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2024-04-27 04:44:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014286 5009 bp mRNA linear PRI 29-JUN-2013
DEFINITION Homo sapiens neuronal calcium sensor 1 (NCS1), transcript variant
1, mRNA.
ACCESSION NM_014286
VERSION NM_014286.3 GI:192447421
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5009)
AUTHORS Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M. and Green,R.C.
CONSRTM The GENAROADS Consortium, and The Alzheimer's Disease Neuroimaging
Initiative
TITLE Genome-wide association study of the rate of cognitive decline in
Alzheimer's disease
JOURNAL Alzheimers Dement (2013) In press
PUBMED 23535033
REMARK Publication Status: Available-Online prior to print
REFERENCE 2 (bases 1 to 5009)
AUTHORS Multani,P.K., Clarke,T.K., Narasimhan,S., Ambrose-Lanci,L.,
Kampman,K.M., Pettinati,H.M., Oslin,D.W., O'Brien,C.P.,
Berrettini,W.H. and Lohoff,F.W.
TITLE Neuronal calcium sensor-1 and cocaine addiction: a genetic
association study in African-Americans and European Americans
JOURNAL Neurosci. Lett. 531 (1), 46-51 (2012)
PUBMED 22999924
REMARK GeneRIF: data suggest that genetic variants in the NCS-1 gene
contribute to susceptibility of Cocaine Abuse in individuals of
African descent.
REFERENCE 3 (bases 1 to 5009)
AUTHORS Heidarsson,P.O., Bjerrum-Bohr,I.J., Jensen,G.A., Pongs,O.,
Finn,B.E., Poulsen,F.M. and Kragelund,B.B.
TITLE The C-terminal tail of human neuronal calcium sensor 1 regulates
the conformational stability of the Ca(2)(+)(-) activated state
JOURNAL J. Mol. Biol. 417 (1-2), 51-64 (2012)
PUBMED 22227393
REMARK GeneRIF: the C-terminal tail is important for regulating the
conformational stability of NCS1 in Ca(2+)-activated state
REFERENCE 4 (bases 1 to 5009)
AUTHORS Woll,M.P., De Cotiis,D.A., Bewley,M.C., Tacelosky,D.M., Levenson,R.
and Flanagan,J.M.
TITLE Interaction between the D2 dopamine receptor and neuronal calcium
sensor-1 analyzed by fluorescence anisotropy
JOURNAL Biochemistry 50 (41), 8780-8791 (2011)
PUBMED 21875085
REMARK GeneRIF: analysis of the interaction between the D2 dopamine
receptor and neuronal calcium sensor-1
REFERENCE 5 (bases 1 to 5009)
AUTHORS Benbow,J.H., DeGray,B. and Ehrlich,B.E.
TITLE Protection of neuronal calcium sensor 1 protein in cells treated
with paclitaxel
JOURNAL J. Biol. Chem. 286 (40), 34575-34582 (2011)
PUBMED 21808066
REMARK GeneRIF: it is possible to protect cells from paclitaxel-induced
degradation of NCS-1 by inhibiting calpain activity
REFERENCE 6 (bases 1 to 5009)
AUTHORS Chen,C., Yu,L., Zhang,P., Jiang,J., Zhang,Y., Chen,X., Wu,Q., Wu,Q.
and Zhao,S.
TITLE Human neuronal calcium sensor-1 shows the highest expression level
in cerebral cortex
JOURNAL Neurosci. Lett. 319 (2), 67-70 (2002)
PUBMED 11825672
REFERENCE 7 (bases 1 to 5009)
AUTHORS Zhao,X., Varnai,P., Tuymetova,G., Balla,A., Toth,Z.E.,
Oker-Blom,C., Roder,J., Jeromin,A. and Balla,T.
TITLE Interaction of neuronal calcium sensor-1 (NCS-1) with
phosphatidylinositol 4-kinase beta stimulates lipid kinase activity
and affects membrane trafficking in COS-7 cells
JOURNAL J. Biol. Chem. 276 (43), 40183-40189 (2001)
PUBMED 11526106
REFERENCE 8 (bases 1 to 5009)
AUTHORS Nakamura,T.Y., Pountney,D.J., Ozaita,A., Nandi,S., Ueda,S., Rudy,B.
and Coetzee,W.A.
TITLE A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4
K+-currents
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (22), 12808-12813 (2001)
PUBMED 11606724
REFERENCE 9 (bases 1 to 5009)
AUTHORS Bourne,Y., Dannenberg,J., Pollmann,V., Marchot,P. and Pongs,O.
