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2024-04-20 08:43:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014253 12886 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens teneurin transmembrane protein 1 (TENM1), transcript
variant 3, mRNA.
ACCESSION NM_014253
VERSION NM_014253.3 GI:253970447
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 12886)
AUTHORS Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
Vierkant,R.A. and Poland,G.A.
TITLE Genome-wide analysis of polymorphisms associated with cytokine
responses in smallpox vaccine recipients
JOURNAL Hum. Genet. 131 (9), 1403-1421 (2012)
PUBMED 22610502
REFERENCE 2 (bases 1 to 12886)
AUTHORS Mejstrikova,E., Janda,A., Hrusak,O., Buckova,H., Vlckova,M.,
Hancarova,M., Freiberger,T., Ravcukova,B., Vesely,K., Fajkusova,L.,
Kopeckova,L., Sumerauer,D., Kabickova,E., Sediva,A., Stary,J. and
Sedlacek,Z.
TITLE Skin lesions in a boy with X-linked lymphoproliferative disorder:
comparison of 5 SH2D1A deletion cases
JOURNAL Pediatrics 129 (2), E523-E528 (2012)
PUBMED 22271700
REMARK GeneRIF: Subsequent analysis showed that the deletion in both
cousins was identical and involved the whole SH2D1A gene and a part
of the adjacent ODZ1 gene.
REFERENCE 3 (bases 1 to 12886)
AUTHORS Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
de Wit,H. and Palmer,A.A.
TITLE Genome-wide association study of d-amphetamine response in healthy
volunteers identifies putative associations, including cadherin 13
(CDH13)
JOURNAL PLoS ONE 7 (8), E42646 (2012)
PUBMED 22952603
REFERENCE 4 (bases 1 to 12886)
AUTHORS Beckmann,J., Vitobello,A., Ferralli,J., Broz,D.K., Rijli,F.M. and
Chiquet-Ehrismann,R.
TITLE Human teneurin-1 is a direct target of the homeobox transcription
factor EMX2 at a novel alternate promoter
JOURNAL BMC Dev. Biol. 11, 35 (2011)
PUBMED 21651764
REMARK GeneRIF: Data show that human teneurin-1 is directly regulated by
EMX2 at a conserved promoter region upstream of the transcription
start site, and identify and characterize the EMX2 dependent
promoter element of human teneurin-1.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 12886)
AUTHORS Nunes,S.M., Ferralli,J., Choi,K., Brown-Luedi,M., Minet,A.D. and
Chiquet-Ehrismann,R.
TITLE The intracellular domain of teneurin-1 interacts with MBD1 and
CAP/ponsin resulting in subcellular codistribution and
translocation to the nuclear matrix
JOURNAL Exp. Cell Res. 305 (1), 122-132 (2005)
PUBMED 15777793
REMARK GeneRIF: teneurin-1 plays a role in intracellular signaling
REFERENCE 6 (bases 1 to 12886)
AUTHORS Feng,K., Zhou,X.H., Oohashi,T., Morgelin,M., Lustig,A.,
Hirakawa,S., Ninomiya,Y., Engel,J., Rauch,U. and Fassler,R.
TITLE All four members of the Ten-m/Odz family of transmembrane proteins
form dimers
JOURNAL J. Biol. Chem. 277 (29), 26128-26135 (2002)
PUBMED 12000766
REFERENCE 7 (bases 1 to 12886)
AUTHORS Brandau,O., Schuster,V., Weiss,M., Hellebrand,H., Fink,F.M.,
Kreczy,A., Friedrich,W., Strahm,B., Niemeyer,C., Belohradsky,B.H.
and Meindl,A.
TITLE Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are
mutated in the SH2D1A gene, as are patients with X-linked
lymphoproliferative disease (XLP)
JOURNAL Hum. Mol. Genet. 8 (13), 2407-2413 (1999)
PUBMED 10556288
REFERENCE 8 (bases 1 to 12886)
AUTHORS Minet,A.D., Rubin,B.P., Tucker,R.P., Baumgartner,S. and
Chiquet-Ehrismann,R.
TITLE Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene
ten-m, is a neuronal protein with a novel type of heparin-binding
domain
JOURNAL J. Cell. Sci. 112 (PT 12), 2019-2032 (1999)
PUBMED 10341219
REFERENCE 9 (bases 1 to 12886)
AUTHORS Ben-Zur,T. and Wides,R.
