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2024-04-24 20:35:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_013434 2928 bp mRNA linear PRI 09-JUN-2013
DEFINITION Homo sapiens Kv channel interacting protein 3, calsenilin (KCNIP3),
transcript variant 1, mRNA.
ACCESSION NM_013434
VERSION NM_013434.4 GI:78190493
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2928)
AUTHORS Holliday,K.L., McBeth,J., Macfarlane,G., Huhtaniemi,I.T.,
Bartfai,G., Casanueva,F.F., Forti,G., Kula,K., Punab,M.,
Vanderschueren,D., Wu,F.C. and Thomson,W.
TITLE Investigating the role of pain-modulating pathway genes in
musculoskeletal pain
JOURNAL Eur J Pain 17 (1), 28-34 (2013)
PUBMED 22730276
REMARK GeneRIF: Genetic variation in the DREAM pathway genes was
associated with the extent of pain reporting in a population-based
cohort.
REFERENCE 2 (bases 1 to 2928)
AUTHORS Quaas,M., Muller,G.A. and Engeland,K.
TITLE p53 can repress transcription of cell cycle genes through a
p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex
binding at CHR promoter elements
JOURNAL Cell Cycle 11 (24), 4661-4672 (2012)
PUBMED 23187802
REMARK GeneRIF: p53 can repress transcription of cell cycle genes through
a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex
binding at CHR promoter elements.
REFERENCE 3 (bases 1 to 2928)
AUTHORS Ramachandran,P.L., Craig,T.A., Atanasova,E.A., Cui,G., Owen,B.A.,
Bergen,H.R. III, Mer,G. and Kumar,R.
TITLE The potassium channel interacting protein 3 (DREAM/KChIP3)
heterodimerizes with and regulates calmodulin function
JOURNAL J. Biol. Chem. 287 (47), 39439-39448 (2012)
PUBMED 23019329
REMARK GeneRIF: The potassium channel interacting protein 3 (DREAM/KChIP3)
heterodimerizes with and regulates calmodulin function.
REFERENCE 4 (bases 1 to 2928)
AUTHORS Jang,C., Choi,J.K., Na,Y.J., Jang,B., Wasco,W., Buxbaum,J.D.,
Kim,Y.S. and Choi,E.K.
TITLE Calsenilin regulates presenilin 1/gamma-secretase-mediated
N-cadherin epsilon-cleavage and beta-catenin signaling
JOURNAL FASEB J. 25 (12), 4174-4183 (2011)
PUBMED 21852538
REMARK GeneRIF: expression of calsenilin leads to a disruption of
presenilin 1/gamma-secretase-mediated epsilon-cleavage of
N-cadherin, which results in the significant accumulation of
N-cadherin C-terminal fragment 1
REFERENCE 5 (bases 1 to 2928)
AUTHORS Nor Rashid,N., Yusof,R. and Watson,R.J.
TITLE Disruption of repressive p130-DREAM complexes by human
papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle
progression in cervical cancer cells
JOURNAL J. Gen. Virol. 92 (PT 11), 2620-2627 (2011)
PUBMED 21813705
REMARK GeneRIF: The results show that continued human papillomavirus 16
E6/E7 expression is necessary in cervical cancer cells to prevent
cell-cycle arrest by a repressive p130-DREAM complex.
REFERENCE 6 (bases 1 to 2928)
AUTHORS Leissring,M.A., Yamasaki,T.R., Wasco,W., Buxbaum,J.D., Parker,I.
and LaFerla,F.M.
TITLE Calsenilin reverses presenilin-mediated enhancement of calcium
signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (15), 8590-8593 (2000)
PUBMED 10900016
REFERENCE 7 (bases 1 to 2928)
AUTHORS An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
Rhodes,K.J.
TITLE Modulation of A-type potassium channels by a family of calcium
sensors
JOURNAL Nature 403 (6769), 553-556 (2000)
PUBMED 10676964
REFERENCE 8 (bases 1 to 2928)
AUTHORS Carrion,A.M., Link,W.A., Ledo,F., Mellstrom,B. and Naranjo,J.R.
