GGRNA Home | Help | Advanced search

2024-03-28 23:22:05, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014077               1464 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens family with sequence similarity 32, member A (FAM32A),
            mRNA.
ACCESSION   NM_014077
VERSION     NM_014077.2  GI:142377168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Chen,X., Zhang,H., Aravindakshan,J.P., Gotlieb,W.H. and Sairam,M.R.
  TITLE     Anti-proliferative and pro-apoptotic actions of a novel human and
            mouse ovarian tumor-associated gene OTAG-12: downregulation,
            alternative splicing and drug sensitization
  JOURNAL   Oncogene 30 (25), 2874-2887 (2011)
   PUBMED   21339736
  REMARK    GeneRIF: study showed that hOTAG-12b increases mRNAs of
            pro-apoptotic genes such as BAD, GADD45alpha and CIEDB, while
            inhibiting anti-apoptotic NAIP and Akt1 expression, suggesting that
            hOTAG-12b-induced apoptosis might be p53-independent
REFERENCE   2  (bases 1 to 1464)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 1464)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am. J. Hum. Genet. 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1464)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep. 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     PREDICTED REFSEQ: This record has not been reviewed and the
            function is unknown. The reference sequence was derived from
            AL050157.1.
            On Apr 6, 2007 this sequence version replaced gi:7661695.
            
            Sequence Note: removed 1 base from the 5' end that did not align to
            the reference genome assembly.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL050157.1, BC000639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1464              AL050157.1         2-1465
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19pter-p13.3"
     gene            1..1464
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="family with sequence similarity 32, member A"
                     /db_xref="GeneID:26017"
                     /db_xref="HGNC:24563"
                     /db_xref="HPRD:13305"
                     /db_xref="MIM:614554"
     exon            1..93
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:1.39.8"
     variation       7
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146095719"
     CDS             20..358
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /note="ovarian tumor associated gene-12; ovarian
                     tumor-associated gene 12"
                     /codon_start=1
                     /product="protein FAM32A"
                     /protein_id="NP_054796.1"
                     /db_xref="GI:7661696"
                     /db_xref="CCDS:CCDS12341.1"
                     /db_xref="GeneID:26017"
                     /db_xref="HGNC:24563"
                     /db_xref="HPRD:13305"
                     /db_xref="MIM:614554"
                     /translation="
MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK
"
     exon            94..235
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:1.39.8"
     variation       112
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200436861"
     variation       123
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368566995"
     variation       147
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372252218"
     variation       157
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199653947"
     variation       229
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201841128"
     exon            236..289
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:1.39.8"
     variation       257
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202245873"
     variation       258
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200244542"
     variation       274
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145584418"
     variation       280
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376369905"
     exon            290..1449
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /inference="alignment:Splign:1.39.8"
     variation       299
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148445686"
     variation       328
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373088103"
     variation       367
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201483276"
     variation       385
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56084066"
     variation       395
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57818321"
     variation       405
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368543360"
     variation       407
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372809693"
     variation       434
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11541648"
     variation       454
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183916631"
     variation       460
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:375817075"
     variation       562
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115233434"
     variation       597
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:188468975"
     variation       631
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192940284"
     variation       640..641
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="tg"
                     /db_xref="dbSNP:199874860"
     variation       656..657
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34796192"
     variation       679
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11086026"
     variation       843..852
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="agggaagcca"
                     /db_xref="dbSNP:138684561"
     variation       850
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:184743116"
     variation       898
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142108512"
     variation       923
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:137936949"
     variation       979
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188810283"
     variation       983
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:191335394"
     variation       990
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:3837931"
     variation       1032
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371609171"
     variation       1036
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183960174"
     variation       1078
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144821408"
     variation       1112..1113
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:373104885"
     STS             1115..1355
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /standard_name="A001W39"
                     /db_xref="UniSTS:5587"
     variation       1192
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189432966"
     STS             1219..1346
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /standard_name="RH47532"
                     /db_xref="UniSTS:56791"
     STS             1295..1406
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /standard_name="D19S655E"
                     /db_xref="UniSTS:86223"
     variation       1339
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112641300"
     variation       1347
                     /gene="FAM32A"
                     /gene_synonym="OTAG-12; OTAG12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376674323"
ORIGIN      
cgaagcactggagagtgtcatggaggcctacgagcaggtccaaaagggacccctgaagctgaaaggcgtcgcagagctgggagtgaccaagcggaagaagaaaaagaaggacaaagacaaagcgaaactcctggaagcaatgggaacgagcaaaaagaacgaggaggagaagcggcgcggcctggacaagcggaccccggcccaggcggccttcgagaaaatgcaggagaagcggcaaatggaaaggatcctaaagaaggcatccaaaacccacaagcagagagtggaggacttcaacagacacctggacacactcacggagcattacgacattcccaaagtcagctggacgaagtagccgcctgcccccagtatggagcagcatcgagggttcgcaaaaggccacactggggttgtgtgtgtttcctttggtatattctggaaacatggctacacacacccttgcatcttctgctacagactgcttttcgaagctgtgtaccctcattctggaacttgattaaagtaagatcgtccttgtactcagtttaggcttcttggcaacatacagaagatacacccttttcgtttggatggaaagtttctaagtttatccagaggtaaagcccattgtgtgtctgtgtcatgtaaaaatgttttcacccgagttgcatgtaatgctctgaggccagccagctgtcttctcctggatgagacagactccagagggtaaggagctagcgccatggtggcctgcagtatgcagagccccgcaggacccagcgtgggcgcccttccaagcttcctctagctttgggcctatgctgtcccctgcaggccctagggaagccacttgcaactatgcggccttcagacttcctcctcagccacctggccactgagacagcatagcctgggtaacggaacagccacctaaggcaagaatggaacggacacaccttgctcctttctgagcccgtttcccaaaaccccccttccaggtgcttctaatgggtgttgccatagcagacgctgctaatgcatcacagcattctttgaaatggaaccagacacagcctgcctctcaatcctcagctgggggctcctagcagcctcttgtatttactcagagttgacacatcacacagatcctgtttggcattcctaccttacggacgtctcaggggtgacaggaccagggcagagccccggtacaaacagacaaggctgcagtcaaatgggagggtccaggtgtccgtgttggagggctgggatcttgtagggcctgtgcgtcctggctgaggatcaaaccacatatgttattgggagaaacgatttctgttgacgtagatattgaaagaataatgaaggcagaagagaaaaacgaagtgtggaatttggggttgtcctgtgtaaattacacaataaagcaaaagtcagttattgtaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:26017 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
            GeneID:26017 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:26017 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:26017 -> Biological process: GO:0008150 [biological_process] evidence: ND
            GeneID:26017 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.