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2024-03-29 08:17:05, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014226               1978 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens MOK protein kinase (MOK), transcript variant 1, mRNA.
ACCESSION   NM_014226
VERSION     NM_014226.2  GI:436408720
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Cha,H.J., Kim,J., Hong,S.M., Hong,S.J., Park,J.H., Kim,E.S.,
            Wang,H.J., Choi,Y.J., Do,I.G., Joh,J.W., Kim,D.S. and Choi,K.Y.
  TITLE     Overexpression of renal tumor antigen is associated with tumor
            invasion and poor prognosis of hepatocellular carcinoma
  JOURNAL   Ann. Surg. Oncol. 19 (SUPPL 3), S404-S411 (2012)
   PUBMED   21717246
  REMARK    GeneRIF: Our results suggest that RAGE may be important in tumor
            invasion and could be a potential predictor for the prognosis of
            hepatocellular carcinoma patients.
            Erratum:[Ann Surg Oncol. 2011 Dec;18 Suppl 3:S321]
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Veloso,C.A., Fernandes,J.S., Volpe,C.M., Fagundes-Netto,F.S.,
            Reis,J.S., Chaves,M.M. and Nogueira-Machado,J.A.
  TITLE     TLR4 and RAGE: similar routes leading to inflammation in type 2
            diabetic patients
  JOURNAL   Diabetes Metab. 37 (4), 336-342 (2011)
   PUBMED   21377387
  REMARK    GeneRIF: PBMNC from type 2 diabetics were more sensitive to innate
            immune stimulation with LPS and monoclonal agonist anti-TLR4 than
            were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE
            potentiated the production of IL-6 and TNF-alpha in both groups.
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Zhang,L., Liu,W., Alizadeh,D., Zhao,D., Farrukh,O., Lin,J.,
            Badie,S.A. and Badie,B.
  TITLE     S100B attenuates microglia activation in gliomas: possible role of
            STAT3 pathway
  JOURNAL   Glia 59 (3), 486-498 (2011)
   PUBMED   21264954
  REMARK    GeneRIF: The RAGE pathway may play an important role in STAT3
            induction in glioma-associated macrophages and microglia, a process
            that may be mediated through S100B.
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Kelley,J.L., Turkheimer,K., Haney,M. and Swanson,W.J.
  TITLE     Targeted resequencing of two genes, RAGE and POLL, confirms
            findings from a genome-wide scan for adaptive evolution and
            provides evidence for positive selection in additional populations
  JOURNAL   Hum. Mol. Genet. 18 (4), 779-784 (2009)
   PUBMED   19060005
  REMARK    GeneRIF: POLL is under genetic selection in Sub-Saharan African
            populations.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Uesaka,T. and Kageyama,N.
  TITLE     Cdx2 homeodomain protein regulates the expression of MOK, a member
            of the mitogen-activated protein kinase superfamily, in the
            intestinal epithelial cells
  JOURNAL   FEBS Lett. 573 (1-3), 147-154 (2004)
   PUBMED   15327990
  REMARK    GeneRIF: identification of MOK, a member of the mitogen-activated
            protein kinase superfamily, as one of the genes induced by a
            caudal-related homeobox transcription factor, Cdx2
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Eichmuller,S., Usener,D., Jochim,A. and Schadendorf,D.
  TITLE     mRNA expression of tumor-associated antigens in melanoma tissues
            and cell lines
  JOURNAL   Exp. Dermatol. 11 (4), 292-301 (2002)
   PUBMED   12190937
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Gotte,K., Usener,D., Riedel,F., Hormann,K., Schadendorf,D. and
            Eichmuller,S.
  TITLE     Tumor-associated antigens as possible targets for immune therapy in
            head and neck cancer: comparative mRNA expression analysis of RAGE
            and GAGE genes
  JOURNAL   Acta Otolaryngol. 122 (5), 546-552 (2002)
   PUBMED   12206267
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat. Biotechnol. 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Miyata,Y., Akashi,M. and Nishida,E.
  TITLE     Molecular cloning and characterization of a novel member of the MAP
            kinase superfamily
  JOURNAL   Genes Cells 4 (5), 299-309 (1999)
   PUBMED   10421840
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Gaugler,B., Brouwenstijn,N., Vantomme,V., Szikora,J.P., Van der
            Spek,C.W., Patard,J.J., Boon,T., Schrier,P. and Van den Eynde,B.J.
  TITLE     A new gene coding for an antigen recognized by autologous cytolytic
            T lymphocytes on a human renal carcinoma
  JOURNAL   Immunogenetics 44 (5), 323-330 (1996)
   PUBMED   8781117
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB037795.1, AB022694.1 and
            DB517173.1.
            On Jan 1, 2013 this sequence version replaced gi:7657497.
            
            Summary: This gene belongs to the MAP kinase superfamily. The gene
            was found to be regulated by caudal type transcription factor 2
            (Cdx2) protein. The encoded protein, which is localized to
            epithelial cells in the intestinal crypt, may play a role in growth
            arrest and differentiation of cells of upper crypt and lower villus
            regions. Multiple alternatively spliced transcript variants
            encoding different isoforms have been observed for this gene.