TITLE Immunocytochemical localization and crystal structure of human
frequenin (neuronal calcium sensor 1)
JOURNAL J. Biol. Chem. 276 (15), 11949-11955 (2001)
PUBMED 11092894
REFERENCE 10 (bases 1 to 5009)
AUTHORS Burgoyne,R.D. and Weiss,J.L.
TITLE The neuronal calcium sensor family of Ca2+-binding proteins
JOURNAL Biochem. J. 353 (PT 1), 1-12 (2001)
PUBMED 11115393
REMARK Review article
Erratum:[Biochem J 2001 Mar 15;354(Pt 3):727]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC004856.2, AF134479.1,
AL161981.1, BM011362.1, BU150740.1, AI564128.1, AI521726.1,
CF453730.1, AI768193.1 and CK301145.1.
On Jun 24, 2008 this sequence version replaced gi:17738307.
Summary: This gene is a member of the neuronal calcium sensor gene
family, which encode calcium-binding proteins expressed
predominantly in neurons. The protein encoded by this gene
regulates G protein-coupled receptor phosphorylation in a
calcium-dependent manner and can substitute for calmodulin. The
protein is associated with secretory granules and modulates
synaptic transmission and synaptic plasticity. Multiple transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC004856.2, AF134479.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-601 BC004856.2 1-601
602-1100 AF134479.1 583-1081
1101-1864 AL161981.1 394-1157
1865-3182 AF134479.1 1846-3163
3183-3609 BM011362.1 300-726
3610-3964 BU150740.1 300-654
3965-4251 AI564128.1 62-348 c
4252-4314 AI521726.1 4-66 c
4315-4817 CF453730.1 275-777
4818-4975 AI768193.1 12-169 c
4976-5009 CK301145.1 1-34 c
FEATURES Location/Qualifiers
source 1..5009
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..5009
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="neuronal calcium sensor 1"
/db_xref="GeneID:23413"
/db_xref="HGNC:3953"
/db_xref="HPRD:04500"
/db_xref="MIM:603315"
exon 1..150
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 15
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:112062984"
variation 49
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:371927482"
CDS 87..659
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="isoform 1 is encoded by transcript variant 1;
frequenin-like ubiquitous protein; frequenin-like protein;
frequenin homolog"
/codon_start=1
/product="neuronal calcium sensor 1 isoform 1"
/protein_id="NP_055101.2"
/db_xref="GI:17738308"
/db_xref="CCDS:CCDS6932.1"
/db_xref="GeneID:23413"
/db_xref="HGNC:3953"
/db_xref="HPRD:04500"
/db_xref="MIM:603315"
/translation="
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
"
misc_feature 90..92
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/experiment="experimental evidence, no additional details
recorded"
/note="myristoylation site"
misc_feature 144..623
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="Ca2+-binding protein (EF-Hand superfamily) [Signal
transduction mechanisms / Cytoskeleton / Cell division and
chromosome partitioning / General function prediction
only]; Region: FRQ1; COG5126"
/db_xref="CDD:227455"
misc_feature 279..461
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:238008"
misc_feature order(303..305,309..311,315..317,336..338,411..413,
417..419,423..425,444..446)
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:238008"
misc_feature 384..602
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:238008"
misc_feature order(411..413,417..419,423..425,444..446,555..557,
561..563,567..569,588..590)
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:238008"
misc_feature 606..656
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P62166.2);
Region: Interaction with IL1RAPL1"
variation 95
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:143247085"
exon 151..175
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
exon 176..314
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 188
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:369569947"
variation 221
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:143750486"
variation 257
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:190718593"
variation 260
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:148178859"
variation 272
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:372862177"
variation 297
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:377343889"
exon 315..393
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 317
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:142005773"
variation 322
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:200938140"
variation 336
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:376137684"
variation 350
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:150683155"
variation 356
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:11552457"
variation 391
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:370911031"
exon 394..482
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 431
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:141503212"
variation 442
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:146218396"
exon 483..560
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 540
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="t"
/db_xref="dbSNP:4524901"
exon 561..676
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 566
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:369600917"
variation 588..589
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="a"
/db_xref="dbSNP:11440892"
variation 591
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552456"
variation 602
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:2277200"
variation 656
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:373209505"
exon 677..4991
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/inference="alignment:Splign:1.39.8"
variation 732