TITLE DREAM is a Ca2+-regulated transcriptional repressor
JOURNAL Nature 398 (6722), 80-84 (1999)
PUBMED 10078534
REFERENCE 9 (bases 1 to 2928)
AUTHORS Carrion,A.M., Mellstrom,B. and Naranjo,J.R.
TITLE Protein kinase A-dependent derepression of the human prodynorphin
gene via differential binding to an intragenic silencer element
JOURNAL Mol. Cell. Biol. 18 (12), 6921-6929 (1998)
PUBMED 9819380
REFERENCE 10 (bases 1 to 2928)
AUTHORS Buxbaum,J.D., Choi,E.K., Luo,Y., Lilliehook,C., Crowley,A.C.,
Merriam,D.E. and Wasco,W.
TITLE Calsenilin: a calcium-binding protein that interacts with the
presenilins and regulates the levels of a presenilin fragment
JOURNAL Nat. Med. 4 (10), 1177-1181 (1998)
PUBMED 9771752
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX491997.1, BI755669.1 and
BC012850.1.
On Oct 27, 2005 this sequence version replaced gi:27894379.
Summary: This gene encodes a member of the family of voltage-gated
potassium (Kv) channel-interacting proteins, which belong to the
recoverin branch of the EF-hand superfamily. Members of this family
are small calcium binding proteins containing EF-hand-like domains.
They are integral subunit components of native Kv4 channel
complexes that may regulate A-type currents, and hence neuronal
excitability, in response to changes in intracellular calcium. The
encoded protein also functions as a calcium-regulated
transcriptional repressor, and interacts with presenilins.
Alternatively spliced transcript variants encoding different
isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ131730.2, AL536227.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-32 BX491997.1 2-33
33-81 BI755669.1 64-112
82-1043 BC012850.1 1-962
1044-2928 BC012850.1 965-2849
FEATURES Location/Qualifiers
source 1..2928
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q21.1"
gene 1..2928
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Kv channel interacting protein 3, calsenilin"
/db_xref="GeneID:30818"
/db_xref="HGNC:15523"
/db_xref="HPRD:05232"
/db_xref="MIM:604662"
exon 1..130
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 9
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:367679428"
misc_feature 29..31
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="upstream in-frame stop codon"
variation 43
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:11674135"
variation 70
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:113604413"
variation 108
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372889311"
CDS 116..886
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="isoform 1 is encoded by transcript variant 1;
calsenilin, presenilin-binding protein, EF hand
transcription factor; DRE-antagonist modulator; A-type
potassium channel modulatory protein 3; potassium channel
interacting protein 3; kv channel-interacting protein 3"
/codon_start=1
/product="calsenilin isoform 1"
/protein_id="NP_038462.1"
/db_xref="GI:7305199"
/db_xref="CCDS:CCDS2013.1"
/db_xref="GeneID:30818"
/db_xref="HGNC:15523"
/db_xref="HPRD:05232"
/db_xref="MIM:604662"
/translation="
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
"
misc_feature 242..244
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Region: alternate start codon"
misc_feature 248..250
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/experiment="experimental evidence, no additional details
recorded"
/note="palmitoylation site; modified site"
misc_feature 251..253
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/experiment="experimental evidence, no additional details
recorded"
/note="palmitoylation site; modified site"
misc_feature 302..304
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK1; propagated from
UniProtKB/Swiss-Prot (Q9Y2W7.1); phosphorylation site"
misc_feature 305..307
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02799"
misc_feature 350..850
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+-binding protein (EF-Hand superfamily) [Signal
transduction mechanisms / Cytoskeleton / Cell division and
chromosome partitioning / General function prediction
only]; Region: FRQ1; COG5126"
/db_xref="CDD:34727"
misc_feature 503..691
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(530..532,536..538,542..544,563..565,638..640,
644..646,650..652,671..673)
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 611..829
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(638..640,644..646,650..652,671..673,782..784,
788..790,794..796,815..817)
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 842..883
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y2W7.1);
Region: Interaction with KCND2 (By similarity)"
exon 131..296
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 142
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11895635"
variation 145
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146247024"
variation 147
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149504046"
variation 173
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142066393"
variation 180
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:141559644"
variation 218
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373425399"
variation 220
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377150082"
variation 231
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35516857"
variation 295
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201339473"