            [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB022694.1, AK312778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               DB037795.1         1-180
            181-1940            AB022694.1         175-1934
            1941-1978           DB517173.1         164-201
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32"
     gene            1..1978
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="MOK protein kinase"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:9833"
                     /db_xref="HPRD:09310"
                     /db_xref="MIM:605762"
     exon            1..239
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    89..91
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="upstream in-frame stop codon"
     CDS             233..1492
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1;
                     renal cell carcinoma antigen"
                     /codon_start=1
                     /product="MAPK/MAK/MRK overlapping kinase isoform 1"
                     /protein_id="NP_055041.1"
                     /db_xref="GI:7657498"
                     /db_xref="CCDS:CCDS9971.1"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:9833"
                     /db_xref="HPRD:09310"
                     /db_xref="MIM:605762"
                     /translation="
MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
"
     misc_feature    242..1087
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; Region: STKc_MOK;
                     cd07831"
                     /db_xref="CDD:173735"
     misc_feature    242..1087
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(260..271,284..286,323..325,329..331,377..379,
                     422..424,476..487,494..496,500..505,614..616,620..622,
                     626..631,635..637,665..667,674..676,707..709,713..724,
                     728..730,842..844)
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="active site"
                     /db_xref="CDD:173735"
     misc_feature    order(260..271,284..286,323..325,329..331,422..424,
                     476..487,494..496,503..505,626..631,635..637,665..667)
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173735"
     misc_feature    order(377..379,500..502,614..616,620..622,674..676,
                     707..709,713..724,728..730,842..844)
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173735"
     misc_feature    662..730
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173735"
     exon            240..354
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            355..444
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            445..515
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            516..594
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            595..643
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            644..822
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            823..924
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            925..1098
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            1099..1213
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            1214..1414
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     exon            1415..1960
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /inference="alignment:Splign:1.39.8"
     variation       1555
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3087686"
     variation       1706
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201440332"
     variation       1712
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1052780"
     STS             1772..1920
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
                     /standard_name="SGC32568"
                     /db_xref="UniSTS:17065"
     polyA_signal    1919..1924
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
     polyA_site      1950
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
     polyA_site      1960
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1"
ORIGIN      
atcttgcgcatgcgcaggcgacagctcatggcgttcagggcctgacggttgctagggtgacagggacacaacatggcggcgggatctctaacgctctccttcgagggaccaccacggagatcctagtgcgggaccccgcctcagggaagtggaaagcagggggacaaccttcctgcttctttcttttccgtccagtgtcggcaaggggttgtcaccggcttccgcatccaagatgaagaactataaagcaattggcaaaataggagagggaacgttttctgaagttatgaagatgcaaagcctgagagatggaaactactatgcatgtaaacaaatgaagcagcgctttgaaagtattgagcaagtcaacaacctacgagagatccaagcactgaggcgcctgaatccgcacccaaacattcttatgttgcatgaagtggtttttgacagaaaatctggttctcttgcactaatatgtgaacttatggacatgaatatttatgagctaatacgagggagaagatacccattatcagaaaaaaaaattatgcactatatgtaccagttatgtaagtccctggatcatattcacagaaatggaatatttcacagagatgtaaaaccagaaaatatactaataaagcaggatgtcctgaaattaggggactttggctcctgccggagtgtctattccaagcagccgtacacggaatacatctccacccgctggtaccgggccccggagtgtctcctcactgatgggttctacacgtacaagatggacctgtggagcgccggctgtgtgttctacgagatcgccagtctgcagcccctctttcctggagtaaatgaactggaccaaatctcaaaaatccacgatgtcatcggcacacccgctcagaagatcctcaccaagttcaaacagtcgagagctatgaattttgattttccttttaaaaagggatcaggaatacctctactaacaaccaatttgtccccacaatgcctctccctcctgcacgcaatggtggcctatgatcccgatgagagaatcgccgcccaccaggccctgcagcacccctacttccaagaacagaggaaaacagagaagcgggctctgggcagccacagaaaagctggctttccggagcaccctgtggcaccggaaccactcagtaacagctgccagatttccaaggagggcagaaagcagaaacagtccctaaagcaagaggaggaccgtcccaagagacgaggaccggcctatgtcatggaactgcccaaactaaagctttcgggagtggtcagactgtcgtcttactccagccccacgctgcagtccgtgcttggatctggaacaaatggaagagtgccggtgctgagacccttgaagtgcatccctgcgagcaagaagacagatccgcagaaggaccttaagcctgccccgcagcagtgtcgcctgcccaccatagtgcggaaaggcggaagataactgagcagcaccgtcgtctcgacttcggaggcaacaccaagcccgaccgggccaggcctgggtgatctgctgctgagacgccacggagggctggggatgcgcctgcgtccgtttcgcgctggccggggctctgggtgctgccctgcgccctgccgcacccgcggcccgcgcagctgcctaggatgttctgggctaatatacttgtaaaaccaccgcattctagggttttctttcattttcgttaagaatttggggcaggaaatactttgtaactttgtatatgaatcaaaacaaacgagcaggcatttctgtgatgtgttgggcgtggttggaaggtgggttctgcgtgtcccttcccagcgctgctggtcagtcgtggagcgccatcatgtcttaccagtgacgctgctgacacccctgacttttattaaagaataagctgtcgttacagtattgcattttaatgttaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5891 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
            GeneID:5891 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
            GeneID:5891 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
            GeneID:5891 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5891 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
            GeneID:5891 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:5891 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_055041 -> EC 2.7.11.22

by @meso_cacase at DBCLS
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