Home |
Help |
Advanced search
2024-04-26 04:28:00, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014330 2399 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens protein phosphatase 1, regulatory subunit 15A
(PPP1R15A), mRNA.
ACCESSION NM_014330
VERSION NM_014330.3 GI:157674362
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2399)
AUTHORS Dalton,L.E., Clarke,H.J., Knight,J., Lawson,M.H., Wason,J.,
Lomas,D.A., Howat,W.J., Rintoul,R.C., Rassl,D.M. and Marciniak,S.J.
TITLE The endoplasmic reticulum stress marker CHOP predicts survival in
malignant mesothelioma
JOURNAL Br. J. Cancer 108 (6), 1340-1347 (2013)
PUBMED 23412101
REMARK GeneRIF: Low GADD34 expression is associated with malignant
mesothelioma.
REFERENCE 2 (bases 1 to 2399)
AUTHORS Zhou,W., Brush,M.H., Choy,M.S. and Shenolikar,S.
TITLE Association with endoplasmic reticulum promotes proteasomal
degradation of GADD34 protein
JOURNAL J. Biol. Chem. 286 (24), 21687-21696 (2011)
PUBMED 21518769
REMARK GeneRIF: the association of with ER modulates intracellular
trafficking and proteasomal degradation of GADD34, and in turn, its
ability to modify ER morphology
REFERENCE 3 (bases 1 to 2399)
AUTHORS Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
Schreiber,S. and Nebel,A.
TITLE Investigation of genetic susceptibility factors for human longevity
- a targeted nonsynonymous SNP study
JOURNAL Mutat. Res. 694 (1-2), 13-19 (2010)
PUBMED 20800603
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2399)
AUTHORS Kepp,O., Galluzzi,L., Giordanetto,F., Tesniere,A., Vitale,I.,
Martins,I., Schlemmer,F., Adjemian,S., Zitvogel,L. and Kroemer,G.
TITLE Disruption of the PP1/GADD34 complex induces calreticulin exposure
JOURNAL Cell Cycle 8 (23), 3971-3977 (2009)
PUBMED 19901557
REMARK GeneRIF: The role of the PP1/GADD34 complex in the molecular
cascade is to the translocation of CRT to the outer leaflet of the
plasma membrane.
REFERENCE 5 (bases 1 to 2399)
AUTHORS Garrido,J.L., Maruo,S., Takada,K. and Rosendorff,A.
TITLE EBNA3C interacts with Gadd34 and counteracts the unfolded protein
response
JOURNAL Virol. J. 6, 231 (2009)
PUBMED 20040105
REMARK GeneRIF: The data suggest that EBNA3C interacts with Gadd34,
activating the upstream component of the UPR-unfolded protein
response (eIF2alpha phosphorylation) while preventing downstream
UPR events (XBP1 activation and ATF6 cleavage).
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2399)
AUTHORS Hasegawa,T., Yagi,A. and Isobe,K.
TITLE Interaction between GADD34 and kinesin superfamily, KIF3A
JOURNAL Biochem. Biophys. Res. Commun. 267 (2), 593-596 (2000)
PUBMED 10631107
REFERENCE 7 (bases 1 to 2399)
AUTHORS Adler,H.T., Chinery,R., Wu,D.Y., Kussick,S.J., Payne,J.M.,
Fornace,A.J. Jr. and Tkachuk,D.C.
TITLE Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and
associate with the GADD34 and hSNF5/INI1 proteins
JOURNAL Mol. Cell. Biol. 19 (10), 7050-7060 (1999)
PUBMED 10490642
REFERENCE 8 (bases 1 to 2399)
AUTHORS Hasegawa,T. and Isobe,K.
TITLE Evidence for the interaction between Translin and GADD34 in
mammalian cells
JOURNAL Biochim. Biophys. Acta 1428 (2-3), 161-168 (1999)
PUBMED 10434033
REFERENCE 9 (bases 1 to 2399)
AUTHORS Korabiowska,M., Betke,H., Kellner,S., Stachura,J. and Schauer,A.
TITLE Differential expression of growth arrest, DNA damage genes and
tumour suppressor gene p53 in naevi and malignant melanomas
JOURNAL Anticancer Res. 17 (5A), 3697-3700 (1997)
PUBMED 9413226
REFERENCE 10 (bases 1 to 2399)
AUTHORS Hollander,M.C., Zhan,Q., Bae,I. and Fornace,A.J. Jr.