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:370470403"
variation 774
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552455"
variation 778
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:189284841"
variation 794
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:11552458"
variation 815
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552454"
variation 851
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:181988596"
variation 881
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:144514863"
variation 889
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:372344853"
variation 960
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:41279184"
variation 1021
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:3088039"
variation 1022
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="a"
/db_xref="dbSNP:141172664"
variation 1030
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:185182501"
variation 1112
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:115131879"
variation 1118
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:190972633"
variation 1132
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:182692714"
variation 1152
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:186544417"
variation 1153
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:368867488"
variation 1176
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:1054879"
variation 1190
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:377351642"
variation 1254..1255
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:200691020"
variation 1257..1258
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:377232982"
variation 1262..1263
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:375941933"
variation 1262
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:191357888"
polyA_site 1269
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
variation 1284
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:370318457"
variation 1298..1299
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="g"
/db_xref="dbSNP:201900282"
variation 1300..1301
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:34319101"
variation 1301..1302
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:11482915"
polyA_site 1340
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
variation 1346
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:183505584"
variation 1392
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:373759435"
variation 1401
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:118092895"
variation 1419
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:8181096"
variation 1484
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="t"
/db_xref="dbSNP:73670524"
variation 1548
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:192350115"
variation 1593
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:73545592"
variation 1597
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="t"
/db_xref="dbSNP:140307449"
variation 1621
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:373779620"
variation 1658
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:56033557"
variation 1668
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:13296233"
variation 1710
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:36073320"
variation 1727
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:116200382"
variation 1745
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:41280142"
variation 1805
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:7033065"
variation 1831
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:183177403"
variation 1865
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:34954279"
variation 1960
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:374154868"
variation 1972
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:187859521"
variation 2000
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:192706555"
variation 2042
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:116694639"
variation 2055
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:6478954"
variation 2076
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:7846906"
variation 2095
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:145263859"
variation 2105
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:112487332"
variation 2161
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:184507086"
variation 2170
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:149159807"
variation 2209
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:145020936"
variation 2220
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:189688335"
STS 2245..2358
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/standard_name="2006"
/db_xref="UniSTS:78302"
variation 2283
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:13300858"
variation 2354
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:41316508"
variation 2439
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:369985853"
variation 2445
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:74914651"
variation 2454
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="t"
/db_xref="dbSNP:140742377"
variation 2474
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:192712220"
variation 2494
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:145896702"
variation 2543
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:114418161"
variation 2545
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:117265449"
variation 2667
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:112803517"
variation 2679
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552450"
variation 2752
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="c"
/db_xref="dbSNP:35657891"
variation 2784
