 2434
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:112976121"
variation 2487
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:376535498"
variation 2501
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78221919"
variation 2507
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:4938797"
variation 2513
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="c"
/db_xref="dbSNP:368955441"
variation 2513
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:200901486"
variation 2514
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:4938798"
variation 2518
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:78177158"
variation 2519
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:185314501"
variation 2578
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:372681012"
variation 2598
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:188928459"
STS 2602..2725
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D11S2560"
/db_xref="UniSTS:37928"
variation 2602
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:181535671"
STS 2606..2739
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D15S1477"
/db_xref="UniSTS:474482"
STS 2613..2706
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2622
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="a"
/replace="g"
/db_xref="dbSNP:11217815"
variation 2641
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:145483650"
variation 2767
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:141111966"
variation 2804
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:112541714"
variation 2877
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:375262616"
variation 2922..2923
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="a"
/db_xref="dbSNP:200735927"
variation 2923
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace=""
/replace="a"
/db_xref="dbSNP:373950522"
variation 2934
/gene="POU2F3"
/gene_synonym="Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1;
Skn-1a"
/replace="c"
/replace="t"
/db_xref="dbSNP:200773770"
ORIGIN
gcgacagtggcggcgacggctccggcagcggctcccgcggcggcggcggccgggaactggaggaaggagaccctggcttcgcaggggccccggctggggcagaggcgaggggcctgggggggcgctggctttggccccgcctggggcaggatggtgaatctggagtccatgcacacagatatcaagatgagtggggatgtagccgattccacggatgctcgcagcactctcagccaggtggagccaggaaatgatcgaaatggcctagatttcaacaggcagattaaaaccgaagatctcagtgactccctgcagcagaccctctcccatcggccatgccacctgagtcaaggacctgccatgatgtccggaaaccaaatgtctgggctaaatgccagcccatgtcaggacatggcttccctccatccgctccagcagcttgtgctggttcccggccacttacagtctgtatcccagttcctgctatctcagacccagcctgggcagcaaggtctgcagccaaatctcctcccctttccacagcaacaaagcggtctcctcctcccacagactgggccgggactggcatcccaggcatttgggcaccctgggctgccaggatcctctttagaaccccacctggaagcatcccagcatctcccagtgcccaagcatctacccagctctggaggggccgatgagcccagtgacctcgaggagctggagaagtttgccaagaccttcaagcagaggcgcattaagctgggcttcacacagggagatgtggggctggcgatgggaaagctgtatggcaacgacttcagccagaccaccatctcacgatttgaggccctcaacctgagcttcaagaacatgtgcaagctcaagcccctgctggagaagtggctgaatgatgcagagtcctctccgtcagacccctcagtgagcacgcccagctcctaccccagcctcagtgaagtatttggtaggaagagaaagaaacggaccagcatcgagaccaacatccgcctgactctggagaagaggtttcaagataacccaaaacccagctcggaggagatctccatgattgcagagcagttgtccatggagaaggaggtggtgagggtctggttctgcaaccgacgccaaaaggagaagcgaatcaactgccctgtggccacacccatcaaaccacctgtctacaactcccggctggtatctccctcagggtctctgggccccctctctgtccctcctgtccacagtaccatgcctggaacagtaacgtcatcctgttcccctgggaacaacagcaggccttcatctcctggctcaggactccacgccagcagccccactgcatctcaaaataactccaaagcagcagtgaactccgcctccagttttaactcttcaggatcttggtaccgatggaatcattccacctacctccactgagaccaaaaagtttctcctactccagctggccctgtattccccctggaaggaagggaatcatgccttctatatacagacagattgccttcagaagagtggaagaaaatctccactatcaatgaacccagactcttgtcttcttcaagagcaagggcctccggagatccaaactgtgattgaaccaagtgcagactcctaatgctcttgaaatacacagcccctcctaggagcttaccattttcaccttccttgcctatgcccttgccttctagttccaaatattttagccagcttcactgtggcaatagtctttcagagaaaagacttcttgctgttattctccaactcatccgtgggcttctggggacagccatttggctggggtgccaaacaccagaaggggagataatagttttgactctgaacttggccacaacccctgaactgatcccaaaatctgtgaaaagatttgaatctgatatctccaccaaagccttgatgttttctctgtacagctaagttttctgatggaatcttcatctcaccccattttctttttaacctcgcccccttttctacaatcaaatccattcattattgcgccctccaggtcccctcctttttgcagaaggtgtaaaagagctgcccttggtgggtgccctgggcatgttgcaacgcctgctggtgcccttctgtctgtccacgtctgcctagggctcaggagtgcttgttctttcccttcctccctgtgtttctctttatcctgtcccctctcctttctcctggcagcagaaaaggaagaacacaagagcaaacacacaacaatgatggtggcaaagtacctgtatatagccctttcccattttttgcattatgttcttaactccttaatgtggaattttccagcaaaatgtttaactcaggtgtgatttttgaaaatgtctctgtaatattttatcttctttaaaaaaaagggggggaaataccaaagtgtgaaatactgtgctaccttccagagttcccacatgggctgggatttttttttctttttcttttttttttttttttttgagacagtcttgctccagcccaggctggagtgcagtggcatgatcttggctcactgcatgctctgccacttgggttcaagcgattctcctgcctcagcctctcaagtagcgggattacaggcgcccaccaccaaaaattagcccagctaatttttgtatttttagtagagatggggtttcaccatgttggtcaggctggtcttgaactcctgacctcctgatccacccacctcagcgtcccgaagtgctgggattacaggtgtgagccaccgcgcctggcctgggctgggaatctttgttgacttctttgggaacattatctctagagtctgcttttttgtgggccagtttgtagagatgtaacatgaagccattccagaaatggtaacttaaaaaaaaaaagactacatgtctaggaaactgttgagattcaaaggaatctcactgttcctaaataaatgtgtatagtgattatgaaaagt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25833 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:25833 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25833 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:25833 -> Molecular function: GO:0046983 [protein dimerization activity] evidence: IEA
GeneID:25833 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:25833 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:25833 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:25833 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:25833 -> Biological process: GO:0042060 [wound healing] evidence: IEA
GeneID:25833 -> Biological process: GO:0043922 [negative regulation by host of viral transcription] evidence: IDA
GeneID:25833 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:25833 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:25833 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
GeneID:25833 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:25833 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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