TITLE Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
JOURNAL J. Biol. Chem. 272 (21), 13731-13737 (1997)
PUBMED 9153226
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA484808.1 and AK225632.1.
On Sep 26, 2007 this sequence version replaced gi:9790902.
Summary: This gene is a member of a group of genes whose transcript
levels are increased following stressful growth arrest conditions
and treatment with DNA-damaging agents. The induction of this gene
by ionizing radiation occurs in certain cell lines regardless of
p53 status, and its protein response is correlated with apoptosis
following ionizing radiation. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK225632.1, BC003067.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-29 DA484808.1 1-29
30-2399 AK225632.1 1-2370
FEATURES Location/Qualifiers
source 1..2399
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.2"
gene 1..2399
/gene="PPP1R15A"
/gene_synonym="GADD34"
/note="protein phosphatase 1, regulatory subunit 15A"
/db_xref="GeneID:23645"
/db_xref="HGNC:14375"
/db_xref="MIM:611048"
exon 1..260
/gene="PPP1R15A"
/gene_synonym="GADD34"
/inference="alignment:Splign:1.39.8"
variation 23
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:113445675"
variation 28
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:638050"
variation 33
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:190969435"
variation 45
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:376198987"
variation 64
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:182628860"
variation 123
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:187780713"
misc_feature 198..200
/gene="PPP1R15A"
/gene_synonym="GADD34"
/note="upstream in-frame stop codon"
variation 250
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:370247809"
variation 252
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:626974"
exon 261..1934
/gene="PPP1R15A"
/gene_synonym="GADD34"
/inference="alignment:Splign:1.39.8"
variation 268
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="t"
/db_xref="dbSNP:373036822"
CDS 270..2294
/gene="PPP1R15A"
/gene_synonym="GADD34"
/note="growth arrest and DNA-damage-inducible 34; growth
arrest and DNA damage-inducible protein GADD34; myeloid
differentiation primary response protein MyD116 homolog;
protein phosphatase 1, regulatory (inhibitor) subunit 15A"
/codon_start=1
/product="protein phosphatase 1 regulatory subunit 15A"
/protein_id="NP_055145.3"
/db_xref="GI:157674363"
/db_xref="CCDS:CCDS12738.1"
/db_xref="GeneID:23645"
/db_xref="HGNC:14375"
/db_xref="MIM:611048"
/translation="
MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG
"
misc_feature 270..809
/gene="PPP1R15A"
/gene_synonym="GADD34"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75807.1);
Region: Required for localization in the endoplasmic
reticulum"
misc_feature 1278..1799
/gene="PPP1R15A"
/gene_synonym="GADD34"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75807.1);
Region: 4 X 34 AA approximate repeats"
misc_feature 1278..1799
/gene="PPP1R15A"
/gene_synonym="GADD34"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75807.1);
Region: Interaction with SMAD7"
misc_feature 1716..1934
/gene="PPP1R15A"
/gene_synonym="GADD34"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75807.1);
Region: Interaction with MLL"
misc_feature 1875..2018
/gene="PPP1R15A"
/gene_synonym="GADD34"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O75807.1);
Region: Interaction with SMARCB1"
misc_feature <1923..2093
/gene="PPP1R15A"
/gene_synonym="GADD34"
/note="Phosphatase-1 catalytic subunit binding region;
Region: PP1c_bdg; pfam10488"
/db_xref="CDD:151049"
misc_feature 270..2294
/gene="PPP1R15A"
/gene_synonym="GADD34"
/product="protein phosphatase 1, regulatory subunit 15A
variant"
variation 305
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:149778673"
variation 321
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:369896585"
variation 361
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:564196"
variation 363
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:3786734"
variation 382
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:143549142"
variation 390
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:374067843"
variation 427
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:201905583"
variation 454
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:148034650"
variation 460
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:369203609"
variation 462
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:45533432"
variation 498
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="t"
/db_xref="dbSNP:146194308"
variation 572
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:201458751"
variation 613
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:73942337"
variation 631
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:200986283"
variation 654
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:374482307"
variation 656
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:142686151"
variation 676
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:150728200"
variation 680
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:368648855"
variation 684
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:137978264"
variation 685
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:371798766"
variation 690
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:149496861"
variation 744
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:144761982"
variation 747
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:139708522"
variation 759
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:144473195"
variation 771
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:199891815"
variation 778
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="t"
/db_xref="dbSNP:367785147"
variation 798
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:372017913"
variation 818
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:371690928"
variation 821
