Home |
Help |
Advanced search
2024-04-19 22:40:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_013399 2742 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens cell death-inducing p53 target 1 (CDIP1), transcript
variant 2, mRNA.
ACCESSION NM_013399
VERSION NM_013399.2 GI:118344449
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2742)
AUTHORS Brown-Endres,L., Schoenfeld,D., Tian,F., Kim,H.G., Namba,T.,
Munoz-Fontela,C., Mandinova,A., Aaronson,S.A. and Lee,S.W.
TITLE Expression of the p53 target CDIP correlates with sensitivity to
TNFalpha-induced apoptosis in cancer cells
JOURNAL Cancer Res. 72 (9), 2373-2382 (2012)
PUBMED 22549949
REMARK GeneRIF: CDIP expression correlates with sensitivity of cancer
cells with TNFalpha, and CDIP seems to be a regulator of the
p53-mediated death versus survival response of cells to TNFalpha.
REFERENCE 2 (bases 1 to 2742)
AUTHORS Brown,L., Ongusaha,P.P., Kim,H.G., Nuti,S., Mandinova,A., Lee,J.W.,
Khosravi-Far,R., Aaronson,S.A. and Lee,S.W.
TITLE CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated
apoptosis in a p53-dependent manner
JOURNAL EMBO J. 26 (14), 3410-3422 (2007)
PUBMED 17599062
REMARK GeneRIF: These findings support a novel p53 --> CDIP --> TNF-alpha
apoptotic pathway that directs apoptosis after exposure of cells to
genotoxic stress.
REFERENCE 3 (bases 1 to 2742)
AUTHORS Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
TITLE A germline-specific class of small RNAs binds mammalian Piwi
proteins
JOURNAL Nature 442 (7099), 199-202 (2006)
PUBMED 16751776
REFERENCE 4 (bases 1 to 2742)
AUTHORS Bhalla,K., Eyre,H.J., Whitmore,S.A., Sutherland,G.R. and
Callen,D.F.
TITLE C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed
in the brain
JOURNAL J. Hum. Genet. 44 (6), 383-387 (1999)
PUBMED 10570909
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DA055704.1, BC002882.2 and AC007606.8.
On Nov 23, 2006 this sequence version replaced gi:7019336.
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 both encode the same isoform (a).
##Evidence-Data-START##
Transcript exon combination :: DQ167023.1, AL136698.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-54 DA055704.1 14-67
55-2093 BC002882.2 1-2039
2094-2742 AC007606.8 59240-59888 c
FEATURES Location/Qualifiers
source 1..2742
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..2742
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/note="cell death-inducing p53 target 1"
/db_xref="GeneID:29965"
/db_xref="HGNC:13234"
/db_xref="MIM:610503"
exon 1..114
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
exon 115..204
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
misc_feature 201..203
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/note="upstream in-frame stop codon"
exon 205..303
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
CDS 219..845
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/note="isoform a is encoded by transcript variant 2;
LITAF-like protein; cell death inducing protein;
transmembrane protein I1; cell death-inducing protein;
cell death involved p53-target; lipopolysaccharide-induced
tumor necrosis factor-alpha-like protein; cell
death-inducing p53-target protein 1"
/codon_start=1
/product="cell death-inducing p53-target protein 1 isoform
a"
/protein_id="NP_037531.2"
/db_xref="GI:118344450"
/db_xref="CCDS:CCDS42114.1"
/db_xref="GeneID:29965"
/db_xref="HGNC:13234"
/db_xref="MIM:610503"
/translation="
MSSEPPPPYPGGPTAPLLEEKSGAPPTPGRSSPAVMQPPPGMPLPPADIGPPPYEPPGHPMPQPGFIPPHMSADGTYMPPGFYPPPGPHPPMGYYPPGPYTPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYIYTYKRLC
"
misc_feature 627..836
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/note="LITAF-like zinc ribbon domain; Region:
zf-LITAF-like; pfam10601"
/db_xref="CDD:204526"
exon 304..459
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
exon 460..733
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
exon 734..2742
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/inference="alignment:Splign:1.39.8"
