2024-03-28 23:22:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014077 1464 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens family with sequence similarity 32, member A (FAM32A), mRNA. ACCESSION NM_014077 VERSION NM_014077.2 GI:142377168 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1464) AUTHORS Chen,X., Zhang,H., Aravindakshan,J.P., Gotlieb,W.H. and Sairam,M.R. TITLE Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization JOURNAL Oncogene 30 (25), 2874-2887 (2011) PUBMED 21339736 REMARK GeneRIF: study showed that hOTAG-12b increases mRNAs of pro-apoptotic genes such as BAD, GADD45alpha and CIEDB, while inhibiting anti-apoptotic NAIP and Akt1 expression, suggesting that hOTAG-12b-induced apoptosis might be p53-independent REFERENCE 2 (bases 1 to 1464) AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V., Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S. CONSRTM DREAM investigators TITLE Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study JOURNAL Diabetes Care 33 (10), 2250-2253 (2010) PUBMED 20628086 REMARK GeneRIF: Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) REFERENCE 3 (bases 1 to 1464) AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C., Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R., Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A., Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C., Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S., Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N., Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D. CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium TITLE Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009) PUBMED 19913121 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 1464) AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and Wiemann,S. TITLE Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing JOURNAL EMBO Rep. 1 (3), 287-292 (2000) PUBMED 11256614 COMMENT PREDICTED REFSEQ: This record has not been reviewed and the function is unknown. The reference sequence was derived from AL050157.1. On Apr 6, 2007 this sequence version replaced gi:7661695. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly. ##Evidence-Data-START## Transcript exon combination :: AL050157.1, BC000639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1464 AL050157.1 2-1465 FEATURES Location/Qualifiers source 1..1464 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19pter-p13.3" gene 1..1464 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /note="family with sequence similarity 32, member A" /db_xref="GeneID:26017" /db_xref="HGNC:24563" /db_xref="HPRD:13305" /db_xref="MIM:614554" exon 1..93 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /inference="alignment:Splign:1.39.8" variation 7 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="c" /db_xref="dbSNP:146095719" CDS 20..358 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /note="ovarian tumor associated gene-12; ovarian tumor-associated gene 12" /codon_start=1 /product="protein FAM32A" /protein_id="NP_054796.1" /db_xref="GI:7661696" /db_xref="CCDS:CCDS12341.1" /db_xref="GeneID:26017" /db_xref="HGNC:24563" /db_xref="HPRD:13305" /db_xref="MIM:614554" /translation="
MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK
" exon 94..235 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /inference="alignment:Splign:1.39.8" variation 112 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="c" /db_xref="dbSNP:200436861" variation 123 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="g" /db_xref="dbSNP:368566995" variation 147 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:372252218" variation 157 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="g" /db_xref="dbSNP:199653947" variation 229 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:201841128" exon 236..289 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /inference="alignment:Splign:1.39.8" variation 257 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:202245873" variation 258 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="c" /db_xref="dbSNP:200244542" variation 274 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:145584418" variation 280 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="g" /replace="t" /db_xref="dbSNP:376369905" exon 290..1449 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /inference="alignment:Splign:1.39.8" variation 299 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:148445686" variation 328 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:373088103" variation 367 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:201483276" variation 385 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:56084066" variation 395 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:57818321" variation 405 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="t" /db_xref="dbSNP:368543360" variation 407 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:372809693" variation 434 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="t" /db_xref="dbSNP:11541648" variation 454 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:183916631" variation 460 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="c" /db_xref="dbSNP:375817075" variation 562 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:115233434" variation 597 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="g" /replace="t" /db_xref="dbSNP:188468975" variation 631 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:192940284" variation 640..641 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="tg" /db_xref="dbSNP:199874860" variation 656..657 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="t" /db_xref="dbSNP:34796192" variation 679 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:11086026" variation 843..852 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="agggaagcca" /db_xref="dbSNP:138684561" variation 850 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="g" /db_xref="dbSNP:184743116" variation 898 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="t" /db_xref="dbSNP:142108512" variation 923 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="g" /db_xref="dbSNP:137936949" variation 979 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:188810283" variation 983 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="c" /db_xref="dbSNP:191335394" variation 990 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="g" /db_xref="dbSNP:3837931" variation 1032 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:371609171" variation 1036 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="g" /db_xref="dbSNP:183960174" variation 1078 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:144821408" variation 1112..1113 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="" /replace="c" /db_xref="dbSNP:373104885" STS 1115..1355 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /standard_name="A001W39" /db_xref="UniSTS:5587" variation 1192 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:189432966" STS 1219..1346 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /standard_name="RH47532" /db_xref="UniSTS:56791" STS 1295..1406 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /standard_name="D19S655E" /db_xref="UniSTS:86223" variation 1339 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="c" /replace="t" /db_xref="dbSNP:112641300" variation 1347 /gene="FAM32A" /gene_synonym="OTAG-12; OTAG12" /replace="a" /replace="g" /db_xref="dbSNP:376674323" ORIGIN
cgaagcactggagagtgtcatggaggcctacgagcaggtccaaaagggacccctgaagctgaaaggcgtcgcagagctgggagtgaccaagcggaagaagaaaaagaaggacaaagacaaagcgaaactcctggaagcaatgggaacgagcaaaaagaacgaggaggagaagcggcgcggcctggacaagcggaccccggcccaggcggccttcgagaaaatgcaggagaagcggcaaatggaaaggatcctaaagaaggcatccaaaacccacaagcagagagtggaggacttcaacagacacctggacacactcacggagcattacgacattcccaaagtcagctggacgaagtagccgcctgcccccagtatggagcagcatcgagggttcgcaaaaggccacactggggttgtgtgtgtttcctttggtatattctggaaacatggctacacacacccttgcatcttctgctacagactgcttttcgaagctgtgtaccctcattctggaacttgattaaagtaagatcgtccttgtactcagtttaggcttcttggcaacatacagaagatacacccttttcgtttggatggaaagtttctaagtttatccagaggtaaagcccattgtgtgtctgtgtcatgtaaaaatgttttcacccgagttgcatgtaatgctctgaggccagccagctgtcttctcctggatgagacagactccagagggtaaggagctagcgccatggtggcctgcagtatgcagagccccgcaggacccagcgtgggcgcccttccaagcttcctctagctttgggcctatgctgtcccctgcaggccctagggaagccacttgcaactatgcggccttcagacttcctcctcagccacctggccactgagacagcatagcctgggtaacggaacagccacctaaggcaagaatggaacggacacaccttgctcctttctgagcccgtttcccaaaaccccccttccaggtgcttctaatgggtgttgccatagcagacgctgctaatgcatcacagcattctttgaaatggaaccagacacagcctgcctctcaatcctcagctgggggctcctagcagcctcttgtatttactcagagttgacacatcacacagatcctgtttggcattcctaccttacggacgtctcaggggtgacaggaccagggcagagccccggtacaaacagacaaggctgcagtcaaatgggagggtccaggtgtccgtgttggagggctgggatcttgtagggcctgtgcgtcctggctgaggatcaaaccacatatgttattgggagaaacgatttctgttgacgtagatattgaaagaataatgaaggcagaagagaaaaacgaagtgtggaatttggggttgtcctgtgtaaattacacaataaagcaaaagtcagttattgtaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:26017 -> Molecular function: GO:0003674 [molecular_function] evidence: ND GeneID:26017 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:26017 -> Biological process: GO:0007049 [cell cycle] evidence: IEA GeneID:26017 -> Biological process: GO:0008150 [biological_process] evidence: ND GeneID:26017 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
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