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:184428199"
variation 2791
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:79944590"
variation 2807..2808
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="c"
/db_xref="dbSNP:5900889"
variation 2815
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:10988649"
variation 2877
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:79156389"
variation 2974
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:372893934"
variation 3003
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:371937919"
variation 3034
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:79697564"
variation 3092
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:138455912"
variation 3127
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:189134100"
variation 3132
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:377618746"
variation 3183
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:13710"
variation 3233
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:11552452"
variation 3281
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:115545523"
variation 3329
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:114502717"
variation 3346
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:12377152"
variation 3470
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:377713517"
variation 3527
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:181712022"
variation 3548
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043368"
variation 3557
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:141952514"
variation 3574
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:186370226"
variation 3607
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988650"
variation 3620
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:190581729"
variation 3627
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:150659490"
variation 3628
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552453"
variation 3731
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:113812485"
variation 3754
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:28678653"
variation 3767
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:709611"
variation 3846..3847
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:71805474"
variation 3870
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:180862513"
variation 3934
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:112065411"
STS 3962..4116
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/standard_name="RH93523"
/db_xref="UniSTS:85258"
variation 3965
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:11552451"
variation 4009
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:140302160"
variation 4028
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:186003263"
variation 4063
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:76680931"
variation 4088
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:41281144"
variation 4101
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:368270639"
STS 4195..4308
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/standard_name="A001U14"
/db_xref="UniSTS:22548"
variation 4234
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:113006781"
variation 4235..4236
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/db_xref="dbSNP:11432743"
variation 4244..4245
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/replace="tt"
/db_xref="dbSNP:66906315"
variation 4252..4253
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="t"
/replace="tt"
/db_xref="dbSNP:66505642"
polyA_signal 4291..4296
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
polyA_site 4314
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
variation 4450
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:201757038"
variation 4489
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="g"
/replace="t"
/db_xref="dbSNP:35224766"
variation 4590
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:7847694"
variation 4591
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:191248234"
variation 4631
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:73545596"
variation 4697
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:73545599"
variation 4698
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:181242413"
variation 4754..4755
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace=""
/replace="caaa"
/db_xref="dbSNP:367634079"
variation 4776
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="g"
/db_xref="dbSNP:185596487"
variation 4807
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="a"
/replace="c"
/db_xref="dbSNP:147435932"
variation 4866
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="g"
/db_xref="dbSNP:1055663"
variation 4956
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:148474902"
polyA_signal 4961..4966
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
variation 4969
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
/replace="c"
/replace="t"
/db_xref="dbSNP:190403603"
polyA_site 4991
/gene="NCS1"
/gene_synonym="FLUP; FREQ"
ORIGIN