exon 297..421
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 304
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:368408153"
variation 305
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199867139"
variation 332
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199540663"
variation 333
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370915474"
STS 338..464
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="MARC_13819-13820:1006878275:1"
/db_xref="UniSTS:267569"
STS 370..468
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="MARC_16025-16026:1017084488:1"
/db_xref="UniSTS:267937"
variation 374
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:145627120"
variation 376
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374545956"
STS 380..734
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="Kcnip3"
/db_xref="UniSTS:478921"
variation 397
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:368795741"
exon 422..491
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 432
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:141060640"
variation 469
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187761251"
variation 471
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:35658670"
variation 486..487
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="g"
/db_xref="dbSNP:35743633"
exon 492..562
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 502
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138182369"
variation 534
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199875087"
variation 535
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374058648"
variation 539
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144496841"
variation 544
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376244075"
exon 563..670
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 572
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:141755482"
variation 634
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:147356740"
variation 637
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145007185"
variation 638
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148795481"
variation 657
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:151292265"
exon 671..775
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 673
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:146570394"
variation 674
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="t"
/db_xref="dbSNP:368098567"
variation 685
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371878238"
variation 697
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:113278660"
variation 732
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201212949"
variation 742
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370900651"
variation 744
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367742048"
variation 745
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200368654"
variation 748
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138092705"
exon 776..838
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 806
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:373974351"
exon 839..2914
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/inference="alignment:Splign:1.39.8"
variation 878
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143143467"
variation 889
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375950494"
STS 890..1065
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="D2S2159"
/db_xref="UniSTS:9796"
variation 902
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369341853"
variation 903
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:201316906"
variation 953..954
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="t"
/db_xref="dbSNP:34912974"
variation 1006..1009
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/db_xref="dbSNP:375367798"
variation 1007..1008
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/db_xref="dbSNP:72135616"
variation 1014..1015
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ac"
/replace="cacacacaca"
/db_xref="dbSNP:10656976"
variation 1016..1017
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ca"
/replace="cacaca"
/db_xref="dbSNP:67633424"
variation 1043..1044
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="ca"
/replace="cacaca"
/db_xref="dbSNP:58903840"
variation 1143
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:149210524"
variation 1148
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:143382219"
variation 1155
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:6730587"
variation 1238..1239
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace=""
/replace="g"
/db_xref="dbSNP:35454355"
variation 1267
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376247477"
variation 1671
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:190606635"
variation 1777
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374641024"
variation 1786
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368385894"
STS 1849..1973
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/standard_name="RH18424"
/db_xref="UniSTS:58637"
variation 1905
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:115648949"
variation 2008
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:183191177"
variation 2077