TITLE Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse
chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human
chromosome Xq25
JOURNAL Genomics 58 (1), 102-103 (1999)
PUBMED 10331952
REFERENCE 10 (bases 1 to 12886)
AUTHORS Coffey,A.J., Brooksbank,R.A., Brandau,O., Oohashi,T., Howell,G.R.,
Bye,J.M., Cahn,A.P., Durham,J., Heath,P., Wray,P., Pavitt,R.,
Wilkinson,J., Leversha,M., Huckle,E., Shaw-Smith,C.J., Dunham,A.,
Rhodes,S., Schuster,V., Porta,G., Yin,L., Serafini,P., Sylla,B.,
Zollo,M., Franco,B., Bolino,A., Seri,M., Lanyi,A., Davis,J.R.,
Webster,D., Harris,A., Lenoir,G., de St Basile,G., Jones,A.,
Behloradsky,B.H., Achatz,H., Murken,J., Fassler,R., Sumegi,J.,
Romeo,G., Vaudin,M., Ross,M.T., Meindl,A. and Bentley,D.R.
TITLE Host response to EBV infection in X-linked lymphoproliferative
disease results from mutations in an SH2-domain encoding gene
JOURNAL Nat. Genet. 20 (2), 129-135 (1998)
PUBMED 9771704
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF100772.1, BC140783.1,
AK055765.1, AL022718.1, BX478232.1, AI498402.1, CF454574.1 and
BC030766.2.
This sequence is a reference standard in the RefSeqGene project.
On Jul 15, 2009 this sequence version replaced gi:110347399.
Summary: The protein encoded by this gene belongs to the tenascin
family and teneurin subfamily. It is expressed in the neurons and
may function as a cellular signal transducer. Several alternatively
spliced transcript variants encoding different isoforms have been
found for this gene. [provided by RefSeq, Sep 2009].
Transcript Variant: This variant (3) lacks an in-frame coding exon
compared to variant 1. This results in a shorter isoform (3)
missing an internal 7 aa protein segment compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF100772.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-845 AF100772.1 1-845
846-3759 BC140783.1 843-3756
3760-5049 BC140783.1 3778-5067
5050-5785 AF100772.1 5050-5785
5786-8271 BC140783.1 5804-8289
8272-8297 AF100772.1 8272-8297
8298-9523 AK055765.1 18-1243
9524-9524 AL022718.1 71932-71932 c
9525-10768 AK055765.1 1245-2488
10769-10805 BX478232.1 524-560
10806-11529 AL022718.1 69927-70650 c
11530-11999 AI498402.1 1-470 c
12000-12634 CF454574.1 97-731
12635-12886 BC030766.2 861-1112
FEATURES Location/Qualifiers
source 1..12886
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq25"
gene 1..12886
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="teneurin transmembrane protein 1"
/db_xref="GeneID:10178"
/db_xref="HGNC:8117"
/db_xref="MIM:300588"
exon 1..281
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
misc_feature 56..58
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="upstream in-frame stop codon"
CDS 65..8242
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="isoform 3 is encoded by transcript variant 3; odz
(odd Oz/ten-m, Drosophila) homolog 3; odz, odd Oz/ten-m
homolog 1(Drosophila); teneurin-1; teneurin 1; tenascin
M1; ten-1; tenascin-M1; protein Odd Oz/ten-m homolog 1"
/codon_start=1
/product="teneurin-1 isoform 3"
/protein_id="NP_055068.2"
/db_xref="GI:110347400"
/db_xref="CCDS:CCDS14609.1"
/db_xref="GeneID:10178"
/db_xref="HGNC:8117"
/db_xref="MIM:300588"
/translation="
MEQTDCKPYQPLPKVKHEMDLAYTSSSDESEDGRKPRQSYNSRETLHEYNQELRMNYNSQSRKRKEVEKSTQEMEFCETSHTLCSGYQTDMHSVSRHGYQLEMGSDVDTETEGAASPDHALRMWIRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENGFKFSPVCCDMEAQAGSTQDVQSSPHNQFTFRPLPPPPPPPHACTCARKPPPAADSLQRRSMTTRSQPSPAAPAPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRSTFSRPAFTFNKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVEGELYANGVSKGNRGTESMDTTYSPIGGKVSDKSEKKVFQKGRAIDTGEVDIGAQVMQTIPPGLFWRFQITIHHPIYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLVKQDSKGSDDTQHSPRNLILTSLQETGFIEYMDQGPWYLAFYNDGKKMEQVFVLTTAIEIMDDCSTNCNGNGECISGHCHCFPGFLGPDCARDSCPVLCGGNGEYEKGHCVCRHGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSNHGICVKGECHCSTGWGGVNCETPLPVCQEQCSGHGTFLLDAGVCSCDPKWTGSDCSTELCTMECGSHGVCSRGICQCEEGWVGPTCEERSCHSHCTEHGQCKDGKCECSPGWEGDHCTIAHYLDAVRDGCPGLCFGNGRCTLDQNGWHCVCQVGWSGTGCNVVMEMLCGDNLDNDGDGLTDCVDPDCCQQSNCYISPLCQGSPDPLDLIQQSQTLFSQHTSRLFYDRIKFLIGKDSTHVIPPEVSFDSRRACVIRGQVVAIDGTPLVGVNVSFLHHSDYGFTISRQDGSFDLVAIGGISVILIFDRSPFLPEKRTLWLPWNQFIVVEKVTMQRVVSDPPSCDISNFISPNPIVLPSPLTSFGGSCPERGTIVPELQVVQEEIPIPSSFVRLSYLSSRTPGYKTLLRILLTHSTIPVGMIKVHLTVAVEGRLTQKWFPAAINLVYTFAWNKTDIYGQKVWGLAEALVSVGYEYETCPDFILWEQRTVVLQGFEMDASNLGGWSLNKHHILNPQSGIIHKGNGENMFISQQPPVISTIMGNGHQRSVACTNCNGPAHNNKLFAPVALASGPDGSVYVGDFNFVRRIFPSGNSVSILELSTSPAHKYYLAMDPVSESLYLSDTNTRKVYKLKSLVETKDLSKNFEVVAGTGDQCLPFDQSHCGDGGRASEASLNSPRGITVDRHGFIYFVDGTMIRKIDENAVITTVIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLAVNPMDNSLYVLDNNIVLQISENRRVRIIAGRPIHCQVPGIDHFLVSKVAIHSTLESARAISVSHSGLLFIAETDERKVNRIQQVTTNGEIYIIAGAPTDCDCKIDPNCDCFSGDGGYAKDAKMKAPSSLAVSPDGTLYVADLGNVRIRTISRNQAHLNDMNIYEIASPADQELYQFTVNGTHLHTLNLITRDYVYNFTYNSEGDLGAITSSNGNSVHIRRDAGGMPLWLVVPGGQVYWLTISSNGVLKRVSAQGYNLALMTYPGNTGLLATKSNENGWTTVYEYDPEGHLTNATFPTGEVSSFHSDLEKLTKVELDTSNRENVLMSTNLTATSTIYILKQENTQSTYRVNPDGSLRVTFASGMEIGLSSEPHILAGAVNPTLGKCNISLPGEHNANLIEWRQRKEQNKGNVSAFERRLRAHNRNLLSIDFDHITRTGKIYDDHRKFTLRILYDQTGRPILWSPVSRYNEVNITYSPSGLVTFIQRGTWNEKMEYDQSGKIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQPDCLLSVTMPSMVRHSLQTMLSVGYYRNIYTPPDSSTSFIQDYSRDGRLLQTLHLGTGRRVLYKYTKQARLSEVLYDTTQVTLTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGLVNARFDYSYNNFRVTSMQAVINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKAIAYWMTIQYDNVGRMVICDIRVGVDANITRYFYEYDADGQLQTVSVNDKTQWRYSYDLNGNINLLSHGKSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRGNDIFEYNSNGLLQKAYNKASGWTVQYYYDGLGRRVASKSSLGQHLQFFYADLTNPIRVTHLYNHTSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVIKEILYTPYGDIYHDTYPDFQVIIGFHGGLYDFLTKLVHLGQRDYDVVAGRWTTPNHHIWKQLNLLPKPFNLYSFENNYPVGKIQDVAKYTTDIRSWLELFGFQLHNVLPGFPKPELENLELTYELLRLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYNDGRCLEGGKQPRFAAVPSVFGKGIKFAIKDGIVTADIIGVANEDSRRLAAILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLVLIGNTGGRRILENGVNVTVSQMTSVLNGRTRRFADIQLQHGALCFNIRYGTTVEEEKNHVLEIARQRAVAQAWTKEQRRLQEGEEGIRAWTEGEKQQLLSTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR
"
misc_feature 131..1015
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Teneurin Intracellular Region; Region: Ten_N;
pfam06484"
/db_xref="CDD:148223"
misc_feature 248..259
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: Nuclear localization signal (NLS) (By similarity)"
misc_feature 932..955
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: Required for interaction with SORBS1 (Ten-1 ICD
form) (By similarity)"
misc_feature 1037..1099
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
transmembrane region"
misc_feature 1658..1738
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 1961..2029
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 2159..2227
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 2246..2320
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Calcium-binding EGF-like domain, present in a large
number of membrane-bound and extracellular (mostly animal)
proteins. Many of these proteins require calcium for their
biological function and calcium-binding sites have been
found to be located at the...; Region: EGF_CA; cl09941"
/db_xref="CDD:209104"
misc_feature 3644..3721
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: NHL 1"
misc_feature 3938..4072
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: NHL 2"
misc_feature 4115..4270
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: NHL 3"
misc_feature 4304..4438
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: NHL 4"
misc_feature 4505..4636
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: NHL 5"
misc_feature 4664..4723
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 1"
misc_feature 4772..4834
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 2"
misc_feature 4886..4960
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 3"
misc_feature 4961..5026
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 4"
misc_feature 5027..5089
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 5"
misc_feature 5516..>7225
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="Rhs family protein [Cell envelope biogenesis, outer
membrane]; Region: RhsA; COG3209"