STS 1177..1304
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/standard_name="SHGC-60771"
/db_xref="UniSTS:77968"
STS 1725..1986
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/standard_name="SHGC-60849"
/db_xref="UniSTS:58310"
variation 1824
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:200555498"
STS 1889..2062
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/standard_name="D16S2655"
/db_xref="UniSTS:152395"
variation 1942
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/replace="g"
/replace="t"
/db_xref="dbSNP:17137100"
STS 2582..2687
/gene="CDIP1"
/gene_synonym="C16orf5; CDIP; I1; LITAFL"
/standard_name="SHGC-61112"
/db_xref="UniSTS:51490"
ORIGIN
gggcctcggccctggtccaaagtctacccgcctccttgtgacagaagtgcgactgccagctgccgaggcgttcggtcctgctgttgcggccgctgccccagggctgcggggacgctcccggagccctgcctgttccctgtccatccaggccagcagctgaaggagcctcacctgcctcccttctctgagtagcacggatttgaggagaagcagcgaagatgtccagcgagcctccccctccttatcctgggggccccacagccccacttctggaagagaaaagtggagccccgcccaccccaggccgttcctccccagctgtgatgcagccccctccaggcatgccactgccccctgcggacattggccccccaccctatgagccgccgggtcacccaatgccccagcctggcttcatcccaccacacatgagtgcagatggcacctacatgcctccgggtttctaccctcctccaggcccccacccacccatgggctactaccccccagggccctacacgccagggccctaccctggccctgggggccacacagccacagtcctggtcccttcaggagctgccaccacggtgacagtgctgcagggagagatctttgagggagcgcctgtgcagacggtgtgtccccactgccagcaggccatcaccaccaagatctcctacgagattggcttgatgaatttcgtgctgggtttcttctgttgcttcatgggatgtgatctgggctgctgcctgatcccctgcctcatcaatgacttcaaggatgtgacgcacacatgccccagctgcaaagcctacatctacacgtacaagcgcctgtgctaacggagctgggactcgggactcccccgcctgtcagtctggccccctgtgctttgctccctgtgctcagtggtcactttcccgctcccacttggggctgggagccgtgccaccatcccctagaagtcctgtcctcttcaccctgccctacctgagccgctgactcttctggcaaaaattctgttgggatttaaggccaagggtcagtgggtggcagggggctgacaatgagcttgtgtgttgttggtctgcttggtgtgtgtgatcgggaagataagctgggaggggtctcctgctggggtcctgatgcctctgtttccaaacaaggtacaggttcagtccagactctttccccctgggaccaacagcagccagagcagttagccagttagtccccaggcctgtggccacaggcgtttctgacctgctgggccgagaatgggtaagttgtctggagtcaggtgggcccacgtaggacagggtcacaaagcctgggtttgtttctgggtactttgcgcctctggggtgctagaggtggggcatggtggctggaagtaaaactgccaactctggccctcagaactctcaggtatagaagcccaggatgtctaataccctgtcccagtgcccgagagctgcctggtgtcaggtagagaggacactgtacctgggtgaatgatcagaccctggtagctaagaaggaacttgtccctttgagtcagtgtgcagaccccctttcaggccatgcctctgtgaaccctgtattgctggggccggaaggagcccctgagcctagccccttcccgtctgccctgtgtcctcactgcgtgtgggtatgacctctgcctggtggctggtgtatcccaactgggcaagagatggcagagggtcccccttgtgggtgcgcttggatgtgcagagccttctccatggattttcttccctgtaagtgccgggcccctcaccccagctgacaggctgttgctgtgcctgctcacacctgctcctgcaggcacactgggctagggacgaggaaggagcagccacaagtggtagaactgccttggtggacaccagcctcgccctgtctttatttcctgaatggtttgtgaacttgctcacctggaccactgtatcctgccactgtccttcctggtctcgcactgccactgcatggcctcctgtcactgtgaatcgtggcccagtctcagtttgtagtttctcattaaattggccctttcactcccccgccctgggcctctgctctcttgcctggcttccttcttttttgagggaaagagggtggggctgcaggcagtctactggcaggacgggaggctgagtcctcagggtctcacaccctcagtgctgatgccatgccaactgcctgggacaacaccaacacgtaaggacctaattaaaccaaaccagagtcgggtgtagaccagccctgggatttccagctgtgactgggccagggcacacgttggtctcggcagtggctgtaaggtcaccttccttcctctgatgctggtttcaaccatctatatatggcatccacgcatgggatctgcaagctggagccctcctacccgcaggcttgagcacagcatcatccagccctggggaggcgcacccttaagcaacacagactgggctgaggctgacaggcagaagactaacagagcgcagtctgcacacgcaggttctgggcgacctctggccctggccatctctgcactaactcatctgaattatgaaggtggcagtcttggtcagtagtttaaagagtttccctactttttaaccctttttgaaataaaacttttacaggtagtagattcctattaataaaattatttaagttcatgtttctcttttagagaatgaattgtttaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:29965 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:29965 -> Biological process: GO:0006915 [apoptotic process] evidence: IGI
GeneID:29965 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IDA
GeneID:29965 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IGI
GeneID:29965 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IMP
GeneID:29965 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:29965 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.