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371897976"
variation 2109
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373407358"
variation 2198
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376849218"
variation 2330
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:185608702"
variation 2395
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:115884085"
variation 2582
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3732333"
variation 2630
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140694377"
variation 2695
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:15981"
variation 2711
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:17119268"
variation 2819
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367927662"
variation 2831
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371747275"
polyA_signal 2892..2897
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
polyA_signal 2897..2902
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
polyA_site 2914
/gene="KCNIP3"
/gene_synonym="CSEN; DREAM; KCHIP3"
ORIGIN
gacaattacgtctgggtccaagcaaacatgaggcagctgccagccggcctgggcagtcttgtctgcctcggctgtgaagtggggaggctggcaacagttttcttcagcgcccaggatgcagccggctaaggaagtgacaaaggcgtcggacggcagcctcctgggggacctcgggcacacaccacttagcaagaaggagggtatcaagtggcagaggccgaggctcagccgccaggctttgatgagatgctgcctggtcaagtggatcctgtccagcacagccccacagggctcagatagcagcgacagtgagctggagctgtccacggtgcgccaccagccagaggggctggaccagctgcaggcccagaccaagttcaccaagaaggagctgcagtctctctacaggggctttaagaatgagtgtcccacgggcctggtggacgaagacaccttcaaactcatttacgcgcagttcttccctcagggagatgccaccacctatgcacacttcctcttcaacgcctttgatgcggacgggaacggggccatccactttgaggactttgtggttggcctctccatcctgctgcggggcacagtccacgagaagctcaagtgggcctttaatctctacgacattaacaaggatggctacatcaccaaagaggagatgctggccatcatgaagtccatctatgacatgatgggccgccacacctaccccatcctgcgggaggacgcgccggcggagcacgtggagaggttcttcgagaaaatggaccggaaccaggatggggtagtgaccattgaagagttcctggaggcctgtcagaaggatgagaacatcatgagctccatgcagctgtttgagaatgtcatctaggacacgtccaaaggagtgcatggccacagccacctccacccccaagaaacctccatcctgccaggagcagcctccaagaaacttttaaaaaatagatttgcaaaaagtgaacagattgctacacacacacacacacacacacacacacacacacacagccattcatctgggctggcagaggggacagagttcagggaggggctgagtctggctaggggccgagtccaggagccccagccagcccttcccaggccagcgaggcgaggctgcctctgggtgagtggctgacagagcaggtctgcaggccaccagctgctggatgtcaccaagaaggggctcgagtgcccctgcaggggagggtccaatctccggtgtgagcccacctcgtcccgttctccattctgctttcttgccacacagtgggccggccccaggctcccctggtctcctccccgtagccactctctgcccactacctatgcttctagaaagcccctcacctcaggaccccagagggaccagctggggggcaggggggagagggggtaatggaggccaagcctgcagctttctggaaattcttccctgggggtcccaggatcccctgctactccactgacctggaagagctgggtaccaggccacccactgtggggcaagcctgagtggtgaggggccactgggccccattctccctccatggcaggaaggcgggggatttcaagtttagggattgggtcgtggtggagaatctgagggcactctctgccagctccacagggtgggatgagcctctccttgccccagtcctggttcagtgggaatgcagtgggtggggctgtacacaccctccagcacagactgttccctccaaggtcctcttaggtcccgggaggaacgtggttcagagactggcagccagggagcccggggcagagctcagaggagtctgggaaggggcgtgtccctcctcttcctgtagtgcccctcccatggcccagcagcttggctgagccccctctcctgaagcagtgtcgccgtccctctgccttgcacaaaaagcacaagcattccttagcagctcaggcgcagccctagtgggagcccagcacactgcttctcggaggccaggccctcctgctggctgaggcttgggcccagtagccccaatatggtggccctggggaagaggccttgggggtctgctctgtgcctgggatcagtggggccccaaagcccagcccggctgaccaacattcaaaagcacaaaccctggggactctgcttggctgtcccctccatctggggatggagaatgccagcccaaagctggagccaatggtgagggctgagagggctgtggctgggtggtcagcagaaacccccaggaggagagagatgctgctcccgcctgattggggcctcacccagaaggaacccggtcccaggccgcatggcccctccaggaacattcccacataatacattccatcacagccagcccagctccactcagggctggcccggggagtccccgtgtgccccaagaggctagccccagggtgagcagggccctcagaggaaaggcagtatggcggaggccatgggggcccctcggcattcacacacagcctggcctcccctgcggagctgcatggacgcctggctccaggctccaggctgactgggggcctctgcctccaggagggcatcagctttccctggctcagggatcttctccctcccctcacccgctgcccagccctcccagctggtgtcactctgcctctaaggccaaggcctcaggagagcatcaccaccacacccctgccggccttggccttggggccagactggctgcacagcccaaccaggaggggtctgcctcccacgctgggacacagaccggccgcatgtctgcatggcagaagcgtctcccttggccacggcctgggagggtggttcctgttctcagcatccactaatattcagtcctgtatattttaataaaataaacttgacaaaggaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:30818 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: TAS
GeneID:30818 -> Molecular function: GO:0005244 [voltage-gated ion channel activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0005267 [potassium channel activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IEA
GeneID:30818 -> Molecular function: GO:0015459 [potassium channel regulator activity] evidence: IEA
GeneID:30818 -> Molecular function: GO:0048306 [calcium-dependent protein binding] evidence: IEA
GeneID:30818 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:30818 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:30818 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:30818 -> Biological process: GO:0006886 [intracellular protein transport] evidence: IEA
GeneID:30818 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:30818 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:30818 -> Biological process: GO:0007610 [behavior] evidence: IEA
GeneID:30818 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
GeneID:30818 -> Biological process: GO:0043523 [regulation of neuron apoptotic process] evidence: IEA
GeneID:30818 -> Biological process: GO:0048265 [response to pain] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:30818 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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