/db_xref="CDD:33022"
misc_feature 5597..5719
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="YD repeat (two copies); Region: YD_repeat_2x;
TIGR01643"
/db_xref="CDD:211675"
misc_feature 5597..5656
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 6"
misc_feature 5657..5719
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 7"
misc_feature 5720..5776
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 8"
misc_feature 5777..5839
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 9"
misc_feature 5861..5911
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 10"
misc_feature 5912..5971
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 11"
misc_feature 5972..6031
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 12"
misc_feature 6038..6100
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 13"
misc_feature 6107..6169
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 14"
misc_feature 6317..6379
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 15"
misc_feature 6401..6463
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 16"
misc_feature 6521..6583
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 17"
misc_feature 6584..6646
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 18"
misc_feature 6650..6712
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 19"
misc_feature 6746..6808
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 20"
misc_feature 6812..6874
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 21"
misc_feature 6950..7003
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 22"
misc_feature 7004..7075
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UKZ4.2);
Region: YD 23"
misc_feature 7079..7315
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/note="RHS repeat-associated core domain; Region:
Rhs_assc_core; TIGR03696"
/db_xref="CDD:211864"
misc_feature 7802..7804
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9UKZ4.2); phosphorylation site"
misc_feature 7847..7852
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage (Probable); propagated from
UniProtKB/Swiss-Prot (Q9UKZ4.2); cleavage site"
variation 182
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:36065191"
exon 282..542
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
variation 391
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34981391"
exon 543..599
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 600..840
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 841..1079
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 1080..1232
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
variation 1176
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2213591"
exon 1233..1432
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 1433..1643
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 1644..1745
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 1746..1940
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 1941..2141
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2142..2327
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2328..2351
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2352..2498
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2499..2715
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2716..2835
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 2836..3097
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 3098..3365
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 3366..3509
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 3510..3759
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
STS 3513..3685
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/standard_name="stSG38425"
/db_xref="UniSTS:181784"
exon 3760..3992
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 3993..4147
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 4148..4514
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 4515..5025
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
STS 4903..5017
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/standard_name="ODZ1"
/db_xref="UniSTS:506644"
exon 5026..5198