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:77377218"
variation 836
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:375361440"
variation 837
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:184379585"
variation 839
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:144588770"
variation 840
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:199990581"
variation 865
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:611251"
variation 868
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:148069203"
variation 899
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:34899467"
variation 908
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:150011740"
variation 965
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:202101320"
variation 991
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:114477690"
variation 1010
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:141730546"
variation 1020
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:201262597"
variation 1021
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:557806"
variation 1034
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:377143682"
variation 1040
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:373338552"
variation 1052
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:138912909"
variation 1057
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:148913925"
variation 1060
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:143444771"
variation 1070
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:147982816"
variation 1073
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:200339215"
variation 1094
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:187493181"
variation 1097
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:201073468"
variation 1098
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:610308"
variation 1122
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:374662559"
variation 1133
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:113525688"
variation 1163
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:377303017"
variation 1166
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:138608463"
variation 1174
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:369701184"
variation 1197
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:11541191"
variation 1202
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:147205273"
variation 1203
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:11541192"
variation 1204
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:376576127"
variation 1215
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:556052"
variation 1251
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:201957583"
variation 1252..1254
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace=""
/replace="gtc"
/db_xref="dbSNP:371526108"
variation 1271
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:149431519"
variation 1275
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:373762322"
variation 1294
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:375792716"
variation 1298
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:144656026"
variation 1411
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:1050166"
variation 1441
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:142855954"
variation 1456
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:201542761"
variation 1490
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:371012590"
variation 1500
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:368379467"
variation 1525
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:372040847"
variation 1528
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:147687948"
variation 1532
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:373166701"
variation 1560
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:140853052"
variation 1568
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:192997367"
variation 1572
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:144400267"
variation 1584
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:199960462"
variation 1589
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:140767023"
variation 1593
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:75202631"
variation 1649
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:368067897"
variation 1652
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:35023389"
variation 1664
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:200581070"
variation 1668
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:144876462"
variation 1688
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:184810900"
variation 1697
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35087747"
variation 1712
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:372192564"
variation 1723
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:200976816"
variation 1731
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:80213386"
variation 1757
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:201162503"
variation 1770
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:369038624"
variation 1784
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:371401814"
variation 1792
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:111401415"
variation 1804
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:201432621"
variation 1810
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:200237494"
variation 1825
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:144621980"
variation 1851
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:199543396"
variation 1857
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="c"
/db_xref="dbSNP:112209279"
variation 1860
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:374652703"
variation 1862
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:138580661"
variation 1868
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:202096859"
variation 1870
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:114326964"