ccggcccggcccgcccggcccagccgctcctgctgggcgccccaaccgggtccggcccgggggggcgggggccgcggccgccgaggatggggaaatccaacagcaagttgaagcccgaagttgtggaggagctgaccaggaagacctactttaccgagaaggaggtccagcagtggtacaaaggcttcatcaaggactgccccagtgggcagctggatgcggcaggcttccagaagatctacaagcaattcttcccgttcggagaccccaccaagtttgccacatttgttttcaacgtctttgatgaaaacaaggacgggcgaattgagttctccgagttcatccaggcgctgtcggtgacctcacggggaaccctggatgagaagctacggtgggccttcaagctctacgacttggacaatgatggctacatcaccaggaatgagatgctggacattgtggatgccatttaccagatggtggggaataccgtggagctcccagaggaggagaacactcctgagaagagggtggaccggatctttgccatgatggataagaatgccgacgggaagctgaccctgcaggagttccaggagggttccaaggcagacccgtccattgtgcaggcgctgtccctctacgacgggctggtatagtcccaggctggagctggatgcctgggaaccactcacctccttctgtgccatgaggccacctcagccctgacaccaaccccgtgcgtccacccagccttcttccgcatccacacacagccggctgcccttgacccgggaggccccggctctcctctcccctgtcctgcacccatcccccgcctgaagccaccggctccaattgccagcaacctctgcttgtccggaaaacgacaacacgaaatggaaaaggctacagccctctgcataaaccaaggacttggctgcctcgcaggcagcctccgttcctcccgctctcttgcgcgtgtgcttttgttttttattttgaacagacgttttaaaagaaaaaaaaacaactaccttctgtcctagaagacacagactgacagatggggtgaaggcctggggacctcagagaactctgccttgccctcgtccctcgtccttcggcagccggagaggctgtgggtgggccgagggtgtctaggggttctgcctggtcaacgttatttgtcgtcccatcttttggcagcaaaaccacctgcgtggctaggatgattaattatgaggatgatgattttttttgtgataacagtattgtgctttttgtggggaaagtgaggtttttttttatatacatatataattgatatctttaatttattggttgttaactgttgctgctgcctggtgtgtcctcagctcccagggctgcgggcccaccgtttacatgtgcacgccctgacccacctgcccacgccgacttgggaggatggtggcctgcagcggccaagaagccaaaaaaaattttttttttttcagatactgtgcttgatttttggagaggggagaggtggaaattcctaaatggctaatgcactgttccctccagcccgaatgcctcctgccaaaccccttttccctgctgcctctgtccccgcatccttgttctcccctgggtccgtaacattttttccgaggatgaacaggggacatctttaggtttctcaactcttgctttggtgtttgccgcagcatggaaaacagggcgcctaaggctgggagctggaagaaggggcattgggtacccaggcagagtcaggagaggtggtctttgaagtaagttagcagaaatcaaggggacccccgcctccttgggctggggaggggatttcaagatagttcatgactctctcccgctctgccttccctccttcctatctgctttttccagtaaactgcatggtgtccttccctggccttctcttggctcaaaggctgggagggagggaaggagagaagagttccaggcaatcccatcaatatagtccctacacctggggctgcggcccacatgtcttcacggaggcttccagcggtgcctgccactgaggcaggtgcggccccaggaccatcaccaggaatgcgaggccaccctggaccagaggtaggagcccaaggtccggcccttgctctttgattgtgggcagcctcctgccctctctgggtctcagttgccccatctgcagagcgaggaggcccgggctggttggtcttgaaggcccttttccatgccgacatcatgtcactctaggcctggggttcagtttcctgtggctggtgatgctgtggttaagtttgcttgaccccagcagcccgagggactgtctgagtcacagcacagcccctattgcgtggctgctggtgtgtggggtcagttccagcagatgaatgtgtcatgtggcacaccttgtcccttcccgcagcatttcctggttccccccagacccttgagcgctctttgggacccagaaggagtccttgcacagggaaggcttgaggtgagaagccgcttcccagactgtcagggccaggcctgggtctagaattcttgctgctgctttgcagagtcaacagcccatcagcccatgttttagaggggacactttggtcctcggttcccaccctcagcaagcaggcctccagcccgaggaaggcctctgccgtagtgacgttgccgtgtggggctgcgtggctgttccccttggctggagcattcagccaaccccagcgtcccccctgaggcgttcattggcagccccctaggactgcacgctggccccacggtaaccccccctcccccaccaacatcctgcagggatggggtcagtggttccaccttcacaggccactttgaagggtggattctttgaggcccctgccagtcggctccctgctcagctgctggcccgggcgacctgggactcagcaccaacggctgaagtttctcagctgggctctgacctggggtctggggcagggaacgaacatggtggctttgggctgagaggatgagggaggtctttcccaggtcaaattactttcctttggcctctgcctgaggctcgatttgcctctctggtccaatgggactgacactgttgtacaacctgacctgtggctgagggtgtctgggcttaagcatgtggaccccttcggtgtgtccggccttcctccatcgtcctgccctttggccttttggtttgaagccacaggtgtggcttctggccttagcagatggtatgcttgcggaccgcagcccagcatgccggtgggcccacagcccgagccagcccagagctgccggaagggccgcccttcccggccctggcggggtgctggacactggccattttcactagagtttgcctggcagggaccgatctctgccccctcctctccccaggcctctggctgcagtgatgccgcagaatcctgagccaggtgcctcctgagcagcccgtgcgcctctccacagcggcgtttgccacccaatgcggctcgcttcagatgctctgatgcagagggcacgcccatagtccctctgcagagcctcgcactggggccagggcaggcaccagccccaggcggccagtcggccacggcctgtcctcttcctcgtagcgtctgctcctcactttgtgttgatggtgacttaggagaatgttccgattttccatgatctaagcaggccacgtttaaaataacatcaaggcaagcgtacgtgtcaccctctgtactgacatctcttcccctgaaatgcttttcagtttgacagcccgtttcctagacaagtgcacctggggtttcaggaactttgtgttttttcggagggggttggtggggaggtcgggatgcctgggatcccttcctggagaggcaggctgtctctggaaaaagcctccattgcccacccgccaggcggaaagtcaccctgttcccagcgcggtttcagcatttaattttaagggagctaaggaagcgcggcgcgccccctggtggtggtaagccgccaacgcacctgggggctgcaaccccaccggacgggtggtccggagggaggctggagcggggaggcgaggagggggctgtgagtcctcagaggccctgggccaccacatttctggcagcgtttcccagacacccctctgctaggccatccctggatagcaagtgaattaacttaagggcactgtgatgggaagccttgcccccctcttttttttttttttttaatatctgcggaataaacccaatggttaatttttgaatgaataaaaggcttttgttgaataaacagctggtcccatcttctgtcttggcatcttagcatccaggctcaggctctgccccttctccaggatggggtagccccgagtcgccctccccagtctgcacattccctgttgtccctgttcctgcagtggctcccggccccagggaggcccacctcactcccagcctgactcggtggctggcttccttcaggactttgcgcaagtcagttctgctcattgggtctcaatttccccatcccttggatgggagcaagagtctctgctgggcctgcctcgcaggggcctggtgagacccaaatgtgagtgtcatcatcaaagcccctcacagaagtggaggacggtgcccaagagtagcggtttggactgctgctgcctcccacccggagcctgccacttgggggagaaattggtataatgcttgcaaaaacaaacaaacaaaaggcaatgtcttctggttgtggttatttcctttcctgcttgcctccccagccccctttgagtctctttttggggtgccgtcctgtctgaacctgccggtgtgtgtctctggggccagggtcagggcgaggcccaggggtggacaggggccgtgtagcatgccccagcctccccaagctcctgctgtatgtcgtccatgtcacgccaattaaacacgcttcctggacttgtcctcgccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23413 -> Molecular function: GO:0005245 [voltage-gated calcium channel activity] evidence: ISS
GeneID:23413 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
GeneID:23413 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23413 -> Biological process: GO:0010975 [regulation of neuron projection development] evidence: ISS
GeneID:23413 -> Biological process: GO:0045921 [positive regulation of exocytosis] evidence: IEA
GeneID:23413 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: IEA
GeneID:23413 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:23413 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:23413 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:23413 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IEA
GeneID:23413 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
GeneID:23413 -> Cellular component: GO:0030424 [axon] evidence: IEA
GeneID:23413 -> Cellular component: GO:0030425 [dendrite] evidence: IEA
GeneID:23413 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IEA
GeneID:23413 -> Cellular component: GO:0032580 [Golgi cisterna membrane] evidence: IEA
GeneID:23413 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
GeneID:23413 -> Cellular component: GO:0045211 [postsynaptic membrane] evidence: IEA
GeneID:23413 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
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