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 5199..5434
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 5435..5731
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 5732..6119
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 6120..7340
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 7341..7483
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
exon 7484..12875
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/inference="alignment:Splign:1.39.8"
STS 7673..8319
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/standard_name="ODZ1_364"
/db_xref="UniSTS:277542"
variation 9470
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199823021"
STS 11422..11557
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/standard_name="A007A29"
/db_xref="UniSTS:56832"
variation 11433
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="g"
/replace="t"
/db_xref="dbSNP:15910"
variation 11629
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1045966"
STS 11732..11957
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
/standard_name="STS-T61382"
/db_xref="UniSTS:34097"
polyA_signal 12855..12860
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
polyA_site 12875
/gene="TENM1"
/gene_synonym="ODZ1; ODZ3; TEN-M1; TNM; TNM1"
ORIGIN
gactgcttgcattaaaggacttcctcatcctttttttcatgaaactgagcttgcttaatcagagatggagcaaactgactgcaaaccctaccagcctctaccaaaagtcaagcatgaaatggatctagcttacaccagttcttctgatgagagtgaagatggaagaaaaccaagacagtcatacaactccagggagaccctgcacgagtataaccaggagctgaggatgaattacaatagccagagtagaaagaggaaagaagtagaaaaatctactcaagagatggaattctgtgaaacctctcacactctgtgctctggctaccaaacagacatgcacagcgtttctcggcatggctaccagctagagatgggatctgatgtggacacagagacagaaggtgctgcctcacctgaccatgcactaagaatgtggataaggggaatgaaatcagagcatagttcctgtttgtccagccgggccaactctgcattatccttgactgacactgaccatgaaaggaagtctgatggggaaaatggtttcaaattctctcctgtttgttgtgacatggaggctcaagctgggtctactcaagatgtgcagagcagcccacacaaccagttcaccttcagacccctcccaccgccacctccgcctcctcatgcctgcacctgtgccaggaagccaccccctgcagcggactctcttcagaggagatcaatgactacccgcagccagcccagcccagctgctccagctcccccaaccagcacgcaggattcagtccatctgcataacagctgggtcctgaacagcaacataccattggagaccaggcatttcctgttcaaacatggatctggttcctctgcgatcttcagtgcagccagtcagaactaccctctgacatccaataccgtgtactcgccccctcccaggcctcttcctcgaagcaccttttcccgacctgcctttacctttaacaaaccttacaggtgctgcaactggaagtgcacagcattgagcgccactgcaatcacagtgactttggccttgttactagcctatgtgattgcagtgcatttgttcggcctgacttggcagttgcaaccagttgaaggagagctgtatgcaaatggagttagcaaagggaacagggggaccgagtccatggacactacttactctccaattggaggaaaagtttctgataaatcagagaaaaaagtgtttcagaagggacgggcgatagacactggagaagttgacattggtgcacaggtcatgcagaccattccacctggtttattctggcgtttccagattactatccaccatccaatatatctgaagttcaatatttctttagccaaggactctctgctgggaatttatggcagaagaaacattccacctacacatactcagtttgattttgtaaaactaatggatggcaaacagctggtcaagcaggactccaagggctctgatgatacacagcactcccctcggaacctgatcttaacttcgcttcaggagacaggtttcatagagtatatggatcaaggaccttggtatctggcgttttacaatgatggaaaaaagatggagcaagtattcgtgttaactacagcaattgaaataatggatgactgttcaaccaattgcaatggaaatggagagtgtatctctggccattgtcattgtttcccaggattccttggacctgactgtgctagagattcctgccctgtgctgtgtggtgggaatggagaatacgagaaaggacactgtgtctgccggcatggctggaaggggccagagtgtgacgttccggaagaacaatgcattgatccaacatgctttggccacggcacctgcatcatgggagtctgcatctgtgtgccaggatacaaaggagaaatatgcgaggaagaggactgcctagacccaatgtgttccaaccatggcatctgtgtaaaaggagaatgtcactgttctactggctggggaggagttaactgtgaaacaccacttcctgtatgtcaagagcagtgctcaggacacggaacttttcttctggacgctggagtatgcagctgtgatcccaagtggacaggatctgactgctcaacagagctgtgtaccatggagtgtggtagccatggagtctgctcaagaggaatttgccagtgtgaagaaggctgggtaggaccaacatgtgaggaacgctcctgtcattctcattgtactgagcatggccaatgcaaagatggaaaatgtgagtgtagccctggatgggagggcgaccactgcacaattgctcactacttagatgctgtccgagatggctgcccagggctctgctttggaaatggacgatgtaccctggatcaaaatggttggcactgtgtgtgtcaggtgggttggagtgggacaggctgcaatgttgtcatggaaatgctttgtggagataacttggacaatgatggagatggtttaaccgactgtgtggatcctgactgttgtcaacaaagcaactgttatataagtcctctctgccagggctcaccagatcctcttgacctcattcagcaaagccaaactctcttctctcagcacacttcaagacttttttatgatcgaatcaaattcctcattggcaaggacagtactcatgtcattcctcctgaggtgtcatttgacagcaggcgtgcctgtgtgattcgaggccaagtggtggccatagatggaactcctctagtgggagtgaatgtcagtttcttgcaccacagtgattatgggtttaccatcagccggcaagatggaagctttgacctcgtggccatcggtggcatctctgtcatcttaatcttcgaccgatcccctttcctgcctgagaagagaacactctggttgccttggaatcagtttattgtggtagagaaagtcaccatgcagagagttgtatcagacccgccatcctgcgatatctccaactttatcagcccaaaccctattgtgcttccttcaccgctcacatcatttggagggtcctgtccagagaggggaactattgttcctgagctgcaggttgtacaggaggaaattcccattccctccagctttgtgaggctgagttacctgagcagccgcacccctgggtataaaaccctgctacggatccttctgacacattcaacgattcctgtaggcatgataaaagtacacctcacagtagctgtggaagggcgactcacacagaagtggtttcccgccgcaattaatcttgtctacacatttgcttggaacaagaccgacatctatggacagaaggtttggggcctggcagaggctttggtatctgtgggatatgaatatgaaacgtgccctgactttattctctgggagcaaaggacagtcgttttacaaggttttgagatggatgcttctaacctaggaggctggtctttgaataagcatcacattttgaatcctcaaagtggaatcatacataaagggaatggagaaaatatgttcatttcccagcagcccccagtcatatcaaccataatgggtaatggacaccaaaggagtgtagcctgcaccaactgcaatggcccagcccacaacaacaaactctttgctcctgtcgccttagcttctggccctgatggcagtgtgtatgttggcgacttcaattttgtaaggagaatatttccctcgggaaactccgttagtattttggaattaagcacaagtcctgctcacaaatactatctggctatggaccctgtgtctgaatcactctatctatcagacaccaatactcgcaaagtctacaagttgaaatctcttgtggagacgaaagatctgtccaagaattttgaagtggtggcaggaactggtgatcagtgccttccctttgaccagagtcattgtggagatggtgggagagcatcggaagcttcactgaatagccctcgaggcatcacagttgataggcatggatttatttactttgtggatgggactatgattcgcaaaattgatgagaatgctgtgatcacaactgtaatcggctcaaatggtctgacttccacacaaccactgagctgtgactcaggaatggacatcactcaggtgcgattagagtggccaacagaccttgcagtaaatcctatggacaattcattgtatgtcttggataacaacattgtgctgcaaatttctgagaacaggcgtgttcggatcatcgcaggacgccccattcactgccaggtgccaggcatcgatcatttcctggtcagcaaggtagcaattcactccactctagagtcagcgagggccatcagtgtctcccacagcgggctgctcttcatagctgaaacagacgagaggaaagtaaaccgcattcagcaagtaaccaccaatggggagatctacatcatcgctggtgcccccactgactgtgactgcaaaattgatccaaactgtgactgtttttcaggtgatggtggctatgccaaagatgcaaagatgaaagccccttcctccttagcagtgtcgcctgatggaaccctctatgtggcagacctcggaaatgttcgaattcgtaccatcagcaggaaccaagcccacctgaatgacatgaacatttatgagattgcttcacccgctgatcaggaactgtaccagttcactgtaaatggaacccacctacacaccctgaacttgataacaagggactatgtttataacttcacctacaattctgaaggtgacttgggcgcgattaccagcagcaatggcaattcagtgcacattcgccgtgatgcaggcggaatgccgctatggcttgtggtgcctggcggacaagtatactggctgactataagcagcaatggagtcctgaaaagagtgtcagcccaaggctataatctggccttaatgacctatccaggaaacacagggcttctggctaccaaaagtaacg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//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10178 -> Molecular function: GO:0008201 [heparin binding] evidence: TAS
GeneID:10178 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:10178 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: ISS
GeneID:10178 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:10178 -> Biological process: GO:0006359 [regulation of transcription from RNA polymerase III promoter] evidence: ISS
GeneID:10178 -> Biological process: GO:0006950 [response to stress] evidence: IEA
GeneID:10178 -> Biological process: GO:0006955 [immune response] evidence: TAS
GeneID:10178 -> Biological process: GO:0007218 [neuropeptide signaling pathway] evidence: IEA
GeneID:10178 -> Biological process: GO:0007399 [nervous system development] evidence: TAS
GeneID:10178 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: TAS
GeneID:10178 -> Biological process: GO:0030838 [positive regulation of actin filament polymerization] evidence: ISS
GeneID:10178 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: ISS
GeneID:10178 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: ISS
GeneID:10178 -> Biological process: GO:0051491 [positive regulation of filopodium assembly] evidence: ISS
GeneID:10178 -> Biological process: GO:0090316 [positive regulation of intracellular protein transport] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:10178 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005856 [cytoskeleton] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS
GeneID:10178 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: ISS
GeneID:10178 -> Cellular component: GO:0016363 [nuclear matrix] evidence: ISS
GeneID:10178 -> Cellular component: GO:0016607 [nuclear speck] evidence: ISS
GeneID:10178 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: ISS
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