variation 1874
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:34457521"
variation 1896
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:138968424"
variation 1903
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:116429715"
variation 1904
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:376245715"
exon 1935..2383
/gene="PPP1R15A"
/gene_synonym="GADD34"
/inference="alignment:Splign:1.39.8"
variation 1939
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:77919834"
variation 1947
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:368302218"
variation 1947
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace=""
/replace="g"
/db_xref="dbSNP:71819374"
variation 1975
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="g"
/replace="t"
/db_xref="dbSNP:199878289"
variation 1987
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:371089180"
variation 2002
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:200500833"
variation 2010
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:139425008"
variation 2040
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:374535887"
variation 2049
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:2270946"
variation 2052
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:147256383"
variation 2053
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:201012471"
variation 2058
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:500079"
variation 2062
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:144725427"
variation 2072
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:372233957"
variation 2084
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:147814056"
variation 2119
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:142378074"
variation 2121
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:148460066"
variation 2122
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:146849578"
STS 2176..2302
/gene="PPP1R15A"
/gene_synonym="GADD34"
/standard_name="RH71420"
/db_xref="UniSTS:33075"
variation 2188
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:373351648"
STS 2190..2314
/gene="PPP1R15A"
/gene_synonym="GADD34"
/standard_name="STS-R32980"
/db_xref="UniSTS:62928"
variation 2209
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:202191597"
variation 2220
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:370969118"
variation 2231
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:524"
variation 2241
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:35007147"
variation 2246
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="g"
/db_xref="dbSNP:527"
variation 2261
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="a"
/replace="g"
/db_xref="dbSNP:186438232"
variation 2266
/gene="PPP1R15A"
/gene_synonym="GADD34"
/replace="c"
/replace="t"
/db_xref="dbSNP:146665963"
ORIGIN
ataaaagcctagtggccattgtgttcgttgctcttatcggttcccatcccagttgttgatcttatgcaagacgctgcacgaccccgcgcccgcttgtcgccacggcacttgaggcagccggagatactctgagttactcggagcccgacgcctgagggtgagatgaacgcgctggcctccctaaccgtccggacctgtgatcgcttctggcagaccgaaccggcgctcctgcccccggggtgacgcgcagctcccagccgcccagacacatggccccaggccaagcaccccatcaggctaccccgtggagggatgcccaccctttcttcctcctgtccccagtgatgggcctcctcagccgcgcctggagccgcctgaggggcctgggacctctagagccctggctggtggaagcagtaaaaggagcagctctggtagaagctggcctggagggagaagctaggactcctctggcaatcccccataccccttggggcagacgccctgaagaggaggctgaagacagtggaggccctggagaggacagagaaacactggggctgaaaaccagcagttcccttcctgaagcctggggacttttggatgatgatgatggcatgtatggtgagcgagaggcaaccagtgtccctagagggcagggaagtcaatttgcagatggccagcgtgctcccctgtctcccagccttctgataaggacactgcaaggttctgataagaacccaggggaggagaaagccgaggaagagggagttgctgaagaggagggagttaacaagttctcttatccaccatcacaccgggagtgttgtccagccgtggaggaggaggacgatgaagaagctgtaaagaaagaagctcacagaacctctacttctgccttgtctccaggatccaagcccagcacttgggtgtcttgcccaggggaggaagagaatcaagccacggaggataaaagaacagaaagaagtaaaggagccaggaagacctccgtgtccccccgatcttcaggctccgaccccaggtcctgggagtatcgttcaggagaggcgtccgaggagaaggaggaaaaggcacacaaagaaactgggaaaggagaagctgccccagggccgcaatcctcagccccagcccagaggccccagctcaagtcctggtggtgccaacccagtgatgaagaggagggtgaggtcaaggctttgggggcagctgagaaggatggagaagctgagtgtcctccctgcatccccccaccaagtgccttcctgaaggcctgggtgtattggccaggagaggacacagaggaagaggaagatgaggaagaagatgaggacagtgactctggatcagatgaggaagagggagaagctgaggcttcctcttccactcctgctacaggtgtcttcttgaagtcctgggtctatcagccaggagaggacacagaggaggaggaagatgaggacagtgatacaggatcagccgaggatgaaagagaagctgagacttctgcttccacaccccctgcaagtgctttcttgaaggcctgggtgtatcggccaggagaggacacggaggaggaggaagatgaggatgtggatagtgaggataaggaagatgattcagaagcagccttgggagaagctgagtcagacccacatccctcccacccggaccagagggcccacttcaggggctggggatatcgacctggaaaagagacagaggaagaggaagctgctgaggactggggagaagctgagccctgccccttccgagtggccatctatgtacctggagagaagccaccgcctccctgggctcctcctaggctgcccctccgactgcaaaggcggctcaagcgcccagaaacccctactcatgatccggaccctgagactcccctaaaggccagaaaggtgcgcttctccgagaaggtcactgtccatttcctggctgtctgggcagggccggcccaggccgcccgccagggcccctgggagcagcttgctcgggatcgcagccgcttcgcacgccgcatcacccaggcccaggaggagctgagcccctgcctcacccctgctgcccgggccagagcctgggcacgcctcaggaacccacctttagcccccatccctgccctcacccagaccttgccttcctcctctgtcccttcgtccccagtccagaccacgcccttgagccaagctgtggccacaccttcccgctcgtctgctgctgcagcggctgccctggacctcagtgggaggcgtggctgagaccaactggtttgcctataatttattaactatttattttttctaagtgtgggtttatataaggaataaagccttttgatttgtagcgaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23645 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23645 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
GeneID:23645 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:23645 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:23645 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: TAS
GeneID:23645 -> Biological process: GO:0007050 [cell cycle arrest] evidence: TAS
GeneID:23645 -> Biological process: GO:0007179 [transforming growth factor beta receptor signaling pathway] evidence: TAS
GeneID:23645 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: TAS
GeneID:23645 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: IEA
GeneID:23645 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:23645 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.